Abstract:
:It has been suggested that survivin, a member of the inhibitor of apoptosis protein (IAP) family, is an attractive novel target for anticancer therapy. The present study investigated the expression of survivin during the early stages of hepatocellular carcinoma (HCC) and associated hepatitis, and attempted to elucidate how this expression is correlated with clinicopathological factors. Twenty-two patients (15 men and 7 women) underwent a liver tissue biopsy for the diagnosis of HCC. In the HCC and surrounding hepatitis-infected tissues, the average survivin expression rate was 62.36 and 31.41% (median), respectively. The serum level of ALT was correlated with the survivin expression rate in the HCC (r=-0.60, P<0.01) and hepatitis specimens (r=-0.43, P<0.05). The data suggest that certain clinicopathological factors may in future serve as useful indicators for the selection of patients responsive to the inhibition of survivin.
journal_name
Mol Med Repjournal_title
Molecular medicine reportsauthors
Mamori S,Matsushima M,Matsuura T,Tajiri Hdoi
10.3892/mmr_00000191subject
Has Abstractpub_date
2009-11-01 00:00:00pages
911-5issue
6eissn
1791-2997issn
1791-3004journal_volume
2pub_type
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journal_title:Molecular medicine reports
pub_type: 杂志文章
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journal_title:Molecular medicine reports
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journal_title:Molecular medicine reports
pub_type: 杂志文章
doi:10.3892/mmr_00000171
更新日期:2009-09-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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doi:10.3892/mmr.2020.11176
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journal_title:Molecular medicine reports
pub_type: 杂志文章
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更新日期:2015-06-01 00:00:00
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journal_title:Molecular medicine reports
pub_type: 杂志文章
doi:10.3892/mmr.2013.1868
更新日期:2014-02-01 00:00:00
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journal_title:Molecular medicine reports
pub_type: 杂志文章
doi:
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journal_title:Molecular medicine reports
pub_type: 杂志文章
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journal_title:Molecular medicine reports
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pub_type: 杂志文章
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journal_title:Molecular medicine reports
pub_type: 杂志文章
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journal_title:Molecular medicine reports
pub_type: 杂志文章
doi:10.3892/mmr.2012.1010
更新日期:2012-10-01 00:00:00
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journal_title:Molecular medicine reports
pub_type: 杂志文章,meta分析
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更新日期:2017-11-01 00:00:00
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journal_title:Molecular medicine reports
pub_type: 杂志文章,撤回出版物
doi:10.3892/mmr.2016.5267
更新日期:2016-07-01 00:00:00
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journal_title:Molecular medicine reports
pub_type: 杂志文章
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更新日期:2017-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2017-09-01 00:00:00
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journal_title:Molecular medicine reports
pub_type: 杂志文章
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更新日期:2017-09-01 00:00:00