Annexin A2 knockdown inhibits hepatoma cell growth and sensitizes hepatoma cells to 5-fluorouracil by regulating β-catenin and cyclin D1 expression.

abstract：:An increasing amount of evidence indicates that the inhibition of β adrenergic signaling can result in the inhibition of tumor growth. However, the role of propranolol in liver cancer and the underlying mechanism remain to be elucidated. The present study aimed to investigate the role of propranolol in liver cancer ce...

journal_title：Molecular medicine reports

authors： Wang F,Liu H,Wang F,Xu R,Wang P,Tang F,Zhang X,Zhu Z,Lv H,Han T

更新日期：2018-04-01 00:00:00

abstract：:Platanus acerifolia is one of the major sources of outdoor allergens to humans, and can induce allergic asthma, rhinitis, dermatitis and other allergic diseases. Pla a 2 is a polygalacturonase and represents the major allergen identified in P. acerifolia pollen. The aim of the present study was to express and purify P...

journal_title：Molecular medicine reports

authors： Wang DW,Ni WW,Zhou YJ,Huang W,Cao MD,Meng L,Wei JF

更新日期：2018-01-01 00:00:00

abstract：:The aim of the present study was to evaluate the effect of astragalosides (ASTs) on angiogenesis, as well as the expression of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) following myocardial infarction (MI). MI was induced in rats by ligation of the left coronary artery. Twenty...

journal_title：Molecular medicine reports

authors： Yu JM,Zhang XB,Jiang W,Wang HD,Zhang YN

更新日期：2015-11-01 00:00:00

abstract：:Cervical cancer (CC) is a frequently occurring cancer in women with a high mortality rate. Despite improvements to therapeutic strategies, the survival outcome for patients with CC remains poor. Therefore, the present study aimed to investigate the molecular mechanism underlying CC inhibition involving microRNA (miR)‑...

journal_title：Molecular medicine reports

authors： Guo Y,Luo S

更新日期：2020-12-01 00:00:00

abstract：:Portal hypertension (PHT) is one of the most severe consequences of liver cirrhosis. Carvedilol is a first‑line pharmacological treatment of PHT. However, the antifibrogenic effects of carvedilol on liver cirrhosis and the intrinsic mechanisms underlying these effects have not been thoroughly investigated. The present...

journal_title：Molecular medicine reports

authors： Ling L,Li G,Wang G,Meng D,Li Z,Zhang C

更新日期：2019-08-01 00:00:00

abstract：:Histone deacetylase inhibitor (HDACi) has been a major target of anticancer agents. Quisinostat (JNJ‑26481585), a novel second‑generation HDACi, has previously demonstrated antiproliferative activity against non‑small cell lung cancer; however, the function of quisinostat in hepatocellular carcinoma (HCC) remains to b...

journal_title：Molecular medicine reports

authors： Li F,Wang T,Wang Z,Chen X,Liu R

更新日期：2017-11-01 00:00:00

abstract：:The aim of the present study was to identify key genes and signaling pathways associated with the pathogenesis of juvenile spondyloarthritis (JSA). The gene expression profile dataset GSE58667, including data from 15 human whole blood samples collected from 11 patients with JSA and four healthy controls, was analyzed ...

journal_title：Molecular medicine reports

authors： Wang Z,Han Y,Zhang Z,Jia C,Zhao Q,Song W,Chen T,Zhang Y,Wang X

更新日期：2018-08-01 00:00:00

abstract：:Wear particles serve a central role in periprosthetic osteolysis, which leads to the aseptic loosening of prostheses. In the present study a lentiviral vector was constructed to silence macrophage colony stimulating factor (M‑CSF) and receptor activator of nuclear factor κ‑B ligand (RANKL) genes, which synergistically...

journal_title：Molecular medicine reports

authors： Zhang Y,Jiang P,Li W,Liu X,Lu Y,Huang Z,Song K

更新日期：2017-12-01 00:00:00

abstract：:The oral fluoropyrimidine S-1 has marked efficacy in treating metastatic colorectal cancer patients. In the present study, we explored the therapeutic potential of combined in vivo treatment in the human colon cancer cell lines COL-1, KM12C and KM20C with consecutive oral S-1 and leucovorin (LV) in 2-week therapeutic ...

journal_title：Molecular medicine reports

authors： Tsukioka S,Uchida J,Tsujimoto H,Nakagawa F,Sugimoto Y,Oka T,Kiniwa M

更新日期：2009-05-01 00:00:00

abstract：:Parkinson's disease (PD) is one of the most common neurodegenerative diseases. For decades, the unilateral 6‑hydroxydopamine (6‑OHDA) rat model has been employed to investigate the pathogenesis and therapy of PD. However, the behavior and associated pathological features of the model long term have not previously been...

journal_title：Molecular medicine reports

authors： Su RJ,Zhen JL,Wang W,Zhang JL,Zheng Y,Wang XM

更新日期：2018-02-01 00:00:00

abstract：:In order to investigate the two members of the EF‑hand Ca2+ binding protein S100 family, S100A8 and S100A9, in renal cell carcinoma (RCC), serum samples were collected from patients with RCC, transitional cell carcinoma in the kidney, benign renal masses and normal controls. The samples were analyzed by isobaric tags ...

journal_title：Molecular medicine reports

authors： Zhang L,Jiang H,Xu G,Wen H,Gu B,Liu J,Mao S,Na R,Jing Y,Ding Q,Zhang Y

更新日期：2015-06-01 00:00:00

abstract：:Circular RNAs (circRNAs) are class of endogenous RNAs that have a role in the regulation of gene expression. The present study aimed to investigate the diagnostic value and role of circRNA in the pathogenesis of leukoaraiosis (LA). The present study performed Arraystar Human circRNA Array analysis of 6 samples from LA...

journal_title：Molecular medicine reports

authors： Mi T,Luo C,Hu Y,Qu C,Wang X,Guo S,Du Y

更新日期：2017-09-01 00:00:00

abstract：:Indoxyl sulfate (IS), a typical uremic toxin, is of great importance in the development of chronic kidney disease. In addition to its nephrotoxicity, previous studies have provided increasing evidence for its cardiovascular toxicity. The mechanism underlying IS‑induced cardiovascular toxicity has been elusive to date....

journal_title：Molecular medicine reports

authors： Tan X,Cao XS,Zhang P,Xiang FF,Teng J,Zou JZ,Ding XQ

更新日期：2018-12-01 00:00:00

abstract：:Skeletal myogenesis is a highly ordered and complex biological process that is mediated by numerous regulatory factors. In previous studies, it has been demonstrated that microRNAs (miRs) and long non‑coding RNAs (lncRNAs) serve key roles in skeletal myogenesis. The present study showed that the expression levels of m...

journal_title：Molecular medicine reports

authors： Zhao X,Gu H,Wang L,Zhang P,Du J,Shen L,Jiang D,Wang J,Li X,Zhang S,Li M,Zhu L

更新日期：2020-11-01 00:00:00

abstract：:The present study aimed to explore the effect of Saikosaponin D (SSD) and its underlying mechanism on apoptosis and autophagy in human breast cancer MDA‑MB‑231 cells. MTT assay, flow cytometry, western blotting and confocal fluorescence microscopy detection were employed. SSD, a kind of triterpenoid saponins extracted...

journal_title：Molecular medicine reports

authors： Fu R,Zhang L,Li Y,Li B,Ming Y,Li Z,Xing H,Chen J

更新日期：2020-08-01 00:00:00

abstract：:Cervical cancer is the third highest cause of death in developing countries and most commonly results from high‑risk human papillomavirus (HR‑HPV) infection. Among HR‑HPV genotypes, HPV16 and HPV18 are the most prevalent in cervical cancers. Therefore, the present study aimed to develop a detection assay for HPV16 and...

journal_title：Molecular medicine reports

authors： Kumvongpin R,Jearanaikoon P,Wilailuckana C,Sae-Ung N,Prasongdee P,Daduang S,Wongsena M,Boonsiri P,Kiatpathomchai W,Swangvaree SS,Sandee A,Daduang J

更新日期：2017-05-01 00:00:00

abstract：:The activation of the (pro)renin receptor (PRR) may be potentially active in the development of atherosclerotic plaques independent of angiotensin II. Our previous studies demonstrated that high glucose was able to induce the activation of PRR. The present study was designed to determine the function of oxidized low‑d...

journal_title：Molecular medicine reports

authors： Cheng Y,Liu X,Zhang L,Zhang Y,Liu Y,Lu Y,Jiang Y

更新日期：2015-06-01 00:00:00

abstract：:LL‑37 is the only known member of the cathelicidin family of antimicrobial peptides in humans. In addition to its broad spectrum of antimicrobial activities, LL‑37 may modulate various inflammatory reactions. The authors previously revealed that LL‑37 improves the survival of a murine cecal ligation and puncture (CLP)...

journal_title：Molecular medicine reports

authors： Hosoda H,Nakamura K,Hu Z,Tamura H,Reich J,Kuwahara-Arai K,Iba T,Tabe Y,Nagaoaka I

更新日期：2017-10-01 00:00:00

abstract：:As a member of the cysteine protease family, cathepsin S (CTSS) serves an important role in diseases such as cancer, arthritis and atherosclerosis. Nevertheless, its role in renal fibrosis is unknown. In the present study, the effects of CTSS on renal fibrosis in mild (group M) and severe (group S) hydronephrosis were...

journal_title：Molecular medicine reports

authors： Yao X,Cheng F,Yu W,Rao T,Li W,Zhao S,Zhou X,Ning J

更新日期：2019-07-01 00:00:00

abstract：:Neutrophilic asthma (NA) is characterized by neutrophil‑mediated inflammation and the presence of Th17 cells. However, the mechanisms underlying Th17 cell responses in NA remain unknown. The aim of the present study was to examine the effects of interleukin (IL)‑7 on Th17 cell responses in NA. A NA mouse model was sen...

journal_title：Molecular medicine reports

authors： Zhang X,Zhang M,Jiang M,Nong G

更新日期：2020-08-01 00:00:00

abstract：:Myocardial ischemia/reperfusion (I/R) injury is a major pathological process in coronary heart disease and cardiac surgery, and is associated with aberrant microRNA (miR) expression. Previous studies have demonstrated that inhibition of miR-15a expression may ameliorate I/R‑induced myocardial injury. In the present st...

journal_title：Molecular medicine reports

authors： Yang Y,Ding S,Xu G,Chen F,Ding F

更新日期：2017-06-01 00:00:00

abstract：:The present study characterizes the effects of resveratrol (Res) on vascular endothelial growth factor (VEGF) secretion in retinal pigment epithelial (RPE) cells. ARPE-19 cells were treated with CoCl2, a hypoxia mimetic agent. CoCl2 treatment increased protein levels of hypoxia inducible factor-1α (HIF-1α) and CXC-che...

journal_title：Molecular medicine reports

authors： Seong H,Ryu J,Jeong JY,Chung IY,Han YS,Hwang SH,Park JM,Kang SS,Seo SW

更新日期：2015-07-01 00:00:00

abstract：:More than 60 years after their isolation and characterization, aminoglycoside (AG) antibiotics remain powerful agents in the treatment of severe gram-negative, enterococcal or mycobacterial infections. However, the clinical use of AGs is hampered by nephrotoxicity and ototoxicity, which often develop as a consequence ...

journal_title：Molecular medicine reports

authors： Perletti G,Vral A,Patrosso MC,Marras E,Ceriani I,Willems P,Fasano M,Magri V

更新日期：2008-01-01 00:00:00

abstract：:Varicella‑zoster virus (VZV), a ubiquitous human α‑herpesvirus, is the causative agent of chickenpox and shingles. In the present study, we investigated the antiviral activity of a 70% ethanol extract of Lysimachia mauritiana (LME) against VZV. LME strongly interfered with the replication of both laboratory and clinic...

journal_title：Molecular medicine reports

authors： Bae S,Song YJ

更新日期：2017-06-01 00:00:00

abstract：:Transcription intermediary factor 1γ (Tif1γ), a ubiquitous nuclear protein, is a regulator of transforming growth factor‑β (TGF‑β)/Smad signaling. Tif1γ can function as an oncogene and as a tumor suppressor. In the present study, Tif1γ levels were measured in the plasma of patients with breast cancer in order to inves...

journal_title：Molecular medicine reports

authors： Cai F,Cai L,Zhou Z,Pan X,Wang M,Chen S,Luis MAF,Cen C,Biskup E

更新日期：2019-05-01 00:00:00

abstract：:Ezrin is involved in maintaining cell structure and cell motility. Expression levels of the ezrin gene correlate with numerous human malignancies. The aim of this study was to explore the role of ezrin in tumor progression and the prognostic evaluation of colorectal adenocarcinoma (CRA). The levels of ezrin protein in...

journal_title：Molecular medicine reports

authors： Lin LJ,Chen LT

更新日期：2013-07-01 00:00:00

abstract：:Disruption of the intestinal mucosal barrier integrity is a pathogenic process in inflammatory bowel disease (IBD) development, and is therefore considered a drug discovery target for IBD. The well‑known traditional Chinese formulation Qing Hua Chang Yin (QHCY) has been suggested as a potential therapeutic agent for t...

journal_title：Molecular medicine reports

authors： Fang W,Zhao P,Shen A,Liu L,Chen H,Chen Y,Peng J,Sferra TJ,Sankararaman S,Luo Y,Ke X

更新日期：2021-03-01 00:00:00

abstract：:Aquaporin 4 (AQP4) is a widely distributed membrane protein, which is found in glial cells, ependymocytes and capillary endothelial cells in the brain, and particularly in the choroid plexus. AQP4 is a key regulator of water metabolism, and changes in its expression following brain injury are associated with pathologi...

journal_title：Molecular medicine reports

authors： Zhang C,Chen J,Lu H

更新日期：2015-11-01 00:00:00

abstract：:Tubeimoside-1 (TBMS1), a traditional Chinese herb extracted from Bolbostemma paniculatum (Maxim.), induces apoptosis in a number of human cancer cell lines. TBMS1 has been reported to induce apoptosis in human glioma cells, however the mechanism remains to be elucidated. The present study explored TBMS1‑induced PI3K/A...

journal_title：Molecular medicine reports

authors： Cao LJ,Xie HT,Chu ZX,Ma Y,Wang MM,Shi Z

更新日期：2020-08-01 00:00:00

abstract：:Subsequent to the publication of the above paper, the authors have realized that there were errors in Fig. 1 on page 902; essentially, the experimental data described as being 'Preterm' and 'Infected preterm' should have been labelled as 'Full‑term without labor' and 'Preterm', respectively. Note that these errors in ...

journal_title：Molecular medicine reports

authors： Chen J,Zheng D,Cui H,Liu S,Zhang L,Liu C

更新日期：2018-04-01 00:00:00