Pathological features and prognosis of different molecular subtypes of breast cancer.

abstract：:Cervical cancer is a prevalent disease that may lead to mortality in women. In spite of the development of common therapeutic agents to treat cancer, there are several limitations of their use owing to side effects and drug resistance, which may induce cancer recurrence. The anticancer effects of the new herbal mixtur...

journal_title：Molecular medicine reports

authors： Lee KM,Lee K,Choi YK,Choi YJ,Seo HS,Ko SG

更新日期：2017-12-01 00:00:00

abstract：:MicroRNAs (miRNAs) are non‑coding RNAs of ~22 nucleotides in length, which serve an important role in numerous diseases. Asthma is a chronic airway inflammatory disease, which is the most common chronic disease among children. The role of miRNA (miR)‑16 in asthma is unclear. The objective of the present study was to e...

journal_title：Molecular medicine reports

authors： Yu B,Yao L,Liu C,Tang L,Xing T

更新日期：2019-05-01 00:00:00

abstract：:Functional appliances correct dental malocclusion, partly by exerting an indirect mechanical stimulus on the condylar cartilage, initiating novel bone formation in the condyle. Angiopoietin is involved in the angiogenesis associated with novel bone formation. This study aimed to determine the expression of angiopoieti...

journal_title：Molecular medicine reports

authors： Jing Z,Gu Z,Feng J

更新日期：2013-10-01 00:00:00

abstract：:As the resident macrophages of the brain's innate immune system, microglial cells are key modulators in the neurodegenerative disease Alzheimer's disease (AD). In particular, the activation and accumulation of microglial cells around amyloid plaques is considered to result in chronic neuroinflammation. Although the pa...

journal_title：Molecular medicine reports

authors： Chen PL,Wang WJ,Rao YQ,Li J,Cheng MJ

更新日期：2018-04-01 00:00:00

abstract：:The aim of the present study was to identify differentially expressed genes and biological processes associated with periodontitis. In this study, the most significant 200 differentially expressed genes associated with periodontitis were identified using integrated analysis of multiple microarray data in combination w...

journal_title：Molecular medicine reports

authors： Guo X,Wang Y,Wang C,Chen J

更新日期：2015-04-01 00:00:00

abstract：:Breast cancer (BC) is the most common cancer among women worldwide. However, there is insufficient research that focuses on the expression and molecular mechanisms of microRNA (miR)‑204‑5p in BC. In the current study, data were downloaded from the Cancer Genome Atlas (TCGA), the Gene Expression Omnibus (GEO) and the U...

journal_title：Molecular medicine reports

authors： Cai KT,Liu AG,Wang ZF,Jiang HW,Zeng JJ,He RQ,Ma J,Chen G,Zhong JC

更新日期：2019-02-01 00:00:00

abstract：:Ovarian cancer (OC) is associated with a poor prognosis due to difficulties in early detection. The aims of the present study were to construct a recurrence risk prediction model and to reveal important OC genes or pathways. RNA sequencing data was obtained for 307 OC samples, and the corresponding clinical data were ...

journal_title：Molecular medicine reports

authors： Cheng L,Li L,Wang L,Li X,Xing H,Zhou J

更新日期：2018-09-01 00:00:00

abstract：:The spliceosome, the large RNA‑protein molecular complex, is crucial for pre‑mRNA splicing. Several antitumor drugs have been found to tightly bind to the components of the spliceosome and mutations in the spliceosome have been reported in several types of cancer. However, the involvement of the spliceosome in pancrea...

journal_title：Molecular medicine reports

authors： Ma J,Zhang Z,Wang J

更新日期：2015-10-01 00:00:00

abstract：:Sepsis is a leading killer of children worldwide with numerous differentially expressed genes reported to be associated with sepsis. Identifying core pathways in an individual is important for understanding septic mechanisms and for the future application of custom therapeutic decisions. Samples used in the study were...

journal_title：Molecular medicine reports

authors： Li B,Zeng Q

更新日期：2017-10-01 00:00:00

abstract：:It has been suggested that survivin, a member of the inhibitor of apoptosis protein (IAP) family, is an attractive novel target for anticancer therapy. The present study investigated the expression of survivin during the early stages of hepatocellular carcinoma (HCC) and associated hepatitis, and attempted to elucidat...

journal_title：Molecular medicine reports

authors： Mamori S,Matsushima M,Matsuura T,Tajiri H

更新日期：2009-11-01 00:00:00

abstract：:Patients with skull base chordomas have a poor prognosis, and the role of the protein expression of brachyury in chordomas remains to be fully elucidated. The present study used immunohistochemistry to analyze 57 cases of skull base chordoma, and analyzed the clinical data of the patients. The results demonstrated tha...

journal_title：Molecular medicine reports

authors： Wang K,Tian K,Wang L,Wu Z,Ren C,Hao S,Feng J,Li J,Wan H,Jia G,Zhang L,Zhang J

更新日期：2015-09-01 00:00:00

abstract：:Interleukin-8 (IL-8) possesses tumorigenic and proangiogenic properties, and is overexpressed in many human cancer types. However, only few studies have demonstrated the mechanisms of action of IL‑8 regarding the ability to promote proliferation and to inhibit apoptosis in prostate cancer. Here, the aim of the present...

journal_title：Molecular medicine reports

authors： Guo Y,Zang Y,Lv L,Cai F,Qian T,Zhang G,Feng Q

更新日期：2017-12-01 00:00:00

abstract：:Cnidium monnieri (L.) Cusson is a frequently used traditional Chinese medicine that treats gynecological diseases and carbuncles. However, the mechanism of action of C. monnieri remains to be fully elucidated. The present study examined the cell cycle arrest and apoptotic effects resulting from ethanol extract of C. m...

journal_title：Molecular medicine reports

authors： Lim EG,Kim GT,Kim BM,Kim EJ,Kim SY,Kim YM

更新日期：2018-02-01 00:00:00

abstract：:Rutin has extensive pharmacological activities, including antibacterial and anti-inflammatory activities, cooling of the blood to inhibit bleeding, reducing capillary wall fragility and anti-influenza activities. However, whether rutin can ameliorate neuropathic function in spinal cord injury (SCI) in constriction-ind...

journal_title：Molecular medicine reports

authors： Zhang P,Ma X

更新日期：2015-11-01 00:00:00

abstract：:Lower back pain (LBP) is one of the predominant factors contributing to dyskinesia and remains a serious social and economic burden worldwide. Intervertebral disc degeneration (IDD) is the leading cause of LBP; the existing IDD treatments cannot completely prevent IDD. Circular RNAs (circRNAs) are non‑coding RNAs resu...

journal_title：Molecular medicine reports

authors： Li Y,Zhou S,Peng P,Wang X,Du L,Huo Z,Xu B

更新日期：2020-10-01 00:00:00

abstract：:Dysregulation of collagen type XII α1 chain (COL12A1) has been found in several cancer types and could be involved in tumor progression. However, its clinical significance in gastric cancer (GC) remains under exploration. Online databases (Gene Expression Omnibus and UALCAN), reverse transcription‑quantitative PCR and...

journal_title：Molecular medicine reports

authors： Jiang X,Wu M,Xu X,Zhang L,Huang Y,Xu Z,He K,Wang H,Wang H,Teng L

更新日期：2019-10-01 00:00:00

abstract：:Liver fibrosis is the common outcome of almost all cases of chronic liver disease. The hallmark of liver fibrosis is the activation of hepatic stellate cells (HSCs). microRNA‑34a (miR‑34a), which regulates a plethora of target proteins involved in the cell cycle, apoptosis, differentiation and cellular development, is...

journal_title：Molecular medicine reports

authors： Li X,Chen Y,Wu S,He J,Lou L,Ye W,Wang J

更新日期：2015-02-01 00:00:00

abstract：:Laparoscopic surgery induces a milder inflammatory response than open surgery, however, the precise mechanisms underlying this phenomenon remain to be elucidated. Our previous study demonstrated that stimulation of sensory neurons inhibited hepatic apoptosis and inflammatory responses in rats subjected to hepatic isch...

journal_title：Molecular medicine reports

authors： Kawai M,Zhao J,Ishiguro H,Takeyama H

更新日期：2014-09-01 00:00:00

abstract：:The use of small molecule compounds to inhibit cell proliferation is one of the most promising approaches in cancer therapy. In the present study, a cell viability assay, flow cytometry analysis, western blotting and mouse xenograft models were used to investigate the anticancer activities of #2714 and its underlying ...

journal_title：Molecular medicine reports

authors： Lu W,Sun Q,Chen B,Li Y,Xu Y,Wang S

更新日期：2019-06-01 00:00:00

abstract：:The present study aimed to investigate the anticancer effect of sorafenib combined with silencing of activating transcription factor 2 (ATF2) in hepatocellular carcinoma (HCC) cells and to assess the underlying molecular mechanisms. Huh‑7 HCC cell line was selected for the present study. Small interfering RNA (siRNA)‑...

journal_title：Molecular medicine reports

authors： Luo L,Cai L,Luo L,Tang Z,Meng X

更新日期：2018-06-01 00:00:00

abstract：:Gestational diabetes mellitus (GDM) is a type of diabetes mellitus (DM) that occurs during pregnancy. The present study aimed to investigate the roles of microRNA (miR)‑195‑5p and enhancer of zeste homolog 2 (EZH2) in GDM, and their potential association. Human umbilical vein endothelial cells (HUVECs) were collected ...

journal_title：Molecular medicine reports

authors： Liao X,Zhou Z,Zhang X

更新日期：2020-08-01 00:00:00

abstract：:Human mucin 1 (MUC1) is a target for immunotherapy. The major problem associated with MUC1‑based cancer vaccines is the weakness of the immunogenicity of MUC1. The present study aimed to develop an efficient cancer vaccine through generating a recombinant fusion protein consisting of MUC1 and maltose‑binding protein (...

journal_title：Molecular medicine reports

authors： Fang F,Ma J,Ni W,Wang F,Sun X,Li Y,Li Q,Xie F,Wang J,Zhai R,Liu Z,Gao S,Tai G

更新日期：2014-08-01 00:00:00

abstract：:Calcium dyshomeostasis is an important pathology of memory impairment. However, the mechanism of how calcium dyshomeostasis impairs neurons has remained elusive. The aim of the present study was to reveal the influence of calcium dyshomeostasis on the expression of calcium memory‑associated proteins and the ability of...

journal_title：Molecular medicine reports

authors： Zhou X,Yang Z,Han L,Li X,Feng M,Zhang T,Luo H,Zhu L,Zhang J,Zhang Q,Hu Q

更新日期：2015-10-01 00:00:00

abstract：:Dysregulation of microRNAs (miRNAs) is associated with the occurrence and development of clear cell renal cell carcinoma (ccRCC) through their participation in a number of critical biological processes. Therefore, an in‑depth investigation into miRNAs and their biological roles within ccRCC may provide useful insights...

journal_title：Molecular medicine reports

authors： Zhao H,Zhao H,Xia X,Liu X

更新日期：2018-05-01 00:00:00

abstract：:The poor prognosis of non‑small cell lung cancer (NSCLC) is related to epithelial‑mesenchymal transition (EMT). Recent studies demonstrated that non‑coding RNA activated by DNA damage (NORAD) displays a carcinogenic effect and targets microRNA (miR)‑422a, which may be involved in tumor cell migration and invasion. The...

journal_title：Molecular medicine reports

authors： Chen Z,Che Q,Xie C

更新日期：2021-02-01 00:00:00

abstract：:CD44 is closely linked to breast cancer progression; however, the regulatory functions of microRNAs (miRs) in breast cancer have yet to be fully elucidated. In order to investigate the regulation of CD44 by miRs in breast cancer, the present study isolated CD44+ and CD44- breast cancer cells by flow cytometry, reveali...

journal_title：Molecular medicine reports

authors： Yang Z,Chen D,Nie J,Zhou S,Wang J,Tang Q,Yang X

更新日期：2016-06-01 00:00:00

abstract：:Chronic iron overload may result in hepatic fibrosis and even neoplastic transformation due to a burst of reactive oxygen species (ROS). Mitochondria have been proposed to be important in the production of ROS. The purpose of this study was to investigate the role of the mitochondrial permeability transition pore (mPT...

journal_title：Molecular medicine reports

authors： Liu D,He H,Yin D,Que A,Tang L,Liao Z,Huang Q,He M

更新日期：2013-04-01 00:00:00

abstract：:The present study aimed to investigate the effects of the long non‑coding RNA (lncRNA) growth arrest‑specific transcript 5 (GAS5) on proliferation, apoptosis and the inflammatory response of osteoarthritic chondrocytes (OACs) and its associated mechanism of action. Primary chondrocytes were isolated from cartilage tis...

journal_title：Molecular medicine reports

authors： Ji Q,Qiao X,Liu Y,Wang D,Yan J

更新日期：2020-03-01 00:00:00

abstract：:The tumor suppressor gene CD82, also known as KAI1, may act as a general suppressor of metastasis in numerous types of cancer. It is hypothesized that downregulation of CD82 gene expression may be an important factor in the induction of hepatocellular carcinoma (HCC), however the mechanism for this requires further st...

journal_title：Molecular medicine reports

authors： Yu G,Bing Y,Li W,Xia L,Liu Z

更新日期：2014-11-01 00:00:00

abstract：:The present study aimed to determine the intracellular localization of Cpn0425 in Chlamydophila pneumoniae-infected cells. The recombinant plasmid pGEX-6p/Cpn0425 was transformed into E.coli Bl21 cells to express the fusion protein. Following purification with glutathione S-transfer...

journal_title：Molecular medicine reports

authors： Liu L,You X,Chen L,Zeng Y,Tang S,Yu M,Wu Y,Xhen X

更新日期：2012-12-01 00:00:00