Overexpression of caudal type homeobox transcription factor 2 inhibits the growth of the MGC-803 human gastric cancer cell line in vivo.

abstract：:Long non‑coding RNAs (lncRNAs) have been reported to serve a key role in a variety of cardiovascular diseases, including in cardiac fibrosis. The present study aimed to investigate the biological role and underlying mechanisms of the induction of cardiac fibroblasts by the lncRNA, RNA component of mitochondrial RNA pr...

journal_title：Molecular medicine reports

authors： Zhang SY,Huang SH,Gao SX,Wang YB,Jin P,Lu FJ

更新日期：2019-10-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common cancer types, and chemotherapy plays an important role in treatment of HCC. However, long‑term treatment with chemotherapeutic drugs such as 5‑fluorouracil (5‑FU) often results in chemoresistance, and the underlying mechanisms remain unclear. In this study, we s...

journal_title：Molecular medicine reports

authors： Wang C,Guo Y,Wang J,Min Z

更新日期：2015-03-01 00:00:00

abstract：:BCL6ZF is a novel transcript of BCL6, which lacks the first two zinc fingers of BCL6. It has been established that BCL6 acts as a sequence‑specific transcriptional repressor, however, the functions of BCL6ZF remain undefined. By generating stably overexpressed BCL6 and BCL6ZF in NCI‑H1299 lung cancer cells, it was fou...

journal_title：Molecular medicine reports

authors： Fu X,Hao Y,Mao Y,Qian Y,Qian Z,Li T,He D,Xiao X

更新日期：2015-05-01 00:00:00

abstract：:Recombinant Ganoderma lucidum immunomodu-latory protein (rLZ-8) expressed using the Pichia yeast eukaryotic expression system is a potential new drug for cancer therapy; however, it has a short half-life in the body. In order to optimize the potency and stability of rLZ-8, we modifi...

journal_title：Molecular medicine reports

authors： Zhang X,Sun F,Liu Z,Zhang S,Liang C

更新日期：2013-03-01 00:00:00

abstract：:An increasing amount of evidence indicates that the inhibition of β adrenergic signaling can result in the inhibition of tumor growth. However, the role of propranolol in liver cancer and the underlying mechanism remain to be elucidated. The present study aimed to investigate the role of propranolol in liver cancer ce...

journal_title：Molecular medicine reports

authors： Wang F,Liu H,Wang F,Xu R,Wang P,Tang F,Zhang X,Zhu Z,Lv H,Han T

更新日期：2018-04-01 00:00:00

abstract：:Radix Dipsaci total saponins (RTS) are primary active components of Radix Dipsaci, which is administered orally for the treatment of osteoporosis according to Chinese Medicine. RTS have also been shown to reduce the risk of bone fractures in rats. However, the detailed molecular mechanisms underlying their action rema...

journal_title：Molecular medicine reports

authors： Niu YB,Kong XH,Li YH,Fan L,Pan YL,Li CR,Wu XL,Lu TL,Mei QB

更新日期：2015-06-01 00:00:00

abstract：:Adrenomedullin (ADM), initially identified in human pheochromocytoma, participates in a wide range of physiological and pathological processes, including vasorelaxation, angiogenesis and apoptosis. Recent studies have reported that ADM protected tumor cells against apoptotic cell de...

journal_title：Molecular medicine reports

authors： Kim JY,Park WD,Lee S,Park JH

更新日期：2012-11-01 00:00:00

abstract：:Cancer stem cells (CSCs) have been found to play a decisive role in cancer recurrence, metastasis, and chemo‑, radio‑ and immuno‑resistance. Understanding the mechanism of CSC self‑renewal and proliferation may help overcome the limitations of clinical treatment. The microenvironment of tumor growth consists of a lack...

journal_title：Molecular medicine reports

authors： Zhang Q,Han Z,Zhu Y,Chen J,Li W

更新日期：2021-01-01 00:00:00

abstract：:The present study aimed to determine the profile of differentially expressed circular RNAs (circRNAs) in infertile patients treated with acupuncture and moxibustion and verify the role of acupuncture and moxibustion in altering endometrial receptivity (ER). High‑throughput RNA sequencing and bioinformatics analysis of...

journal_title：Molecular medicine reports

authors： Shen J,Chen L,Cheng J,Jin X,Mu Y,Li Q,Xia L,Gao Y,Xia Y

更新日期：2019-08-01 00:00:00

abstract：:Studies have shown that the cerebrospinal fluid‑contacting nucleus (CSF‑CN) may be associated with the transduction and regulation of pain signals. However, the role of the CSF‑CN remains to be elucidated. Emerging evidence has suggested that neurokinin 1 receptor (NK1R) is important in the development of visceral pai...

journal_title：Molecular medicine reports

authors： Zhang C,Li Y,Wang X,Fei Y,Zhang L

更新日期：2017-06-01 00:00:00

abstract：:The results of surgical repair of extensive muscle tissue defects are still of primary concern, leaving patients with residual cosmetic and functional impairments. Therefore, skeletal muscle tissue engineering attempts to grow functional neo‑tissue from human stem cells to promote tissue regeneration and support defec...

journal_title：Molecular medicine reports

authors： Mueller CE,Birk R,Kramer B,Wenzel A,Sommer JU,Hörmann K,Stern-Straeter J,Weilbach C

更新日期：2018-03-01 00:00:00

abstract：:Matrilin-2 (matn2) contains a unique domain, between the second von Willebrand factor A (vWFA) domain and the C-terminal coiled-coil domain, with no sequence homology with other family members. Complementary DNA (cDNA) sequence analysis of matn2 expression in both mice and humans re...

journal_title：Molecular medicine reports

authors： Li L,Zhang L,Shao Y,Wang G,Gong R,Wang Z,Peng J,Wang S,Genochio D,Zhao B,Luo J

更新日期：2012-11-01 00:00:00

abstract：:Histone deacetylases (HDACs) are important in chromatin remodeling and epigenetic regulation of gene expression. Histone deacetylase inhibitors (HDACi) have highly effective anti-metastatic and anti-angiogenic activity in various types of cancer, while the molecular mechanisms involved in this process are not fully un...

journal_title：Molecular medicine reports

authors： Lu HG,Zhan W,Yan L,Qin RY,Yan YP,Yang ZJ,Liu GC,Li GQ,Wang HF,Li XL,Li Z,Gao L,Chen GQ

更新日期：2014-11-01 00:00:00

abstract：:Breast cancer ranks as the second most common cause of cancer death among women in the United States. Anticancer agents are an important component of breast cancer therapy. Drugs frequently used to treat breast cancer include methotrexate, 5-fluorouracil (5-FU), cyclophosphamide, anthracyclines, taxanes, trastuzumab, ...

journal_title：Molecular medicine reports

authors： Steelman LS,Navolanic PM,Franklin RA,Bonati A,Libra M,Stivala F,Martelli AM,McCubrey JA

更新日期：2008-03-01 00:00:00

abstract：:Post‑cardiac arrest myocardial dysfunction (PAMD) is a leading cause of death in patients undergoing resuscitation patients following cardiac arrest (CA). Although prostaglandin E1 (PGE1) is a clinical drug used to mitigate ischemia injury, its effect on PAMD remains unknown. In the present study, the protective effec...

journal_title：Molecular medicine reports

authors： Su C,Fan X,Xu F,Wang J,Chen Y

更新日期：2021-02-01 00:00:00

abstract：:Few studies have investigated the changes of Th1- and Th2-type cytokines in pulmonary embolism (PE) patients. In this study, the gene expression of interleukins and the balance of Th1- and Th2-type cytokines in the peripheral blood mononuclear cells (PBMCs) of PE patients and controls were investigated. A total of 20 ...

journal_title：Molecular medicine reports

authors： Duan Q,Lv W,Wang L,Gong Z,Wang Q,Song H,Wang H

更新日期：2013-01-01 00:00:00

abstract：:Patients with skull base chordomas have a poor prognosis, and the role of the protein expression of brachyury in chordomas remains to be fully elucidated. The present study used immunohistochemistry to analyze 57 cases of skull base chordoma, and analyzed the clinical data of the patients. The results demonstrated tha...

journal_title：Molecular medicine reports

authors： Wang K,Tian K,Wang L,Wu Z,Ren C,Hao S,Feng J,Li J,Wan H,Jia G,Zhang L,Zhang J

更新日期：2015-09-01 00:00:00

abstract：:Dysregulation of microRNAs (miRNAs) is involved in the pathogenesis of esophageal cancer. miRNA (miR)‑542‑3p is a tumor suppressor in multiple types of cancer. However, whether and how miR‑542‑3p contributes to the progression of esophageal cancer remains unknown, and this is the aim of the present study. In the curre...

journal_title：Molecular medicine reports

authors： Sun J,Deng Y,Shi J,Yang W

更新日期：2020-01-01 00:00:00

abstract：:In order to evaluate SCN2A as a candidate gene for epileptic susceptibility and the use of a Cu-Zn superoxide dismutase (SOD) supplement as a potential therapy for epilepsy, SCN2A expression in the cortex and the correlation between SCN2A and Cu-Zn SOD in SH-SY5Y cells were examined. SCN2A expression and the concentra...

journal_title：Molecular medicine reports

authors： Xiang J,Jiang Y

更新日期：2014-01-01 00:00:00

abstract：:Lysyl oxidase-like 2 (LOXL2) is key in the hepatocellular carcinoma (HCC) tumor microenvironment and metastatic niche formation. However, its effect on proliferation and clinical parameters in HCC require further elucidation. The present study aimed to investigate LOXL2 expression in HCC from in vitro and clinical asp...

journal_title：Molecular medicine reports

authors： Wu L,Zhang Y,Zhu Y,Cong Q,Xiang Y,Fu L

更新日期：2016-09-01 00:00:00

abstract：:Low shear stress serves an important role in the initiation and progression of atherosclerotic lesions, with an impact on progression, but its detailed mechanisms are .not yet fully known. The present study aimed to investigate endothelial cell (EC) apoptosis, as well as monocyte adhesion induced by low shear stress a...

journal_title：Molecular medicine reports

authors： Xie X,Wang F,Zhu L,Yang H,Pan D,Liu Y,Qu X,Gu Y,Li X,Chen S

更新日期：2020-06-01 00:00:00

abstract：:Streptococcus mutans (S. mutans) bacterium is the most well recognized pathogen involved in pathogenesis of dental caries. Its virulence arises from its ability to produce a biofilm and acidogenicity, causing tooth decay. Discovery of natural products capable to inhibit biofilm formation is of high importance for deve...

journal_title：Molecular medicine reports

authors： Kacergius T,Abu-Lafi S,Kirkliauskiene A,Gabe V,Adawi A,Rayan M,Qutob M,Stukas R,Utkus A,Zeidan M,Rayan A

更新日期：2017-07-01 00:00:00

abstract：:In the present study, the effect of glucosamine administration (1.5 or 3 g/day) on cartilage and bone metabolism was investigated in bicycle racers, using cartilage‑ and bone‑specific biomarkers, including C‑terminal cross‑linked telopeptides of type II collagen (CTX‑II), C‑terminal...

journal_title：Molecular medicine reports

authors： Momomura R,Naito K,Igarashi M,Watari T,Terakado A,Oike S,Sakamoto K,Nagaoka I,Kaneko K

更新日期：2013-03-01 00:00:00

abstract：:Diabetic infected foot is the outcome of progressive vascular and neurological damage caused by persistent chronic hyperglycemia. Due to acute hypoxia and infection, the tissues develop extensive necrosis and gangrene, which often require amputation. The decision regarding the level of amputation relies mainly on the ...

journal_title：Molecular medicine reports

authors： Bekker-Méndez C,Guzmán-Aguilar RM,Hernández-Cueto MA,Huerta-Yepez S,Jarillo-Luna RA,González-Veyrand E,González-Bonilla CR

更新日期：2012-02-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) has been ranked the second leading cause of cancer‑associated mortality in China and the third leading cause of cancer‑associated mortality worldwide. A number of previous studies investigating SLC44A5 have revealed important biological insight and disease‑specific functions. Therefore, ...

journal_title：Molecular medicine reports

authors： Peng GZ,Ye QF,Wang R,Li MX,Yang ZX

更新日期：2016-06-01 00:00:00

abstract：:MicroRNAs (miRs) exhibit oncogenic or tumor suppressive functions that contribute to the initiation and development of various types of human cancer. miR‑149‑3p has been reported to serve multiple roles in the regulation of proliferation, apoptosis and metastasis. However, the effects and detailed mechanism of miR‑149...

journal_title：Molecular medicine reports

authors： Shen Q,Zhu H,Lei Q,Chen L,Yang D,Sui W

更新日期：2021-03-01 00:00:00

abstract：:The aim of the present study was to investigate the molecular mechanism of nasopharyngeal carcinoma (NPC) primary tumor development through the identification of key genes using bioinformatics approaches. Using the GSE53819 microarray dataset, acquired from the Gene Expression Omnibus database, differentially expresse...

journal_title：Molecular medicine reports

authors： An F,Zhang Z,Xia M

更新日期：2015-10-01 00:00:00

abstract：:Indoleamine 2,3‑dioxygenase (IDO), through L‑tryptophan depletion, activates general control non‑derepressible (GCN) 2 kinase and suppresses T‑cell proliferation, in addition to suppressing aerobic glycolysis and glutaminolysis, which are required for these rapidly proliferating cells. A number of, however not all of ...

journal_title：Molecular medicine reports

authors： Eleftheriadis T,Pissas G,Antoniadi G,Tsogka K,Sounidaki M,Liakopoulos V,Stefanidis I

更新日期：2016-01-01 00:00:00

abstract：:Cinobufacini is widely used in the treatment of advanced cancers. It has been previously reported that microRNA (miR)‑494 was upregulated in cinobufacini‑treated gastric cancer cells; however, the detailed role of miR‑494 in the anti‑tumor activity of cinobufacini is unclear. The present study aimed to clarify the fun...

journal_title：Molecular medicine reports

authors： Shen Z,Li Y,Zhao C,Wang F,Zhou R,Chen G

更新日期：2018-05-01 00:00:00

abstract：:The aim of the present study was to evaluate differences in the expression of complement system genes, and serum levels of CH50, C3 and C4 in peripheral blood mononuclear cells from patients with myocardial infarction (AMI), stable angina pectoris (SA) and controls. A total of 100 patients with AMI, 100 with SA and 10...

journal_title：Molecular medicine reports

authors： Yan W,Che L,Jiang J,Yang F,Duan Q,Song H,Liu X,Shen Y,Wang L

更新日期：2016-12-01 00:00:00