Abstract:
:Patients with skull base chordomas have a poor prognosis, and the role of the protein expression of brachyury in chordomas remains to be fully elucidated. The present study used immunohistochemistry to analyze 57 cases of skull base chordoma, and analyzed the clinical data of the patients. The results demonstrated that the protein expression of brachyury was negative in 8.8% (5/57) of the cases. The weak/positive, positive and strong/positive rates were 5.3% (3/57), 21.1% (12/57) and 64.9% (37/57), respectively. The association between the expression of brachyury and recurrence was not statistically significant. Kaplan‑Meier analysis revealed that the degree of surgery, rather than the expression of brachyury, was associated with tumor recurrence (P=0.001). In conclusion, the results of the present study demonstrated that the expression of Brachyury offers a sensitive marker, but not a risk factor, for skull base chordomas, and radical surgery is recommended.
journal_name
Mol Med Repjournal_title
Molecular medicine reportsauthors
Wang K,Tian K,Wang L,Wu Z,Ren C,Hao S,Feng J,Li J,Wan H,Jia G,Zhang L,Zhang Jdoi
10.3892/mmr.2015.3976subject
Has Abstractpub_date
2015-09-01 00:00:00pages
4298-4304issue
3eissn
1791-2997issn
1791-3004journal_volume
12pub_type
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