Nuclear-translocated endostatin downregulates hypoxia inducible factor-1α activation through interfering with Zn(II) homeostasis.

abstract：:Adrenomedullin (ADM), initially identified in human pheochromocytoma, participates in a wide range of physiological and pathological processes, including vasorelaxation, angiogenesis and apoptosis. Recent studies have reported that ADM protected tumor cells against apoptotic cell de...

journal_title：Molecular medicine reports

authors： Kim JY,Park WD,Lee S,Park JH

更新日期：2012-11-01 00:00:00

abstract：:Partial splenic embolization (PSE) or splenectomy is widely performed to increase platelet counts for interferon (IFN) therapy. The aim of the present study was to evaluate the long-term effects of splenectomy and subsequent IFN therapy in patients with hepatitis C virus (HCV)-related liver cirrhosis (LC). The present...

journal_title：Molecular medicine reports

authors： Inagaki Y,Sugimoto K,Shiraki K,Tameda M,Kusagawa S,Nojiri K,Ogura S,Yamamoto N,Takei Y,Ito M,Mizuno S,Usui M,Sakurai H,Isaji S

更新日期：2014-02-01 00:00:00

abstract：:To identify the key genes and pathways in the development of hepatocellular carcinoma (HCC) from hepatitis B virus (HBV)‑positive liver cirrhosis, differentially expressed genes (DEGs) between HCC and liver cirrhosis tissue samples from the GSE17548 gene expression profile dataset were screened. A total of 1,845 DEGs ...

journal_title：Molecular medicine reports

authors： Chen QF,Xia JG,Li W,Shen LJ,Huang T,Wu P

更新日期：2018-12-01 00:00:00

abstract：:Angiopoietin-like protein 4 (Angptl4) is a secreted protein predominantly expressed in liver and adipose tissues, and has been identified as an adipokine. Angptl4 is the target gene of peroxisome proliferator‑activated receptors, which are widely used as lipid‑lowering and anti‑diabetic drugs, and previous studies hav...

journal_title：Molecular medicine reports

authors： Wang Y,Liu LM,Wei L,Ye WW,Meng XY,Chen F,Xiao Q,Chen JY,Zhou Y

更新日期：2016-10-01 00:00:00

abstract：:The primary aim of the present study was to evaluate the effects of liraglutide on glucolipotoxicity‑induced liver cell apoptosis and the underlying mechanisms in Zucker diabetic fatty (ZDF) rats. The results revealed that liraglutide significantly decreased the body weight, hyperglycemia and hyperlipidemia of ZDF rat...

journal_title：Molecular medicine reports

authors： Guo J,Li C,Yang C,Li B,Wei J,Lin Y,Ye P,Hu G,Li J

更新日期：2018-06-01 00:00:00

abstract：:Decoy receptor 3 (DcR3) competitively binds to three ligands, Fas ligand, lymphotoxin‑related inducible ligand that competes for glycoprotein D binding to herpesvirus entry mediator on T cells and tumor necrosis factor‑like ligand 1A (TL1A), to prevent their effects. Recent studies have suggested that DcR3 directly af...

journal_title：Molecular medicine reports

authors： Fukuda K,Miura Y,Maeda T,Hayashi S,Kurosaka M

更新日期：2016-04-01 00:00:00

abstract：:The sonic hedgehog (SHH) morphogen regulates cell differentiation and controls a number of genes during renal morphogenesis. To date, the effects of SHH on fibroblast growth factors (Fgfs) in embryonic kidney development remain unclear. In the present study, explants of BALB/c mouse embryonic kidney tissues were used ...

journal_title：Molecular medicine reports

authors： Chen X,Hou XM,Fan YF,Jin YT,Wang YL

更新日期：2016-10-01 00:00:00

abstract：:Functional appliances correct dental malocclusion, partly by exerting an indirect mechanical stimulus on the condylar cartilage, initiating novel bone formation in the condyle. Angiopoietin is involved in the angiogenesis associated with novel bone formation. This study aimed to determine the expression of angiopoieti...

journal_title：Molecular medicine reports

authors： Jing Z,Gu Z,Feng J

更新日期：2013-10-01 00:00:00

abstract：:The cooperation and communication between different cell signaling transduction pathways are considered critical in the development of various types of cancer as well as drug resistance. There is evidence of crosstalk between the G protein-coupled receptor 30 (GPR30), the newly discovered estrogen receptor (ER), and t...

journal_title：Molecular medicine reports

authors： Ruan SQ,Wang SW,Wang ZH,Zhang SZ

更新日期：2012-07-01 00:00:00

abstract：:Doxorubicin (ADR) is successfully used to treat breast cancer, however, it is often associated with the acquired resistance of breast cancer cells which eliminates the therapeutic efficiency of ADR, leading to relapse and a poorer prognosis. It has been reported that microRNA-200c (miRNA-200c), a non-coding RNA, is im...

journal_title：Molecular medicine reports

authors： Chen Y,Sun Y,Chen L,Xu X,Zhang X,Wang B,Min L,Liu W

更新日期：2013-05-01 00:00:00

abstract：:Intervertebral disc degeneration (IDD) and ligamentum flavum hypertrophy (LFH) are major causes of degenerative spinal disorders. Comparative and proteomic analysis was used to identify differentially expressed proteins (DEPs) in IDD and LFH discs compared with normal discs. Subsequent gene ontology term enrichment an...

journal_title：Molecular medicine reports

authors： Liu C,Yang M,Liu L,Zhang Y,Zhu Q,Huang C,Wang H,Zhang Y,Li H,Li C,Huang B,Feng C,Zhou Y

更新日期：2020-01-01 00:00:00

abstract：:Upregulated gene 11 (URG11) represents a gene upregulated by hepatitis B virus X protein and is involved in the biological processes of multifarious tumors. The present study aimed to investigate the protective effects and regulatory mechanisms of URG11 in benign prostatic hyperplasia (BPH). URG11, Ras homolog family ...

journal_title：Molecular medicine reports

authors： Zhang G,Zhu F,Han G,Li Z,Yu Q,Li Z,Li J

更新日期：2018-07-01 00:00:00

abstract：:Pioglitazone (PIO) has been reported to be effective for nonalcoholic fatty liver disease (NAFLD) and alogliptin (ALO) may have efficacy against NAFLD progression in patients with type 2 diabetes mellitus (T2DM). The present study examined the effectiveness of ALO in a rodent model of NAFLD and diabetes mellitus. KK‑A...

journal_title：Molecular medicine reports

authors： Tobita H,Sato S,Yazaki T,Mishiro T,Ishimura N,Ishihara S,Kinoshita Y

更新日期：2018-05-01 00:00:00

abstract：:Activin receptor‑like kinases (ALKs), members of the type I activin receptor family, belong to the serine/threonine kinase receptors of the transforming growth factor‑β (TGF‑β) superfamily. ALKs mediate the roles of activin/TGF‑β in a wide variety of physiological and pathological processes, ranging from cell differen...

journal_title：Molecular medicine reports

authors： Cui X,Shang S,Lv X,Zhao J,Qi Y,Liu Z

更新日期：2019-06-01 00:00:00

abstract：:Cardiac fibrosis is considered an important pathological mechanism in the progression of cardiac remodeling and heart failure. Astragaloside IV (AsIV) is a major active ingredient in Astragalus membranaceus. In a preliminary experiment, it was demonstrated that this naturally occurring substance exhibited cardioprotec...

journal_title：Molecular medicine reports

authors： Dai H,Jia G,Lu M,Liang C,Wang Y,Wang H

更新日期：2017-04-01 00:00:00

abstract：:Curcumin is a well‑known phenolic substance and has many pharmacological effects associated with metabolism. However, the exact molecular mechanisms underlying this process have yet to be determined. The Notch pathway is a signal transduction pathway involved in energy metabolism. The present study aimed to investigat...

journal_title：Molecular medicine reports

authors： Zhao NJ,Liao MJ,Wu JJ,Chu KX

更新日期：2018-01-01 00:00:00

abstract：:Chronic iron overload may result in hepatic fibrosis and even neoplastic transformation due to a burst of reactive oxygen species (ROS). Mitochondria have been proposed to be important in the production of ROS. The purpose of this study was to investigate the role of the mitochondrial permeability transition pore (mPT...

journal_title：Molecular medicine reports

authors： Liu D,He H,Yin D,Que A,Tang L,Liao Z,Huang Q,He M

更新日期：2013-04-01 00:00:00

abstract：:Circling mice is a mutant model of spontaneous deafness exhibiting degenerated spiral ganglion cells in the cochlea and loss of organ of Corti. The balance between glycinergic inhibition and glutamatergic excitation in the lateral superior olive (LSO) is essential for the detection of interaural level differences. Lon...

journal_title：Molecular medicine reports

authors： Yoo YB,Maskey D,Kim MJ

更新日期：2015-12-01 00:00:00

abstract：:Cisplatin is a first generation platinum‑based chemotherapeutic agent, however, the extensive application of cisplatin inevitably results in drug resistance, which is a major obstacle in cancer chemotherapy. The aim of the present study was to investigate the efficiency of reversing cisplatin‑resistance with the use o...

journal_title：Molecular medicine reports

authors： Ma S,Tan W,Du B,Liu W,Li W,Che D,Zhang G

更新日期：2016-04-01 00:00:00

abstract：:In this study, we aimed to explore the radio-sensitization of the SHG44 glioma cell line by Aidi injection and the possible mechanisms involved. The growth curve, cloning efficiency and divisional index of the SHG44 cell line were observed. The inhibition ratio was determined by MTT assay, the change in the cell cycle...

journal_title：Molecular medicine reports

authors： Xu XT,Song Y,Qin S,Wang LL,Zhou JY

更新日期：2012-06-01 00:00:00

abstract：:Doxorubicin (Dox)-induced cardiotoxicity has been a well‑known phenomenon to clinicians and scientists for decades. It has been confirmed that Dox‑dependent cardiotoxicity is accompanied by cardiac cellular senescence. However, the molecular mechanisms underlying Dox cardiotoxicity remains to be fully elucidated. Long...

journal_title：Molecular medicine reports

authors： Xie Z,Xia W,Hou M

更新日期：2018-02-01 00:00:00

abstract：:Hemophagocytic lymphohistiocytosis (HLH) is a rare but severe disease characterized by immune hyperactivation and cytokine storm. Given the high mortality rate of HLH, there is a need for more effective diagnostic tools and treatments. The present study developed a dendrimer‑based protein biochip for rapid, sensitive ...

journal_title：Molecular medicine reports

authors： Du YX,Ye L,Song ZJ,Lv H,Liu Q,Li SG,Liu SS,Hong J,Gao Y,Schneider ME,Du WD

更新日期：2020-12-01 00:00:00

abstract：:Our previous study demonstrated that type II cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG II) inhibited epidermal growth factor (EGF)-induced phosphorylation/activation of epidermal growth factor receptor (EGFR). Since human epidermal growth factor receptor 2 (HER2) has a similar molecular struc...

journal_title：Molecular medicine reports

authors： Zhu M,Yao X,Wu M,Qian H,Wu Y,Chen Y

更新日期：2016-02-01 00:00:00

abstract：:To investigate the role of microRNA (miR)‑149 in the cardiac differentiation of mouse bone marrow mesenchymal stem cells (MSCs) in vitro, MSCs were infected with a lentivirus overexpressing miR‑149 and the effect on cardiac differentiation was determined. The quantitative polymerase chain reaction results demonstrated...

journal_title：Molecular medicine reports

authors： Lu M,Xu L,Wang M,Guo T,Luo F,Su N,Yi S,Chen T

更新日期：2018-06-01 00:00:00

abstract：:Honokiol is the main active constituent of Magnolia officinalis. With effective and long‑term pharmacological functions of being antibacterial, anti‑oxidative, anti‑inflammatory, antitumor, anti‑spasmic, anti‑anxiety and anti‑viral, Honokiol is clinically used in the treatment of acute enteritis and chronic gastritis....

journal_title：Molecular medicine reports

authors： Li Z,Dong H,Li M,Wu Y,Liu Y,Zhao Y,Chen X,Ma M

更新日期：2018-02-01 00:00:00

abstract：:Oxidative stress serves important roles in cardiac injury during the process of ischemia/reperfusion (I/R). Y‑box protein 1 (YB1), a member of the highly conserved Y‑box protein family, is closely associated with inflammation and stress responses by regulating gene transcription, RNA splicing and mRNA translation. How...

journal_title：Molecular medicine reports

authors： Wang S,He F,Li Z,Hu Y,Huangfu N,Chen X

更新日期：2019-06-01 00:00:00

abstract：:The aim of this study was to explore the effect of bisphenol A (BPA) on the EGFR-STAT3 pathway in breast cancer. We applied 3-(4,5-dimethylthiazol-2-yl)2,5-diphenyl tetrazolium bromide (MTT) cytotoxicity assay to the analysis of the responsiveness of MCF-7 cells to BPA. Gene expression was assayed at the transcription...

journal_title：Molecular medicine reports

authors： Zhang W,Fang Y,Shi X,Zhang M,Wang X,Tan Y

更新日期：2012-01-01 00:00:00

abstract：:Histone deacetylase 9 (HDAC9) is involved in a variety of malignant tumors, and leads to malignant tumor development and poor prognosis. However, the association between HDAC9 expression, and the prognosis and clinicopathological features of patients with pancreatic ductal adenocarcinoma (PDAC) remains unclear. The pr...

journal_title：Molecular medicine reports

authors： Li H,Li X,Lin H,Gong J

更新日期：2020-02-01 00:00:00

abstract：:In the present study, optically active cis and trans α-hydroxy-β-lactams were prepared by Baker's yeast reduction of a racemic α-keto-β-lactam and by the hydrolysis of a racemic α-acetoxy β-lactam with the resting cells of Bacillus Subtilis. ...

journal_title：Molecular medicine reports

authors： Banik BK,Negi M,Manhas MS,Bose AK

更新日期：2010-03-01 00:00:00

abstract：:As a member of the cysteine protease family, cathepsin S (CTSS) serves an important role in diseases such as cancer, arthritis and atherosclerosis. Nevertheless, its role in renal fibrosis is unknown. In the present study, the effects of CTSS on renal fibrosis in mild (group M) and severe (group S) hydronephrosis were...

journal_title：Molecular medicine reports

authors： Yao X,Cheng F,Yu W,Rao T,Li W,Zhao S,Zhou X,Ning J

更新日期：2019-07-01 00:00:00