Abstract：
:The role of Toll-like receptor-2 (TLR2) in radio-resistance remained largely unknown. TLR2 knockout (TLR2(-/-)) mice received radiation of 6.5 Gy, and then were studied. We found that radiation resulted in more severe mortality and morbidity rates in TLR2(-/-) mice. The cause of death in TLR2(-/-) mice may be severe and persistent bone marrow cell loss. Injection of the TLR2 agonist Pam3CSK4 into wild type (WT) mice induced radio-resistance. Myd88(-/-) mice were more susceptible to radiation. In conclusion, our data indicate that, similar to TLR4, TLR2 plays a critical role in radio-resistance.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Gao F,Zhang C,Zhou C,Sun W,Liu X,Zhang P,Han J,Xian L,Bai D,Liu H,Cheng Y,Li B,Cui J,Cai J,Liu Cdoi
10.1038/srep13004subject
Has Abstractpub_date
2015-08-13 00:00:00pages
13004issn
2045-2322pii
srep13004journal_volume
5pub_type
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