HIF-1α silencing suppresses growth of lung adenocarcinoma A549 cells through induction of apoptosis.

abstract：:Extracellular potassium homeostasis is dependent on the activity of potassium channels, which are expressed on the apical membrane of epithelial tubular cells. The renal outer medullary potassium channel (ROMK) is considered to be the major route for potassium transport into the tubule lumen. Hepatocyte growth factor ...

journal_title：Molecular medicine reports

authors： Kato T,Oka K,Nakamura T

更新日期：2018-01-01 00:00:00

abstract：:Curcumin, which is an extract from a traditional Chinese medicine, has previously been demonstrated to exhibit an anti‑atherosclerotic effect, which is closely associated with an increase in cholesterol efflux. However, it is unclear as to whether the increased effect is mediated by heme oxygenase (HO)‑1. Macrophages ...

journal_title：Molecular medicine reports

authors： Zhong Y,Feng J,Fan Z,Li J

更新日期：2018-04-01 00:00:00

abstract：:Cerebral hypoperfusion is a common feature of vascular dementia and has recently been recognized to contribute to the progression of cognitive decline. The present study aimed to investigate the effects of Bushen Huoxue decoction (BHD), a two‑herb Chinese Medicine, on cognitive impairment in a rat model of cerebral hy...

journal_title：Molecular medicine reports

authors： Ye S,Gu Y,Xu Y,Fan W,Wang X,Chen S,Cai S,Lv S,Tong Y,Cai J

更新日期：2014-09-01 00:00:00

abstract：:The interaction between the host and human cytomegalovirus (HCMV) is important in determining the outcome of a viral infection. The HCMV RL13 gene product exerts independent, inhibitory effects on viral growth in fibroblasts and epithelial cells. At present, there are few reports on the interactions between the HCMV R...

journal_title：Molecular medicine reports

authors： Wang G,Ren G,Cui X,Lu Z,Ma Y,Qi Y,Huang Y,Liu Z,Sun Z,Ruan Q

更新日期：2016-03-01 00:00:00

abstract：:Long non‑coding RNAs (lncRNAs) affect atherosclerosis by regulating the physiological and pathological processes of endothelial cells; however, the role of lncRNA WEE2 antisense RNA 1 (WEE2‑AS1) in arteriosclerosis obliterans (ASO) is not completely understood. The present study aimed to explore the function of lncRNA...

journal_title：Molecular medicine reports

authors： Jiang B,Wang R,Lin Z,Ma J,Cui J,Wang M,Liu R,Wu W,Zhang C,Li W,Wang S

更新日期：2020-12-01 00:00:00

abstract：:The aim of the present study was to explore the effects of co‑culturing bone marrow‑derived mesenchymal stem cells (BM-MSCs) cultured with hepatitis B virus (HBV)‑infected lymphocytes in vitro. BM‑MSCs and lymphocytes from Brown Norway rats were obtained from the bone marrow and spleen, respectively. Rats were divided...

journal_title：Molecular medicine reports

authors： Zheng WP,Zhang BY,Shen ZY,Yin ML,Cao Y,Song HL

更新日期：2017-05-01 00:00:00

abstract：:Nuclear factor-κB (NF-κB) is involved in the regulation of inflammation‑associated genes. NF-κB forms dimers which bind with sequences referred to as NF-κB sites (9-11 bp). A disintegrin-like and metalloproteinase with thrombospondin type 1 motif 9 (ADAMTS9) is a type of proteoglycanase, which proteolytically cleaves ...

journal_title：Molecular medicine reports

authors： Altuntas A,Halacli SO,Cakmak O,Erden G,Akyol S,Ugurcu V,Hirohata S,Demircan K

更新日期：2015-07-01 00:00:00

abstract：:MicroRNAs (miRNAs) negatively regulate the expression of the target genes by binding to 'seed sequences' in the 3'‑untranslated region (3'‑UTR) mRNA transcripts, and the variants within or nearby 'seed sequences' may compromise or enhance miRNA/mRNA interaction leading to either 'loss‑of‑function' or 'gain‑of‑function...

journal_title：Molecular medicine reports

authors： Zhao Y,Li X,Zhu S

更新日期：2016-09-01 00:00:00

abstract：:Human keratinocytes are located in the outermost skin layer and thus particularly vulnerable to ultraviolet B (UVB) radiation exposure. Previous studies have focused on the cellular and molecular perspectives of UVB-induced keratinocyte damage. In the present study, it was demonstrated that pretreatment with the phyto...

journal_title：Molecular medicine reports

authors： Cha HJ,Lee GT,Lee KS,Lee KK,Hong JT,Lee NK,Kim SY,Lee BM,An IS,Hahn HJ,Ahn KJ,Lee SJ,An S,Bae S

更新日期：2014-09-01 00:00:00

abstract：:Vascular smooth muscle cell (VSMC) proliferation is a primary pathological event in the development of atherosclerosis (AS), and the presence of homocysteine (Hcy) acts as an independent risk factor for AS. However, the underlying mechanisms remain to be elucidated. Phosphatase and tensin homologue on chromosome 10 (P...

journal_title：Molecular medicine reports

authors： Ma SC,Zhang HP,Jiao Y,Wang YH,Zhang H,Yang XL,Yang AN,Jiang YD

更新日期：2018-04-01 00:00:00

abstract：:The aim of the current study was to identify hub pathways of rheumatoid arthritis (RA) using a novel method based on differential pathway network (DPN) analysis. The present study proposed a DPN where protein‑protein interaction (PPI) network was integrated with pathway‑pathway interactions. Pathway data was obtained ...

journal_title：Molecular medicine reports

authors： Wei ST,Sun YH,Zong SH

更新日期：2017-09-01 00:00:00

abstract：:Ubiquitin‑specific‑processing protease 34 (USP34) is a deubiquitinase that is involved in the pathogenesis of various cancers. Its roles in diffuse large B‑cell lymphoma (DLBCL) are unknown. The present study aimed to determine the level of USP34 expression and to explore its association with clinicopathological featu...

journal_title：Molecular medicine reports

authors： Li C,Huang L,Lu H,Wang W,Chen G,Gu Y,Zhou Q,Peng Z,Feng Z

更新日期：2018-11-01 00:00:00

abstract：:Fatty acid synthase (FASN) is a key anabolic enzyme for de novo fatty acid synthesis, which is important in the development of colon carcinoma. The high expression of FASN is considered a promising molecular target for colon cancer therapy. Emodin, a naturally occurring anthraquinone, exhibits an anticancer effect in ...

journal_title：Molecular medicine reports

authors： Lee KH,Lee MS,Cha EY,Sul JY,Lee JS,Kim JS,Park JB,Kim JY

更新日期：2017-04-01 00:00:00

abstract：:Cobalt nanoparticles (CoNPs) released from metal‑on‑metal implants have caused considerable concern. Oxidative stress is associated with the mechanism underlying cobalt‑induced cytotoxicity and genotoxicity. The indolamine melatonin exhibits protective effects against damage induced by metals. The present study invest...

journal_title：Molecular medicine reports

authors： Liu Y,Yang X,Wang W,Wu X,Zhu H,Liu F

更新日期：2017-10-01 00:00:00

abstract：:Small non‑coding RNAs from the microRNA family (miRs) are important elements in the posttranscriptional control of gene expression. miRs are known to regulate numerous cellular processes and are of crucial importance during development and in pathological conditions, including tumor initiation and progression. In the ...

journal_title：Molecular medicine reports

authors： Wang F,Sun JY,Zhu YH,Liu NT,Wu YF,Yu F

更新日期：2014-10-01 00:00:00

abstract：:The aim of the present study was to investigate the possible metabolic alterations in the frontal cortex and parietal white matter in patients with diabetic hypertension (DHT) using proton magnetic resonance (MR) spectroscopic imaging. A total of 33 DHT patients and 30 healthy control subjects aged between 45 and 75 w...

journal_title：Molecular medicine reports

authors： Cao Z,Ye BD,Shen ZW,Cheng XF,Yang ZX,Liu YY,Wu RH,Geng K,Xiao YY

更新日期：2015-06-01 00:00:00

abstract：:In the present study, the effect of glucosamine administration (1.5 or 3 g/day) on cartilage and bone metabolism was investigated in bicycle racers, using cartilage‑ and bone‑specific biomarkers, including C‑terminal cross‑linked telopeptides of type II collagen (CTX‑II), C‑terminal...

journal_title：Molecular medicine reports

authors： Momomura R,Naito K,Igarashi M,Watari T,Terakado A,Oike S,Sakamoto K,Nagaoka I,Kaneko K

更新日期：2013-03-01 00:00:00

abstract：:Studies have shown that the cerebrospinal fluid‑contacting nucleus (CSF‑CN) may be associated with the transduction and regulation of pain signals. However, the role of the CSF‑CN remains to be elucidated. Emerging evidence has suggested that neurokinin 1 receptor (NK1R) is important in the development of visceral pai...

journal_title：Molecular medicine reports

authors： Zhang C,Li Y,Wang X,Fei Y,Zhang L

更新日期：2017-06-01 00:00:00

abstract：:N-acetyl cysteine (NAC) has been extensively reported to exert neuroprotective effects on the central nervous system. Oxidative stress may contribute to the underlying mechanisms causing Alzheimer's disease (AD). The effect of NAC against oxidative stress injury was investigated in a cellular model of AD in the presen...

journal_title：Molecular medicine reports

authors： Wu W,Liu BH,Xie CL,Xia XD,Zhang YM

更新日期：2018-05-01 00:00:00

abstract：:MicroRNAs (miRNAs) regulate biogenesis and disease development by targeting numerous mRNAs. miRNA (miR)‑124 and its direct target, inhibitor of apoptosis‑stimulating protein of p53 (iASPP), may be involved in tumor development and progression. The aim of the present study was to explore the role of miR‑124‑targeted iA...

journal_title：Molecular medicine reports

authors： Liu X,Kang J,Sun S,Luo Y,Ji X,Zeng X,Zhao S

更新日期：2018-01-01 00:00:00

abstract：:As one of main active ingredients of salvia miltiorrhizae, which is a traditional Chinese medicine, tanshinone IIA is the basis of its pharmacological activities. In the present study, the effect of tanshinone IIA on weakening spastic cerebral palsy (SCP) in neonatal rats was investigated. Radial arm water maze and ho...

journal_title：Molecular medicine reports

authors： Zhang WL,Cao YA,Xia J,Tian L,Yang L,Peng CS

更新日期：2018-01-01 00:00:00

abstract：:Aberrant epigenetic modification is associated with the development and progression of cancer. Hypermethylation of tumor suppressor gene promoters and cooperative histone modification have been considered to be the primary mechanisms of epigenetic modification. Ovary granulosa cell tumors (GCTs) are relatively rare, a...

journal_title：Molecular medicine reports

authors： Xu Y,Li X,Wang H,Xie P,Yan X,Bai Y,Zhang T

更新日期：2016-09-01 00:00:00

abstract：:The clinical significance of microRNA (miR)‑136‑5p in hepatocellular carcinoma (HCC) has not been verified. Therefore, in the current study, the authors aimed to explore miR‑136‑5p expression and its clinical significance in HCC, as well as to investigate its potential target genes function. The authors detected the l...

journal_title：Molecular medicine reports

authors： Ding H,Ye ZH,Wen DY,Huang XL,Zeng CM,Mo J,Jiang YQ,Li JJ,Cai XY,Yang H,Chen G

更新日期：2017-10-01 00:00:00

abstract：:Dexamethasone (Dex) and other glucocorticoids are widely used to treat serious infections and immunological diseases, however they may cause steroid‑induced avascular necrosis of the femoral head (SANFH). Salidroside (Sal) has demonstrated an anti‑apoptotic effect on neurocytes by activating the phosphoinositide 3‑kin...

journal_title：Molecular medicine reports

authors： Xue XH,Feng ZH,Li ZX,Pan XY

更新日期：2018-03-01 00:00:00

abstract：:Benign thyroid nodules are among the most common endocrine disorders. Recent advances in diagnostic imaging and pathology have significantly contributed to better risk stratification of thyroid nodules. However, current treatment options, beyond surgical approaches are limited. The following placebo-controlled study p...

journal_title：Molecular medicine reports

authors： Stancioiu F,Mihai D,Papadakis GZ,Tsatsakis A,Spandidos DA,Badiu C

更新日期：2019-09-01 00:00:00

abstract：:The objective of the present study was to evaluate the influence of TAAAA repeat allele length on the levels of serum sex hormone binding globulin (SHBG) and cardiovascular risk factors in patients with polycystic ovary syndrome (PCOS). The study included 91 females with PCOS and 99 healthy controls. Phenotypic hypera...

journal_title：Molecular medicine reports

authors： Baldani DP,Skrgatic L,Cerne JZ,Oguic SK,Gersak BM,Gersak K

更新日期：2015-05-01 00:00:00

abstract：:Gli proteins are key transcription factors of the Hedgehog (HH) signaling pathway, which is associated with tumorigenesis and drug resistance. However, the role of the HH signaling pathway in epithelial ovarian cancer (EOC) remains unclear. Studies have demonstrated that in some tumors, homeobox protein NANOG (NANOG),...

journal_title：Molecular medicine reports

authors： Zhao H,Li N,Pang Y,Zhao J,Wu X

更新日期：2021-02-01 00:00:00

abstract：:Lumbar disc disease (LDD) is common in aged populations, and it is primarily caused by intervertebral disc degeneration (IDD). Cartilage intermediate layer protein (CILP), which is specifically expressed in intervertebral discs (IVDs), is suspected to be associated with IDD. However, it remains unclear whether CILP co...

journal_title：Molecular medicine reports

authors： He J,Feng C,Sun J,Lu K,Chu T,Zhou Y,Pan Y

更新日期：2018-04-01 00:00:00

abstract：:The poor prognosis of non‑small cell lung cancer (NSCLC) is related to epithelial‑mesenchymal transition (EMT). Recent studies demonstrated that non‑coding RNA activated by DNA damage (NORAD) displays a carcinogenic effect and targets microRNA (miR)‑422a, which may be involved in tumor cell migration and invasion. The...

journal_title：Molecular medicine reports

authors： Chen Z,Che Q,Xie C

更新日期：2021-02-01 00:00:00

abstract：:The aim of the present study was to investigate the possible role of cytotoxic T lymphocytes (CTL) and mononuclear macrophages in the pathogenic processes of experimental animals. To construct a chronic experimental allergic encephalomyelitis (EAE) model, an artificially synthesized myelin oligodendrocyte glycoprotein...

journal_title：Molecular medicine reports

authors： Zhou X,Li X,Feng M,Zhang Q,Yang Z

更新日期：2015-11-01 00:00:00