Effect of IL‑7 on Th17 cell responses in a mouse model of neutrophilic asthma.

abstract：:Bone morphogenetic proteins (BMPs) are involved in diverse biological processes, including cell proliferation, differentiation and apoptosis. Results from the MTT assay revealed that BMP-2 significantly inhibited the proliferation of MDA-MB‑231 and MCF-7 breast cancer cells. The flo...

journal_title：Molecular medicine reports

authors： Chen A,Wang D,Liu X,He S,Yu Z,Wang J

更新日期：2012-09-01 00:00:00

abstract：:Leukemia inhibitory factor (LIF) modulates various biological processes. Although previous studies have described the effects of LIF on adipocyte differentiation, the role of LIF receptor (LIFR) on adipocyte differentiation remains unclear. Using reverse transcription‑quantitative PCR (RT‑qPCR), LIFR expression was de...

journal_title：Molecular medicine reports

authors： Wang T,Yan R,Xu X,Yu H,Wu J,Yang Y,Li W

更新日期：2019-06-01 00:00:00

abstract：:Metabolic syndrome based on insulin resistance (IR) and hypertension is a risk factor for advanced liver disease and cardiovascular disease in patients with nonalcoholic steatohepatitis (NASH). The present study investigated the effects of severe hypertension induced by a high‑salt (HS) diet and antihypertensive thera...

journal_title：Molecular medicine reports

authors： Kozono M,Uto H,Ibusuki R,Arima S,Oda K,Taguchi H,Sasaki F,Nasu Y,Hashimoto S,Setoyama H,Kanmura S,Numata M,Tsubouchi H,Ido A

更新日期：2016-12-01 00:00:00

abstract：:Repair of cartilage defects remains a challenge for surgeons, owing to its poor self‑repairing capacity. Cartilage tissue engineering, particularly marrow stem cell‑based cartilage regeneration, provides a promising option for the regeneration of damaged cartilage. Although producing tissue‑engineered cartilage from m...

journal_title：Molecular medicine reports

authors： Zhang X,Xue K,Zhou J,Xu P,Huang H,Liu K

更新日期：2015-10-01 00:00:00

abstract：:Ampelopsin (AMP), a plant flavonoid, has been reported to inhibit cell growth and/or induce apoptosis in various types of tumor. The aim of the present study was to assess the apoptosis-inducing activity of AMP in A549 human lung adenocarcinoma epithelial cells and the associated underlying mechanism. A549 cells were ...

journal_title：Molecular medicine reports

authors： Chen XM,Xie XB,Zhao Q,Wang F,Bai Y,Yin JQ,Jiang H,Xie XL,Jia Q,Huang G

更新日期：2015-01-01 00:00:00

abstract：:The present study aimed to investigate the role of Bruton's tyrosine kinase (BTK) in the pathogenesis of lung injury induced by trauma‑hemorrhagic shock (THS), and to examine the pulmonary protective effects of BTK inhibition. Male Sprague‑Dawley rats were divided into four groups (n=12/group): i) A Sham group, which ...

journal_title：Molecular medicine reports

authors： Liu X,Zhang J,Han W,Wang Y,Liu Y,Zhang Y,Zhou D,Xiang L

更新日期：2017-07-01 00:00:00

abstract：:A previous study has demonstrated a progression in the nerve regeneration by polyaniline/cellulose (PANI/RC), although the underlying mechanism was not elucidated. In the present study, regenerated nerves were investigated, using histological techniques, functional assays and western blot analysis. The triceps surae m...

journal_title：Molecular medicine reports

authors： Fan L,Xiong Y,Fu Z,Xu D,Wang L,Chen Y,Xia H,Peng N,Ye S,Wang Y,Zhang L,Ye Q

更新日期：2017-11-01 00:00:00

abstract：:To identify novel candidate genes associated with osteoporosis, RNA‑sequence analysis of human mesenchymal stem cells (hMSCs) from patients with osteoporosis (G3) and osteopenia (G2), and healthy controls (G1) was performed. Differentially expressed genes (DEGs) from among the three groups were identified. DEGs were s...

journal_title：Molecular medicine reports

authors： Song I,Choi YJ,Jin Y,Kim JW,Koh JT,Ji HM,Jeong SY,Won YY,Kim W,Chung YS

更新日期：2017-10-01 00:00:00

abstract：:Intracerebral hemorrhage (ICH) is a disease associated with high mortality and morbidity. MicroRNAs (miRNAs) have been reported to be associated with the pathogenesis of numerous cerebrovascular diseases, including ICH. miR‑222 has been revealed to play important roles in various physiological and pathological process...

journal_title：Molecular medicine reports

authors： Bai YY,Niu JZ

更新日期：2020-03-01 00:00:00

abstract：:In the present study, the effect of fatty acid synthase (FASN) inhibition on cell invasion and migration in vitro was investigated. A recombinant plasmid containing a microRNA targeting the FASN gene was used to inhibit FASN expression in U2‑OS cells. Cell migration and invasion were investigated using wound healing a...

journal_title：Molecular medicine reports

authors： Liu ZL,Mao JH,Peng AF,Yin QS,Zhou Y,Long XH,Huang SH

更新日期：2013-02-01 00:00:00

abstract：:Taraxacum coreanum Nakai is a dandelion that is native to Korea, and is widely used as an edible and medicinal herb. The present study revealed the neuroprotective effect of this plant against glutamate-induced oxidative stress in HT22 murine hippocampal neuronal cells. Ethanolic extracts from the aerial (TCAE) and th...

journal_title：Molecular medicine reports

authors： Yoon CS,Ko W,Lee DS,Kim DC,Kim J,Choi M,Beom JS,An RB,Oh H,Kim YC

更新日期：2017-04-01 00:00:00

abstract：:The present study investigated the immunopathological effect of Echinococcus multilocularis (Em) using cytokine detection. Expression of the T‑helper (Th) 17‑cytokine, interleukin 17 (IL‑17), was observed using immunohistochemical staining, and levels of cytokines, including IL‑17, transforming growth factor β1 (TGF‑β...

journal_title：Molecular medicine reports

authors： Ma X,Wang L,Zhao H,Pang N,Zhang F,Jiang T,Liu X,Mamuti W,Wen H,Ding J

更新日期：2014-07-01 00:00:00

abstract：:Dehydrocostuslactone is a sesquiterpene lactone derived from Saussurea lappa, a plant used in traditional herbal medicines. The anti-proliferative activity of dehydrocostuslactone was investigated in human breast cancer (MDA-MB-231, MDA-MB-453 and SK-BR-3) and ovarian cancer (SK-OV-3 and OVCAR3) cell lines using the m...

journal_title：Molecular medicine reports

authors： Choi EJ,Kim GH

更新日期：2010-01-01 00:00:00

abstract：:Obesity is marked by deposition of collagen I in adipose tissue. Toll like receptor (TLR)2 is involved in lipid metabolism, however the association between TLR2 and collagen I remains unclear. The present study was designed to investigate the effect of TLR2 knockout on collagen I in adipose tissue in obese mice. TLR2 ...

journal_title：Molecular medicine reports

authors： Song B,Zhang H,Zhang S

更新日期：2018-04-01 00:00:00

abstract：:Prostaglandin E2 has exhibited pleiotropic effects in the regulation of glomerulosclerosis progression through its four receptors. The current study aimed to evaluate the effect of prostaglandin receptor EP4 on mesangial cell proliferation. In vivo, 5/6 nephrectomy was introduced into EP4+/‑ and wild‑type (WT) mice. C...

journal_title：Molecular medicine reports

authors： Cao Y,Pan T,Chen X,Wu J,Guo N,Wang B

更新日期：2018-12-01 00:00:00

abstract：:The aim of the present study was to investigate the possible role of cytotoxic T lymphocytes (CTL) and mononuclear macrophages in the pathogenic processes of experimental animals. To construct a chronic experimental allergic encephalomyelitis (EAE) model, an artificially synthesized myelin oligodendrocyte glycoprotein...

journal_title：Molecular medicine reports

authors： Zhou X,Li X,Feng M,Zhang Q,Yang Z

更新日期：2015-11-01 00:00:00

abstract：:The aim of the present study was to investigate the role of microRNA (miR)‑34a expression in the proliferation, invasion and metastasis of colon cancer and its underlying mechanisms. HCT116 cells were cultured in high‑sugar Dulbecco's modified Eagle's medium (DMEM) containing 10% fetal bovine serum and 1000 U/ml penic...

journal_title：Molecular medicine reports

authors： Li C,Lu S,Wang Y,Guo S,Zhao T,Wang X,Song B

更新日期：2017-02-01 00:00:00

abstract：:It is well known that the occupational exposure to contaminants and carcinogens leads to the development of cancer in exposed workers. In the 18th century, Percivall Pott was the first to hypothesize that chronic exposure to dust in the London chimney sweeps was associated with an increased risk of developing cancer. ...

journal_title：Molecular medicine reports

authors： Falzone L,Marconi A,Loreto C,Franco S,Spandidos DA,Libra M

更新日期：2016-11-01 00:00:00

abstract：:MicroRNAs (miRs) exhibit oncogenic or tumor suppressive functions that contribute to the initiation and development of various types of human cancer. miR‑149‑3p has been reported to serve multiple roles in the regulation of proliferation, apoptosis and metastasis. However, the effects and detailed mechanism of miR‑149...

journal_title：Molecular medicine reports

authors： Shen Q,Zhu H,Lei Q,Chen L,Yang D,Sui W

更新日期：2021-03-01 00:00:00

abstract：:The zinc-fingers and homeoboxes protein 1 (ZHX1) consists of 873 amino acid residues, is localized in the cell nucleus and appears to act as a transcriptional repressor. Previous studies have shown that ZHX1 interacts with nuclear factor Y subunit α (NF-YA), DNA methyltransferases (DNMT) 3B and ZHX2, all of which are ...

journal_title：Molecular medicine reports

authors： Wang J,Liu D,Liang X,Gao L,Yue X,Yang Y,Ma C,Liu J

更新日期：2013-11-01 00:00:00

abstract：:Dysregulation of microRNAs (miRNAs) is involved in the pathogenesis of esophageal cancer. miRNA (miR)‑542‑3p is a tumor suppressor in multiple types of cancer. However, whether and how miR‑542‑3p contributes to the progression of esophageal cancer remains unknown, and this is the aim of the present study. In the curre...

journal_title：Molecular medicine reports

authors： Sun J,Deng Y,Shi J,Yang W

更新日期：2020-01-01 00:00:00

abstract：:The present study detected p75 neurotrophin receptor (p75NTR) expression in tongue squamous cell carcinoma (TSCC) cell lines, in order to define the biological properties of p75NTR+ cells and to confirm the use of p75NTR+ as a surface marker for TSCC stem cells. p75NTR+ cells were separated from Tca‑8113 and CAL‑27 TS...

journal_title：Molecular medicine reports

authors： Tong D,Sun J,Huang P,Li M,Zhang F

更新日期：2017-05-01 00:00:00

abstract：:Hepatoblastoma (HB) is the most common type of pediatric liver malignancy, which predominantly occurs in young children (aged <5 years), and continues to be a therapeutic challenge in terms of metastasis and drug resistance. As a new pattern of tumor blood supply, vasculogenic mimicry (VM) is a channel structure lined...

journal_title：Molecular medicine reports

authors： Zhang F,Zhang CM,Li S,Wang KK,Guo BB,Fu Y,Liu LY,Zhang Y,Jiang HY,Wu CJ

更新日期：2018-01-01 00:00:00

abstract：:Despite advances in the treatment of T‑cell acute lymphoblastic leukemia (T‑ALL), the outcome of T‑ALL treatment remains unsatisfactory, therefore, more effective treatment is urgently required. The present study examined the cytotoxicities of bortezomib in combination with daunorubicin against human Jurkat and Molt‑4...

journal_title：Molecular medicine reports

authors： Du X,Tong J,Lu H,He C,Du S,Jia P,Zhao W,Xu H,Li J,Shen Z,Wu Y,Tong J,Zhou L

更新日期：2017-07-01 00:00:00

abstract：:B-cell lymphoma-extra large (Bcl-xl) is an anti-apoptotic member of the B-cell lymphoma 2 (Bcl-2) family that is often found to be overexpressed in human hepatocellular carcinoma (HCC), therefore conferring a survival advantage to tumor cells. microRNA (miRNA) let-7b is downregulated in HCC and its expression correlat...

journal_title：Molecular medicine reports

authors： Ma J,Guo R,Wang T,Pan X,Lei X

更新日期：2015-01-01 00:00:00

abstract：:Diabetes mellitus is known to cause kidney impairment; however, the mechanism remains elusive. The aim of this study was to investigate the role of C/EBP homologous protein (CHOP), an important protein in endoplasmic reticulum stress‑mediated mesangial cell apoptosis in hyperglycemia. Mesangial cells were cultured in ...

journal_title：Molecular medicine reports

authors： He D,Li J,Zhao J,Fei J,Zhang X

更新日期：2013-02-01 00:00:00

abstract：:Multidrug resistance (MDR) is a major impediment to cancer therapy. MG‑132 has been identified to be effective against MDR in several types of cancer. However, the mechanism of MG‑132 in head and neck squamous cell carcinomas remains unknown. Based on our previous study, the present detected P‑gp and P‑gp expression i...

journal_title：Molecular medicine reports

authors： Ma J,Lv Z,Liu X,Liu X,Xu W

更新日期：2018-08-01 00:00:00

abstract：:Aloperine (Alo), as a quinolizidine alkaloid extracted from S. alopecuroide, has the positive activities of anti-inflammatory, anti-allergenic, antitumor and anti-viral. However, the role and mechanism of Alo in breast cancer have not been studied yet. In the present study, Alo markedly inhibited the proliferation and...

journal_title：Molecular medicine reports

authors： Tian D,Li Y,Li X,Tian Z

更新日期：2018-10-01 00:00:00

abstract：:Embryonic stem cells (ESCs) have unlimited expansion potential and the ability to differentiate into all somatic cell types for regenerative medicine and disease model studies. Octamer‑binding transcription factor 4 (OCT4), encoded by the POU domain, class 5, transcription factor 1 gene, is a transcription factor vita...

journal_title：Molecular medicine reports

authors： She S,Wei Q,Kang B,Wang YJ

更新日期：2017-11-01 00:00:00

abstract：:Runt-related transcription factor 2 (RUNX2) is a vital regulatory factor that controls osteoblast-specific gene expression; however, RUNX2‑regulated genes in human mesenchymal stem cells (hMSCs) remain to be fully elucidated. In the present study, chromatin immunoprecipitation (ChIP)-on-chip analysis of RUNX2 in hMSCs...

journal_title：Molecular medicine reports

authors： Xiong J,Hu Z,Wang T,Xu X,Liu J,Wu P,Che X,Li W

更新日期：2016-08-01 00:00:00