Antihypertensive therapy improves insulin resistance and serum levels of interleukin-6 and -10 in spontaneously hypertensive rats with steatohepatitis.

Abstract:

:Metabolic syndrome based on insulin resistance (IR) and hypertension is a risk factor for advanced liver disease and cardiovascular disease in patients with nonalcoholic steatohepatitis (NASH). The present study investigated the effects of severe hypertension induced by a high‑salt (HS) diet and antihypertensive therapy on the pathophysiological condition of spontaneously hypertensive rats (SHRs) with steatohepatitis. Steatohepatitis was induced using a choline-deficient, L-amino acid-defined diet (CDAA). Male SHRs (7‑week‑old) were randomly divided into five groups: Those receiving 6 weeks of standard chow with a normal salt concentration, followed by an additional 8 weeks of standard chow or CDAA with a normal salt concentration (control and CDAA groups, respectively); and those receiving 6 weeks of standard chow with HS, followed by CDAA with HS for an additional 8 weeks, with or without the antihypertensive agents, amlodipine (Aml) or hydralazine. In the CDAA and CDAA+HS groups, blood pressure was significantly correlated with serum levels of insulin, fasting blood glucose and homeostasis model assessment (HOMA)‑IR. Antihypertensive therapy ameliorated the elevated glucose, insulin and HOMA‑IR. Furthermore, the increased levels of serum interleukin (IL)‑6 following the CDAA+HS diet were attenuated by antihypertensive therapy. The serum levels of IL‑10 were increased by antihypertensive therapy, and the decrease in the proportion of splenic CD4+CD25+forkhead box P3+ T cells observed following the CDAA+HS diet tended to be restored by Aml. In conclusion, antihypertensive therapy improved glucose metabolism and imbalances in cytokine expression in the rat model of hypertension with steatohepatitis, suggesting that antihypertensive therapy acting through immunological factors may be beneficial for patients with metabolic syndrome-associated NASH.

journal_name

Mol Med Rep

authors

Kozono M,Uto H,Ibusuki R,Arima S,Oda K,Taguchi H,Sasaki F,Nasu Y,Hashimoto S,Setoyama H,Kanmura S,Numata M,Tsubouchi H,Ido A

doi

10.3892/mmr.2016.5875

subject

Has Abstract

pub_date

2016-12-01 00:00:00

pages

5385-5394

issue

6

eissn

1791-2997

issn

1791-3004

journal_volume

14

pub_type

杂志文章
  • Unique dose-dependent effects of the human pregnancy hormone estriol on the ratio of blood IgM to IgG in female mice.

    abstract::The present study aimed to investigate the dose-dependent modulating effect of estriol (E3), an estrogen predominantly produced during human pregnancy, on antigen‑induced production of specific antibodies in female BALB/c mice. The animals were immunized either with bovine serum albumin (BSA) or the pneumococcal polys...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2015.4491

    authors: Ding J,Zhu BT

    更新日期:2016-01-01 00:00:00

  • Oleuropein induces apoptosis via activation of caspases and suppression of phosphatidylinositol 3-kinase/protein kinase B pathway in HepG2 human hepatoma cell line.

    abstract::Oleuropein is a polyphenol, that is found in extra‑virgin olive oil. Previous studies have shown that oleuropein inhibits cell proliferation and induces apoptosis in breast cancer, colorectal cancer and thyroid cancer. The aim of the present study was to investigate the effects of oleuropein in hepatocellular carcinom...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2015.3266

    authors: Yan CM,Chai EQ,Cai HY,Miao GY,Ma W

    更新日期:2015-06-01 00:00:00

  • Decreased expression of TERT correlated with postnatal cochlear development and proliferation reduction of cochlear progenitor cells.

    abstract::Cochlear progenitor cells are considered as one of the best candidates for hair cell regeneration, thus, the regulation of cochlear progenitor cell proliferation has become a focus in this field. Several genes expressed in the inner ear during postnatal development have been demonstrated to be involved in maintaining ...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2018.8565

    authors: Song YL,Tian KY,Mi WJ,Ding ZJ,Qiu Y,Chen FQ,Zha DJ,Qiu JH

    更新日期:2018-04-01 00:00:00

  • Bone morphogenetic protein‑9 promotes the differentiation of mouse spleen macrophages into osteoclasts via the ALK1 receptor and ERK 1/2 pathways in vitro.

    abstract::It has been confirmed that bone morphogenetic protein-9 (BMP-9) promotes the differentiation of osteoblasts. However, the ways in which BMP‑9 exerts its effects on the differentiation of osteoclasts and bone resorption remain to be elucidated. The present study was designed to investigate the roles and the molecular m...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2016.5803

    authors: Li H,Zhao D,Wang S,Ding J,Zhao L

    更新日期:2016-11-01 00:00:00

  • Long non‑coding RNA ZFPM2‑AS1 promotes colorectal cancer progression by sponging miR‑137 to regulate TRIM24.

    abstract::Accumulating evidence indicates that long non‑coding RNAs (lncRNAs) may serve essential roles during tumorigenesis of colorectal cancer (CRC). The lncRNA ZFPM2‑AS1 was observed to be involved in the progression of numerous types of cancer, such as lung adenocarcinoma and cervical cancer. The aim of the present study w...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2020.11737

    authors: Xiao M,Liang Z,Yin Z

    更新日期:2021-02-01 00:00:00

  • Montelukast inhibits RANKL‑induced osteoclast formation and bone loss via CysLTR1 and P2Y12.

    abstract::Osteoclasts (OCs) are resorptive cells responsible for bone erosion in diseases, including osteoporosis, periodontitis and rheumatoid arthritis. Montelukast is a cysteinyl leukotriene receptor 1 (CysLTR1) antagonist clinically used for the treatment of asthma. In the present study, the role of CysLTR1 on OC formation ...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2018.9179

    authors: Kang JH,Lim H,Lee DS,Yim M

    更新日期:2018-08-01 00:00:00

  • Optimization of molecular detection of GD2 synthase mRNA in retinoblastoma.

    abstract::Extraocular dissemination is the main cause of death in patients with retinoblastoma (RB) in developing countries, and there are few molecular markers that are useful for the evaluation of minimal disseminated disease. The GD2 ganglioside is known to be expressed by RB cells that metastasize in bone marrow, and the ac...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr_00000248

    authors: Laurent VE,Otero LL,Vazquez V,Camarero S,Gabri MR,Labraga M,De Dávila MT,Chantada GL,Alonso DF

    更新日期:2010-03-01 00:00:00

  • Clinical and molecular genetic analysis of a new mutation in children with Wolfram syndrome: a case report.

    abstract::A 12‑year‑old Chinese girl presented with gradual vision loss and insulin‑dependent diabetes mellitus and was suspected to suffer from Wolfram syndrome (WFS). A series of clinical examinations were performed, as well as direct DNA sequencing to screen the entire coding region of the...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2013.1277

    authors: Xu Q,Qu H,Wei S

    更新日期:2013-03-01 00:00:00

  • CLCN7 and TCIRG1 mutations in a single family: Evidence for digenic inheritance of osteopetrosis.

    abstract::Osteopetrosis is a monogenic condition with various inheritance patterns, including autosomal dominant, autosomal recessive and X‑linked. Several disease‑causing genes have been identified and three distinguished types of osteopetrosis have been reported. In the present study, a family with osteopetrosis was investiga...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2018.9648

    authors: Yang Y,Ye W,Guo J,Zhao L,Tu M,Zheng Y,Li L

    更新日期:2019-01-01 00:00:00

  • Secretory leukocyte protease inhibitor promotes differentiation and mineralization of MC3T3-E1 preosteoblasts on a titanium surface.

    abstract::Mineralized bone matrix constituted with collagenous and non-collagenous proteins was synthesized by osteoblasts differentiated from mesenchymal stem cells. Secretory leukocyte protease inhibitor (SLPI), a serine protease inhibitor, promotes cell migration and proliferation, and suppresses the inflammatory response. R...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2016.5381

    authors: Choi BD,Lee SY,Jeong SJ,Lim DS,Cha HJ,Chung WG,Jeong MJ

    更新日期:2016-08-01 00:00:00

  • Circular RNA expression profiling identifies specific circular RNAs in tongue squamous cell carcinoma.

    abstract::Tongue squamous cell carcinoma (TSCC) is the most frequent type of oral cancer associated with high malignancy. Circular RNAs (circRNAs) are a form of non‑coding RNA with stable and conserved expression in mammalian cells. The aim of the present study was to investigate circRNAs expression profiles in TSCC, and examin...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2020.10980

    authors: Wei T,Ye P,Yu GY,Zhang ZY

    更新日期:2020-04-01 00:00:00

  • Implantation of bone mesenchymal stem cells overexpressing miRNA‑705 mitigated ischemic brain injury.

    abstract::Ischemic brain damage remains the major cause of death and disability worldwide. Bone mesenchymal stem cell (BMSC) transplantation has been identified to serve important roles in cerebral infarction due to its multi‑directional differentiation and proliferative ability. However, the function of miR‑705 combined with B...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2017.7626

    authors: Ji M,Wang W,Li S,Hu W

    更新日期:2017-12-01 00:00:00

  • Ehlers-Danlos syndrome type IV is associated with a novel G984R COL3A1 mutation.

    abstract::Ehlers-Danlos syndrome type IV is an autosomal dominant connective tissue disease. Mutations in COL3A1 have been identified to underlie this disease; however, to the best of our knowledge, no COL3A1 mutations have been reported in Ehlers-Danlos syndrome type IV patients with an ascending aortic aneurysm. In order to d...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2015.3488

    authors: Deng Y,Wei S,Hu S,Chen J,Tan Z,Yang Y

    更新日期:2015-07-01 00:00:00

  • Changes in mesenchymal stem cells following long-term culture in vitro.

    abstract::Mesenchymal stem cells (MSCs), which can be isolated from umbilical cords and induced to differentiate into multiple cell types in vitro, represent an ideal source for cell and gene therapy. MSCs are typically expanded in culture prior to their therapeutic application. However, similar to other types of stem cell, MSC...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2016.5169

    authors: Gu Y,Li T,Ding Y,Sun L,Tu T,Zhu W,Hu J,Sun X

    更新日期:2016-06-01 00:00:00

  • Norepinephrine inhibits the cytotoxicity of NK92‑MI cells via the β2‑adrenoceptor/cAMP/PKA/p‑CREB signaling pathway.

    abstract::Norepinephrine (NE) can regulate natural killer (NK) cell activity, but the mechanism remains unclear. In the present study the roles of adrenergic receptors (ARs) in inhibiting NK92‑MI cells‑mediated cytotoxicity by NE were investigated. To examine the effect of NE on NK92‑MI cytotoxicity, a lactate dehydrogenase‑rel...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2018.8872

    authors: Sun Z,Hou D,Liu S,Fu W,Wang J,Liang Z

    更新日期:2018-06-01 00:00:00

  • Association between CLOCK, PER3 and CCRN4L with non‑small cell lung cancer in Brazilian patients.

    abstract::Circadian rhythms comprise of daily oscillations in a variety of biological processes and are regulated by an endogenous clock. Disruption of these rhythms has been associated with cancer progression, and understanding natural oscillations in cellular growth control, tumor suppression and cancer treatment, may reveal ...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2014.2224

    authors: Couto P,Miranda D,Vieira R,Vilhena A,De Marco L,Bastos-Rodrigues L

    更新日期:2014-07-01 00:00:00

  • Hepatitis B virus inhibits the expression of CD82 through hypermethylation of its promoter in hepatoma cells.

    abstract::The tumor suppressor gene CD82, also known as KAI1, may act as a general suppressor of metastasis in numerous types of cancer. It is hypothesized that downregulation of CD82 gene expression may be an important factor in the induction of hepatocellular carcinoma (HCC), however the mechanism for this requires further st...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2014.2495

    authors: Yu G,Bing Y,Li W,Xia L,Liu Z

    更新日期:2014-11-01 00:00:00

  • Osteo-/odontogenic differentiation of BMP2 and VEGF gene-co-transfected human stem cells from apical papilla.

    abstract::Stem cells from apical papilla (SCAP) possess clear osteo‑/odontogenic differentiation capabilities, and are regarded as the major cellular source for root dentin development. Bone morphogenetic protein 2 (BMP2) and vascular endothelial growth factor (VEGF) serve pivotal roles in the modulation of tooth development an...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2016.4993

    authors: Zhang W,Zhang X,Ling J,Wei X,Jian Y

    更新日期:2016-05-01 00:00:00

  • Intermittent fasting increases SOD2 and catalase immunoreactivities in the hippocampus but does not protect from neuronal death following transient ischemia in gerbils.

    abstract::Intermittent fasting has been shown to have neuroprotective effects against transient focal cerebral ischemic insults. However, the effects of intermittent fasting on transient global ischemic insult has not been studied much yet. The present study examined effects of intermittent fasting on endogenous antioxidant enz...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2018.9503

    authors: Ahn JH,Noh Y,Shin BN,Kim SS,Park JH,Lee TK,Song M,Kim H,Lee JC,Yong JH,Kang IJ,Lee YL,Won MH,Kim JD

    更新日期:2018-12-01 00:00:00

  • Anti-proliferative effects of cucurmosin on human hepatoma HepG2 cells.

    abstract::We extracted cucurmosin (CUS) from the sarcocarp of Cucrubita moschata (pumpkin). Recently, a number of studies have indicated that CUS has cytotoxic properties and induces apoptosis in a number of human tumor cells. However, the detailed mechanisms are largely unknown. The aim of this study was to confirm CUS's antic...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2011.605

    authors: Xie J,Que W,Liu H,Liu M,Yang A,Chen M

    更新日期:2012-01-01 00:00:00

  • The role of the TLR4 signaling pathway in cognitive deficits following surgery in aged rats.

    abstract::Postoperative cognitive dysfunction (POCD), common in elderly patients, refers to a decline in cognitive function following surgery, which may persist or even evolve into Alzheimer's disease (AD). Despite great efforts, the mechanism of POCD remains unclear. In the present study, we tested the hypothesis that Toll-lik...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2013.1322

    authors: Wang Y,He H,Li D,Zhu W,Duan K,Le Y,Liao Y,Ou Y

    更新日期:2013-04-01 00:00:00

  • Screening key genes and signaling pathways in colorectal cancer by integrated bioinformatics analysis.

    abstract::The aim of the present study was to identify potential key genes associated with the progression and prognosis of colorectal cancer (CRC). Differentially expressed genes (DEGs) between CRC and normal samples were screened by integrated analysis of gene expression profile datasets, including the Gene Expression Omnibus...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2019.10336

    authors: Yu C,Chen F,Jiang J,Zhang H,Zhou M

    更新日期:2019-08-01 00:00:00

  • Contribution of human osteoblasts and macrophages to bone matrix degradation and proinflammatory cytokine release after exposure to abrasive endoprosthetic wear particles.

    abstract::One of the major reasons for failure after total joint arthroplasty is aseptic loosening of the implant. At articulating surfaces, defined as the interface between implant and surrounding bone cement, wear particles can be generated and released into the periprosthetic tissue, resulting in inflammation and osteolysis....

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2016.5415

    authors: Jonitz-Heincke A,Lochner K,Schulze C,Pohle D,Pustlauk W,Hansmann D,Bader R

    更新日期:2016-08-01 00:00:00

  • MicroRNA-106a confers cisplatin resistance in non-small cell lung cancer A549 cells by targeting adenosine triphosphatase-binding cassette A1.

    abstract::MicroRNAs (miRNAs) have been discovered to have pivotal roles in regulating the drug resistance of various types of human cancer, including cisplatin (DDP) resistance in non-small cell lung cancer (NSCLC). Fewer studies have explored the roles of miR-106a in NSCLC-cell resistance to DDP and its precise molecular mecha...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2014.2688

    authors: Ma Y,Li X,Cheng S,Wei W,Li Y

    更新日期:2015-01-01 00:00:00

  • Module-based functional pathway enrichment analysis of a protein-protein interaction network to study the effects of intestinal microbiota depletion in mice.

    abstract::Complex communities of microorganisms play important roles in human health, and alterations in the intestinal microbiota may induce intestinal inflammation and numerous diseases. The purpose of this study was to identify the key genes and processes affected by depletion of the intestinal microbiota in a murine model. ...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2014.2137

    authors: Jia ZY,Xia Y,Tong D,Yao J,Chen HQ,Yang J

    更新日期:2014-06-01 00:00:00

  • Weighted gene co‑expression network analysis for identifying hub genes in association with prognosis in Wilms tumor.

    abstract::Wilms tumor (WT) is the most common type of renal malignancy in children. Survival rates are low and high‑risk WT generally still carries a poor prognosis. To better elucidate the pathogenesis and tumorigenic pathways of high‑risk WT, the present study presents an integrated analysis of RNA expression profiles of high...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2019.9881

    authors: Wang X,Song P,Huang C,Yuan N,Zhao X,Xu C

    更新日期:2019-03-01 00:00:00

  • Effect of rutin on spinal cord injury through inhibition of the expression of MIP-2 and activation of MMP-9, and downregulation of Akt phosphorylation.

    abstract::Rutin has extensive pharmacological activities, including antibacterial and anti-inflammatory activities, cooling of the blood to inhibit bleeding, reducing capillary wall fragility and anti-influenza activities. However, whether rutin can ameliorate neuropathic function in spinal cord injury (SCI) in constriction-ind...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2015.4357

    authors: Zhang P,Ma X

    更新日期:2015-11-01 00:00:00

  • Paeoniflorin inhibits IL-1β-induced chondrocyte apoptosis by regulating the Bax/Bcl-2/caspase-3 signaling pathway.

    abstract::Apoptosis serves a pivotal role in the pathogenesis of osteoarthritis (OA). Increasing evidence has demonstrated that paeoniflorin exerts key properties (including anticancer, anti-inflammation and neuroprotective) for clinical applications. However, the precise role of paeoniflorin in articular cartilage apoptosis re...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2018.8631

    authors: Hu PF,Chen WP,Bao JP,Wu LD

    更新日期:2018-04-01 00:00:00

  • Microarray data analysis of neuroblastoma: Expression of SOX2 downregulates the expression of MYCN.

    abstract::The present study aimed to identify the genes directly or indirectly correlated with the amplification of MYCN in neuroblastoma (NB). Microarray data (GSE53371) were downloaded from Gene Expression Omnibus, and included 10 NB cell lines with MYCN amplification and 10 NB cell lines with normal MYCN copy numbers. Differ...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2015.4311

    authors: Bao J,Qin L,Cui L,Wang X,Meng Q,Zhu L,Zhang S

    更新日期:2015-11-01 00:00:00

  • Effect of TFAM on ATP content in tachypacing primary cultured cardiomyocytes and atrial fibrillation patients.

    abstract::Atrial fibrillation (AF) is one of the most common types of arrhythmia worldwide; although a number of theories have been proposed to explain the mechanisms of AF, the treatment of AF is far from satisfactory. Energy metabolism is associated with the development of AF. Mitochondrial transcription factor A (TFAM) serve...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2020.11593

    authors: Liu Y,Zhao Y,Tang R,Jiang X,Wang Y,Gu T

    更新日期:2020-12-01 00:00:00