Abstract：
:Clinical trials in the last decade have improved the quality of evidence to support preventive medical strategies to reduce the risk of recurrences after pericarditis. There are essentially three main strategies: (1) to use full anti-inflammatory doses for the treatment of each attack of pericarditis till symptoms resolution and normalization of markers of inflammation (i.e., C-reactive protein); (2) to limit the use of corticosteroids and, if used, to use low to moderate doses (i.e., prednisone 0.2 to 0.5 mg/kg/day or equivalent) followed by slow tapering; and (3) to add colchicine to improve the response to conventional anti-inflammatory therapies and reduce the risk of recurrences. Recommended regimens include weight-adjusted doses (i.e., 0.5-0.6 mg twice daily for patients weighing >70 kg or 0.5-0.6 mg once daily for patients weighing ≤70 kg for 3 months for acute pericarditis and 6 months for recurrences) without a loading dose to improve patients' compliance. Using these doses and appropriate selection of patients (e.g. to avoid severe renal impairment or adjust doses according to comorbid conditions and concomitant therapies), the drug is well tolerated, may cause reversible gastrointestinal intolerance (mainly diarrhea) in about 8 to 10% of cases but has no severe side effects.
journal_name
Curr Cardiol Repjournal_title
Current cardiology reportsauthors
Imazio Mdoi
10.1007/s11886-015-0575-ysubject
Has Abstractpub_date
2015-01-01 00:00:00pages
23issue
4eissn
1523-3782issn
1534-3170journal_volume
17pub_type
杂志文章,评审abstract：:Angiotensin-converting enzyme (ACE) inhibitors have become the cornerstone of therapy for congestive heart failure (CHF). Because ischemic heart disease is the most common cause of CHF, aspirin is frequently given concomitantly with ACE inhibitors in patients with CHF. Increased bradykinin levels, with the consequent ...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-001-0030-0
更新日期：2001-05-01 00:00:00
abstract：PURPOSE OF REVIEW:Drug-coated balloons (DEB) and drug-eluting stents (DES) emerged as a tool to aid in lowering the rates of neointimal hyperplasia and target lesion restenosis following endovascular peripheral arterial disease (PAD) interventions. RECENT FINDINGS:Although the initial trials comparing these devices wi...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-019-1211-z
更新日期：2019-09-07 00:00:00
abstract：:Diabetic patients who present with an acute coronary syndrome (ACS) have a particularly adverse prognosis, largely contributed by increased platelet reactivity and higher burden of disease severity. Diabetic patients with ACS derive a greater benefit from established therapies, particularly platelet-inhibiting therapi...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-010-0118-5
更新日期：2010-07-01 00:00:00
abstract：:The rapid growth of medical knowledge during the past few decades has created many potential advances in the therapeutics of chronic disease, and cardiovascular disease has been at the center of this phenomenon. Translation of these advances into everyday care of patients with chronic disease continues to be problemat...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-001-0039-4
更新日期：2001-03-01 00:00:00
abstract：PURPOSE OF REVIEW:Several interrelated mechanisms promote the development of hypertension in obesity, often contributing to end organ damage including cardiovascular disease and chronic kidney disease. RECENT FINDINGS:The treatment of hypertension in obesity is complicated by a high prevalence of resistant hypertensio...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-017-0912-4
更新日期：2017-08-24 00:00:00
abstract：PURPOSE OF REVIEW:Assessing the cardiovascular risk associated with hypertriglyceridemia can be challenging due to frequent confounding conditions such as hypertension, diabetes mellitus, and hyperlipidemia. We sought to quantify this risk by examining several meta-analyses as well as subgroup analyses of previously pu...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-018-1013-8
更新日期：2018-07-10 00:00:00
abstract：PURPOSE OF REVIEW:Interventional cardiology and in particular the field of renal denervation is subject to constant change. This review provides an up to date overview of renal denervation trials and an outlook on what to expect in the future. RECENT FINDINGS:After the sham-controlled SYMPLICITY HTN-3 trial dampened t...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-019-1164-2
更新日期：2019-07-05 00:00:00
abstract：PURPOSE OF REVIEW:Coronary artery bypass grafting is a preferred strategy for complete coronary revascularization in patients who have multi-vessel coronary artery disease, left ventricular dysfunction, and/or diabetes. Both arterial (internal thoracic artery/radial artery) and venous grafts are utilized to bypass the ...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-019-1112-1
更新日期：2019-03-22 00:00:00
abstract：:Resistant hypertension has evolved as an important global health care problem. Primary aldosteronism is one of several potentially reversible causes of resistant hypertension. Primary aldosteronism can be effectively treated, when recognized, with a mineralocorticoid receptor antagonist, such as spironolactone and epl...
journal_title：Current cardiology reports
pub_type： 杂志文章
doi：10.1007/s11886-011-0224-z
更新日期：2011-12-01 00:00:00
abstract：:Echocardiography is the most common noninvasive tool used in assessing cardiac masses. Real-time three-dimensional echocardiography expands the diagnostic capabilities of cardiac ultrasound in assessing the location, composition, size, and relationship to other structures of cardiac masses. The improved characterizati...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-009-0029-5
更新日期：2009-05-01 00:00:00
abstract：PURPOSE OF REVIEW:Acute pulmonary embolism (PE) is a common condition associated with high morbidity and mortality. Prior studies have evaluated the role of systemic fibrinolysis and catheter-directed therapy (CDT) in the management of PE. In this review, we examine current data on risk stratification and the appropria...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-017-0864-8
更新日期：2017-06-01 00:00:00
abstract：:Atherosclerosis is the proximate cause of arterial thrombosis, leading to acute occlusive cardiovascular syndromes. Thrombosis in atherosclerosis usually results from rupture of the fibrous cap of atherosclerotic plaques with a smaller proportion resulting from superficial endothelial erosion. Ruptured plaques are oft...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-014-0547-7
更新日期：2014-12-01 00:00:00
abstract：:Sodium is an essential nutrient, mostly ingested as salt (sodium chloride). Average sodium intake ranges from 3 to 6 g per day (7.5-15 g/day of salt) in most countries, with regional variations. Increasing levels of sodium intake have a positive association with higher blood pressure. Randomized controlled trials repo...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-014-0529-9
更新日期：2014-01-01 00:00:00
abstract：:Although overall stroke incidence has been declining in developed countries, there is evidence that stroke in the young is increasing. Increasing incidence may be particularly pronounced among minorities in whom historically a higher burden of stroke has been reported. Compared with older adults, time spent with disab...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-013-0421-z
更新日期：2013-12-01 00:00:00
abstract：PURPOSE OF REVIEW:To review methodological and logistical aspects of CT myocardial perfusion, current clinical evidence and possible future directions, with specific focus on use in patients with coronary artery disease (CAD). RECENT FINDINGS:CT myocardial perfusion imaging may be performed as an add-on to standard co...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-017-0937-8
更新日期：2017-10-25 00:00:00
abstract：:Spontaneous coronary artery dissection is an important etiology of nonatherosclerotic acute coronary syndrome, myocardial infarction, and sudden death. Innovations in the catheterization laboratory including optical coherence tomography and intravascular ultrasound have enhanced the ability to visualize intimal disrup...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-016-0737-6
更新日期：2016-07-01 00:00:00
abstract：:Although differences diminish with age, outcomes are overall worse for women compared to men who present with suspected acute coronary syndrome. The reasons for this discrepancy are multifactorial, including sex-related differences in atherosclerosis biology and fluid dynamics, as well as a premature conclusion by pro...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-016-0767-0
更新日期：2016-09-01 00:00:00
abstract：PURPOSE OF REVIEW:Cardiac troponin (cTn) plays an essential role for assessment of outcome in acute coronary syndrome (ACS). However, the prognostic value of cTn is not absolute. In this mini-review, we summarize the evidence on the utility of established biomarkers of left-ventricular dysfunction, hemodynamic stress, ...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-017-0840-3
更新日期：2017-04-01 00:00:00
abstract：PURPOSE OF REVIEW:Variant angina, which is characterized by recurrent chest pain and transient ECG changes along with angiographic evidence of coronary artery spasm, generally has a favorable prognosis. However, episodes of ischemia caused by vasospasm may lead to potentially life-threatening ventricular arrhythmias an...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-018-0963-1
更新日期：2018-03-08 00:00:00
abstract：:Thrombolytic therapy aims to achieve rapid and sustained infarct-related artery patency, although this results in a procoagulant state. Heparin has limitations as an antithrombin agent, which has led to clinical investigation of alternative agents. Direct thrombin inhibitors, as adjuncts to thrombolytic therapy, have ...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-999-0021-0
更新日期：1999-09-01 00:00:00
abstract：PURPOSE OF REVIEW:Results from cardiovascular (CV) outcome trials have revealed important insights into the CV safety and efficacy of glucose-lowering agents, including dipeptidyl peptidase-4 inhibitors (DPP-4i) and glucagon-like peptide-1 receptor agonists (GLP-1RA). RECENT FINDINGS:Among patients with T2DM, DPP-4i h...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-020-01355-5
更新日期：2020-08-08 00:00:00
abstract：PURPOSE OF REVIEW:Transcatheter aortic valve replacement (TAVR) has developed into an important alternative to surgical aortic valve replacement (SAVR) for patients with severe aortic stenosis (AS). Adjuvant antithrombotic therapies are commonly used during and after TAVR to decrease the risk of valve thrombosis and th...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-017-0850-1
更新日期：2017-05-01 00:00:00
abstract：:Aldosterone is known to have multiple adverse cardiovascular effects that are reminiscent of but independent from angiotensin II. These effects include endothelial dysfunction, heightened thrombogenicity, inflammation, and reparative fibrosis, and have been described in experimental and human models of aldosterone exc...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-004-0073-0
更新日期：2004-07-01 00:00:00
abstract：:Cardiovascular mortality continues to be high and events continue to occur in patients taking antiplatelet medications. Aspirin and clopidogrel have become integral parts of management in patients with coronary artery disease and after percutaneous angioplasty. However, the platelet responses to aspirin and clopidogre...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-005-0044-0
更新日期：2005-07-01 00:00:00
abstract：PURPOSE OF REVIEW:Real-time 3-dimensional (3-D) imaging of cardiovascular injury and regeneration remains challenging. We introduced a multi-scale imaging strategy that uses light-sheet illumination to enable applications of cardiovascular injury and repair in models ranging from zebrafish to rodent hearts. RECENT FIN...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-018-0979-6
更新日期：2018-03-24 00:00:00
abstract：PURPOSE OF REVIEW:This is an in-depth review on the mechanism of action, clinical utility, and drug-drug interactions of colchicine in the management of pericardial disease. RECENT FINDINGS:Recent evidence about therapeutic targets on pericarditis has demonstrated that NALP3 inflammasome blockade is the cornerstone in...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-018-1008-5
更新日期：2018-06-14 00:00:00
abstract：:Imaging with radionuclides has historically played an important role in detection of cardiovascular disease as well as in risk stratification and prognostication. With the growth of molecular biology have come new therapeutic interventions and the requirement for new diagnostic imaging approaches. Noninvasive targeted...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-005-0025-3
更新日期：2005-03-01 00:00:00
abstract：:Despite a vast body of research on antithrombotic therapy for patients with cardiac disease, there are few clinical settings where robust evidence of their benefit exists. Patients with heart failure often have vascular disease and atrial fibrillation contributing to their poor prognosis. For patients with heart failu...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-012-0266-x
更新日期：2012-06-01 00:00:00
abstract：:Revascularization in stable ischemic heart disease (SIHD) is indicated in patients on optimal medical therapy with angina and/or demonstrable ischemia and a significant stenosis in one or more epicardial coronary arteries. Angiography alone, however, cannot accurately determine the hemodynamic significance of coronary...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-016-0711-3
更新日期：2016-04-01 00:00:00
abstract：:The heart and kidney interact in terms of hemodynamics and neurohumoral regulatory mechanisms, and this helps to maintain circulatory homeostasis under normal conditions. However, the normal regulatory mechanisms become inappropriate in the setting of congestive heart failure (CHF), and significant renal dysfunction o...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-012-0258-x
更新日期：2012-06-01 00:00:00
