Metabolomic identification of biochemical changes induced by fluoxetine and imipramine in a chronic mild stress mouse model of depression.

abstract：:Self-cleaving ribozymes fold into intricate structures, which orient active site groups into catalytically competent conformations. Most ribozyme families have distinct catalytic cores stabilized by tertiary interactions between domains peripheral to those cores. We show that large hepatitis delta virus (HDV)-like rib...

journal_title：Scientific reports

authors： Webb CH,Nguyen D,Myszka M,Lupták A

更新日期：2016-06-15 00:00:00

abstract：:The association of cabbage white butterflies (Pieris spec., Lepidoptera: Pieridae) with their glucosinolate-containing host plants represents a well-investigated example of the sequential evolution of plant defenses and insect herbivore counteradaptations. The defensive potential of glucosinolates, a group of amino ac...

journal_title：Scientific reports

authors： Steiner AM,Busching C,Vogel H,Wittstock U

更新日期：2018-07-17 00:00:00

abstract：:Controlling the angular momentum of spins with very short external perturbations is a key issue in modern magnetism. For example it allows manipulating the magnetization for recording purposes or for inducing high frequency spin torque oscillations. Towards that purpose it is essential to modify and control the angula...

journal_title：Scientific reports

authors： Kim JW,Vomir M,Bigot JY

更新日期：2015-02-17 00:00:00

abstract：:Multiple parasitic arthropods of medical importance depend on symbiotic bacteria. While the link between scabies and secondary bacterial infections causing post infective complications of Group A streptococcal and staphylococcal pyoderma is increasingly recognized, very little is known about the microbiota of Sarcopte...

journal_title：Scientific reports

authors： Swe PM,Zakrzewski M,Waddell R,Sriprakash KS,Fischer K

更新日期：2019-08-13 00:00:00

abstract：:Nitric oxide (NO)-induced apoptosis in neurons is an important cause of neurodegenerative disease in humans. The cold-inducible protein RBM3 mediates the protective effects of cooling on apoptosis induced by various insults. However, whether RBM3 protects neural cells from NO-induced apoptosis is unclear. This study a...

journal_title：Scientific reports

authors： Yang HJ,Ju F,Guo XX,Ma SP,Wang L,Cheng BF,Zhuang RJ,Zhang BB,Shi X,Feng ZW,Wang M

更新日期：2017-01-30 00:00:00

abstract：:We investigate instability mechanisms in amorphous In-Ga-Zn-O transistors based on bias and illumination stress-recovery experiments coupled with analysis using stretched exponentials and inverse Laplace transform to retrieve the distribution of activation energies associated with metastable oxygen defects. Results sh...

journal_title：Scientific reports

authors： Lee S,Nathan A,Jeon S,Robertson J

更新日期：2015-10-08 00:00:00

abstract：:N-myc downstream regulated gene 1 (NDRG1) is a responsible gene for a hereditary motor and sensory neuropathy-Lom (Charcot-Marie-Tooth disease type 4D). This is the first study aiming to assess the contribution of NDRG1 to differentiation of macrophage lineage cells, which has important implications for bone remodelin...

journal_title：Scientific reports

authors： Watari K,Shibata T,Nabeshima H,Shinoda A,Fukunaga Y,Kawahara A,Karasuyama K,Fukushi J,Iwamoto Y,Kuwano M,Ono M

更新日期：2016-01-18 00:00:00

abstract：:Controlling thickness and tightness of surface passivation shells is crucial for many applications of core-shell nanoparticles (NP). Usually, to determine shell thickness, core and core/shell particle are measured individually requiring the availability of both nanoobjects. This is often not fulfilled for functional n...

journal_title：Scientific reports

authors： Weigert F,Müller A,Häusler I,Geißler D,Skroblin D,Krumrey M,Unger W,Radnik J,Resch-Genger U

更新日期：2020-11-26 00:00:00

abstract：:We provide a unified and exact framework for the variance-based uncertainty relations. This unified framework not only recovers some well-known previous uncertainty relations, but also fixes the deficiencies of them. Utilizing the unified framework, we can construct the new uncertainty relations in both product and su...

journal_title：Scientific reports

authors： Zheng X,Ma SQ,Zhang GF,Fan H,Liu WM

更新日期：2020-01-10 00:00:00

abstract：:Stabilization exercise (SE) is evident for the management of chronic non-specific low back pain (LBP). The optimal dose-response-relationship for the utmost treatment success is, thus, still unknown. The purpose is to systematically review the dose-response-relationship of stabilisation exercises on pain and disabilit...

journal_title：Scientific reports

authors： Mueller J,Niederer D

更新日期：2020-10-09 00:00:00

abstract：:Aluminum-based quasicrystals typically form across narrow composition ranges within binary to quaternary alloys, which makes their fabrication and characterization challenging. Here, we use combinatorial approaches together with fast characterization techniques to study a wide compositional range including known quasi...

journal_title：Scientific reports

authors： Wolf W,Kube SA,Sohn S,Xie Y,Cha JJ,Scanley BE,Kiminami CS,Bolfarini C,Botta WJ,Schroers J

更新日期：2019-05-09 00:00:00

abstract：:Dynamical polarization of nuclear spin ensembles is of central importance for magnetic resonance studies, precision sensing and for applications in quantum information theory. Here we propose a scheme to generate long-lived singlet pairs in an unpolarized nuclear spin ensemble which is dipolar coupled to the electron ...

journal_title：Scientific reports

authors： Greiner JN,Dasari DBR,Wrachtrup J

更新日期：2017-04-03 00:00:00

abstract：:Ants are a dominant insect group in terrestrial ecosystems and many myrmecophilous species evolve to associate with ants to gain benefits. One iconic example is myrmecophilous butterflies that often produce ant-mimicking vibrational calls to modulate ant behaviors. Despite its popularity, empirical exploration of how ...

journal_title：Scientific reports

authors： Lin YH,Liao YC,Yang CS,Billen J,Yang MM,Hsu YF

更新日期：2019-12-06 00:00:00

abstract：:c-FLIP (cellular FLICE-inhibitory protein) is the pivotal regulator of TRAIL resistance in cancer cells, It is a short-lived protein degraded through the ubiquitin/proteasome pathway. The discovery of factors and mechanisms regulating its protein stability is important for the comprehension of TRAIL resistance by tumo...

journal_title：Scientific reports

authors： Gao X,Feng J,He Y,Xu F,Fan X,Huang W,Xiong H,Liu Q,Liu W,Liu X,Sun X,He QY,Zhang Q,Liu L

更新日期：2016-03-14 00:00:00

abstract：:Methods for estimating the spatial distribution of PM2.5 concentrations have been developed but have not yet been able to effectively include spatial correlation. We report on the development of a spatial back-propagation neural network (S-BPNN) model designed specifically to make such correlations implicit by incorpo...

journal_title：Scientific reports

authors： Wang W,Zhao S,Jiao L,Taylor M,Zhang B,Xu G,Hou H

更新日期：2019-09-24 00:00:00

abstract：:The Na+;HCO3- co-transporter NBCn1 (SLC4A7) is a major regulator of intracellular pH yet its trafficking and turnover are essentially unstudied. Here, we used MDCK-II and MCF-7 cells to investigate these processes in epithelial cells. GFP-NBCn1 membrane localization was abolished by truncation of the full NBCn1 C-term...

journal_title：Scientific reports

authors： Olesen CW,Vogensen J,Axholm I,Severin M,Schnipper J,Pedersen IS,von Stemann JH,Schrøder JM,Christensen DP,Pedersen SF

更新日期：2018-05-09 00:00:00

abstract：:The aim of this study was to evaluate and compare the diagnostic accuracy, the inter-rater agreement and raters' certainty of cone beam computed tomography (CBCT) and radiography for the detection of scaphoid fractures. Our hypothesis is that the CBCT has a higher diagnostic accuracy for scaphoid fractures than radiog...

journal_title：Scientific reports

authors： Neubauer J,Benndorf M,Ehritt-Braun C,Reising K,Yilmaz T,Klein C,Zajonc H,Kotter E,Langer M,Goerke SM

更新日期：2018-03-02 00:00:00

abstract：:Glomerular permeability and subsequent albuminuria are early clinical markers for glomerular injury in hypertensive nephropathy. Albuminuria predicts mortality and cardiovascular morbidity. AT1 receptor blockers protect from albuminuria, cardiovascular morbidity and mortality. A blood pressure independent, molecular m...

journal_title：Scientific reports

authors： Königshausen E,Zierhut UM,Ruetze M,Potthoff SA,Stegbauer J,Woznowski M,Quack I,Rump LC,Sellin L

更新日期：2016-12-22 00:00:00

abstract：:Human motor skill learning is driven by the necessity to adapt to new situations. While supportive contacts are essential for many tasks, little is known about their impact on motor learning. To study the effect of contacts an innovative full-body experimental paradigm was established. The task of the subjects was to ...

journal_title：Scientific reports

authors： Rueckert E,Čamernik J,Peters J,Babič J

更新日期：2016-06-22 00:00:00

abstract：:Although collateral vessel growth is distinctly enhanced by elevated fluid shear stress (FSS), the underlying regulatory mechanism of this process remains incompletely understood. Recent studies have shown that microRNAs (miRNAs) play a pivotal role in vascular development, homeostasis and a variety of diseases. There...

journal_title：Scientific reports

authors： Guan Y,Cai B,Wu X,Peng S,Gan L,Huang D,Liu G,Dong L,Xiao L,Liu J,Zhang B,Cai WJ,Schaper J,Schaper W

更新日期：2017-07-27 00:00:00

abstract：:Phytoplasmas are transmitted by insect vectors in a persistent propagative manner; however, detailed movements and multiplication patterns of phytoplasmas within vectors remain elusive. In this study, spatiotemporal dynamics of onion yellows (OY) phytoplasma in its vector Macrosteles striifrons were investigated by im...

journal_title：Scientific reports

authors： Koinuma H,Maejima K,Tokuda R,Kitazawa Y,Nijo T,Wei W,Kumita K,Miyazaki A,Namba S,Yamaji Y

更新日期：2020-03-09 00:00:00

abstract：:This study aimed to explore the risk of dementia in a middle- and older-aged population with severe or profound hearing impairments. Data were collected for the Korean National Health Insurance Service-National Sample Cohort from 2002 to 2013. Participants aged 40 or older were selected. The 4,432 severely hearing-imp...

journal_title：Scientific reports

authors： Kim SY,Lim JS,Kong IG,Choi HG

更新日期：2018-10-15 00:00:00

abstract：:Individuals differ in their level of general anxiety as well as in their level of anxiety towards specific activities, such as mathematics and spatial tasks. Both specific anxieties correlate moderately with general anxiety, but the aetiology of their association remains unexplored. Moreover, the factor structure of s...

journal_title：Scientific reports

authors： Malanchini M,Rimfeld K,Shakeshaft NG,Rodic M,Schofield K,Selzam S,Dale PS,Petrill SA,Kovas Y

更新日期：2017-02-21 00:00:00

abstract：:Telomere DNA ends with a single-stranded 3' overhang. Long 3' overhangs may cause aberrant DNA damage responses and accelerate telomere attrition, which is associated with cancer and aging, respectively. Genetic studies have indicated several important players in preventing 5' end hyper-resection, yet detailed knowled...

journal_title：Scientific reports

authors： Runnberg R,Narayanan S,Cohn M

更新日期：2017-08-18 00:00:00

abstract：:The human brain contains areas that respond selectively to faces, bodies and scenes. Neuroimaging studies have shown that a subset of these areas preferentially respond more to moving than static stimuli, but the reasons for this functional dissociation remain unclear. In the present study, we simultaneously mapped th...

journal_title：Scientific reports

authors： Pitcher D,Ianni G,Ungerleider LG

更新日期：2019-06-03 00:00:00

abstract：:Direct estimation of Lagrangian turbulence statistics is essential for the proper modeling of dispersion and transport in highly obstructed canopy flows. However, Lagrangian flow measurements demand very high rates of data acquisition, resulting in bottlenecks that prevented the estimation of Lagrangian statistics in ...

journal_title：Scientific reports

authors： Shnapp R,Shapira E,Peri D,Bohbot-Raviv Y,Fattal E,Liberzon A

更新日期：2019-05-15 00:00:00

abstract：:Histone lysine methyltransferases (KMTs) play an important role in epigenetic gene regulation and have emerged as promising targets for drug discovery. However, the scope and limitation of KMT catalysis on substrates possessing substituted lysine side chains remain insufficiently explored. Here, we identify new unnatu...

journal_title：Scientific reports

authors： Al Temimi AHK,Merx J,van Noortwijk CJ,Proietti G,Buijs R,White PB,Rutjes FPJT,Boltje TJ,Mecinović J

更新日期：2020-12-09 00:00:00

abstract：:A tetrameric N-acetyl galactosaminyl (GalNAc) peptidomimetic was constructed by N-acetylation of repeating proline-based hydroxamic acid units, followed by a convergent 'click chemistry' coupling. This novel glycopeptidomimetic was determined to effectively antagonize the interaction between a transmembrane hepatic le...

journal_title：Scientific reports

authors： Zhang HL,Zang Y,Xie J,Li J,Chen GR,He XP,Tian H

更新日期：2014-07-01 00:00:00

abstract：:Local mRNA translation occurs in growing axons enabling precise control of the proteome in response to signals. To measure quantitatively the spatiotemporal dynamics of protein synthesis in growth cones, we further developed a technique for single molecule translation imaging (SMTI). We report that Netrin-1 triggers a...

journal_title：Scientific reports

authors： Ströhl F,Lin JQ,Laine RF,Wong HH,Urbančič V,Cagnetta R,Holt CE,Kaminski CF

更新日期：2017-04-06 00:00:00

abstract：:Fluorescent probes that can distinguish different DNA topologies through changes in optical readout are sought after for DNA-based diagnostics. In this work, the 4,4-difluoro-4-bora-3a, 4a-diaza-s-indacene (BODIPY) chromophore attached to cyanophenyl substituents (BODIPY-CN) has been tethered to the 5'-end of the 15-m...

journal_title：Scientific reports

authors： Deore PS,Soldatov DV,Manderville RA

更新日期：2018-11-15 00:00:00