Antisense long non‑coding RNA WEE2‑AS1 regulates human vascular endothelial cell viability via cell cycle G2/M transition in arteriosclerosis obliterans.

abstract：:The expression and function of microRNA-497 (miR-497) has previously been reported in various types of human cancer; however, miR-497 has not previously been investigated in human osteosarcoma (OS). In the present study, the expression levels of miR‑497 were analyzed by reverse transcription‑quantitative polymerase ch...

journal_title：Molecular medicine reports

authors： Liu Q,Wang H,Singh A,Shou F

更新日期：2016-07-01 00:00:00

abstract：:To determine the effect of the down-regulation of osteopontin (OPN) expression on the sensitivity of breast cancer cells to doxorubicin, a chemotherapeutic drug, OPN shRNA was used to transfect the OPN-positive breast cancer cell line MDA-MB-231. The expression of OPN mRNA and protein was analyzed by RT-PCR and Wester...

journal_title：Molecular medicine reports

authors： Yang L,Wei L,Zhao W,Wang X,Zheng G,Zheng M,Song X,Zuo W

更新日期：2012-02-01 00:00:00

abstract：:Renal ischemia/reperfusion (I/R) is a common risk factor for renal failure. Expression of endothelin‑1 (ET‑1) and its receptor ETA were also reported to be involved in the development of acute and chronic renal disease. The present study was designed to investigate the association between inflammation and ET‑1/ETA exp...

journal_title：Molecular medicine reports

authors： Niu J,Wu J,Li X,Zhang F

更新日期：2015-05-01 00:00:00

abstract：:There is a distinct lack of knowledge on the prevalence of skin disorders in Tuvalu. The aim of the current study was to assess the prevalence of cutaneous diseases and to evaluate access dermatological care in Tuvalu. Cutaneous disorders in the people of Tuvalu between 2009 and 2012 were examined. The most common ski...

journal_title：Molecular medicine reports

authors： Lan LJ,Lien YS,Wang SC,Ituaso-Conway N,Tsai MC,Tseng PY,Yeh YL,Chen CT,Lue KH,Chung JG,Hsiao YP

更新日期：2015-09-01 00:00:00

abstract：:To examine the pathological features and prognosis of different molecular subtypes of breast cancer, the clinical data of 892 breast cancer patients were retrospectively analyzed and divided into four subtypes according to hormone receptor expression in breast cancer tissue: Her-2 overexpression, luminal A, luminal B ...

journal_title：Molecular medicine reports

authors： Wang GS,Zhu H,Bi SJ

更新日期：2012-10-01 00:00:00

abstract：:The thioredoxin (Trx) and peroxiredoxin (Prx) redox system is associated with neuronal damage and neuroprotective effects via the regulation of oxidative stress in brain ischemia. In the present study, ischemia-induced changes in the protein expression levels of Trx2 and Prx3 in the stratum pyramidale (SP) of the hipp...

journal_title：Molecular medicine reports

authors： Lee CH,Park JH,Cho JH,Ahn JH,Bae EJ,Won MH

更新日期：2015-08-01 00:00:00

abstract：:In the present study, mutL homolog 1 (MLH1) small interfering (si)RNA, KU‑55933, an ataxia‑telangiectasia mutated (ATM) inhibitor, and compound C, an adenosine monophosphate‑activated protein kinase (AMPK) inhibitor, were used to investigate the mechanisms underlying temozolomide (TMZ)‑induced autophagy and to determi...

journal_title：Molecular medicine reports

authors： Zou Y,Wang Q,Wang W

更新日期：2015-06-01 00:00:00

abstract：:The aim of the present study was to compare the phosphatidylinositol 3-kinase (PI3KCA)-AKT serine/threonine kinase (AKT) pathway in circulating tumor cells (CTCs) and corresponding cancerous tissues. Stemness‑like circulating tumor cells (slCTCs) and CTCs in epithelial-mesenchymal transition (EMT) have been implicated...

journal_title：Molecular medicine reports

authors： Bredemeier M,Kasimir-Bauer S,Kolberg HC,Herold T,Synoracki S,Hauch S,Edimiris P,Bankfalvi A,Tewes M,Kimmig R,Aktas B

更新日期：2017-05-01 00:00:00

abstract：:Sphincter of Oddi dysfunction (SOD) is a benign obstructive disorder predominantly resulting from spasms of the SO. Pharmacological therapies aim to induce SO relaxation; the hypercholesterolemic (HC) rabbit is the only SOD model available for study. In the present study, SO muscle strips, intracellular calcium ion co...

journal_title：Molecular medicine reports

authors： Wang F,Yang Y,Ji X,Tao X,Wang Y,Wang C

更新日期：2019-06-01 00:00:00

abstract：:The present study aimed to investigate the effects of neuropeptide Y (NPY) on the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor glutamate receptor 2 (GluR2) subunit in epileptiform discharge hippocampal neurons. Hippocampal neurons were harvested from neonatal Sprague‑Dawley rats aged <24 h and ...

journal_title：Molecular medicine reports

authors： Bu W,Zhao WQ,Li WL,Dong CZ,Zhang Z,Li QJ

更新日期：2017-07-01 00:00:00

abstract：:Cinobufacini is widely used in the treatment of advanced cancers. It has been previously reported that microRNA (miR)‑494 was upregulated in cinobufacini‑treated gastric cancer cells; however, the detailed role of miR‑494 in the anti‑tumor activity of cinobufacini is unclear. The present study aimed to clarify the fun...

journal_title：Molecular medicine reports

authors： Shen Z,Li Y,Zhao C,Wang F,Zhou R,Chen G

更新日期：2018-05-01 00:00:00

abstract：:Senescence is a result of cellular stress and is a potential mechanism for regulating cancer. As a member of the mitogen‑activated protein kinase family, ERK1/2 (extracellular signal‑regulated protein kinase) has an important role in delivering extracellular signals to the nucleus, and these signals regulate the cell ...

journal_title：Molecular medicine reports

authors： Zou J,Lei T,Guo P,Yu J,Xu Q,Luo Y,Ke R,Huang D

更新日期：2019-02-01 00:00:00

abstract：:Laparoscopic surgery induces a milder inflammatory response than open surgery, however, the precise mechanisms underlying this phenomenon remain to be elucidated. Our previous study demonstrated that stimulation of sensory neurons inhibited hepatic apoptosis and inflammatory responses in rats subjected to hepatic isch...

journal_title：Molecular medicine reports

authors： Kawai M,Zhao J,Ishiguro H,Takeyama H

更新日期：2014-09-01 00:00:00

abstract：:Keloids are benign fibrous overgrowths that occur as a result of abnormal wound healing following cutaneous injury. MicroRNAs (miRNAs/miRs) are short non‑coding RNAs that serve critical roles in numerous important biological processes, such as cell proliferation, differentiation and apoptosis. However, their role in k...

journal_title：Molecular medicine reports

authors： Jian X,Qu L,Wang Y,Zou Q,Zhao Q,Chen S,Gao X,Chen H,He C

更新日期：2019-06-01 00:00:00

abstract：:The silent information regulator 2 related enzyme 2 (SIRT2) has been reported to have an important role in tumorigenesis. Although two distinct effects of SIRT2 have recently been revealed, which explain opposing expression patterns in different types of cancer, the specific function of SIRT2 in ovarian cancer remains...

journal_title：Molecular medicine reports

authors： Du Y,Wu J,Zhang H,Li S,Sun H

更新日期：2017-04-01 00:00:00

abstract：:Gemcitabine is a first‑line chemotherapeutic agent used in the treatment of pancreatic cancer; however resistance of the disease to the drug often develops over time. Agents that can either enhance the effects of gemcitabine, or help to overcome the chemoresistance to the drug are needed for the successful treatment o...

journal_title：Molecular medicine reports

authors： Liu DL,Bu HQ,Jin HM,Zhao JF,Li Y,Huang H

更新日期：2014-12-01 00:00:00

abstract：:Although imatinib is effective in chronic myeloid leukemia treatment, imatinib resistance due to the T315I mutation and/or other mutations is a challenge to be overcome. However, how DNA mutation occurs, particularly the T315I mutation, remains unclear. In the current study, the mutagenesis of BCR‑ABL was analyzed via...

journal_title：Molecular medicine reports

authors： Dong Y,Gao X,Zhao Y,Wei M,Xu L,Yang G,Liu L

更新日期：2017-12-01 00:00:00

abstract：:The aim of the present study was to evaluate the protective effect and mechanism of Astragaloside IV (ASIV) on myocardial injury induced by type 2 diabetes, with a focus on energy metabolism. Blood glucose, the hemodynamic index, left ventricular weight/heart weight (LVW/HW), the left ventricular systolic pressure (LV...

journal_title：Molecular medicine reports

authors： Zhang Z,Wang J,Zhu Y,Zhang H,Wang H

更新日期：2019-11-01 00:00:00

abstract：:Hirschsprung disease (HSCR) is a newborn colorectal disease characterized by an absence of ganglia in the distal gut. Hedgehog (Hh) and endothelin signaling serve important roles in gastrointestinal tract formation. Alterations in the signaling pathways disrupt the development of enteric neural crest cells (ENCCs). It...

journal_title：Molecular medicine reports

authors： Liu W,Pan J,Gao J,Shuai X,Tang S,Wang G,Tao K,Wu C

更新日期：2018-04-01 00:00:00

abstract：:Patients with degenerative disc disease (DDD) experience serious clinical symptoms, including chronic low back pain. A series of therapies have been developed to treat DDD, including physical therapy and surgical treatment. However, the therapeutic effect of such treatments has remained insufficient. Recently, stem ce...

journal_title：Molecular medicine reports

authors： Song K,Gu T,Shuang F,Tang J,Ren D,Qin J,Hou S

更新日期：2015-09-01 00:00:00

abstract：:Skeletal myogenesis is a highly ordered and complex biological process that is mediated by numerous regulatory factors. In previous studies, it has been demonstrated that microRNAs (miRs) and long non‑coding RNAs (lncRNAs) serve key roles in skeletal myogenesis. The present study showed that the expression levels of m...

journal_title：Molecular medicine reports

authors： Zhao X,Gu H,Wang L,Zhang P,Du J,Shen L,Jiang D,Wang J,Li X,Zhang S,Li M,Zhu L

更新日期：2020-11-01 00:00:00

abstract：:Regulator of G protein signaling (RGS) proteins are responsible for the rapid turnoff of G protein-coupled receptor signaling pathways. RGS9‑2, a brain‑specific splice variant of the RGS9 gene, is highly expressed in the striatum but lowly expressed in the periaqueductal gray and spinal cord, which mediate various act...

journal_title：Molecular medicine reports

authors： Zhu Y,Zhang H

更新日期：2015-05-01 00:00:00

abstract：:Aldosterone has an important role in the progression of renal fibrosis. In the present study, the concentration of aldosterone and klotho (KL) in the serum of patients with chronic kidney disease (CKD) were analyzed. A negative correlation was observed between aldosterone and KL, suggesting that KL may serve a protect...

journal_title：Molecular medicine reports

authors： Lai L,Cheng P,Yan M,Gu Y,Xue J

更新日期：2019-03-01 00:00:00

abstract：:Hepatitis C virus (HCV)‑encoded protein p7 is a viroporin that acts as an ion channel and is indispensable for HCV particle production. Although the main target of HCV p7 is the endoplasmic reticulum, it also targets mitochondria. HCV‑infected cells show mitochondrial depolarization and ATP depletion; however, the fun...

journal_title：Molecular medicine reports

authors： You DG,Lee HR,Kim WK,Kim HJ,Lee GY,Yoo YD

更新日期：2017-12-01 00:00:00

abstract：:The aim of this meta-analysis was to explore the association between the manganese superoxide dismutase (MnSOD) gene polymorphism and breast cancer risk, and to investigate the interaction of this gene polymorphism with known risk factors for breast cancer. Crude odds ratios (ORs) with 95% confidence intervals (CIs) f...

journal_title：Molecular medicine reports

authors： Liu G,Sun G,Wang Y,Wang D,Hu W,Zhang J

更新日期：2012-10-01 00:00:00

abstract：:Human glioma is a pernicious tumor from the central nervous system; it has been reported that microRNAs (miRs) may have carcinogenic or tumor suppressor effects on human glioma. The aim of the present study was to assess miR‑141 expression and functional role in human primary glioma, as well as in tumor‑derived cell l...

journal_title：Molecular medicine reports

authors： Li G,Huang M,Cai Y,Ke Y,Yang Y,Sun X

更新日期：2018-08-01 00:00:00

abstract：:Multipotent differentiation ability, low expression of co‑stimulatory molecules and immunosuppressive effects render mesenchymal stem cells (MSCs) the best candidate for use in cell‑based therapy. At present, MSCs are widely used in clinical trials, which have, however, failed to demonstrate any long‑term therapeutic ...

journal_title：Molecular medicine reports

authors： Li Q,Ma Y,Li L,Bao J,Zhang L

更新日期：2015-11-01 00:00:00

abstract：:Pancreatic adenocarcinoma (PA) is a leading cause of adult cancer mortality, and surgery is still the best available treatment strategy. However, PA can recur at any time and has limited prognosis. It is therefore necessary to explore novel serum biomarkers of PA to allow the early diagnosis of PA. Soluble a-prolifera...

journal_title：Molecular medicine reports

authors： Han L,Zhang W,Song F,Guo Y,Guo K,Zhou W

更新日期：2014-10-01 00:00:00

abstract：:Fibroblast growth factor receptors (FGFRs) have been implicated in the malignant transformation and chemoresistance of epithelial ovarian cancer; however, the underlying molecular mechanisms are poorly understood. Increased sialyltransferase activity that enhances protein sialylation is an important post‑translational...

journal_title：Molecular medicine reports

authors： Ou L,He X,Liu N,Song Y,Li J,Gao L,Huang X,Deng Z,Wang X,Lin S

更新日期：2020-03-01 00:00:00

abstract：:Propofol is widely used for the induction and maintenance of pediatric anesthesia. Previous studies have indicated that propofol can induce apoptosis, and damage cognitive and memory functions. Dexmedetomidine is a potent α‑2 adrenoceptor agonist with high selectivity. Previous observations have shown that dexmedetomi...

journal_title：Molecular medicine reports

authors： Wei Y,Hu J,Liang Y,Zhong Y,He D,Qin Y,Li L,Chen J,Xiao Q,Xie Y

更新日期：2016-10-01 00:00:00