Abstract:
:G-protein-coupled receptor 30 (GPR30) has been reported to act as a membrane-bound estrogen receptor that is involved in the mediation of non-genomic estradiol signalling. In this study, we demonstrated that male, but not female, GPR30-deficient mice suffer from impaired left‑ventricular cardiac function. Left ventricles from male mutant mice were enlarged. There were no malformations in the valves or outflow tract of the heart. Both the contractility and relaxation capacity of the left ventricle were reduced, leading to increased left‑ventricular end-diastolic pressure in GPR30-deficient mice. In conclusion, our data support a role for GPR30 in the gender-specific aspects of heart failure.
journal_name
Mol Med Repjournal_title
Molecular medicine reportsauthors
Delbeck M,Golz S,Vonk R,Janssen W,Hucho T,Isensee J,Schäfer S,Otto Cdoi
10.3892/mmr.2010.402subject
Has Abstractpub_date
2011-01-01 00:00:00pages
37-40issue
1eissn
1791-2997issn
1791-3004journal_volume
4pub_type
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