Abstract:
:Even though standard treatment options are available for prostate cancer patients, prostate cancer is still a leading cause of death in many Western countries due to drug resistance and recurrence. Immune checkpoint blockade therapy has been proved to be very effective in some melanoma patients, which might dependent on the preconditioned immune system. Here we explored the effect of chemotherapy (oxaliplatin) in combination with immune checkpoint blockade therapy (anti‑PD‑1 treatment) in prostate cancer cell lines and pre‑clinical animal models. We found that oxaliplatin is effective in castration‑resistant cells and enhanced the response of prostate cancer to anti‑PD‑1 antibody treatment. Oxaliplatin stimulated the immunogenic potential and established a pro‑immune microenvironment in prostate cancer. In conclusion, oxaliplatin sensitized anti‑PD‑1 treatment in prostate cancer and this combination may be an option for castration‑resistant prostate cancer patients.
journal_name
Mol Med Repjournal_title
Molecular medicine reportsauthors
Zhou J,Yang T,Liu L,Lu Bdoi
10.3892/mmr.2017.6908subject
Has Abstractpub_date
2017-09-01 00:00:00pages
2868-2874issue
3eissn
1791-2997issn
1791-3004journal_volume
16pub_type
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