Astragaloside IV alleviates myocardial damage induced by type 2 diabetes via improving energy metabolism.

abstract：:Neonatal hypoxic-ischemic encephalopathy (HIE) is one of the main causes of death and nervous system damage in neonates. The aim of the present study was to investigate the effect of the Toll‑like receptor 4 (TLR4) antagonist TAK‑242 on HIE. The Rice‑Vannucci method was used for ligation of the left common carotid art...

journal_title：Molecular medicine reports

authors： Jiang L,Xu Z,Li H,Wu M,Wang F,Liu S,Tao J,Feng X

更新日期：2020-08-01 00:00:00

abstract：:Interleukin (IL)-35 is the latest member of IL-12 family, which plays an important role in other autoimmune diseases. Bone marrow mononuclear cells Coombs test‑positive hemocytopenia, also termed immunorelated hemocytopenia (IRH) is a type of autoimmune-associated diseases. The present study investigated the relations...

journal_title：Molecular medicine reports

authors： Li Y,Wang Y,Liu H,Ding K,Hao S,Shao Y,Wang H,Chen J,Huang L,Shao Z,Fu R

更新日期：2018-02-01 00:00:00

abstract：:Small non‑coding RNAs from the microRNA family (miRs) are important elements in the posttranscriptional control of gene expression. miRs are known to regulate numerous cellular processes and are of crucial importance during development and in pathological conditions, including tumor initiation and progression. In the ...

journal_title：Molecular medicine reports

authors： Wang F,Sun JY,Zhu YH,Liu NT,Wu YF,Yu F

更新日期：2014-10-01 00:00:00

abstract：:Despite advances in the treatment of T‑cell acute lymphoblastic leukemia (T‑ALL), the outcome of T‑ALL treatment remains unsatisfactory, therefore, more effective treatment is urgently required. The present study examined the cytotoxicities of bortezomib in combination with daunorubicin against human Jurkat and Molt‑4...

journal_title：Molecular medicine reports

authors： Du X,Tong J,Lu H,He C,Du S,Jia P,Zhao W,Xu H,Li J,Shen Z,Wu Y,Tong J,Zhou L

更新日期：2017-07-01 00:00:00

abstract：:Liver fibrosis is the common outcome of almost all cases of chronic liver disease. The hallmark of liver fibrosis is the activation of hepatic stellate cells (HSCs). microRNA‑34a (miR‑34a), which regulates a plethora of target proteins involved in the cell cycle, apoptosis, differentiation and cellular development, is...

journal_title：Molecular medicine reports

authors： Li X,Chen Y,Wu S,He J,Lou L,Ye W,Wang J

更新日期：2015-02-01 00:00:00

abstract：:Angiogenesis is the formation of new vessels starting from pre-existing vasculature. Tumour environment is characterized by 'aberrant angiogenesis', whose main features are tortuous and permeable blood vessels, heterogeneous both in their structure and in efficiency of perfusion and very different from normal vessels....

journal_title：Molecular medicine reports

authors： Caporarello N,Lupo G,Olivieri M,Cristaldi M,Cambria MT,Salmeri M,Anfuso CD

更新日期：2017-10-01 00:00:00

abstract：:The aim of the present was to evaluate the effects of DNA methylation and histone acetylation on 2,3,7,8‑tetrachlorodibenzo‑p‑dioxin (TCDD)‑induced cleft palate in fetal mice. Pregnant mice (n=10) were randomly divided into two groups: i) TCDD group, mice were treated with 28 µg/kg TCDD on gestation day (GD) 10 by ora...

journal_title：Molecular medicine reports

authors： Yuan X,Qiu L,Pu Y,Liu C,Zhang X,Wang C,Pu W,Fu Y

更新日期：2016-08-01 00:00:00

abstract：:Heat stress is demonstrated to have an effect on the function of the male testis, however, limited information has been reported on its effects on sperm maturation. In the present study, a comparative proteomic analysis was performed on the rat caput epididymal fluids responsible for sperm maturation, to identify key ...

journal_title：Molecular medicine reports

authors： Wang X,Liu F,Gao X,Liu X,Kong X,Wang H,Li J

更新日期：2016-04-01 00:00:00

abstract：:Skeletal myogenesis is a highly ordered and complex biological process that is mediated by numerous regulatory factors. In previous studies, it has been demonstrated that microRNAs (miRs) and long non‑coding RNAs (lncRNAs) serve key roles in skeletal myogenesis. The present study showed that the expression levels of m...

journal_title：Molecular medicine reports

authors： Zhao X,Gu H,Wang L,Zhang P,Du J,Shen L,Jiang D,Wang J,Li X,Zhang S,Li M,Zhu L

更新日期：2020-11-01 00:00:00

abstract：:The present study characterizes the effects of resveratrol (Res) on vascular endothelial growth factor (VEGF) secretion in retinal pigment epithelial (RPE) cells. ARPE-19 cells were treated with CoCl2, a hypoxia mimetic agent. CoCl2 treatment increased protein levels of hypoxia inducible factor-1α (HIF-1α) and CXC-che...

journal_title：Molecular medicine reports

authors： Seong H,Ryu J,Jeong JY,Chung IY,Han YS,Hwang SH,Park JM,Kang SS,Seo SW

更新日期：2015-07-01 00:00:00

abstract：:Glioma is the most common malignant and fatal primary tumor in the central nervous system in adults. Recent data has suggested a profound role for microRNAs (miRs) in cancer progression. The present study demonstrated, via quantitative polymerase chain reaction (qPCR) analysis, that miR-203 expression was markedly low...

journal_title：Molecular medicine reports

authors： Tang G,Wu J,Xiao G,Huo L

更新日期：2015-04-01 00:00:00

abstract：:Studies have shown that the cerebrospinal fluid‑contacting nucleus (CSF‑CN) may be associated with the transduction and regulation of pain signals. However, the role of the CSF‑CN remains to be elucidated. Emerging evidence has suggested that neurokinin 1 receptor (NK1R) is important in the development of visceral pai...

journal_title：Molecular medicine reports

authors： Zhang C,Li Y,Wang X,Fei Y,Zhang L

更新日期：2017-06-01 00:00:00

abstract：:Artesunate is a semi-synthetic derivative of artemisinin that is used in the treatment of patients with malaria. Artesunate has also been reported to exert immune‑regulatory, antitumor, hepatoprotective, anti‑inflammatory and smooth muscle relaxing functions. The present study aimed to investigate the putative protect...

journal_title：Molecular medicine reports

authors： Lu H,Wang B,Cui N,Zhang Y

更新日期：2018-05-01 00:00:00

abstract：:It has been previously reported that increased expression of coiled‑coil domain containing 34 (CCDC34), a member of the CCDCs family, may promote the proliferation and invasion of bladder cancer cells. However, its role in colorectal cancer (CRC) remains unclear. The present study investigated CCDC34 expression in CRC...

journal_title：Molecular medicine reports

authors： Geng W,Liang W,Fan Y,Ye Z,Zhang L

更新日期：2018-01-01 00:00:00

abstract：:The transmembrane 7 superfamily member 2 (Tm7sf2) gene been reported to be involved in the reduced cholesterol levels of patients with large burn areas. To investigate the importance of Tm7sf2 in the burn wound healing process, a total of 10 Sprague‑Dawley rats underwent electrical burns. Blood serum was collected for...

journal_title：Molecular medicine reports

authors： Lei N,Wang P,Meng Q

更新日期：2016-07-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic inflammatory joint disease characterized by synovial inflammation. Fibroblast‑like synoviocytes (FLS) serve a vital role in the initiation and perpetuation of the immune response in patients with RA. The present study aimed to investigate the potential role of microRNA (miR)‑34a‑...

journal_title：Molecular medicine reports

authors： Hou C,Wang D,Zhang L

更新日期：2019-09-01 00:00:00

abstract：:Chronic bacterial prostatitis (CBP) is a persistent infection of the prostate characterized by poor quality of life mainly due to frequent relapse episodes caused by incomplete eradication of causative pathogens. Aggressive antibacterial therapy is required to attenuate the severe symptoms of CBP and to achieve a perm...

journal_title：Molecular medicine reports

authors： Perletti G,Skerk V,Magri V,Markotic A,Mazzoli S,Parnham MJ,Wagenlehner FM,Naber KG

更新日期：2011-11-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) has been ranked the second leading cause of cancer‑associated mortality in China and the third leading cause of cancer‑associated mortality worldwide. A number of previous studies investigating SLC44A5 have revealed important biological insight and disease‑specific functions. Therefore, ...

journal_title：Molecular medicine reports

authors： Peng GZ,Ye QF,Wang R,Li MX,Yang ZX

更新日期：2016-06-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) and Angiotensin II (Ang-II) are important in glomerulosclerosis, which is one of the main causes of chronic kidney disease. Previous studies have demonstrated that angiotensin type 1 receptor blocker (ARB) can inhibit the synthesis of VEGF mediated by Ang‑II and can effectivel...

journal_title：Molecular medicine reports

authors： Liu X,Zhang H,Wang Q,Yu K,Wang R,Sun J

更新日期：2015-09-01 00:00:00

abstract：:In the last 30 years, the 5-year-survival rate of patients with osteosarcoma has not improved as a result of the low prevalence and large tumor heterogeneity. Therefore, the development of novel drugs for the treatment of osteosarcoma is urgently required. The present study aimed to identify potential novel drugs for ...

journal_title：Molecular medicine reports

authors： Zou Y,Yang J,Jiang D

更新日期：2015-11-01 00:00:00

abstract：:Quercetin (a natural polyphenolic compound) is a polyphenolic flavonoid compound found in a variety of plants. It has been demonstrated to exert cytostatic activity against a variety of human cancer cell lines, including the human osteosarcoma cell line, MG-63. However, its effects on osteosarcoma cell apoptosis are s...

journal_title：Molecular medicine reports

authors： Liang W,Li X,Li C,Liao L,Gao B,Gan H,Yang Z,Liao L,Chen X

更新日期：2011-09-01 00:00:00

abstract：:Progressive cardiac conduction defect (PCCD) is an inherited autosomal dominant cardiac disorder characterized by an age‑dependent cardiac electrical conduction block. Several genes have been associated with the genetic pathogenesis of PCCD. The present study aimed to identify the causal mutation of PCCD and to invest...

journal_title：Molecular medicine reports

authors： Fan P,Zhang D,Yang KQ,Tian T,Luo F,Liu YX,Wang LP,Zhou XL

更新日期：2020-06-01 00:00:00

abstract：:The tumor suppressor protein LKB1 is a serine/threonine kinase that plays a critical role in cell proliferation, and its inactivation has been linked to tumorigenesis in various cancer types. Current understanding of the LKB1 function is largely restricted to results from experiments on LKB1‑deficient cancer cells, wh...

journal_title：Molecular medicine reports

authors： Liang X,Wang P,Gao Q,Tao X

更新日期：2014-03-01 00:00:00

abstract：:Human mucin 1 (MUC1) is a target for immunotherapy. The major problem associated with MUC1‑based cancer vaccines is the weakness of the immunogenicity of MUC1. The present study aimed to develop an efficient cancer vaccine through generating a recombinant fusion protein consisting of MUC1 and maltose‑binding protein (...

journal_title：Molecular medicine reports

authors： Fang F,Ma J,Ni W,Wang F,Sun X,Li Y,Li Q,Xie F,Wang J,Zhai R,Liu Z,Gao S,Tai G

更新日期：2014-08-01 00:00:00

abstract：:Quantification of testosterone serves an important role in the differential diagnosis of androgen‑related endocrine diseases. Mass spectrometry exhibits higher accuracy and lower variability than immunoassays, especially at low testosterone concentrations. The present study developed and validated an isotope dilution ...

journal_title：Molecular medicine reports

authors： Sun G,Xue J,Li L,Li X,Cui Y,Qiao B,Wei D,Li H

更新日期：2020-08-01 00:00:00

abstract：:Hepatitis C virus (HCV) infection induces not only chronic liver disease, but also extrahepatic manifestations such as thyroid disease and oral cancer. Thyroid dysfunction is also a complication known to be associated with interferon (IFN) therapy for HCV infection. We report on a 69-year-old Japanese man who develope...

journal_title：Molecular medicine reports

authors： Nagao Y,Hiromatsu Y,Nakashima T,Sata M

更新日期：2008-09-01 00:00:00

abstract：:Psoriasis is a common chronic inflammatory skin disease and its underlying pathogenesis is still not fully understood. Therapeutic interventions are currently limited and restricted to the treatment of symptoms rather than targeting the mechanisms underlying the disease. Vascular remodeling is a hallmark of psoriasis;...

journal_title：Molecular medicine reports

authors： Yan HX,Wang Y,Yang XN,Fu LX,Tang DM

更新日期：2013-08-01 00:00:00

abstract：:Hypoxemia and hypercarbia resulting from a lack of surfactant is considered to be the primary mechanism underlying neonatal respiratory distress syndrome (NRDS). Surfactant replacement therapy may mitigate the symptoms of the disease by decreasing the surface tension of alveoli and facilitating inflation. However, sur...

journal_title：Molecular medicine reports

authors： Mei H,Zhang Y,Liu C,Zhang Y,Liu C,Song D,Xin C,Wang J,Josephs-Spaulding J,Zhu Y,Tang F

更新日期：2018-01-01 00:00:00

abstract：:Puerarin has attracted increasing attention because of its beneficial effects on anti‑osteoporosis, but the molecular mechanisms underlying its actions on osteoblasts are not fully understood. The current study aimed to investigate the effect of puerarin on the cell viability and differentiation of mouse MC3T3‑E1 oste...

journal_title：Molecular medicine reports

authors： Zhan XQ,Zeng XW,Zhang YY,Feng Q,Zhao FM,Jiang ZQ,Sun C

更新日期：2017-11-01 00:00:00

abstract：:Endoplasmic reticulum (ER) stress plays a key role in the development of neurodegenerative diseases, including Parkinson's disease (PD). Sulforaphane (SF) is a natural drug derived from isothiocyanate found in cruciferous vegetables. Although there are reports indicating that SF is ...

journal_title：Molecular medicine reports

authors： Deng C,Tao R,Yu SZ,Jin H

更新日期：2012-07-01 00:00:00