Gangliosides and CD82 inhibit the motility of colon cancer by downregulating the phosphorylation of EGFR at different tyrosine sites and signaling pathways.

abstract：:Y‑box binding protein‑1 (YB‑1) has been identified as an oncoprotein in various malignancies. The aim of this study was to investigate the biological role of YB‑1 and its association with epithelial‑to‑mesenchymal transition (EMT) in colorectal cancer (CRC). The expression of YB‑1 and three EMT‑related proteins (E‑cad...

journal_title：Molecular medicine reports

authors： Yan XB,Zhu QC,Chen HQ,Peng JY,Chao HL,Du HX,Wang ZG,Jin ZM

更新日期：2014-11-01 00:00:00

abstract：:The oral fluoropyrimidine S-1 has marked efficacy in treating metastatic colorectal cancer patients. In the present study, we explored the therapeutic potential of combined in vivo treatment in the human colon cancer cell lines COL-1, KM12C and KM20C with consecutive oral S-1 and leucovorin (LV) in 2-week therapeutic ...

journal_title：Molecular medicine reports

authors： Tsukioka S,Uchida J,Tsujimoto H,Nakagawa F,Sugimoto Y,Oka T,Kiniwa M

更新日期：2009-05-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) possess three characteristics critical to tissue regeneration; multipotency, low immunogenicity and an undifferentiated status, providing plasticity. However, increasing evidence has indicated that induction of an immune response in vivo can injure and reject MSC‑based tissues. Toll‑like ...

journal_title：Molecular medicine reports

authors： Yang Y,Wang Y,Li L,Bao J,Chen F,Zhang L

更新日期：2015-12-01 00:00:00

abstract：:Glaucoma is one of the leading causes of blindness. Previous studies have indicated that the oxidative stress‑induced apoptosis of trabecular meshwork cells (TMCs) may serve a key role in the pathogenesis of glaucoma, and that micro RNA(miR)‑17‑5p may be involved in this process. However, the specific mechanisms requi...

journal_title：Molecular medicine reports

authors： Wang X,Li Z,Bai J,Song W,Zhang F

更新日期：2019-04-01 00:00:00

abstract：:B7-H4 is a co‑inhibitory molecule of the B7 family, which is expressed on antigen‑presenting cells (APCs) and is able to limit the T‑cell immune response. Macrophages act as professional APCs and are important for immunoregulation of the tumor microenvironment in breast cancer. In order to identify the association bet...

journal_title：Molecular medicine reports

authors： Liu L,Li D,Chen S,Zhao R,Pang D,Li D,Fu Z

更新日期：2016-09-01 00:00:00

abstract：:Ginsenosides exhibit various neuroprotective effects against oxidative stress. However, which ginsenoside provides optimal effects for the treatment of neurological disorders as a potent antioxidant remains to be elucidated. Therefore, the present study investigated and compared the neuroprotective effects of the Rb1,...

journal_title：Molecular medicine reports

authors： Ye J,Yao JP,Wang X,Zheng M,Li P,He C,Wan JB,Yao X,Su H

更新日期：2016-04-01 00:00:00

abstract：:G-protein-coupled receptor 30 (GPR30) has been reported to act as a membrane-bound estrogen receptor that is involved in the mediation of non-genomic estradiol signalling. In this study, we demonstrated that male, but not female, GPR30-deficient mice suffer from impaired left‑ventricular cardiac function. Left ventric...

journal_title：Molecular medicine reports

authors： Delbeck M,Golz S,Vonk R,Janssen W,Hucho T,Isensee J,Schäfer S,Otto C

更新日期：2011-01-01 00:00:00

abstract：:Several single nucleotide polymorphisms (SNPs) influencing DNA repair capacity and apoptotic status may confer genetic predisposition to Philadelphia‑chromosome negative myeloproliferative neoplasms (PN‑MPNs), and influence therapeutic response and the clinical course. In the present study, whether SNPs in genes invol...

journal_title：Molecular medicine reports

authors： Azevedo AP,Silva SN,Reichert A,Lima F,Júnior E,Rueff J

更新日期：2018-12-01 00:00:00

abstract：:The purpose of the present study was to examine the effects of myricetin on reducing cerebral ischemia injury in a rat model. A rat model of permanent middle cerebral artery occlusion (pMCAO) was used in the present study. Rats were randomized into the following five groups: Sham, model, low‑myricetin (1 mg/kg), mediu...

journal_title：Molecular medicine reports

authors： Sun L,Xu P,Fu T,Huang X,Song J,Chen M,Tian X,Yin H,Han J

更新日期：2018-02-01 00:00:00

abstract：:Centromere protein M (CENPM), a protein required for chromosome separation, is involved in in mitosis. However, little has been reported about the roles of CENPM in various types of cancer. The present study identified that the mRNA expression levels of CENPM were significantly upregulated in 14 types of human cancer ...

journal_title：Molecular medicine reports

authors： Liu Y,Yu W,Ren P,Zhang T

更新日期：2020-11-01 00:00:00

abstract：:Prostate cancer (PCa) poses a high risk to older men and it is the second most common type of male malignant tumor in western developed countries. Additionally, there is a lack of effective therapies for PCa at advanced stages. Novel treatment strategies such as adenovirus‑mediated gene therapy and virotherapy involve...

journal_title：Molecular medicine reports

authors： Cai Z,Lv H,Cao W,Zhou C,Liu Q,Li H,Zhou F

更新日期：2017-11-01 00:00:00

abstract：:Saikosaponin‑d (SSd) the primary active component of triterpene saponin derived from Bupleurum falcatum L., possesses anti‑inflammatory and antioxidant properties. The present study aimed to examine the potential therapeutic effects of SSd on carbon tetrachloride (CCl4)‑induced acute hepatocellular injury in the HL‑77...

journal_title：Molecular medicine reports

authors： Lin L,Que R,Shen Y,Chen Y,Yan N,Li Y

更新日期：2018-06-01 00:00:00

abstract：:Gastric cancer (GC) is a leading cause of cancer‑associated mortality worldwide. Previous studies demonstrated that long noncoding RNAs (lncRNAs) may be dysregulated in GC and may serve important roles in cancer progression. The present study aimed to investigate the role of the novel lncRNA stomach cancer‑associated ...

journal_title：Molecular medicine reports

authors： Zhang JF,Jiang W,Zhang QF,Kuai XL,Mao ZB,Wang ZW

更新日期：2019-06-01 00:00:00

abstract：:Subsequently to the publication of the above article, the authors have realized that the bar charts shown for Fig. 3A and B, as they appeared in the paper, were the same as the bar charts shown for Fig. 4B and D. Fig. 3, as it should have appeared, is shown below. All the authors agree to this Corrigendum. Note that t...

journal_title：Molecular medicine reports

authors： Zhang L,Dai F,Chen G,Wang Y,Liu S,Zhang L,Xian S,Yuan M,Yang D,Zheng Y,Deng Z,Cheng Y,Yang X

更新日期：2021-01-01 00:00:00

abstract：:Circular RNAs (circRNAs) are class of endogenous RNAs that have a role in the regulation of gene expression. The present study aimed to investigate the diagnostic value and role of circRNA in the pathogenesis of leukoaraiosis (LA). The present study performed Arraystar Human circRNA Array analysis of 6 samples from LA...

journal_title：Molecular medicine reports

authors： Mi T,Luo C,Hu Y,Qu C,Wang X,Guo S,Du Y

更新日期：2017-09-01 00:00:00

abstract：:Vascular smooth muscle cell (VSMC) proliferation is a primary pathological event in the development of atherosclerosis (AS), and the presence of homocysteine (Hcy) acts as an independent risk factor for AS. However, the underlying mechanisms remain to be elucidated. Phosphatase and tensin homologue on chromosome 10 (P...

journal_title：Molecular medicine reports

authors： Ma SC,Zhang HP,Jiao Y,Wang YH,Zhang H,Yang XL,Yang AN,Jiang YD

更新日期：2018-04-01 00:00:00

abstract：:The PTEN induced putative kinase 1 (PINK1) mutation is the second most common cause of autosomal recessive adolescent Parkinson's disease (PD). Furthermore, mitochondrial disorders and oxidative stress are important mechanisms in the pathogenesis of PD. Numerous members of the Wnt family have been found to be associat...

journal_title：Molecular medicine reports

authors： Xia SR,Wen XY,Fan XL,Chen XR,Wei ZW,Li QH,Sun L

更新日期：2020-06-01 00:00:00

abstract：:The mammalian target of rapamycin/eukaryotic translation inititiation factor 4E binding protein 1 (mTOR/4E-BP1) transduction pathway is activated in a range of malignant cancers, but its role in human gastric cardiac adenocarcinoma (GCA) has not been well defined. The present study used western blotting and reverse tr...

journal_title：Molecular medicine reports

authors： Yang HY,Xue LY,Xing LX,Wang J,Wang JL,Yan X,Zhang XH

更新日期：2013-02-01 00:00:00

abstract：:Twenty‑three clinical Streptococcus pneumoniae (SP) strains were isolated from blood and sputum specimens from the Second Affiliated Hospital of Wenzhou Medical College in 2009. These strains and the ATCC 49619 standard strain were cultured and suspended in normal saline (at a turbidity of 1.0 McFarland). The producti...

journal_title：Molecular medicine reports

authors： Zhang J,Hu DK,Wang DG,Liu Y,Liu CB,Yu LH,Qu Y,Luo XH,Yang JH,Yu J,Liu SC,Li XY

更新日期：2013-11-01 00:00:00

abstract：:Glioma is the most common primary brain tumor in adults and the second most common malignant tumor in children. Aberrant expression of signal transducer and activator of transcription 1 (STAT‑1) and p53 are known to affect the occurrence and progression of malignant tumors. The aim of the present study was to investig...

journal_title：Molecular medicine reports

authors： Yang W,Wang H,Ju H,Dou C

更新日期：2018-06-01 00:00:00

abstract：:Diabetic cardiomyopathy (DCM) is a major cause of mortality in patients with diabetes, particularly those with type 2 diabetes. Long non‑coding RNAs (lncRNAs), including terminal differentiation‑induced lncRNA (TINCR), myocardial infarction‑associated transcript (MIAT) and H19, serve a key role in the regulation of DC...

journal_title：Molecular medicine reports

authors： Chen K,Ma Y,Wu S,Zhuang Y,Liu X,Lv L,Zhang G

更新日期：2019-08-01 00:00:00

abstract：:Promoter hypermethylation is a marginal approach to inactivating tumor suppressor genes in cancer. DNA hypermethylation is a well-recognized epigenetic malfunction observed in several malignancies, most predominantly in prostate cancer. Aberrant DNA methylation patterns are considered to be the earliest somatic genome...

journal_title：Molecular medicine reports

authors： Syeed N,Syed Sameer A,Hamid A,Shah ZA,Afroze D,Rasool R,Siddiqi MA

更新日期：2010-09-01 00:00:00

abstract：:Human mucin 1 (MUC1) is a target for immunotherapy. The major problem associated with MUC1‑based cancer vaccines is the weakness of the immunogenicity of MUC1. The present study aimed to develop an efficient cancer vaccine through generating a recombinant fusion protein consisting of MUC1 and maltose‑binding protein (...

journal_title：Molecular medicine reports

authors： Fang F,Ma J,Ni W,Wang F,Sun X,Li Y,Li Q,Xie F,Wang J,Zhai R,Liu Z,Gao S,Tai G

更新日期：2014-08-01 00:00:00

abstract：:Antimycin A (AMA) is an inhibitor of the electron transport chain in mitochondria. In this study, we investigated the anti-apoptotic effects of pan-caspase inhibitor (Z-VAD), superoxide dismutase (SOD) or catalase on AMA-induced HeLa cell death in relation to the cell cycle. Treatment with Z-VAD, SOD or catalase rescu...

journal_title：Molecular medicine reports

authors： Han YH,Kim SH,Kim SZ,Park WH

更新日期：2009-03-01 00:00:00

abstract：:In the present study, the effect of glucosamine administration (1.5 or 3 g/day) on cartilage and bone metabolism was investigated in bicycle racers, using cartilage‑ and bone‑specific biomarkers, including C‑terminal cross‑linked telopeptides of type II collagen (CTX‑II), C‑terminal...

journal_title：Molecular medicine reports

authors： Momomura R,Naito K,Igarashi M,Watari T,Terakado A,Oike S,Sakamoto K,Nagaoka I,Kaneko K

更新日期：2013-03-01 00:00:00

abstract：:High density lipoproteins (HDL) are heterogeneous particles regarding their size and composition. They have vital functions in reverse cholesterol transport (RCT). RCT occurs when lipid-free apolipoprotein AI recruits cholesterol and phospholipid to form nascent HDL particles. Adenosine triphosphate‑binding cassette t...

journal_title：Molecular medicine reports

authors： Zhou L,Li C,Gao L,Wang A

更新日期：2015-09-01 00:00:00

abstract：:Different sources of mesenchymal stem cells (MSCs) may differ in their biological characteristics, which are important for their clinical application. In the present study, MSCs were isolated from human exfoliated deciduous teeth (SHED), bone marrow, gingival tissue and umbilical cord tissue, and their biological char...

journal_title：Molecular medicine reports

authors： Li J,Xu SQ,Zhao YM,Yu S,Ge LH,Xu BH

更新日期：2018-12-01 00:00:00

abstract：:Cholangiocarcinoma (CCA) is a rare but devastating malignancy. Up to 90% of patients presenting with CCA have no identifiable risk factors. The base excision repair (BER) pathway has a principal role in the repair of mutations caused by oxidized or reduced bases. The MutY homolog (MUTYH, MYH) is one of the key protein...

journal_title：Molecular medicine reports

authors： You SH,Wang X,Huang S,Wang M,Ji GZ,Xia JR,Fan ZN

更新日期：2013-01-01 00:00:00

abstract：:Malignant glioma is the most common type of cancer in the central nervous system, with highly invasive characteristics. The Rho-associated protein kinase (ROCK1) has been found to act as key regulator of actin cytoskeleton reorganization, a process closely associated with cancer cell invasion. microRNA-145 (miRNA-145)...

journal_title：Molecular medicine reports

authors： Wan X,Cheng Q,Peng R,Ma Z,Chen Z,Cao Y,Jiang B

更新日期：2014-05-01 00:00:00

abstract：:The early diagnosis of acute rejection is crucial for graft survival after kidney transplantation. The interferon-γ (IFNγ)-CXCR3-chemokine-dependent inflammatory loop plays a pivotal role in the recruitment of T lymphocytes during acute rejection. Previously published studies have typically focused on the CXCR3 recept...

journal_title：Molecular medicine reports

authors： Huang H,Xu X,Yao C,Cai M,Qian Y,Wang X,Shi B

更新日期：2014-01-01 00:00:00