Cardiovascular Risk Assessment in Patients with Hypertriglyceridemia.

Abstract:

PURPOSE OF REVIEW:Assessing the cardiovascular risk associated with hypertriglyceridemia can be challenging due to frequent confounding conditions such as hypertension, diabetes mellitus, and hyperlipidemia. We sought to quantify this risk by examining several meta-analyses as well as subgroup analyses of previously published major randomized controlled trials that focused on the treatment of hyperlipidemia. RECENT FINDINGS:Recent trials measuring the effects of PCSK9 inhibitors such as evolocumab and alirocumab on cardiovascular outcomes have demonstrated a high degree of residual cardiovascular risk even after profound reductions in low-density-lipoprotein cholesterol (LDL-C). Despite optimization of LDL-C through the use of statins, PCSK9 inhibitors and adjunctive therapies such as ezetimibe, bile acid sequestrants and niacin, residual cardiovascular risk remains significant. Several ongoing trials are assessing the efficacy of pemafibrate and omega-3 fatty acids for the treatment of hypertriglyceridemia and their effects on major cardiovascular outcomes.

journal_name

Curr Cardiol Rep

authors

Evans MC,Stalam T,Miller M

doi

10.1007/s11886-018-1013-8

subject

Has Abstract

pub_date

2018-07-10 00:00:00

pages

71

issue

9

eissn

1523-3782

issn

1534-3170

pii

10.1007/s11886-018-1013-8

journal_volume

20

pub_type

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