Abstract：
:Atherosclerosis is the proximate cause of arterial thrombosis, leading to acute occlusive cardiovascular syndromes. Thrombosis in atherosclerosis usually results from rupture of the fibrous cap of atherosclerotic plaques with a smaller proportion resulting from superficial endothelial erosion. Ruptured plaques are often associated with intimal and adventitial inflammation, increased size of lipid-rich necrotic core with thinned out collagen-depleted fibrous cap, outward remodeling, increased plaque neovascularity, intraplaque hemorrhage, and microcalcification. By inference, non-ruptured plaques with similar compositional features are considered to be at risk for rupture and hence are labeled vulnerable plaques or high-risk plaques. Identification of vulnerable plaques may help in predicting the risk of acute occlusive syndromes and may also allow targeting for aggressive systemic and possibly local therapies. Plaque rupture is believed to result from extracellular matrix (which comprises the protective fibrous cap) dysregulation due to excessive proteolysis in the context of diminished matrix synthesis. Inflammation is believed to play a key role by providing matrix-degrading metalloproteinases and also by inducing death of matrix-synthesizing smooth muscle cells. Systemic markers of inflammation are thus the most logical forms of potential biomarkers which may predict the presence of vulnerable or high-risk plaques. Several studies have suggested the potential prognostic value of a variety of systemic markers, but regrettably, their overall clinical predictive value is modestly incremental at best, especially for individual subjects compared to groups of patients. Nevertheless, continued investigation of reliable, cost-effective biomarkers that predict the presence of a high-risk plaque and future athero-thrombotic cardiovascular events with greater sensitivity and specificity is warranted.
journal_name
Curr Cardiol Repjournal_title
Current cardiology reportsauthors
Shah PKdoi
10.1007/s11886-014-0547-7subject
Has Abstractpub_date
2014-12-01 00:00:00pages
547issue
12eissn
1523-3782issn
1534-3170journal_volume
16pub_type
杂志文章,评审abstract：:Frailty is increasingly recognized in older adults with cardiovascular disease, particularly in those with heart failure (HF). A growing body of evidence has shown that frailty has a negative effect on survival, hospitalizations, disability, and quality of life. Beyond frailty, additional domains captured by a compreh...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-015-0651-3
更新日期：2015-11-01 00:00:00
abstract：:The article title in the original publication contains a mistake. ...
journal_title：Current cardiology reports
pub_type： 已发布勘误
doi：10.1007/s11886-020-01403-0
更新日期：2020-09-08 00:00:00
abstract：:Intracranial stenosis accounts for 8-10% of all ischemic strokes in North America, a frequency slightly less than that of extracranial carotid stenosis. Among patients presenting with transient ischemic attack or stroke due to intracranial stenosis, the risk of recurrent stroke in the first year after initial symptoms...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-009-0070-4
更新日期：2010-01-01 00:00:00
abstract：:Innate differences in gender physiology result in unique exposures, risk, and protection that are specific to women. Recognition and appreciation of these differences results in better treatment adaptations for women and better outcomes. Disparities between genders in the treatment of major cardiovascular risk factors...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-010-0135-4
更新日期：2010-11-01 00:00:00
abstract：:Heart failure is becoming increasingly prevalent, and currently coronary artery disease (CAD) is the primary cause of left ventricular (LV) systolic dysfunction. A potential therapeutic option for patients with severe CAD and LV dysfunction is a strategy of revascularization. In this review, we summarize the available...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-006-0055-5
更新日期：2006-07-01 00:00:00
abstract：:Cardiac implantable electronic device (CIED) infections are complex medical problems that are increasingly encountered. They are associated with significant morbidity and mortality with tremendous economic cost. The current review will emphasize the prevention, diagnosis, and treatment of this clinical entity using th...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-016-0733-x
更新日期：2016-06-01 00:00:00
abstract：PURPOSE OF REVIEW:Machine learning (ML) and deep learning (DL) are two important categories of AI algorithms. Nowadays, AI technology has been gradually applied to cardiac magnetic resonance imaging (CMRI), covering the fields of myocardial contrast enhancement (MCE) pattern and automatic ventricular segmentation. This...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-020-01306-0
更新日期：2020-07-07 00:00:00
abstract：PURPOSE OF THE REVIEW:The aim of this review was to discuss the role of cardiac magnetic resonance (CMR) for the prognostic stratification of cardiomyopathies, highlighting strengths and limitations. RECENT FINDINGS:CMR is considered as a diagnostic pillar in the management of non-ischemic cardiomyopathies. Over the l...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-020-01311-3
更新日期：2020-06-19 00:00:00
abstract：PURPOSE OF REVIEW:Although rare, sudden cardiac death (SCD) in the young is a tragic event, having a dramatic impact upon all involved. The psychosocial burden associated with SCD can leave friends, families, and entire communities bereft. With only limited evidence to describe the volatile emotional reactions associat...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-020-01419-6
更新日期：2020-10-10 00:00:00
abstract：PURPOSE OF REVIEW:To analyze the current state of the art of functional mitral regurgitation (FMR) treatment. RECENT FINDINGS:The first-line treatment of severe FMR consists of guideline medical therapy (GMT) and resynchronization therapy when indicated; the impact of new medical therapies like sacubitril/valsartan ne...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-019-1221-x
更新日期：2019-11-16 00:00:00
abstract：:As women with congenital heart disease (CHD) approach childbearing age, issues such as pregnancy and contraception need to be addressed. Women with CHD represent a heterogeneous population. While some have simple cardiac lesions and thus have contraceptive risks that are no different from those of the general populati...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-009-0043-7
更新日期：2009-07-01 00:00:00
abstract：PURPOSE OF REVIEW:Acute rejection is one of the most feared complications of cardiac transplantation. Developing non-invasive methods for detection and surveillance of acute rejection have long been a goal for post-transplant care. RECENT FINDINGS:Here, we will review molecular diagnostic tests that are currently in u...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-017-0915-1
更新日期：2017-10-13 00:00:00
abstract：PURPOSE OF REVIEW:In this review, we summarise the evidence on the association between cardiovascular disease (CVD) and cognitive impairment and explore the role of the nitric oxide (NO) pathway as a causal mechanism. RECENT FINDINGS:Evidence from epidemiological studies suggests that the presence of CVD and its risk ...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-017-0898-y
更新日期：2017-08-11 00:00:00
abstract：:Percutaneous coronary intervention (PCI) of multivessel and/or left main stem disease have been shown to be potentially legitimate revascularization alternatives in appropriately selected patients. Risk stratification is an important component in guiding patients to identify the most appropriate revascularization moda...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-011-0202-5
更新日期：2011-10-01 00:00:00
abstract：:Basic and animal research implicate inflammatory mechanisms in the pathogenesis and progression of atherosclerosis, plaque rupture, thrombosis, and stroke. Inflammatory biomarkers, particularly high-sensitivity C-reactive protein and lipoprotein-associated phospholipase A2, have been identified as potential predictors...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-009-0003-2
更新日期：2009-01-01 00:00:00
abstract：:Spontaneous coronary artery dissection is an important etiology of nonatherosclerotic acute coronary syndrome, myocardial infarction, and sudden death. Innovations in the catheterization laboratory including optical coherence tomography and intravascular ultrasound have enhanced the ability to visualize intimal disrup...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-016-0737-6
更新日期：2016-07-01 00:00:00
abstract：:Randomized clinical trials have established that lipid- lowering pharmacologic therapy can substantially reduce morbidity and mortality in patients with known coronary artery disease (CAD). Researchers are now working to define the role of lipid-lowering agents in the primary prevention of CAD to extend their benefit ...
journal_title：Current cardiology reports
pub_type： 杂志文章
doi：10.1007/s11886-000-0056-8
更新日期：2000-09-01 00:00:00
abstract：:Aldosterone is known to have multiple adverse cardiovascular effects that are reminiscent of but independent from angiotensin II. These effects include endothelial dysfunction, heightened thrombogenicity, inflammation, and reparative fibrosis, and have been described in experimental and human models of aldosterone exc...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-004-0073-0
更新日期：2004-07-01 00:00:00
abstract：:The most common cause of acute coronary syndrome (ACS) is rupture of an atherosclerotic lesion containing a large necrotic core and a thin fibrous cap followed by acute luminal thrombosis because the rupture of the thin fibrous cap allows contact of the platelets with the highly thrombogenic necrotic core. Pathologic ...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-010-0113-x
更新日期：2010-07-01 00:00:00
abstract：:Radiofrequency ablation is a valuable adjunctive therapy to implantable defibrillators in patients with recurrent monomorphic ventricular tachycardia (VT) after myocardial infarction. Episodes of VT are markedly reduced in most patients, and the major complications are less than 5%. Newer approaches allow successful a...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-003-0092-2
更新日期：2003-09-01 00:00:00
abstract：:Viable treatment options for advanced heart failure have not emerged as the number of people afflicted with this condition has grown. Although heart transplantation is the only curative strategy for patients with end-stage heart failure, the relative shortage of donors has led to a worldwide plateau of this option ove...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-014-0468-5
更新日期：2014-04-01 00:00:00
abstract：PURPOSE OF REVIEW:This review provides an update on rheumatic mitral stenosis. Acute rheumatic fever (RF), the sequela of group A β-hemolytic streptococcal infection, is the major etiology for mitral stenosis (MS). RECENT FINDINGS:While the incidence of acute RF in the Western world had substantially declined over the...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-019-1099-7
更新日期：2019-02-28 00:00:00
abstract：PURPOSE OF REVIEW:Acute pulmonary embolism is a major cause of morbidity and mortality in the USA and throughout the world. This review will summarize recent developments in short- and long-term mortality risk assessment after an acute pulmonary embolism. RECENT FINDINGS:Recent guidelines have emphasized risk stratifi...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-018-1084-6
更新日期：2018-10-11 00:00:00
abstract：PURPOSE OF REVIEW:Monoclonal antibodies that inhibit proprotein convertase subtilisin/kexin type 9 (PCSK9) have emerged as a novel approach to low-density lipoprotein cholesterol (LDL-C) lowering. The potential role of PCSK9 inhibitors in clinical practice will be reviewed. RECENT FINDINGS:Clinical trials have demonst...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-017-0882-6
更新日期：2017-08-01 00:00:00
abstract：:Conventional algorithms and noninvasive imaging tests for the identification of stable, hemodynamically significant coronary artery disease offer little insight into the detection of potentially vulnerable and inflamed coronary plaques, those most likely to rupture and cause acute coronary syndromes. Positron emission...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-011-0168-3
更新日期：2011-04-01 00:00:00
abstract：PURPOSE OF REVIEW:To establish the actual role of CT in the growing field of transcatheter valve interventions (THV). RECENT FINDINGS:The development of empirical CT measurements, which are linked with outcomes. CT is a reliable technique for assessing risk and planning transcatheter valve interventions for mitral and...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-019-1241-6
更新日期：2019-11-25 00:00:00
abstract：:Primary aldosteronism with a prevalence of 8 % of hypertension and 20 % of pharmacologically resistant hypertension is the most common secondary cause of hypertension. Yet, the diagnosis is missed in the vast majority of patients. Current clinical practice guidelines recommend screening for primary aldosteronism in pa...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-016-0774-1
更新日期：2016-10-01 00:00:00
abstract：:Echocardiography is the most common noninvasive tool used in assessing cardiac masses. Real-time three-dimensional echocardiography expands the diagnostic capabilities of cardiac ultrasound in assessing the location, composition, size, and relationship to other structures of cardiac masses. The improved characterizati...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-009-0029-5
更新日期：2009-05-01 00:00:00
abstract：PURPOSE OF REVIEW:This is an in-depth review on the mechanism of action, clinical utility, and drug-drug interactions of colchicine in the management of pericardial disease. RECENT FINDINGS:Recent evidence about therapeutic targets on pericarditis has demonstrated that NALP3 inflammasome blockade is the cornerstone in...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-018-1008-5
更新日期：2018-06-14 00:00:00
abstract：:Heart failure management is complex and costly. Genetic variations that alter drug absorption, metabolism, and receptor-ligand interactions have the potential to modify drug response and safety. Evidence shows that genetic factors interact with numerous heart failure medications, including vasodilators, beta blockers,...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-008-0031-3
更新日期：2008-05-01 00:00:00
