Abstract:
:The design and dosimetry of a novel in vitro radon irradiation facility to investigate cytogenetic damage induced by radon and progeny is described. The system offers a 4pi geometry for uniform irradiation, proving a versatile and convenient facility for irradiation of whole blood cells in suspension or media. Doses can be controlled as exact volumes of the gas can be dispensed and measured by the Lucas cell. Irradiation of blood samples could be carried out in a unique and safe manner and the present study is an attempt to demonstrate the usefulness of a facility to expose blood lymphocytes in vitro to radon and its decay products for chromosome aberration analysis. The preliminary results obtained using this facility are presented. Results show an increase in dicentric frequency with increasing concentration of radon (r = 0.97, P < 0.0001). Multiple aberrations in a single cell, characteristic of high linear energy transfer radiation, confirm the effect of alpha exposure.
journal_name
Radiat Prot Dosimetryjournal_title
Radiation protection dosimetryauthors
Hamza VZ,Kumar PR,Jeevanram RK,Santanam R,Danalaksmi B,Mohankumar MNdoi
10.1093/rpd/ncn060subject
Has Abstractpub_date
2008-01-01 00:00:00pages
343-50issue
3eissn
0144-8420issn
1742-3406pii
ncn060journal_volume
130pub_type
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