Fine-tuning of lysine side chain modulates the activity of histone lysine methyltransferases.

abstract：:Sufficient tissue oxygenation is required for regular brain function; thus oxygen supply must be tightly regulated to avoid hypoxia and irreversible cell damage. If hypoxia occurs the transcription factor complex hypoxia-inducible factor (HIF) will accumulate and coordinate adaptation of cells to hypoxia. However, eve...

journal_title：Scientific reports

authors： Kleszka K,Leu T,Quinting T,Jastrow H,Pechlivanis S,Fandrey J,Schreiber T

更新日期：2020-11-05 00:00:00

abstract：:Recent studies suggest that glypican-1 (GPC-1) is a biomarker for prostate cancer, but there are few studies elucidating the role of GPC-1 in prostate cancer progression. We observed high expression of GPC-1 in more aggressive prostate cancer cell lines such as PC-3 and DU-145. While inhibition of GPC-1 expression in ...

journal_title：Scientific reports

authors： Quach ND,Kaur SP,Eggert MW,Ingram L,Ghosh D,Sheth S,Nagy T,Dawson MR,Arnold RD,Cummings BS

更新日期：2019-08-07 00:00:00

abstract：:We investigated the level of amyloid beta (Aβ) in nasal secretions of patients with Alzheimer's disease dementia (ADD) using interdigitated microelectrode (IME) biosensors and determined the predictive value of Aβ in nasal secretions for ADD diagnosis. Nasal secretions were obtained from 35 patients with ADD, 18 with ...

journal_title：Scientific reports

authors： Kim YH,Lee SM,Cho S,Kang JH,Minn YK,Park H,Choi SH

更新日期：2019-03-21 00:00:00

abstract：:In all organisms, salts produce either appetitive or aversive responses depending on the concentration. While low-salt concentration in food elicits positive responses to ingest, high-salt triggers aversion. Still the mechanisms involved in this dual behavior have just started to be uncovered in some organisms. In Rho...

journal_title：Scientific reports

authors： Cano A,Pontes G,Sfara V,Anfossi D,Barrozo RB

更新日期：2017-11-14 00:00:00

abstract：:Intractable diseases such as cancer are associated with breakdown in multiple individual functions, which conspire to create unhealthy phenotype-combinations. An important challenge is to decipher how these functions are coordinated in health and disease. We approach this by drawing on dynamical systems theory. We pos...

journal_title：Scientific reports

authors： Deritei D,Aird WC,Ercsey-Ravasz M,Regan ER

更新日期：2016-03-16 00:00:00

abstract：:Biological computation requires in vivo control of molecular behavior to progress development of autonomous devices. miRNA switches represent excellent, easily engineerable synthetic biology tools to achieve user-defined gene regulation. Here we present the construction of a synthetic network to implement detoxificati...

journal_title：Scientific reports

authors： Pollak NM,Cooper-White JJ,Macdonald J

更新日期：2021-01-28 00:00:00

abstract：:Robot-assisted laparoscopic radical prostatectomy (RALRP) is a minimally invasive procedure; however, some amount of surgical trauma that can trigger systemic inflammation remains. Moreover, pneumoperitoneum during RALRP induces ischemia-reperfusion injury (IRI). Propofol, an anesthetic, is known to have anti-inflamma...

journal_title：Scientific reports

authors： Roh GU,Song Y,Park J,Ki YM,Han DW

更新日期：2019-03-27 00:00:00

abstract：:We present a method by which the spectral intensity of an ultrafast laser pulse can be accumulated at selected frequencies by a controllable amount. Using a 4-f pulse shaper we modulate the phase of the frequency components of a femtosecond laser. By inducing femtosecond filamentation with the modulated pulse, we can ...

journal_title：Scientific reports

authors： Thompson JV,Zhokhov PA,Springer MM,Traverso AJ,Yakovlev VV,Zheltikov AM,Sokolov AV,Scully MO

更新日期：2017-03-07 00:00:00

abstract：:Despite the frequent use of ionising radiation (IR) in therapy and diagnostics and the unavoidable exposure to external radiation sources, our knowledge regarding the radiosensitivity of human blood cell populations is limited and published data, obtained under different experimental conditions, are heterogeneous. To ...

journal_title：Scientific reports

authors： Heylmann D,Ponath V,Kindler T,Kaina B

更新日期：2021-01-28 00:00:00

abstract：:Colloidal particles immersed in a dynamic speckle pattern experience an optical force that fluctuates both in space and time. The resulting dynamics presents many interesting analogies with a broad class of non-equilibrium systems like: active colloids, self propelled microorganisms, transport in dynamical intracellul...

journal_title：Scientific reports

authors： Bianchi S,Pruner R,Vizsnyiczai G,Maggi C,Di Leonardo R

更新日期：2016-06-09 00:00:00

abstract：:Application of PCR to multiplexing assays is not trivial; it requires multiple fluorescent labels for amplicon detection and sophisticated software for data interpretation. Alternative PCR-free methods exploiting new concepts in nanotechnology exhibit high sensitivities but require multiple labeling and/or amplificati...

journal_title：Scientific reports

authors： Papadakis G,Tsortos A,Kordas A,Tiniakou I,Morou E,Vontas J,Kardassis D,Gizeli E

更新日期：2013-01-01 00:00:00

abstract：:Despite the initiative by WHO and other international organizations to eliminate HCV in the medium term, hepatitis C infection is still a major public health problem. Even non-injecting drugs users who engage in harmful or addictive drug use are at greater risk of acquiring the infection, when compared to the general ...

journal_title：Scientific reports

authors： Coutinho C,Bastos LS,da Mota JC,Toledo L,Costa K,Bertoni N,Bastos FI

更新日期：2019-01-24 00:00:00

abstract：:We present a detailed experimental and theoretical study of the acoustic phonon modes in rolled-up multilayers with thickness of the layers in the nanometre and diameters in the micrometre range. We compare our results to planar, unrolled multilayers grown by molecular beam epitaxy. For the planar multilayers the expe...

journal_title：Scientific reports

authors： Brick D,Engemaier V,Guo Y,Grossmann M,Li G,Grimm D,Schmidt OG,Schubert M,Gusev VE,Hettich M,Dekorsy T

更新日期：2017-07-14 00:00:00

abstract：:Angiogenesis is essential in tumor biology and is regulated by vascular endothelial growth factor (VEGF) ligands and receptors. Here we aimed to discover genetic variants associated with levels of circulating angiogenic proteins in cancer patients. Plasma was collected at baseline in 216 pancreatic and 114 colorectal ...

journal_title：Scientific reports

authors： Innocenti F,Jiang C,Sibley AB,Etheridge AS,Hatch AJ,Denning S,Niedzwiecki D,Shterev ID,Lin J,Furukawa Y,Kubo M,Kindler HL,Auman JT,Venook AP,Hurwitz HI,McLeod HL,Ratain MJ,Gordan R,Nixon AB,Owzar K

更新日期：2018-11-05 00:00:00

abstract：:Laser radiation pressure is a basis of numerous applications in science and technology such as atom cooling, particle manipulation, material processing, etc. This light force for the case of scalar beams is proportional to the intensity-weighted wavevector known as optical current. The ability to design the optical cu...

journal_title：Scientific reports

authors： Rodrigo JA,Alieva T

更新日期：2016-10-13 00:00:00

abstract：:We propose a polarization beam splitter (PBS) with a footprint of only 600 × 790 nm2 operating at a wavelength of λ = 1550 nm, which is the smallest PBS ever demonstrated. This device uses CMOS-compatible materials, namely, silicon and silica. The present PBS comprises two Si waveguides with different geometrical aspe...

journal_title：Scientific reports

authors： Lai MS,Huang CC

更新日期：2017-07-03 00:00:00

abstract：:Mycobacterium marinum (M. marinum) is a slowly growing nontuberculous mycobacterium. The incidence of M. marinum infections in Denmark is unknown. We conducted a retrospective nationwide study including all culture confirmed cases of M. marinum from 2004 to 2017 in Denmark. All available medical records were reviewed....

journal_title：Scientific reports

authors： Holden IK,Kehrer M,Andersen AB,Wejse C,Svensson E,Johansen IS

更新日期：2018-04-30 00:00:00

abstract：:Regular exercise elicits advantageous metabolic adaptations in skeletal muscle, such as improved insulin sensitivity. However, the underpinning molecular mechanisms and the effect of diet on muscle exercise training benefits are unclear. We therefore characterized the skeletal muscle proteome following exercise traini...

journal_title：Scientific reports

authors： Kleinert M,Parker BL,Jensen TE,Raun SH,Pham P,Han X,James DE,Richter EA,Sylow L

更新日期：2018-07-16 00:00:00

abstract：:Natural and anthropogenic stressors can cause phase shifts from coral-dominated to algal-dominated states. In the Caribbean, over-fishing of large herbivorous fish and disease among the long-spined urchin, Diadema, have facilitated algal growth on degraded reefs. We found that diminutive species of urchin and parrotfi...

journal_title：Scientific reports

authors： Kuempel CD,Altieri AH

更新日期：2017-01-05 00:00:00

abstract：:Salvia miltiorrhiza is one of the most widely-used medicinal plants. Here, we systematically analyzed the RNA editing events in its mitochondria. We developed a pipeline using REDItools to predict RNA editing events from stand-specific RNA-Seq data. The predictions were validated using reverse transcription, RT-PCR am...

journal_title：Scientific reports

authors： Wu B,Chen H,Shao J,Zhang H,Wu K,Liu C

更新日期：2017-02-10 00:00:00

abstract：:The relationship between alcohol consumption and mortality generally exhibits a U-shaped curve. The longevity observed with moderate alcohol consumption may be explained by other confounding factors, and, if such a relationship is present, the mechanism is not well understood. Indeed, the optimal amount of alcohol con...

journal_title：Scientific reports

authors： Dixit S,Whooley MA,Vittinghoff E,Roberts JD,Heckbert SR,Fitzpatrick AL,Lin J,Leung C,Mukamal KJ,Marcus GM

更新日期：2019-02-05 00:00:00

abstract：:Although most papillary thyroid carcinomas (PTCs) have a good prognosis, a small but certain fraction shows aggressive behavior. Therefore, a novel and well-performing molecular marker is needed. In the present study, we assessed the impact of the combination of the TERT promoter/BRAF mutations and Ki-67 labeling inde...

journal_title：Scientific reports

authors： Matsuse M,Yabuta T,Saenko V,Hirokawa M,Nishihara E,Suzuki K,Yamashita S,Miyauchi A,Mitsutake N

更新日期：2017-02-02 00:00:00

abstract：:Antimicrobial resistant infections are a serious public health threat worldwide. Whole genome sequencing approaches to rapidly identify pathogens and predict antibiotic resistance phenotypes are becoming more feasible and may offer a way to reduce clinical test turnaround times compared to conventional culture-based m...

journal_title：Scientific reports

authors： Nguyen M,Brettin T,Long SW,Musser JM,Olsen RJ,Olson R,Shukla M,Stevens RL,Xia F,Yoo H,Davis JJ

更新日期：2018-01-11 00:00:00

abstract：:Freshwater reservoirs, in particular tropical ones, are an important source of methane (CH4) to the atmosphere, but current estimates are uncertain. The CH4 emitted from reservoirs is microbially produced in their sediments, but at present, the rate of CH4 formation in reservoir sediments cannot be predicted from sedi...

journal_title：Scientific reports

authors： Isidorova A,Grasset C,Mendonça R,Sobek S

更新日期：2019-07-29 00:00:00

abstract：:Invasive fungal infections are a potentially life-threatening complication in immunocompromised patients. The aim of this study was to assess the efficacy and safety of posaconazole as compared with other antifungal agents for preventing invasive fungal infections in immunocompromised patients. Embase, CENTRAL, and ME...

journal_title：Scientific reports

authors： Wong TY,Loo YS,Veettil SK,Wong PS,Divya G,Ching SM,Menon RK

更新日期：2020-09-03 00:00:00

abstract：:Adaptive optics (AO) visual simulators based on deformable mirrors, spatial light modulators or optotunable lenses are increasingly used to simulate vision through different multifocal lens designs. However, the correspondence of this simulation with that obtained through real intraocular lenses (IOLs) tested on the s...

journal_title：Scientific reports

authors： Vinas M,Benedi-Garcia C,Aissati S,Pascual D,Akondi V,Dorronsoro C,Marcos S

更新日期：2019-02-07 00:00:00

abstract：:Converging evidence supports the involvement of pro-inflammatory pathways and the gut microbiome in major depressive disorder (MDD). Pre-clinical and clinical studies suggest that decreasing pro-inflammatory signaling may provide clinical benefit in MDD. In this study, we used the chronic unpredictable stress (CUS) pa...

journal_title：Scientific reports

authors： Inserra A,Choo JM,Lewis MD,Rogers GB,Wong ML,Licinio J

更新日期：2019-04-23 00:00:00

abstract：:Bacterial communities from freshwater lakes are shaped by various factors such as nutrients, pH value, temperature, etc. Their compositions and relative abundances would undergo changes to adapt the changing environments, and in turn could affect the environments of freshwater lakes. Analyses of the freshwater lake's ...

journal_title：Scientific reports

authors： Han M,Gong Y,Zhou C,Zhang J,Wang Z,Ning K

更新日期：2016-07-27 00:00:00

abstract：:The role of Toll-like receptor-2 (TLR2) in radio-resistance remained largely unknown. TLR2 knockout (TLR2(-/-)) mice received radiation of 6.5 Gy, and then were studied. We found that radiation resulted in more severe mortality and morbidity rates in TLR2(-/-) mice. The cause of death in TLR2(-/-) mice may be severe a...

journal_title：Scientific reports

authors： Gao F,Zhang C,Zhou C,Sun W,Liu X,Zhang P,Han J,Xian L,Bai D,Liu H,Cheng Y,Li B,Cui J,Cai J,Liu C

更新日期：2015-08-13 00:00:00

abstract：:(R-)miniCHOP therapy, which delivers approximately half-doses of the (R-)CHOP regimen, has shown efficacy and safety in patients who are more than 80 years old. This study aimed to compare the area under the plasma concentration-time curves (AUCs) of vincristine (VCR), doxorubicin (DXR), and cyclophosphamide (CPA) bet...

journal_title：Scientific reports

authors： Nakagawa J,Takahata T,Hyodo R,Chen Y,Hasui K,Sasaki K,Saito K,Ueno K,Hosoi K,Terui K,Sato A,Niioka T

更新日期：2021-01-12 00:00:00