Abstract:
:An assessment of multiple biomarkers from radiation casualties undergoing limited- or full-supportive care including treatment with filgrastim is critical to develop rapid and effective diagnostic triage strategies. The efficacy of filgrastim with full-supportive care was compared with results with limited-supportive care by analyzing survival, necropsy, histopathology and serial blood samples for hematological, serum chemistry and protein profiles in a non-human primate (Macaca mulatta, male and female) model during 60-d post-monitoring period following sham- and total-body irradiation with 6.5 Gy 60Co gamma-rays at 0.6 Gy min-1 Filgrastim (10 μg kg-1) was administered beginning on Day 1 post-exposure and continued daily until neutrophil counts were ≥2,000 μL-1 for two consecutive days. Filgrastim and full-supportive care significantly decreased the pancytopenia duration and resulted in improved animal survival and recovery compared to animals with a limited-supportive care. These findings also identified and validated a multiparametric biomarker panel to support radiation diagnostic device development.
journal_name
Radiat Prot Dosimetryjournal_title
Radiation protection dosimetryauthors
Ossetrova NI,Blakely WF,Nagy V,McGann C,Ney PH,Christensen CL,Koch AL,Gulani J,Sigal GB,Glezer EN,Hieber KPdoi
10.1093/rpd/ncw176subject
Has Abstractpub_date
2016-12-01 00:00:00pages
174-191issue
1-3eissn
0144-8420issn
1742-3406pii
ncw176journal_volume
172pub_type
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