Hypoxia is important in F‑18 FDG accumulation in thecoma‑fibroma tumors on F‑18 FDG PET/CT scans.

abstract：:Intracranial aneurysm (IA) is a devastating disease, the pathogenesis of which remains to be elucidated. The present study aimed to determine the molecular mechanism of IA and to identify potential therapeutic targets using bioinformatics analysis. The GSE54083 dataset, which includes data from patients with ruptured ...

journal_title：Molecular medicine reports

authors： Wei L,Wang Q,Zhang Y,Yang C,Guan H,Chen Y,Sun Z

更新日期：2018-01-01 00:00:00

abstract：:Glioma is the most common and aggressive of malignant brain tumours. MicroRNAs (miRNAs/miRs) are involved in tumour development of various human cancers, including glioma. Therefore, miRNAs may have potential tumour diagnostic, prognostic and therapeutic values in human glioma. miR‑103 is abnormally expressed in vario...

journal_title：Molecular medicine reports

authors： Wang L,Liu Y,Song J

更新日期：2018-03-01 00:00:00

abstract：:Heat stress is demonstrated to have an effect on the function of the male testis, however, limited information has been reported on its effects on sperm maturation. In the present study, a comparative proteomic analysis was performed on the rat caput epididymal fluids responsible for sperm maturation, to identify key ...

journal_title：Molecular medicine reports

authors： Wang X,Liu F,Gao X,Liu X,Kong X,Wang H,Li J

更新日期：2016-04-01 00:00:00

abstract：:Krüppel-like factors (KLFs) regulate a wide variety of cellular functions and modulate pathological processes. In the present study, a post‑translational mechanism of microRNAs (miRs) was investigated in H2O2-induced human cardiomyocyte (HCM) injury. In H2O2‑cultured HCM cells, reactive oxygen species and apoptotic ce...

journal_title：Molecular medicine reports

authors： Zhang X,Liu F,Wang Q,Geng Y

更新日期：2017-10-01 00:00:00

abstract：:Hypertension affects one billion people worldwide and is an independent risk factor for death after acute coronary syndrome (ACS). The aim of this study was to examine the prevalence and medical treatment of hypertension among 1,301 ACS patients enrolled into the Chinese registry of acute coronary events (CRACE) trial...

journal_title：Molecular medicine reports

authors： Lin Y,Pan W,Ning S,Song X,Jin Z,Lv S

更新日期：2013-07-01 00:00:00

abstract：:Resistin, an adipocytokine secreted by fat tissues, has been shown to be associated with increased local and systemic complications in acute pancreatitis (AP). However, the mechanism underlying the effect of resistin in the aggravation of AP remains to be elucidated. The aim of the present study was to investigate the...

journal_title：Molecular medicine reports

authors： Jiang CY,Wang W

更新日期：2017-01-01 00:00:00

abstract：:Osteoblasts produce various types of cytokines under pathological conditions and control osteoclast differentiation. Tumor necrosis factor-α (TNF-α) has been demonstrated to exert complex effects in osteoblasts under local inflammatory conditions, including in periodontal and periapical diseases. Interleukin-34 (IL-34...

journal_title：Molecular medicine reports

authors： Yu Y,Yang D,Qiu L,Okamura H,Guo J,Haneji T

更新日期：2014-09-01 00:00:00

abstract：:Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. The most significant histological property of AF is atrial fibrosis, but the underlying mechanism is not clear. In this study we investigated the expression of miR-133 and miR-30, anti-fibrotic microRNAs (miRNAs), in chronic AF in canines. A tot...

journal_title：Molecular medicine reports

authors： Li H,Li S,Yu B,Liu S

更新日期：2012-06-01 00:00:00

abstract：:The expression of the metastasis suppressor gene KISS-1 in osteosarcoma cells during apoptosis and autophagy was evaluated. MG-63 osteosarcoma cells were transfected with either KISS-1 overexpression or KISS-1 knockdown expression vector in vitro, and compared with cell lines transfected with empty vector. After 12, 2...

journal_title：Molecular medicine reports

authors： Yin Y,Tang L,Shi L

更新日期：2017-03-01 00:00:00

abstract：:Retroviral vectors have been considered the most promising vehicles for the transfer of therapeutic genes into cells of the hematopoietic system. In clinical studies, however, cases of leukemoid clonogenic expansion of the transduced cells in vivo caused by semirandom integration of the foreign DNA in the genome have ...

journal_title：Molecular medicine reports

authors： Zehnpfennig D,Deissler H,Polack A,Herr D,Bornkamm GW,Kurzeder C

更新日期：2010-07-01 00:00:00

abstract：:The present study aimed to investigate the protective effect of mesenchymal stem cell (MSC) therapy in combination with p38 mitogen‑activated protein (MAPK) inhibition against myocardial infarction (MI) injury in rats, and to elucidate the underlying mechanisms. An MI model was established by ligation of the anterior ...

journal_title：Molecular medicine reports

authors： Zhang Z,Zhou S,Mei Z,Zhang M

更新日期：2017-09-01 00:00:00

abstract：:Numerous studies have demonstrated that pseudolaric acid B (PAB) promotes apoptosis in several cancer cell lines. However, thus far, the effect of PAB on human leukemia cells has not been evaluated. In the present study, the antitumor activity and molecular mechanisms of PAB in human leukemia U937 cells were investiga...

journal_title：Molecular medicine reports

authors： Wang JH,Kan L,Shu LH,Wang N,Li NJ,Zhang M

更新日期：2013-09-01 00:00:00

abstract：:Dbl-family guanine nucleotide exchange factors (GEFs) are important activators of Rho GTPases, which are significantly associated with tumorigenesis and metastasis. The catalytic ability of the Dbl-family GEFs to activate Rho GTPases depends on their Dbl-homology domain followed by a pleckstrin-homology domain. In the...

journal_title：Molecular medicine reports

authors： Wang H,Li Y,Wang Y,Han ZG,Cai B

更新日期：2012-05-01 00:00:00

abstract：:In the past decade, a group of cases with persisting haemocytopenia were separated from those with idiopathic cytopenia of undetermined significance due to the optimal response of these patients to immunosuppression therapy and due to the detection of autoantibodies in the bone marrow of haemopoietic cells. This condi...

journal_title：Molecular medicine reports

authors： Chen J,Liu H,Li L,Wang H,Li Y,Wang Y,Ding K,Hao S,Shao Y,Li L,Song J,Wang G,Shao Z,Fu R

更新日期：2019-11-01 00:00:00

abstract：:Scutellarin (SC), mainly extracted from the Chinese herb Erigeron breviscapus (vant.), has been reported to possess various pharmacological activities; however, its effects on Alzheimer's disease (AD) have not been systemically reported. The protective effects of SC on AD were investigated using an L‑glutamic acid (L‑...

journal_title：Molecular medicine reports

authors： Hu X,Teng S,He J,Sun X,Du M,Kou L,Wang X

更新日期：2018-11-01 00:00:00

abstract：:Viral myocarditis (VM), a severe clinical condition characterized by cardiac inflammation, is most frequently induced as a result of coxsackievirus infection. Evidence suggests that microRNAs may have significant roles in the progression of cardiac injury during coxsackievirus infection. Concurrently, microRNA (miR)-2...

journal_title：Molecular medicine reports

authors： Chen ZG,Liu H,Zhang JB,Zhang SL,Zhao LH,Liang WQ

更新日期：2015-07-01 00:00:00

abstract：:The transforming growth factor-β (TGF-β) signaling pathway exhibits an important role in cancer invasion and metastasis. Excessive expression of TGF-β activates Smad4, leading to the upregulation of downstream metastasis-associated genes. Thus, the inhibition of the TGF-β/Smad4 signaling pathway may be a novel strateg...

journal_title：Molecular medicine reports

authors： Chen F,Zhuang M,Peng J,Wang X,Huang T,Li S,Lin M,Lin H,Xu Y,Li J,Chen Z,Huang Y

更新日期：2014-10-01 00:00:00

abstract：:The use of human bone marrow mesenchymal stem cells (hBMSCs) as a tissue engineering application for individuals affected by osteoporosis and other types of bone loss diseases has been well studied in recent years. The osteogenic differentiation of hBMSCs can be regulated by a number of cues. MicroRNAs (miRNAs/miRs) s...

journal_title：Molecular medicine reports

authors： Zhang Y,Zhou L,Zhang Z,Ren F,Chen L,Lan Z

更新日期：2020-07-01 00:00:00

abstract：:Paraquat (PQ) poisoning‑induced pulmonary fibrosis is one of the primary causes of mortality in patients with PQ poisoning. The potential mechanism of PQ‑induced pulmonary fibrosis was thought to be mediated by inflammation. Recently, bone marrow‑derived mesenchymal stem cells (BMSCs) have been considered as a potenti...

journal_title：Molecular medicine reports

authors： Chen J,Si L,Zhou L,Deng Y

更新日期：2019-04-01 00:00:00

abstract：:Hepatic fibrosis (HF), one of the leading global health problems, is defined as aberrant and excess production of extracellular matrix components. The pathogenesis of HF is complex and poorly understood. Long non‑coding RNAs (LncRNAs) can interact with microRNAs (miRNAs) as competing endogenous RNAs (ceRNAs) to regula...

journal_title：Molecular medicine reports

authors： Jiang H,Wu F,Jiang N,Gao J,Zhang J

更新日期：2019-11-01 00:00:00

abstract：:Ampelopsin (AMP), a plant flavonoid, has been reported to inhibit cell growth and/or induce apoptosis in various types of tumor. The aim of the present study was to assess the apoptosis-inducing activity of AMP in A549 human lung adenocarcinoma epithelial cells and the associated underlying mechanism. A549 cells were ...

journal_title：Molecular medicine reports

authors： Chen XM,Xie XB,Zhao Q,Wang F,Bai Y,Yin JQ,Jiang H,Xie XL,Jia Q,Huang G

更新日期：2015-01-01 00:00:00

abstract：:The present study aimed to examine whether fms‑related tyrosine kinase 3 ligand (Flt3L) protects the organs of mice with multiorgan dysfunction syndrome (MODS). Male C57BL/6 mice were randomly assigned to normal control, MODS and Flt3L treatment groups. The mouse models of MODS were established using intraperitoneal z...

journal_title：Molecular medicine reports

authors： Tian G,Lu J,Guo H,Liu Q,Wang H

更新日期：2015-06-01 00:00:00

abstract：:Acute myeloid leukemia (AML) is a hematological malignancy with a low survival rate. Curcumin, which is a multi-targeted anticancer agent, has been shown to exert anti‑oxidant, anti‑inflammatory, anti‑mutagenic and anti‑carcinogenic activities. Naringenin is extracted from citrus fruits and exerts anti‑mutagenic and a...

journal_title：Molecular medicine reports

authors： Shi D,Xu Y,Du X,Chen X,Zhang X,Lou J,Li M,Zhuo J

更新日期：2015-12-01 00:00:00

abstract：:Osteoclasts (OCs) are resorptive cells responsible for bone erosion in diseases, including osteoporosis, periodontitis and rheumatoid arthritis. Montelukast is a cysteinyl leukotriene receptor 1 (CysLTR1) antagonist clinically used for the treatment of asthma. In the present study, the role of CysLTR1 on OC formation ...

journal_title：Molecular medicine reports

authors： Kang JH,Lim H,Lee DS,Yim M

更新日期：2018-08-01 00:00:00

abstract：:The development of pharmaceutical agents possessing anti‑invasive and anti‑metastatic abilities, as well as apoptotic activity, is important in decreasing the incidence and recurrence of oral cancer. Cancer cells are known to acquire invasiveness not only through epigenetic changes, but also from inflammatory stimuli ...

journal_title：Molecular medicine reports

authors： Cho BH,Jung YH,Kim DJ,Woo BH,Jung JE,Lee JH,Choi YW,Park HR

更新日期：2018-02-01 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) are involved in diverse biological processes, including cell proliferation, differentiation and apoptosis. Results from the MTT assay revealed that BMP-2 significantly inhibited the proliferation of MDA-MB‑231 and MCF-7 breast cancer cells. The flo...

journal_title：Molecular medicine reports

authors： Chen A,Wang D,Liu X,He S,Yu Z,Wang J

更新日期：2012-09-01 00:00:00

abstract：:Caudal type homeobox transcription factor 2 (CDX2) is important in intestinal cell fate specification and multiple lines of evidence have substantiated that CDX2 is important in carcinogenesis of the digestive tract. The CDX2 regulatory network is intricate and remains to be fully elucidated in gastric cancer. The aim...

journal_title：Molecular medicine reports

authors： Wei W,Li L,Wang X,Yan L,Cao W,Zhan Z,Zhang X,Yu H,Xie Y,Xiao Q

更新日期：2015-07-01 00:00:00

abstract：:Mossy fiber sprouting (MFS) is a pathological phenomenon that is commonly observed in temporal lobe epilepsy (TLE). However, the molecular mechanisms underlying MFS remain unclear. It has been demonstrated that the tau protein is important in the progression of MFS by the regulation of microtubule dynamics and axonal ...

journal_title：Molecular medicine reports

authors： Huang WJ,Tian FF,Chen JM,Guo TH,Ma YF,Fang J,Dang J,Song MY

更新日期：2013-11-01 00:00:00

abstract：:Osteosarcoma is the most common type of primary malignant tumor of the bone. However, mechanisms underlying osteosarcoma cell proliferation are poorly understood. The present study shows that RBEL1, a newly identified Rab-like GTPase, may be a key regulator of osteosarcoma cell proliferation. Knockdown of RBEL1 in ost...

journal_title：Molecular medicine reports

authors： Tang H,Ji F,Sun J,Xie Y,Xu Y,Yue H

更新日期：2016-02-01 00:00:00

abstract：:Embryonic stem (ES) cells are pluripotent stem cells derived from a developmental stage of pre‑implanted embryos. The present study investigated the effect of female sex steroid hormones on the characteristics of human ES cells by using a feeder‑free culture protocol. In a feeder‑free condition without sex hormones, h...

journal_title：Molecular medicine reports

authors： Jeon SY,Hwang KA,Kim CW,Jeung EB,Choi KC

更新日期：2017-07-01 00:00:00