Impaired left-ventricular cardiac function in male GPR30-deficient mice.

Abstract:

:G-protein-coupled receptor 30 (GPR30) has been reported to act as a membrane-bound estrogen receptor that is involved in the mediation of non-genomic estradiol signalling. In this study, we demonstrated that male, but not female, GPR30-deficient mice suffer from impaired left‑ventricular cardiac function. Left ventricles from male mutant mice were enlarged. There were no malformations in the valves or outflow tract of the heart. Both the contractility and relaxation capacity of the left ventricle were reduced, leading to increased left‑ventricular end-diastolic pressure in GPR30-deficient mice. In conclusion, our data support a role for GPR30 in the gender-specific aspects of heart failure.

journal_name

Mol Med Rep

authors

Delbeck M,Golz S,Vonk R,Janssen W,Hucho T,Isensee J,Schäfer S,Otto C

doi

10.3892/mmr.2010.402

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

37-40

issue

1

eissn

1791-2997

issn

1791-3004

journal_volume

4

pub_type

杂志文章