Formononetin attenuates monocrotaline‑induced pulmonary arterial hypertension via inhibiting pulmonary vascular remodeling in rats.

abstract：:Aquaporin 4 (AQP4) is a widely distributed membrane protein, which is found in glial cells, ependymocytes and capillary endothelial cells in the brain, and particularly in the choroid plexus. AQP4 is a key regulator of water metabolism, and changes in its expression following brain injury are associated with pathologi...

journal_title：Molecular medicine reports

authors： Zhang C,Chen J,Lu H

更新日期：2015-11-01 00:00:00

abstract：:Previous studies have shown that (GM3), a ganglioside, suppresses hepatoma cell motility and migration by inhibiting phosphorylation of EGFR and the activity of the PI3K/AKT signaling pathway. Therefore, the aim of the present study was to investigate whether the combined treatment of CD82 with gangliosides can exert ...

journal_title：Molecular medicine reports

authors： Huang X,Li Y,He X,Chen Y,Wei W,Yang X,Ma K

更新日期：2020-11-01 00:00:00

abstract：:The aim of the present study was to report on a complete synthetic approach, namely benzylation-hydrolysis-acylation‑hydrogenation, to the synthesis of regioselectively acylated quercetin analogues using low‑cost rutin as a starting material. Three quercetin analogues, quercetin‑3‑O‑propionate (Q‑pr), quercetin‑3‑O‑bu...

journal_title：Molecular medicine reports

authors： Duan Y,Sun N,Xue M,Wang X,Yang H

更新日期：2017-12-01 00:00:00

abstract：:The primary aim of the present study was to evaluate the effects of liraglutide on glucolipotoxicity‑induced liver cell apoptosis and the underlying mechanisms in Zucker diabetic fatty (ZDF) rats. The results revealed that liraglutide significantly decreased the body weight, hyperglycemia and hyperlipidemia of ZDF rat...

journal_title：Molecular medicine reports

authors： Guo J,Li C,Yang C,Li B,Wei J,Lin Y,Ye P,Hu G,Li J

更新日期：2018-06-01 00:00:00

abstract：:Mesenchymal stromal cells (MSCs) have therapeutic potential for repairing tissue damage and are involved in immune regulation. MSCs are predominantly isolated from bone marrow (BM), adipose tissue or placental tissue. Further to these well‑known sources, the isolation of MSCs from human tonsils was previously reported...

journal_title：Molecular medicine reports

authors： Ryu JH,Park M,Kim BK,Kim YH,Woo SY,Ryu KH

更新日期：2016-10-01 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) have been demonstrated to be significant in numerous biological processes. Hypertension is a form of cardiovascular disease with at least one billion cases worldwide. The present study sought to compare the differential expression profiles of lncRNAs in the renal cortex of spontaneously ...

journal_title：Molecular medicine reports

authors： Hou L,Lin Z,Ni Y,Wu Y,Chen D,Song L,Huang X,Hu H,Yang D

更新日期：2016-01-01 00:00:00

abstract：:Caffeine is one of the most widely consumed substances found in beverages, and has demonstrated anticancer effects in several types of cancer. The present study aimed to examine the anticancer effects of caffeine on gastric cancer (GC) cells (MGC‑803 and SGC‑7901) in vitro, and to determine whether the apoptosis‑relat...

journal_title：Molecular medicine reports

authors： Liu H,Zhou Y,Tang L

更新日期：2017-09-01 00:00:00

abstract：:Mutations in the optic atrophy 1 gene (OPA1) are associated with autosomal dominant optic atrophy and 20% of patients demonstrate extra-ocular manifestations. In addition to these autosomal dominant cases, only a few syndromic cases have been reported thus far with compound heterozygous OPA1 mutations, suggestive of e...

journal_title：Molecular medicine reports

authors： Lee J,Jung SC,Hong YB,Yoo JH,Koo H,Lee JH,Hong HD,Kim SB,Chung KW,Choi BO

更新日期：2016-07-01 00:00:00

abstract：:Fluid shear stress has been revealed to differentially regulate endothelial nitric oxide synthase (eNOS) distribution in vessels. eNOS, a key enzyme in controlling nitric oxide (NO) release, has a crucial role in mediating oxidative stress, and resveratrol (RSV)‑mediated eNOS also attenuates oxidative damage and suppr...

journal_title：Molecular medicine reports

authors： Wang Z,Zhang J,Li B,Gao X,Liu Y,Mao W,Chen SL

更新日期：2014-10-01 00:00:00

abstract：:The aim of the present study was to establish an integrated network of DNA methylation and RNA expression in an ovalbumin (OVA)‑induced asthma model, and to investigate the epigenetically‑regulated genes involved in asthma development. Genome‑wide CpG‑DNA methylation profiling was conducted through the use of a methyl...

journal_title：Molecular medicine reports

authors： Kim JS,Shin IS,Shin NR,Nam JY,Kim C

更新日期：2020-09-01 00:00:00

abstract：:Glucosamine is a possible cause of vascular endothelial injury in the initial stages of atherosclerosis, through endoplasmic reticulum (ER) stress resulting in fatty streaks in the vascular wall. Quercetin is an anti‑diabetic and cardiovascular protective agent that has previously been demonstrated to reduce ER stress...

journal_title：Molecular medicine reports

authors： Cai X,Bao L,Ding Y,Dai X,Zhang Z,Li Y

更新日期：2017-02-01 00:00:00

abstract：:Adoptive transfer of bone marrow‑derived mesenchymal stem cells (BMSCs) significantly alleviates smoking‑induced chronic obstructive pulmonary disease (COPD) in rats. Considering the critical roles of T cells during COPD development, the present study aimed to further identify the molecular mechanisms underlying the a...

journal_title：Molecular medicine reports

authors： Li X,Xu J,Li P

更新日期：2020-05-01 00:00:00

abstract：:Mossy fiber sprouting (MFS) is a pathological phenomenon that is commonly observed in temporal lobe epilepsy (TLE). However, the molecular mechanisms underlying MFS remain unclear. It has been demonstrated that the tau protein is important in the progression of MFS by the regulation of microtubule dynamics and axonal ...

journal_title：Molecular medicine reports

authors： Huang WJ,Tian FF,Chen JM,Guo TH,Ma YF,Fang J,Dang J,Song MY

更新日期：2013-11-01 00:00:00

abstract：:The tumor suppressor gene CD82, also known as KAI1, may act as a general suppressor of metastasis in numerous types of cancer. It is hypothesized that downregulation of CD82 gene expression may be an important factor in the induction of hepatocellular carcinoma (HCC), however the mechanism for this requires further st...

journal_title：Molecular medicine reports

authors： Yu G,Bing Y,Li W,Xia L,Liu Z

更新日期：2014-11-01 00:00:00

abstract：:Neutrophilic asthma (NA) is characterized by neutrophil‑mediated inflammation and the presence of Th17 cells. However, the mechanisms underlying Th17 cell responses in NA remain unknown. The aim of the present study was to examine the effects of interleukin (IL)‑7 on Th17 cell responses in NA. A NA mouse model was sen...

journal_title：Molecular medicine reports

authors： Zhang X,Zhang M,Jiang M,Nong G

更新日期：2020-08-01 00:00:00

abstract：:Liver cirrhosis is frequently accompanied by malnutrition and hypoalbuminemia, which in turn commonly induces ascites in patients with liver cirrhosis. Ascites leads to abdominal distention and appetite loss, resulting in a deteriorated quality of life (QOL). Administration of branched-chain amino acid (BCAA)-rich sup...

journal_title：Molecular medicine reports

authors： Itou M,Kawaguchi T,Taniguchi E,Oku Y,Fukushima N,Ando E,Oriishi T,Uchida Y,Otsuka M,Tanaka S,Iwasaki S,Torii M,Yoshida K,Adachi Y,Suga M,Yoshiyama M,Ibi R,Akiyama Y,Takakura M,Mitsuyama K,Tsuruta O,Sata M

更新日期：2009-11-01 00:00:00

abstract：:Interleukin-8 (IL-8) possesses tumorigenic and proangiogenic properties, and is overexpressed in many human cancer types. However, only few studies have demonstrated the mechanisms of action of IL‑8 regarding the ability to promote proliferation and to inhibit apoptosis in prostate cancer. Here, the aim of the present...

journal_title：Molecular medicine reports

authors： Guo Y,Zang Y,Lv L,Cai F,Qian T,Zhang G,Feng Q

更新日期：2017-12-01 00:00:00

abstract：:Triple-negative breast cancer (TNBC) is associated with an aggressive clinical history, high risk of recurrence and metastasis, and shorter patient survival due to lack of targeted therapy. In the present study, UNC0638, a chemical G9a inhibitor, was identified to suppress TNBC cell invasion and migration in vitro at ...

journal_title：Molecular medicine reports

authors： Liu XR,Zhou LH,Hu JX,Liu LM,Wan HP,Zhang XQ

更新日期：2018-02-01 00:00:00

abstract：:Endothelial dysfunction caused by reactive oxygen species (ROS) has been implicated in numerous cardiovascular diseases. Astragalus polysaccharide (APS), an important bioactive component extracted from the Chinese herb Astragalus membranaceus, has been widely used for the treatment of cardiovascular disease. The prese...

journal_title：Molecular medicine reports

authors： Han R,Tang F,Lu M,Xu C,Hu J,Mei M,Wang H

更新日期：2017-06-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have been investigated in the treatment of numerous autoimmune diseases. However, the immune properties of MSCs on the development of asthma have remained to be fully elucidated. Airway dendritic cells (DCs) have an important role in the pathogenesis of allergic asthma, and disrupting the...

journal_title：Molecular medicine reports

authors： Zeng SL,Wang LH,Li P,Wang W,Yang J

更新日期：2015-08-01 00:00:00

abstract：:Oxidized low-density lipoprotein (Ox-LDL), as a strong oxidant, results in renal injury through multiple mechanisms. The aim of the present study was to determine the injury effects of Ox‑LDL and the potential protective effects of the antioxidant reagent probucol on epithelial‑mesenchymal transition (EMT) in human re...

journal_title：Molecular medicine reports

authors： Zhu BB,Wang H,Chi YF,Wang YM,Yao XM,Liu S,Qiu H,Fang J,Yin PH,Zhang XM,Peng W

更新日期：2018-01-01 00:00:00

abstract：:Cancer stem cells (CSCs) have been found to play a decisive role in cancer recurrence, metastasis, and chemo‑, radio‑ and immuno‑resistance. Understanding the mechanism of CSC self‑renewal and proliferation may help overcome the limitations of clinical treatment. The microenvironment of tumor growth consists of a lack...

journal_title：Molecular medicine reports

authors： Zhang Q,Han Z,Zhu Y,Chen J,Li W

更新日期：2021-01-01 00:00:00

abstract：:G-protein-coupled receptor 30 (GPR30) has been reported to act as a membrane-bound estrogen receptor that is involved in the mediation of non-genomic estradiol signalling. In this study, we demonstrated that male, but not female, GPR30-deficient mice suffer from impaired left‑ventricular cardiac function. Left ventric...

journal_title：Molecular medicine reports

authors： Delbeck M,Golz S,Vonk R,Janssen W,Hucho T,Isensee J,Schäfer S,Otto C

更新日期：2011-01-01 00:00:00

abstract：:Angiopoietin-like protein 4 (Angptl4) is a secreted protein predominantly expressed in liver and adipose tissues, and has been identified as an adipokine. Angptl4 is the target gene of peroxisome proliferator‑activated receptors, which are widely used as lipid‑lowering and anti‑diabetic drugs, and previous studies hav...

journal_title：Molecular medicine reports

authors： Wang Y,Liu LM,Wei L,Ye WW,Meng XY,Chen F,Xiao Q,Chen JY,Zhou Y

更新日期：2016-10-01 00:00:00

abstract：:Hypertensive nephrosclerosis (HNS) is a major risk factor for end-stage renal disease. However, the underlying pathogenesis of HNS remains to be fully determined. The gene expression profile of GSE20602, which consists of 14 glomeruli samples from patients with HNS and 4 normal glomeruli control samples, was obtained ...

journal_title：Molecular medicine reports

authors： Liu T,Liu M,Shang P,Jin X,Liu W,Zhang Y,Li X,Ding Y,Li Y,Wen A

更新日期：2018-03-01 00:00:00

abstract：:The mechanisms underlying cancer radioresistance remain unclear. Several studies have found that increased glucose transporter‑1 (GLUT‑1) expression is associated with radioresistance. Recently, the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) pathway was reported to be involved in the control of GLUT‑1...

journal_title：Molecular medicine reports

authors： Fang J,Zhou SH,Fan J,Yan SX

更新日期：2015-03-01 00:00:00

abstract：:Transgelin 2 (TAGLN2) is a cytoskeletal protein of the calponin family. Abnormal expression of TAGLN2 was observed in various types of cancer. Our previous study reported that TAGLN2 expression was reduced in lymph node‑positive breast cancer patients; however, the role of TAGLN2 in breast cancer metastasis remains un...

journal_title：Molecular medicine reports

authors： Yang L,Hong Q,Xu SG,Kuang XY,Di GH,Liu GY,Wu J,Shao ZM,Yu SJ

更新日期：2019-11-01 00:00:00

abstract：:Several environmental contaminants have been linked to the development of diabetes and increased diabetes‑associated mortality. Perfluorooctanoic acid (PFOA) is a widely used perfluoroalkane found in surfactants and lubricants, and in processing aids used in the production of polymers. Furthermore, PFOA has been detec...

journal_title：Molecular medicine reports

authors： Suh KS,Choi EM,Kim YJ,Hong SM,Park SY,Rhee SY,Oh S,Kim SW,Pak YK,Choe W,Chon S

更新日期：2017-06-01 00:00:00

abstract：:Hydroxyapatite scaffolds (HASs) are widely studied as suitable materials for bone replacement scaffolds due to their chemical similarities to organic materials. In our previous study, a novel HAS with a 25‑30‑µm groove structure (HAS‑G) exhibited enhanced osteogenesis of bone mesenchymal stromal cells (BMSCs) compared...

journal_title：Molecular medicine reports

authors： Li C,Yang L,Ren X,Lin M,Shen D,Li Y,Zhang X,Liu C,Mu Y

更新日期：2020-10-01 00:00:00

abstract：:Moscatilin is a bibenzyl derivative extracted from the Dendrobium aurantiacum var. denneanum, which has traditionally been used as an immunomodulatory treatment in China. The present study was designed to determine whether moscatilin is a pro‑apoptotic agent in pancreatic cancer, and to elucidate the underlying mechan...

journal_title：Molecular medicine reports

authors： Zhang L,Fang Y,Xu XF,Jin DY

更新日期：2017-03-01 00:00:00