Abstract:
:Chronic bacterial prostatitis (CBP) is a persistent infection of the prostate characterized by poor quality of life mainly due to frequent relapse episodes caused by incomplete eradication of causative pathogens. Aggressive antibacterial therapy is required to attenuate the severe symptoms of CBP and to achieve a permanent cure. Although fluoroquinolones are currently recommended as first-choice agents, macrolide antibiotics are emerging as a noteworthy option for the treatment of CBP. Macrolide antibiotics are characterized by an impressive array of distinct pharmacokinetic (PK) and pharmacodynamic (PD) properties. These properties include high intracellular accumulation in phagocytes and at sites of infection, including the prostate; broad antibiotic but also biofilm-inhibiting properties; immunomodulating and inflammation-resolving activities. These features offer particular advantages for the treatment of chronic infections of the prostate gland, which are not easily amenable to drug therapy. Macrolides may be exploited to counteract the unsatisfactory rates of clinical symptom improvement and pathogen eradication. The results of a number of clinical trials support this proposal.
journal_name
Mol Med Repjournal_title
Molecular medicine reportsauthors
Perletti G,Skerk V,Magri V,Markotic A,Mazzoli S,Parnham MJ,Wagenlehner FM,Naber KGdoi
10.3892/mmr.2011.575subject
Has Abstractpub_date
2011-11-01 00:00:00pages
1035-44issue
6eissn
1791-2997issn
1791-3004journal_volume
4pub_type
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