Abstract:
:Triple-negative breast cancer (TNBC) is associated with an aggressive clinical history, high risk of recurrence and metastasis, and shorter patient survival due to lack of targeted therapy. In the present study, UNC0638, a chemical G9a inhibitor, was identified to suppress TNBC cell invasion and migration in vitro at a non‑cytotoxic concentration. In addition, UNC0638 reduced the size and number of the tumorsphere and decreased anchor‑independent colony formation in the two TNBC cell lines. Evaluation of the underlying mechanism revealed that the suppressive effect of UNC0638 is associated with modulation of epithelial‑mesenchymal transition through enhancing E‑cadherin promoter activities and restoring its expression. Thus, the current data indicates that UNC0638 may be developed as a chemotherapeutic agent to effectively treat metastatic cancers, including TNBC.
journal_name
Mol Med Repjournal_title
Molecular medicine reportsauthors
Liu XR,Zhou LH,Hu JX,Liu LM,Wan HP,Zhang XQdoi
10.3892/mmr.2017.8190subject
Has Abstractpub_date
2018-02-01 00:00:00pages
2239-2244issue
2eissn
1791-2997issn
1791-3004journal_volume
17pub_type
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