CD146+ skeletal stem cells from growth plate exhibit specific chondrogenic differentiation capacity in vitro.

abstract：:The current study was performed with aim to investigate the fibroblast growth factor receptor 2 (FGFR2) gene in two Chinese families with two different forms of syndromic craniosynostosis, and to characterize their associated clinical features. Two families underwent complete ophthalmic examinations, and two patients ...

journal_title：Molecular medicine reports

authors： Lin Y,Gao H,Ai S,Eswarakumar JVP,Chen C,Zhu Y,Li T,Liu B,Liu X,Luo L,Jiang H,Li Y,Liang X,Jin C,Huang X,Lu L

更新日期：2017-10-01 00:00:00

abstract：:The von Hippel‑Lindau (VHL) gene is a tumor suppressor gene, which is widely expressed in the kidney, lung, breast, eye, ovary and cervix. Mutations of the VHL gene are able to induce VHL disease and tumorigenesis. However, it has yet to be evaluated whether the VHL gene is expressed in the human endometrium. The obje...

journal_title：Molecular medicine reports

authors： Lu YY,Zhu WJ,Xie BG

更新日期：2014-04-01 00:00:00

abstract：:Wound healing impairment is increasingly recognized to be a consequence of hyperglycemia‑induced dysfunction of endothelial precursor cells (EPCs) in type 2 diabetes mellitus (T2DM). Metformin exhibits potential for the improvement of endothelial function and the wound healing process. However, the underlying mechanis...

journal_title：Molecular medicine reports

authors： Han X,Tao Y,Deng Y,Yu J,Sun Y,Jiang G

更新日期：2017-12-01 00:00:00

abstract：:Recent advances in the treatment of non-small cell lung cancer (NSCLC) with new agents require accurate histological subtyping at diagnosis to avoid the higher risk of an adverse response and to obtain the maximum therapeutic response. However, interobserver variability, tumor heterogeneity and the degree of different...

journal_title：Molecular medicine reports

authors： Hamamoto J,Soejima K,Yoda S,Naoki K,Nakayama S,Satomi R,Terai H,Ikemura S,Sato T,Yasuda H,Hayashi Y,Sakamoto M,Takebayashi T,Betsuyaku T

更新日期：2013-08-01 00:00:00

abstract：:The aim of this study was to explore the effect of bisphenol A (BPA) on the EGFR-STAT3 pathway in breast cancer. We applied 3-(4,5-dimethylthiazol-2-yl)2,5-diphenyl tetrazolium bromide (MTT) cytotoxicity assay to the analysis of the responsiveness of MCF-7 cells to BPA. Gene expression was assayed at the transcription...

journal_title：Molecular medicine reports

authors： Zhang W,Fang Y,Shi X,Zhang M,Wang X,Tan Y

更新日期：2012-01-01 00:00:00

abstract：:The tumor suppressor protein LKB1 is a serine/threonine kinase that plays a critical role in cell proliferation, and its inactivation has been linked to tumorigenesis in various cancer types. Current understanding of the LKB1 function is largely restricted to results from experiments on LKB1‑deficient cancer cells, wh...

journal_title：Molecular medicine reports

authors： Liang X,Wang P,Gao Q,Tao X

更新日期：2014-03-01 00:00:00

abstract：:Hypothermia is an effective neuroprotective treatment for brain injury caused by intracerebral hemorrhage (ICH). It is reported to reduce brain edema and neuronal cell death. Thrombin, a coagulation protease released from blood clots, is critical in brain edema formation following ICH. Protease activated receptor‑1 (P...

journal_title：Molecular medicine reports

authors： Gao D,Ding F,Lei G,Luan G,Zhang S,Li K,Wang D,Zhang L,Dai D

更新日期：2015-04-01 00:00:00

abstract：:microRNA‑34a (miRNA‑34a) plays an important role in the pathogenesis of leukemia. This study aimed to explore its role in the proliferation of HL‑60 cells and the correlation with some of its predicted target genes: the cyclin‑dependent kinase 4 (CDK4), the oncogene MYB and the silent information regulator 1 (SIRT1). ...

journal_title：Molecular medicine reports

authors： Tang R,Li J,Yue M,Liu Z,Feng S,Tang S,Wang T

更新日期：2014-04-01 00:00:00

abstract：:Repair of cartilage defects remains a challenge for surgeons, owing to its poor self‑repairing capacity. Cartilage tissue engineering, particularly marrow stem cell‑based cartilage regeneration, provides a promising option for the regeneration of damaged cartilage. Although producing tissue‑engineered cartilage from m...

journal_title：Molecular medicine reports

authors： Zhang X,Xue K,Zhou J,Xu P,Huang H,Liu K

更新日期：2015-10-01 00:00:00

abstract：:Head and neck squamous cell carcinoma (HNSCC) is highly prevalent worldwide, and the outcome of HNSCC is still difficult to predict due to the lack of appropriate prognostic markers. In the present study, a prognostic model based on a miRNA panel was established to better predict the survival of HNSCC patients. miRNA ...

journal_title：Molecular medicine reports

authors： Lu L,Wu Y,Feng M,Xue X,Fan Y

更新日期：2019-11-01 00:00:00

abstract：:Chronic hepatitis B virus (HBV) infection is commonly considered to occur as a result of disturbance of the immune system. T-box expressed in T cells (T-bet) is an essential transcription factor for T helper (Th) cell differentiation and function. The aim of this study was to investigate the effect of T-bet overexpres...

journal_title：Molecular medicine reports

authors： Liu X,Tang Z,Zhang Y,Hu J,Li D,Zang G,Yu Y

更新日期：2012-08-01 00:00:00

abstract：:Increasing evidence has indicated that the generation of reactive oxygen species (ROS) contributes to H2O2‑induced nerve injury. This may result in oxidative stress that leads to cell damage or death. Dietary or pharmaceutical augmentation of the endogenous antioxidant defense capacity is a potential means by which to...

journal_title：Molecular medicine reports

authors： Lin P,Tian XH,Yi YS,Jiang WS,Zhou YJ,Cheng WJ

更新日期：2015-11-01 00:00:00

abstract：:GLI family zinc finger 3 (Gli3), as the upstream transcriptional activator of hedgehog signaling, has previously been demonstrated to participate in the process of liver fibrosis. The present study aimed to investigate the potential functions of microRNA (miR)‑200a and Gli3 in the progression of liver fibrosis. The ex...

journal_title：Molecular medicine reports

authors： Li L,Ran J,Li L,Chen G,Zhang S,Wang Y

更新日期：2020-04-01 00:00:00

abstract：:Several single nucleotide polymorphisms (SNPs) influencing DNA repair capacity and apoptotic status may confer genetic predisposition to Philadelphia‑chromosome negative myeloproliferative neoplasms (PN‑MPNs), and influence therapeutic response and the clinical course. In the present study, whether SNPs in genes invol...

journal_title：Molecular medicine reports

authors： Azevedo AP,Silva SN,Reichert A,Lima F,Júnior E,Rueff J

更新日期：2018-12-01 00:00:00

abstract：:Diabetic infected foot is the outcome of progressive vascular and neurological damage caused by persistent chronic hyperglycemia. Due to acute hypoxia and infection, the tissues develop extensive necrosis and gangrene, which often require amputation. The decision regarding the level of amputation relies mainly on the ...

journal_title：Molecular medicine reports

authors： Bekker-Méndez C,Guzmán-Aguilar RM,Hernández-Cueto MA,Huerta-Yepez S,Jarillo-Luna RA,González-Veyrand E,González-Bonilla CR

更新日期：2012-02-01 00:00:00

abstract：:Osteosarcoma is the most common type of primary malignant tumor of the bone. However, mechanisms underlying osteosarcoma cell proliferation are poorly understood. The present study shows that RBEL1, a newly identified Rab-like GTPase, may be a key regulator of osteosarcoma cell proliferation. Knockdown of RBEL1 in ost...

journal_title：Molecular medicine reports

authors： Tang H,Ji F,Sun J,Xie Y,Xu Y,Yue H

更新日期：2016-02-01 00:00:00

abstract：:Apoptosis serves a pivotal role in the pathogenesis of osteoarthritis (OA). Increasing evidence has demonstrated that paeoniflorin exerts key properties (including anticancer, anti-inflammation and neuroprotective) for clinical applications. However, the precise role of paeoniflorin in articular cartilage apoptosis re...

journal_title：Molecular medicine reports

authors： Hu PF,Chen WP,Bao JP,Wu LD

更新日期：2018-04-01 00:00:00

abstract：:Advances in the treatment of nasopharyngeal carcinoma (NPC) have significantly improved the local control rate; however, distant metastasis remains a principal cause of mortality. Previous studies have demonstrated that the expression levels of amyloid β precursor protein (APP) are increased in NPC. The present study ...

journal_title：Molecular medicine reports

authors： Xu J,Ying Y,Xiong G,Lai L,Wang Q,Yang Y

更新日期：2019-07-01 00:00:00

abstract：:In the present study a rat model of oval cell‑mediated liver regeneration was constructed to examine the molecular mechanisms of matrine in oval cell‑mediated liver regeneration and the effects of matrine on hepatic function and the expression of OV6 protein and recombination signal sequence‑binding protein Jκ (RBP‑Jκ...

journal_title：Molecular medicine reports

authors： Yang ZY,Wang L,Hou YX,Wang XB

更新日期：2013-05-01 00:00:00

abstract：:The hyper-responsiveness of plasma cortisol to vasopressin has been reported in patients with ACTH-independent bilateral macronodular adrenocortical hyperplasia (AIMAH) and in certain cases of Cushing's adenomas with overexpression of V1a receptors in the adrenal gland. We previously reported a high prevalence of the ...

journal_title：Molecular medicine reports

authors： Suzuki S,Uchida D,Koide H,Suyama K,Tanaka T,Noguchi Y,Saito Y,Tatsuno I

更新日期：2009-01-01 00:00:00

abstract：:Glucocorticoid receptor (GR) function is essential for glucocorticoid action on various effector cells. The aim of the present study was to investigate the mRNA expression profiles of GRα and GRβ in peripheral blood mononuclear cells (PBMC) and examine the association between the expression levels of the GR isoforms a...

journal_title：Molecular medicine reports

authors： Mei B,Chen Y,Liu W,Li L,Wang C

更新日期：2015-03-01 00:00:00

abstract：:The aim of this study was to detect class Ⅰ, II and III integrons using multiplex PCR, and to analyze the role that these integrons play in mediating multidrug-resistant Staphylococcus aureus (SA). The sensitivity of SA to 20 types of antibiotics was examined using the K-B method. A...

journal_title：Molecular medicine reports

authors： Ren C,Zhao Y,Shen Y

更新日期：2013-03-01 00:00:00

abstract：:Doxorubicin (Dox)-induced cardiotoxicity has been a well‑known phenomenon to clinicians and scientists for decades. It has been confirmed that Dox‑dependent cardiotoxicity is accompanied by cardiac cellular senescence. However, the molecular mechanisms underlying Dox cardiotoxicity remains to be fully elucidated. Long...

journal_title：Molecular medicine reports

authors： Xie Z,Xia W,Hou M

更新日期：2018-02-01 00:00:00

abstract：:In the present study, a novel monoclonal antibody (MAb) specific for icariin (ICA) was prepared and characterized. A hybridoma‑secreting MAb against icariin was produced by fusing splenocytes immunized with an ICA‑bovine serum albumin conjugate with a hypoxanthine‑aminopterin‑thymidine‑sensitive mouse myeloma SP2/0 ce...

journal_title：Molecular medicine reports

authors： Cheng J,Zhang Y,Liu S,Qu B,Zhang M,Liu X,Zhao Y,Qu H

更新日期：2017-01-01 00:00:00

abstract：:Glucagon-like peptide-1 (GLP-1) analogues are likely to exert cardioprotective effects via balancing the energy metabolism in cardiomyocytes following ischemic or hypoxic insults. The present study aimed to explore the protective effects and mechanism of exendin-4, a GLP-1 analogue, on cardiomyocyte glucose uptake usi...

journal_title：Molecular medicine reports

authors： Lu K,Chang G,Ye L,Zhang P,Li Y,Zhang D

更新日期：2015-08-01 00:00:00

abstract：:The aim of the present study was to investigate the anticancer effects of resveratrol‑4‑O‑D-(2'‑galloyl)-glucopyranoside (REG) on leukemia and the mechanism underlying its effects. Three leukemia cell lines (HL‑60, Jurkat and U937) were used in this study. A Cell Counting kit‑8 assay was performed to evaluate the anti...

journal_title：Molecular medicine reports

authors： Chen P,Wang B,Pan B,Guo W

更新日期：2016-03-01 00:00:00

abstract：:Fluid shear stress has been revealed to differentially regulate endothelial nitric oxide synthase (eNOS) distribution in vessels. eNOS, a key enzyme in controlling nitric oxide (NO) release, has a crucial role in mediating oxidative stress, and resveratrol (RSV)‑mediated eNOS also attenuates oxidative damage and suppr...

journal_title：Molecular medicine reports

authors： Wang Z,Zhang J,Li B,Gao X,Liu Y,Mao W,Chen SL

更新日期：2014-10-01 00:00:00

abstract：:CXC195 exhibits strong protective effects against neuronal apoptosis by exerting antioxidant activity. However, the pharmacological function of CXC195 in cancer remains to be elucidated. The present study demonstrated that CXC195 exhibited significant cytotoxic effects, and induced cell cycle arrest and apoptosis in H...

journal_title：Molecular medicine reports

authors： Chen XL,Fu JP,Shi J,Wan P,Cao H,Tang ZM

更新日期：2015-12-01 00:00:00

abstract：:Tumor necrosis factor α-induced protein 8 (TNFAIP8) has been associated with the tumorigenicity of various types of cancer, however, the expression of TNFAIP8 and its function in gastric cancer remain to be fully elucidated. Therefore, the present study examined the expression and biological function of TNFAIP8 in gas...

journal_title：Molecular medicine reports

authors： Li Y,Jing C,Chen Y,Wang J,Zhou M,Liu X,Sun D,Mu L,Li L,Guo X

更新日期：2015-08-01 00:00:00

abstract：:Extracellular potassium homeostasis is dependent on the activity of potassium channels, which are expressed on the apical membrane of epithelial tubular cells. The renal outer medullary potassium channel (ROMK) is considered to be the major route for potassium transport into the tubule lumen. Hepatocyte growth factor ...

journal_title：Molecular medicine reports

authors： Kato T,Oka K,Nakamura T

更新日期：2018-01-01 00:00:00