Dexmedetomidine pretreatment attenuates propofol‑induced neurotoxicity in neuronal cultures from the rat hippocampus.

abstract：:Mesenchymal stem cells (MSCs) possess three characteristics critical to tissue regeneration; multipotency, low immunogenicity and an undifferentiated status, providing plasticity. However, increasing evidence has indicated that induction of an immune response in vivo can injure and reject MSC‑based tissues. Toll‑like ...

journal_title：Molecular medicine reports

authors： Yang Y,Wang Y,Li L,Bao J,Chen F,Zhang L

更新日期：2015-12-01 00:00:00

abstract：:Previously, we demonstrated that 8-methoxypsoralen (methoxsalen), a potent human cytochrome P450 2A6 (CYP2A6) inhibitor, strongly suppresses lung adenoma induction by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in female A/J mice. In the present study, we examined the inhibitory effects of methoxsalen on the ...

journal_title：Molecular medicine reports

authors： Takeuchi H,Saoo K,Matsuda Y,Yokohira M,Yamakawa K,Zeng Y,Kuno T,Kamataki T,Imaida K

更新日期：2009-07-01 00:00:00

abstract：:This study investigated the role of microRNA-21 (miR-21) and microRNA-24 (miR-24) in the pathological processes that follow cerebral ischemic injury and examined the potential use of miR-21 and -24 in stroke diagnostics as sensitive plasma biomarkers. An oxygen-glucose deprivation (OGD) model was constructed using mou...

journal_title：Molecular medicine reports

authors： Zhou J,Zhang J

更新日期：2014-08-01 00:00:00

abstract：:As demonstrated in previous studies, the phosphorylated form of 4E‑binding protein 1 (p‑4E‑BP1) may be a suitable tumor biomarker. The aim of the current study was to examine the expression status of p‑4E‑BP1 in colorectal cancer (CRC), in order to determine its clinical significance. The present study enrolled 89 pat...

journal_title：Molecular medicine reports

authors： Miao Y,Chen L,Shi C,Fan R,Chen P,Liu H,Xia A,Qian H

更新日期：2017-05-01 00:00:00

abstract：:Hirschsprung's disease (HSCR) is a polygenic disease, of which the cause remains to be elucidated. It has been suggested that SRY-related HMG-box 9 (SOX9) is fundamental for the correct development of oligodendrocytes and astrocytes; however, not the development of neurons. There are currently no reports regarding SOX...

journal_title：Molecular medicine reports

authors： Mi J,Chen D,Wu M,Wang W,Gao H

更新日期：2014-05-01 00:00:00

abstract：:The present study aimed to investigate the clinical significance of histone methylation in sepsis. A total of 43 blood samples from trauma and esophageal cancer patients with or without sepsis were collected. Immunofluorescence staining of isolated peripheral white blood cells (WBCs) was conducted. Co‑stained 293T cel...

journal_title：Molecular medicine reports

authors： Jiang L,Wang Y,Zhu D,Xue Z,Mao H

更新日期：2016-12-01 00:00:00

abstract：:Quercetin (a natural polyphenolic compound) is a polyphenolic flavonoid compound found in a variety of plants. It has been demonstrated to exert cytostatic activity against a variety of human cancer cell lines, including the human osteosarcoma cell line, MG-63. However, its effects on osteosarcoma cell apoptosis are s...

journal_title：Molecular medicine reports

authors： Liang W,Li X,Li C,Liao L,Gao B,Gan H,Yang Z,Liao L,Chen X

更新日期：2011-09-01 00:00:00

abstract：:Ischemic brain damage remains the major cause of death and disability worldwide. Bone mesenchymal stem cell (BMSC) transplantation has been identified to serve important roles in cerebral infarction due to its multi‑directional differentiation and proliferative ability. However, the function of miR‑705 combined with B...

journal_title：Molecular medicine reports

authors： Ji M,Wang W,Li S,Hu W

更新日期：2017-12-01 00:00:00

abstract：:Cancer chemotherapy possesses high toxicity, particularly when a higher concentration of drugs is administered to patients. Therefore, searching for more effective compounds to reduce the toxicity of treatments, while still producing similar effects as current chemotherapy regimens, is required. Currently, the search ...

journal_title：Molecular medicine reports

authors： Xin J,Wan Mahtar WNA,Siah PC,Miswan N,Khoo BY

更新日期：2019-06-01 00:00:00

abstract：:Gabapentin (GBP) and pregabalin (PGB) exert antinociceptive effects on chronic nociceptive responses with neuropathic or inflammatory conditions. Furthermore, it is considered that GBP and PGB exhibit anti‑inflammatory effects by modulating the substance P (SP)‑mediated neurokinin‑1 receptor (NK1R; a SP receptor) resp...

journal_title：Molecular medicine reports

authors： Yamaguchi K,Kumakura S,Someya A,Iseki M,Inada E,Nagaoka I

更新日期：2017-11-01 00:00:00

abstract：:Previous studies have shown that caspase-1 plays an important role in the acute inflammatory response of spinal cord injury (SCI). VX‑765, a novel and irreversible caspase‑1 inhibitor, has been reported to effectively intervene in inflammation. However, the effect of VX‑765 on genome‑wide transcription in acutely inju...

journal_title：Molecular medicine reports

authors： Chen J,Chen YQ,Wang SN,Duan FX,Shi YJ,Ding SQ,Hu JG,Lü HZ

更新日期：2020-07-01 00:00:00

abstract：:Colorectal cancer has become a disease with one of the highest incidence rates worldwide, and liver metastasis threatens the prognosis of colorectal cancer. MicroRNA (miR)‑200 and miR‑141 have been confirmed to be aberrantly expressed in colorectal cancer, however, whether miR‑200 and miR‑141 are involved in the progr...

journal_title：Molecular medicine reports

authors： Ding M,Zhang T,Li S,Zhang Y,Qiu Y,Zhang B

更新日期：2017-11-01 00:00:00

abstract：:To explore the restraining effect of baicalein and the mitogen-activation protein kinase kinase inhibitor, U0126, on human cervical cell line HeLa proliferation, apoptosis and migration. HeLa cells were treated by different concentrations of baicalein or U0126. A Cell Counting Kit (CCK)‑8 assay was applied to examine ...

journal_title：Molecular medicine reports

authors： Ye H,Zhang Y,Wang Y,Xia J,Mao X,Yu X

更新日期：2017-07-01 00:00:00

abstract：:The expression of SET nuclear proto‑oncogene (SET) is commonly associated with cell proliferation and tumorigenesis. In the present study, a eukaryotic SET expression plasmid (pEGFP‑N1‑SET) was constructed and transiently transfected into 293T human embryonic kidney cells. Transfection led to expression of the SET onc...

journal_title：Molecular medicine reports

authors： Wang Y,He PC,Liu YF,Qi J,Zhang M

更新日期：2016-05-01 00:00:00

abstract：:Nutrients are known to display pharmacologic activity against viruses and to exert cooperative effects in cells. To study the influence of nutrient cooperation on HIV production in chronically infected T lymphocytes, we evaluated the individual and combined effects of nutrients on HIV-1 reverse transcriptase (RT) rele...

journal_title：Molecular medicine reports

authors： Jariwalla RJ,Gangapurkar B,Pandit A,Kalinovsky T,Niedzwiecki A,Rath M

更新日期：2010-05-01 00:00:00

abstract：:Retinitis pigmentosa (RP) is a group of inherited diseases that primarily affect light‑sensitive rods and cones in the retina. Rhodopsin mutations, including the T17M mutation, are associated with the autosomal dominant form of retinitis pigmentosa (ADRP) and have been linked to abnormal protein folding. However, the ...

journal_title：Molecular medicine reports

authors： Jiang H,Xiong S,Xia X

更新日期：2014-05-01 00:00:00

abstract：:The purpose of the present study was to examine the effects of myricetin on reducing cerebral ischemia injury in a rat model. A rat model of permanent middle cerebral artery occlusion (pMCAO) was used in the present study. Rats were randomized into the following five groups: Sham, model, low‑myricetin (1 mg/kg), mediu...

journal_title：Molecular medicine reports

authors： Sun L,Xu P,Fu T,Huang X,Song J,Chen M,Tian X,Yin H,Han J

更新日期：2018-02-01 00:00:00

abstract：:Cardiac stem cells (CSCs) can differentiate into cardiac muscle‑like cells; however, it remains unknown whether CSCs may possess the ability to differentiate into pacemaker cells. The aim of the present study was to determine whether angiotensin II (Ang II) could promote the specialization of CSCs into pacemaker‑like ...

journal_title：Molecular medicine reports

authors： Xue C,Zhang J,Lv Z,Liu H,Huang C,Yang J,Wang T

更新日期：2015-05-01 00:00:00

abstract：:The baseline concentration of C-reactive protein (CRP) has been associated with a wide array of human diseases. In epidemiological studies and in the clinic, CRP is typically measured as a pentamer, composed of 5 identical CRP subunits. The present study aimed to determine whether other isoforms were present in the bl...

journal_title：Molecular medicine reports

authors： Li Q,Xu W,Xue X,Wang Q,Han L,Li W,Lv S,Liu D,Richards J,Shen Z,Ma L,Song Q

更新日期：2016-12-01 00:00:00

abstract：:The present study investigated the role of microRNA (miR)‑146a in a diabetic nephropathy (DN) model, and its molecular mechanism. DN mice were given intraperitoneal injections of streptozotocin (55 mg/kg/day) for 5 consecutive days as an in vivo DN model. The HK‑2 human kidney cell line were exposed to 45% D‑glucose a...

journal_title：Molecular medicine reports

authors： Wan RJ,Li YH

更新日期：2018-03-01 00:00:00

abstract：:Indoleamine 2, 3-dioxygenase (IDO) catalyzes the initial and rate‑limiting step in the degradation pathway of the essential amino acid tryptophan and is expressed by professional antigen presenting cells (APCs), epithelial cells, vascular endothelium and tumor cells. IDO‑mediated catabolic products, which are addition...

journal_title：Molecular medicine reports

authors： Wu H,Gong J,Liu Y

更新日期：2018-04-01 00:00:00

abstract：:Scavenger receptor class A, member 5 (SCARA5) is a member of the scavenger receptor family, and is involved in several types of human malignancy; however, its roles in osteosarcoma (OS) remain to be fully elucidated. Therefore, in the present study, the biological functions of SCARA5 in OS, and the potential underlyin...

journal_title：Molecular medicine reports

authors： Wen X,Wang N,Zhang F,Dong C

更新日期：2016-03-01 00:00:00

abstract：:Multidrug resistance (MDR) is a major impediment to cancer therapy. MG‑132 has been identified to be effective against MDR in several types of cancer. However, the mechanism of MG‑132 in head and neck squamous cell carcinomas remains unknown. Based on our previous study, the present detected P‑gp and P‑gp expression i...

journal_title：Molecular medicine reports

authors： Ma J,Lv Z,Liu X,Liu X,Xu W

更新日期：2018-08-01 00:00:00

abstract：:Aberrant epigenetic modification is associated with the development and progression of cancer. Hypermethylation of tumor suppressor gene promoters and cooperative histone modification have been considered to be the primary mechanisms of epigenetic modification. Ovary granulosa cell tumors (GCTs) are relatively rare, a...

journal_title：Molecular medicine reports

authors： Xu Y,Li X,Wang H,Xie P,Yan X,Bai Y,Zhang T

更新日期：2016-09-01 00:00:00

abstract：:Cyclin-dependent kinase inhibitor 3 (CDKN3) belongs to the dual-specificity protein phosphatase family, which is hypothesized to regulate cell cycle progression in tumor cells. However, whether CDKN3 is a potential therapeutic target for breast cancer remains to be elucidated. The present in vitro study aimed to inves...

journal_title：Molecular medicine reports

authors： Deng M,Wang J,Chen Y,Zhang L,Xie G,Liu Q,Zhang T,Yuan P,Liu D

更新日期：2016-08-01 00:00:00

abstract：:Ilexonin A is a compound isolated from the root of a plant commonly used in traditional Chinese medicine. The aim of the present study was to investigate the possible protective mechanism of Ilexonin A in rats subjected to occlusion of the middle cerebral artery (MCAO). Transient focal cerebral ischemia was induced by...

journal_title：Molecular medicine reports

authors： Xu AL,Zheng GY,Wang ZJ,Chen XD,Jiang Q

更新日期：2016-04-01 00:00:00

abstract：:An abundance of studies has demonstrated that disruption of circadian rhythms is one of the factors that may contribute to the initiation and development of human colorectal carcinomas (CRCs). Recently, microRNA‑124 has been demonstrated to suppress tumor growth or metastasis of CRCs. However, the mechanisms of cross‑...

journal_title：Molecular medicine reports

authors： Yu JZ,Sun N,Bei YB,Li XB,Lu C,Hua LC

更新日期：2017-09-25 00:00:00

abstract：:Intervertebral disc degeneration (IDD) has become the most common cause of low‑back pain, and it imposes a heavy burden on patients with IDD and society. The effects of long non‑coding RNAs on the proliferation and development of IDD have attracted increasing attention. The present study aimed to investigate the role ...

journal_title：Molecular medicine reports

authors： Mi D,Cai C,Zhou B,Liu X,Ma P,Shen S,Lu W,Huang W

更新日期：2018-02-01 00:00:00

abstract：:The aim of the present study was to assess the therapeutic effects of atorvastatin on cerebral vessel autoregulation and to explore the underlying mechanisms in a rabbit model of subarachnoid hemorrhage (SAH). A total of 48 healthy male New Zealand rabbits (weight, 2‑2.5 kg) were randomly allocated into SAH, Sham or S...

journal_title：Molecular medicine reports

authors： Chen JH,Wu T,Yang LK,Chen L,Zhu J,Li PP,Hu X,Wang YH

更新日期：2018-01-01 00:00:00

abstract：:Previous studies have demonstrated that calcium channel blockers have protective effects on damaged brains. In the present study, the protective effect of the calcium channel blocker nicardipine against rotenone‑induced apoptosis in SH‑SY5Y human neuroblastoma cells was investigated...

journal_title：Molecular medicine reports

authors： Park HJ,Kim HJ

更新日期：2013-03-01 00:00:00