Abstract:
:We investigated the level of amyloid beta (Aβ) in nasal secretions of patients with Alzheimer's disease dementia (ADD) using interdigitated microelectrode (IME) biosensors and determined the predictive value of Aβ in nasal secretions for ADD diagnosis. Nasal secretions were obtained from 35 patients with ADD, 18 with cognitive decline associated with other neurological disorders (OND), and 26 cognitively unimpaired (CU) participants. Capacitance changes in IMEs were measured by capturing total Aβ (ΔCtAβ). After 4-(2-hydroxyethyl)-1-piperazinepropanesulfonic acid (EPPS) was injected, additional capacitance changes due to the smaller molecular weight Aβ oligomers disassembled from the higher molecular weight oligomeric Aβ were determined (ΔCoAβ). By dividing two values, the capacitance ratio (ΔCoAβ/ΔCtAβ) was determined and then normalized to the capacitance change index (CCI). The CCI was higher in the ADD group than in the OND (p = 0.040) and CU groups (p = 0.007). The accuracy of the CCI was fair in separating into the ADD and CU groups (area under the receiver operating characteristic curve = 0.718, 95% confidence interval = 0.591-0.845). These results demonstrate that the level of Aβ in nasal secretions increases in ADD and the detection of Aβ in nasal secretions using IME biosensors may be possible in predicting ADD.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Kim YH,Lee SM,Cho S,Kang JH,Minn YK,Park H,Choi SHdoi
10.1038/s41598-019-41429-1subject
Has Abstractpub_date
2019-03-21 00:00:00pages
4966issue
1issn
2045-2322pii
10.1038/s41598-019-41429-1journal_volume
9pub_type
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