Downregulation of transgelin 2 promotes breast cancer metastasis by activating the reactive oxygen species/nuclear factor‑κB signaling pathway.

abstract：:Long non-coding RNA (lnc)TCF7 has been reported to promote the self‑renewal of human cancer stem cells, and enhance the aggressiveness of human non‑small cell lung cancer and hepatocellular carcinoma cells. However, the effect of lncTCF7 on colorectal cancer (CRC) tumorigenesis and progression is currently unclear. In...

journal_title：Molecular medicine reports

authors： Jin FS,Wang HM,Song XY

更新日期：2018-05-01 00:00:00

abstract：:The present study aimed to examine the status and clinical significance of cluster of differentiation (CD) 19+CD24highCD38high regulatory B cells (Bregs), serum interleukin (IL)‑10, serum transforming growth factor (TGF)‑β and IL‑10 receptor (IL‑10R) expression in peripheral blood from patients with systemic lupus ery...

journal_title：Molecular medicine reports

authors： Wang T,Li Z,Li X,Chen L,Zhao H,Jiang C,Song L

更新日期：2017-11-01 00:00:00

abstract：:The biochemical events involved in the upregulation of selected glucose‑responsive genes by 3‑O‑methyl‑D‑glucose (3‑MG) remain to be elucidated. The present study mainly aimed to re‑evaluate the possible role of 3‑MG phosphorylation in the upregulation of the thioredoxin interacting protein (TXNIP) and liver pyruvate ...

journal_title：Molecular medicine reports

authors： Svoboda M,Tastenoy M,Zhang Y,Gillet C,Rasschaert J,Malaisse WJ,Sener A

更新日期：2013-09-01 00:00:00

abstract：:Although Frey syndrome is not life-threatening, it is identified as the most serious and widely recognized sequela of parotidectomy and has significant potential negative social and psychological implications. Several studies have investigated whether AlloDerm® implants prevent Frey syndrome effectively and safely, ho...

journal_title：Molecular medicine reports

authors： Zeng XT,Tang XJ,Wang XJ,Li MZ,Guo Y,Huang W,Niu YM,Leng WD

更新日期：2012-04-01 00:00:00

abstract：:TRIO and F-actin-binding protein (TrioBP), which was initially discovered as a binding partner of Trio and F‑actin, is a critical factor associated with hearing loss in humans. However, the function of TrioBP in cancer has not been investigated. In the present study, TrioBP expression was indicated to be highly elevat...

journal_title：Molecular medicine reports

authors： Lee H,Kim M,Park J,Tran Q,Hong Y,Cho H,Park S,Hong S,Brazil DP,Kim SH,Park J

更新日期：2018-03-01 00:00:00

abstract：:Hypoxia‑inducible factor‑1α (HIF‑1α) is key in tumor progression and aggressiveness as it regulates a series of genes involved in angiogenesis and anaerobic metabolism. Previous studies have shown that the transcriptional levels of HIF‑1α may be downregulated by endostatin. However, the molecular mechanism by which en...

journal_title：Molecular medicine reports

authors： Guo L,Chen Y,He T,Qi F,Liu G,Fu Y,Rao C,Wang J,Luo Y

更新日期：2015-05-01 00:00:00

abstract：:Dexamethasone (Dex) and other glucocorticoids are widely used to treat serious infections and immunological diseases, however they may cause steroid‑induced avascular necrosis of the femoral head (SANFH). Salidroside (Sal) has demonstrated an anti‑apoptotic effect on neurocytes by activating the phosphoinositide 3‑kin...

journal_title：Molecular medicine reports

authors： Xue XH,Feng ZH,Li ZX,Pan XY

更新日期：2018-03-01 00:00:00

abstract：:Korean bamboo salt (BS) is known to have therapeutic effects in the treatment of diseases, including viral disease, dental plaque, diabetes, circulatory organ disorders, cancer and inflammatory disorders. However, the effect of BS on immune functions remains to be elucidated. The present study was designed to determin...

journal_title：Molecular medicine reports

authors： Kim NR,Nam SY,Ryu KJ,Kim HM,Jeong HJ

更新日期：2016-08-01 00:00:00

abstract：:The present study aimed to determine the potential molecular mechanisms underlying p21 (RAC1)‑activated kinase 7 (PAK7) expression in glioblastoma (GBM) and evaluate candidate prognosis biomarkers for GBM. Gene expression data from patients with GBM, including 144 tumor samples and 5 normal brain samples, were downloa...

journal_title：Molecular medicine reports

authors： Wang X,Liu S,Shao Z,Zhang P

更新日期：2020-08-01 00:00:00

abstract：:The PTEN induced putative kinase 1 (PINK1) mutation is the second most common cause of autosomal recessive adolescent Parkinson's disease (PD). Furthermore, mitochondrial disorders and oxidative stress are important mechanisms in the pathogenesis of PD. Numerous members of the Wnt family have been found to be associat...

journal_title：Molecular medicine reports

authors： Xia SR,Wen XY,Fan XL,Chen XR,Wei ZW,Li QH,Sun L

更新日期：2020-06-01 00:00:00

abstract：:Puerarin has attracted increasing attention because of its beneficial effects on anti‑osteoporosis, but the molecular mechanisms underlying its actions on osteoblasts are not fully understood. The current study aimed to investigate the effect of puerarin on the cell viability and differentiation of mouse MC3T3‑E1 oste...

journal_title：Molecular medicine reports

authors： Zhan XQ,Zeng XW,Zhang YY,Feng Q,Zhao FM,Jiang ZQ,Sun C

更新日期：2017-11-01 00:00:00

abstract：:B-cell lymphoma-extra large (Bcl-xl) is an anti-apoptotic member of the B-cell lymphoma 2 (Bcl-2) family that is often found to be overexpressed in human hepatocellular carcinoma (HCC), therefore conferring a survival advantage to tumor cells. microRNA (miRNA) let-7b is downregulated in HCC and its expression correlat...

journal_title：Molecular medicine reports

authors： Ma J,Guo R,Wang T,Pan X,Lei X

更新日期：2015-01-01 00:00:00

abstract：:The present study aimed to investigate the effect of Dickkopf-related protein 3 (DKK3) on osteogenic differentiation of rat dental follicle cells (DFCs). A PCR array analysis of Wnt pathway activation in DFCs identified genes dysregulated by mineral induction. Among them, DKK3expression levels were decreased, and furt...

journal_title：Molecular medicine reports

authors： Zhang X,Du Y,Ling J,Li W,Liao Y,Wei X

更新日期：2017-04-01 00:00:00

abstract：:Formononetin (Form), a phytoestrogen extracted from the roots of Astragalus membranaceus, is one of the fundamental herbs used in traditional Chinese medicine because of its protective effects against certain malignant tumors. However, its role in colon carcinoma cells and the underlying molecular mechanisms have not ...

journal_title：Molecular medicine reports

authors： Wang AL,Li Y,Zhao Q,Fan LQ

更新日期：2018-06-01 00:00:00

abstract：:The present study investigated the protective effect of diethylcarbamazine in inhibiting nuclear factor (NF)-κB activation in isoproterenol‑induced acute myocardial infarction (AMI) rats through the poly ADP ribose polymerase (PARP) pathway. Male albino Wistar rats were injected subcutaneously with isoproterenol (100 ...

journal_title：Molecular medicine reports

authors： Jia G,Zao M,Liu X

更新日期：2017-08-01 00:00:00

abstract：:Parkinson's disease (PD) is one of the most common neurodegenerative diseases. For decades, the unilateral 6‑hydroxydopamine (6‑OHDA) rat model has been employed to investigate the pathogenesis and therapy of PD. However, the behavior and associated pathological features of the model long term have not previously been...

journal_title：Molecular medicine reports

authors： Su RJ,Zhen JL,Wang W,Zhang JL,Zheng Y,Wang XM

更新日期：2018-02-01 00:00:00

abstract：:Ilexonin A is a compound isolated from the root of a plant commonly used in traditional Chinese medicine. The aim of the present study was to investigate the possible protective mechanism of Ilexonin A in rats subjected to occlusion of the middle cerebral artery (MCAO). Transient focal cerebral ischemia was induced by...

journal_title：Molecular medicine reports

authors： Xu AL,Zheng GY,Wang ZJ,Chen XD,Jiang Q

更新日期：2016-04-01 00:00:00

abstract：:BCL6ZF is a novel transcript of BCL6, which lacks the first two zinc fingers of BCL6. It has been established that BCL6 acts as a sequence‑specific transcriptional repressor, however, the functions of BCL6ZF remain undefined. By generating stably overexpressed BCL6 and BCL6ZF in NCI‑H1299 lung cancer cells, it was fou...

journal_title：Molecular medicine reports

authors： Fu X,Hao Y,Mao Y,Qian Y,Qian Z,Li T,He D,Xiao X

更新日期：2015-05-01 00:00:00

abstract：:Oxidative stress is known to play a key role in the progression of liver disease, including non-alcoholic steatohepatitis (NASH), which is often accompanied by hyperglycemia. This study examined the influence of high glucose on oxidative stress-induced hepatic cell death. Hc cells, a normal human hepatocyte-derived ce...

journal_title：Molecular medicine reports

authors： Shibata H,Ichikawa T,Nakao K,Miyaaki H,Takeshita S,Akiyama M,Fujimoto M,Miuma S,Kanda S,Yamasaki H,Eguchi K

更新日期：2008-05-01 00:00:00

abstract：:Sepsis is a serious issue in the geriatric population due to its association with high mortality rates in the elderly. The increase in mortality in the elderly correlates with inflammation. We have previously demonstrated that the inflammatory response is exacerbated in a rodent endotoxemia model of sepsis in aged rat...

journal_title：Molecular medicine reports

authors： Lufrano M,Jacob A,Zhou M,Wang P

更新日期：2013-08-01 00:00:00

abstract：:Tissue-engineered bone substitutes are frequently used to repair bone defects. Adipose-derived stem cells (ASCs) are a promising source of cells for repairing bone tissue, however, insufficient osteogenic potency remains the main obstacle for their application. The present study aimed to enhance the osteogenic potency...

journal_title：Molecular medicine reports

authors： Wang Z,Zhang D,Hu Z,Cheng J,Zhuo C,Fang X,Xing Y

更新日期：2015-09-01 00:00:00

abstract：:MicroRNA (miR)-185, which has been reported to be abnormally expressed in some types of cancer, exerts significant effects on the proliferation, apoptosis, drug resistance and metastasis of cancer cells. The present study aimed to explore the effects and underlying molecular mechanisms of miR‑185 upregulation on the a...

journal_title：Molecular medicine reports

authors： Fan L,Tan B,Li Y,Zhao Q,Yuan H,Liu Y,Wang D,Zhang Z

更新日期：2018-02-01 00:00:00

abstract：:Brain‑type glycogen phosphorylase (PYGB) is an enzyme that metabolizes glycogen, whose function is to provide energy for an organism in an emergency state. The present study purposed to investigate the role and mechanism of PYGB silencing on the growth and apoptosis of prostate cancer cells. A cell counting kit‑8 assa...

journal_title：Molecular medicine reports

authors： Wang Z,Han G,Liu Q,Zhang W,Wang J

更新日期：2018-10-01 00:00:00

abstract：:The mortality rate of ovarian cancer is the highest of all gynecological malignancies. Telmisartan is a commonly used clinical angiotensin receptor blocker, which has antihypertensive, anti‑inflammatory and antithrombotic effects. In the present study, it was investigated whether telmisartan could exert anticancer eff...

journal_title：Molecular medicine reports

authors： Pu Z,Zhu M,Kong F

更新日期：2016-01-01 00:00:00

abstract：:Lung adenocarcinoma (AC) is one of the most deadly malignancies. The disease has a low five-year survival rate; therefore, the identification of novel therapeutic agents is required. This study aimed to investigate the effect of small interfering RNA (siRNA) targeting hypoxia‑inducible factor 1α (HIF‑1α) on the growth...

journal_title：Molecular medicine reports

authors： Liao HY,Wang GP,Huang SH,Li Y,Cai SW,Zhang J,Chen HG,Wu WB

更新日期：2014-03-01 00:00:00

abstract：:Cerebral ischemic stroke (IS) is a disease presenting high morbidity and mortality rates worldwide. Understanding of the pathogenesis underlying IS may facilitate the development of effective clinical therapeutic strategies and improve the prevention of this disease, decreasing its occurrence rate. Epigenetic alterati...

journal_title：Molecular medicine reports

authors： Wei Y,Sun Z,Wang Y,Xie Z,Xu S,Xu Y,Zhou X,Bi J,Zhu Z

更新日期：2019-08-01 00:00:00

abstract：:The transmembrane 7 superfamily member 2 (Tm7sf2) gene been reported to be involved in the reduced cholesterol levels of patients with large burn areas. To investigate the importance of Tm7sf2 in the burn wound healing process, a total of 10 Sprague‑Dawley rats underwent electrical burns. Blood serum was collected for...

journal_title：Molecular medicine reports

authors： Lei N,Wang P,Meng Q

更新日期：2016-07-01 00:00:00

abstract：:The aim of the present study was to assess the association between chondrocytes and the extracellular matrix (ECM), and determine whether this contributes to osteoarthritis (OA). Chondrocyte hypertrophy was measured in articular cartilage samples from early-stage OA patients. In addition, rat chondrocytes were culture...

journal_title：Molecular medicine reports

authors： Zhang S,Zhong Y,Li R,Wang W,Zeng L,Wang Z,Jia P,Wu R

更新日期：2014-09-01 00:00:00

abstract：:Curcumin, which is an extract from a traditional Chinese medicine, has previously been demonstrated to exhibit an anti‑atherosclerotic effect, which is closely associated with an increase in cholesterol efflux. However, it is unclear as to whether the increased effect is mediated by heme oxygenase (HO)‑1. Macrophages ...

journal_title：Molecular medicine reports

authors： Zhong Y,Feng J,Fan Z,Li J

更新日期：2018-04-01 00:00:00

abstract：:Metabolic syndrome based on insulin resistance (IR) and hypertension is a risk factor for advanced liver disease and cardiovascular disease in patients with nonalcoholic steatohepatitis (NASH). The present study investigated the effects of severe hypertension induced by a high‑salt (HS) diet and antihypertensive thera...

journal_title：Molecular medicine reports

authors： Kozono M,Uto H,Ibusuki R,Arima S,Oda K,Taguchi H,Sasaki F,Nasu Y,Hashimoto S,Setoyama H,Kanmura S,Numata M,Tsubouchi H,Ido A

更新日期：2016-12-01 00:00:00