Effects of Qing Hua Chang Yin on lipopolysaccharide‑induced intestinal epithelial tight junction injury in Caco‑2 cells.

abstract：:The tumorigenesis and maintenance of a cancer cells is dependent upon the collaboration of multiple signaling pathways. Signal transducer and activator of transcription 3 (STAT3) and β-catenin are at the center of multiple cancer-associated signaling pathways; therefore, simultaneously targeting STAT3 and β-catenin ma...

journal_title：Molecular medicine reports

authors： Wang XH,Liu MN,Huang P,Xu J,Liu AY,Chen J,Lv CQ,Xu RL

更新日期：2015-08-01 00:00:00

abstract：:Subsequently to the publication of this article, the authors have realized that Fig. 4 contained some incorrectly incorporated data panels; specifically, the A‑d, B‑b and B‑c panels did not display the correct data. The revised version of Fig. 4 featuring the correct data for the A‑d, B‑b and B‑c panels is shown on th...

journal_title：Molecular medicine reports

authors： Cheng L,Song J,Li G,Liu Y,Wang Y,Meng X,Sun G,Sun X

更新日期：2019-11-01 00:00:00

abstract：:Heng-Gu-Gu-Shang-Yu-He-Ji, also known as OsteoKing, is used as a herbal Traditional Chinese Medicine for the treatment of bone disease, including femoral head necrosis and osteoarthritis. However, whether OsteoKing has anti-osteoporotic properties has remained to be elucidated. The purpose of the present study was the...

journal_title：Molecular medicine reports

authors： Dai L,Wu H,Yu S,Zhao H,Xue L,Xu M,Shen Z,Hu M

更新日期：2015-07-01 00:00:00

abstract：:Aldose reductase (AR) is involved in the pathogenesis of nonalcoholic steatohepatitis. This study aimed to determine the mechanism by which AR affects the development of murine diet-induced nonalcoholic steatohepatitis. Steatohepatitis was induced in C57BL/6 mice by administration of a methionine-choline-deficient (MC...

journal_title：Molecular medicine reports

authors： Chen T,Shi D,Chen J,Yang Y,Qiu M,Wang W,Qiu L

更新日期：2015-01-01 00:00:00

abstract：:The expression of microRNA‑206 (miR‑206) is aberrantly induced in steroid‑induced avascular necrosis of femoral head (SANFH). Therefore, investigating the function of miR‑206 in SANFH and uncovering the functional mechanism associated with the condition will promote the understanding and treatment of the disease. The ...

journal_title：Molecular medicine reports

authors： Zhang Z,Jin A,Yan D

更新日期：2018-01-01 00:00:00

abstract：:Formononetin (Form), a phytoestrogen extracted from the roots of Astragalus membranaceus, is one of the fundamental herbs used in traditional Chinese medicine because of its protective effects against certain malignant tumors. However, its role in colon carcinoma cells and the underlying molecular mechanisms have not ...

journal_title：Molecular medicine reports

authors： Wang AL,Li Y,Zhao Q,Fan LQ

更新日期：2018-06-01 00:00:00

abstract：:The aim of the present study was to investigate the apoptosis of human ovarian cancer cell lines, A2780 and CP70, induced by a novel curcumin analogue, B19. The proliferation of cells was detected with methyl thiazolyl tetrazolium (MTT) assay and apoptosis was examined by flow cytom...

journal_title：Molecular medicine reports

authors： Zhang X,Zhang HQ,Zhu GH,Wang YH,Yu XC,Zhu XB,Liang G,Xiao J,Li XK

更新日期：2012-03-01 00:00:00

abstract：:Recently, it has been reported that kidney stones are a significant and independent risk factor for chronic kidney disease (CKD) in the general population. However, the prevalence of CKD in patients following successful extracorporeal shockwave lithotripsy (ESWL) has yet to be eluci...

journal_title：Molecular medicine reports

authors： Maeda S,Naganuma T,Takemoto Y,Shoji T,Okamura M,Nakatani T

更新日期：2012-01-01 00:00:00

abstract：:Histone deacetylases (HDACs) are enzymes that catalyze the removal of acetyl from lysine residues in histones and other proteins, which results in gene transcriptional repression and subsequent changes in signaling events. HDACs inhibitors (HDACIs) have been used to reverse the aberrant epigenetic changes associated w...

journal_title：Molecular medicine reports

authors： Han RF,Li K,Yang ZS,Chen ZG,Yang WC

更新日期：2014-12-01 00:00:00

abstract：:Circulating tumor cells (CTCs) are tumor cells present in the bloodstream, which originate from tumor sites, and are ultimately responsible for metastasis or relapse in several types of cancer. However, to the best of our knowledge, only a few studies have investigated these extremely rare cells in esophageal squamous...

journal_title：Molecular medicine reports

authors： Zhang Y,Li J,Wang L,Meng P,Zhao J,Han P,Xia J,Xu J,Wang L,Shen F,Zheng A,Zhou F,Fan R

更新日期：2019-08-01 00:00:00

abstract：:Chloride intracellular channel 1 (CLIC1) has been demonstrated to be overexpressed in gastric cancer, and elevated CLIC1 expression levels are markedly associated with the processes of tumor cell migration and invasion. However, the regulatory mechanism and signaling pathway underlying these processes have remained to...

journal_title：Molecular medicine reports

authors： Zhao W,Lu M,Zhang Q

更新日期：2015-12-01 00:00:00

abstract：:Cardiac fibrosis is considered an important pathological mechanism in the progression of cardiac remodeling and heart failure. Astragaloside IV (AsIV) is a major active ingredient in Astragalus membranaceus. In a preliminary experiment, it was demonstrated that this naturally occurring substance exhibited cardioprotec...

journal_title：Molecular medicine reports

authors： Dai H,Jia G,Lu M,Liang C,Wang Y,Wang H

更新日期：2017-04-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) comprises a range of liver diseases, between steatosis and non‑alcoholic steatohepatitis and liver cirrhosis, which are closely associated with diabetes mellitus. Previous studies have indicated that oxidative stress is a key factor in the development of NAFLD. Molecular hydro...

journal_title：Molecular medicine reports

authors： Zhai X,Chen X,Lu J,Zhang Y,Sun X,Huang Q,Wang Q

更新日期：2017-03-01 00:00:00

abstract：:It is well known that the local renin-angiotensin system (RAS) is activated in the diabetic state, which results in an increase in the level of oxidative stress injury to pancreatic β cells. The angiotensin‑converting enzyme 2 (ACE2)/angiotensin (1‑7) [Ang (1‑7)]/Mas axis is a negative regulator of the classical renin...

journal_title：Molecular medicine reports

authors： Zhang F,Liu C,Wang L,Cao X,Wang YY,Yang JK

更新日期：2016-09-01 00:00:00

abstract：:The use of non‑steroidal anti‑inflammatory drugs (NSAIDs) has been associated with a reduced risk of various types of cancer, including esophageal cancer. However, the mechanisms underlying the antineoplastic effects of NSAIDs in esophageal cancer remain to be elucidated. In the present study, a significant inhibition...

journal_title：Molecular medicine reports

authors： Qin S,Xu C,Li S,Yang C,Sun X,Wang X,Tang SC,Ren H

更新日期：2015-06-01 00:00:00

abstract：:Following the publication of this article, the authors have realized that an error was made with the description of the first and fourth listed affiliation addresses: "North China University of Science and of Technology", should have been written as "North China University of Science and Technology". This error also a...

journal_title：Molecular medicine reports

authors： Bao Z,Hao J,Li Y,Feng F

更新日期：2020-06-01 00:00:00

abstract：:Aberrant DNA methylation is the most common type of epigenetic alteration and is associated with many types of cancer. Although previous studies have provided a few novel DNA methylation markers in hepatocellular carcinoma (HCC), specific DNA methylation patterns and comparisons of the aberrant alterations in methylat...

journal_title：Molecular medicine reports

authors： Sun N,Zhang J,Zhang C,Shi Y,Zhao B,Jiao A,Chen B

更新日期：2018-11-01 00:00:00

abstract：:Cancer stem cells (CSCs) are proposed to be responsible for tumor recurrence, metastasis and the high mortality rate of cancer patients. Isolation and identification of CSCs is crucial for basic and preclinical studies. However, as there are currently no universal markers for the isolation and identification of CSCs i...

journal_title：Molecular medicine reports

authors： Wang L,Guo H,Lin C,Yang L,Wang X

更新日期：2014-06-01 00:00:00

abstract：:Even though standard treatment options are available for prostate cancer patients, prostate cancer is still a leading cause of death in many Western countries due to drug resistance and recurrence. Immune checkpoint blockade therapy has been proved to be very effective in some melanoma patients, which might dependent ...

journal_title：Molecular medicine reports

authors： Zhou J,Yang T,Liu L,Lu B

更新日期：2017-09-01 00:00:00

abstract：:The function of microRNAs (miRNAs) in tumorigenesis has been extensively investigated. In the present study, the aim was to investigate the expression and role of miR‑204 in B‑cell lymphoma. The present study demonstrated that miR‑204 is downregulated in B‑cell lymphoma. Using in vitro studies, overexpression of miR‑2...

journal_title：Molecular medicine reports

authors： Wu L,Li Y,Fan JM,Zhang ZM,Ouyang JL,Ni TT,Wu HX,Li H

更新日期：2015-06-01 00:00:00

abstract：:Hepatic glycoprotein (gp78), a membrane-anchored E3 ubiquitin ligase, has been reported to be involved in regulating lipid and energy metabolism in animals, and cell death‑inducing DFFA‑like effector c (cidec) has emerged as an important regulator of metabolism, which has been implicated in the process of fat differen...

journal_title：Molecular medicine reports

authors： Li J,Liu G,Zhang F,Zhang Z,Xu Y,Li Q

更新日期：2017-08-01 00:00:00

abstract：:Advances in the treatment of nasopharyngeal carcinoma (NPC) have significantly improved the local control rate; however, distant metastasis remains a principal cause of mortality. Previous studies have demonstrated that the expression levels of amyloid β precursor protein (APP) are increased in NPC. The present study ...

journal_title：Molecular medicine reports

authors： Xu J,Ying Y,Xiong G,Lai L,Wang Q,Yang Y

更新日期：2019-07-01 00:00:00

abstract：:Owing to an oversight during the proof checking stage, the above article has been published with the incorrect author listed for correspondence. The first author, Chao Huang, is listed as the corresponding author, although he was only intended to have been temporarily assigned to handle queries during the pre-press st...

journal_title：Molecular medicine reports

authors： Huang C,Liu H,Gong X,Wen B,Chen D,Liu J,Hu F

更新日期：2016-12-01 00:00:00

abstract：:Postoperative cognitive dysfunction (POCD), common in elderly patients, refers to a decline in cognitive function following surgery, which may persist or even evolve into Alzheimer's disease (AD). Despite great efforts, the mechanism of POCD remains unclear. In the present study, we tested the hypothesis that Toll-lik...

journal_title：Molecular medicine reports

authors： Wang Y,He H,Li D,Zhu W,Duan K,Le Y,Liao Y,Ou Y

更新日期：2013-04-01 00:00:00

abstract：:Human glioma is a pernicious tumor from the central nervous system; it has been reported that microRNAs (miRs) may have carcinogenic or tumor suppressor effects on human glioma. The aim of the present study was to assess miR‑141 expression and functional role in human primary glioma, as well as in tumor‑derived cell l...

journal_title：Molecular medicine reports

authors： Li G,Huang M,Cai Y,Ke Y,Yang Y,Sun X

更新日期：2018-08-01 00:00:00

abstract：:Curcumin, which is an extract from a traditional Chinese medicine, has previously been demonstrated to exhibit an anti‑atherosclerotic effect, which is closely associated with an increase in cholesterol efflux. However, it is unclear as to whether the increased effect is mediated by heme oxygenase (HO)‑1. Macrophages ...

journal_title：Molecular medicine reports

authors： Zhong Y,Feng J,Fan Z,Li J

更新日期：2018-04-01 00:00:00

abstract：:Histone deacetylase inhibitor (HDACi) has been a major target of anticancer agents. Quisinostat (JNJ‑26481585), a novel second‑generation HDACi, has previously demonstrated antiproliferative activity against non‑small cell lung cancer; however, the function of quisinostat in hepatocellular carcinoma (HCC) remains to b...

journal_title：Molecular medicine reports

authors： Li F,Wang T,Wang Z,Chen X,Liu R

更新日期：2017-11-01 00:00:00

abstract：:Leptomeningeal fibrosis is important in the pathogenesis of communicating hydrocephalus following subarachnoid hemorrhage; however, the underlying mechanisms of leptomeningeal fibrosis remain largely unclear. In the present study, primary meningeal mesothelial cells (MMCs) were used as a cell model to investigate the ...

journal_title：Molecular medicine reports

authors： Yue XJ,Guo Y,Yang HJ,Feng ZW,Li T,Xu YM

更新日期：2016-08-01 00:00:00

abstract：:The aim of this study was to investigate the expression pattern of regenerating gene I (Reg I) in the lung and intestinal tissues of rats with acute necrotizing pancreatitis (ANP), as well as the correlation of Reg I expression with lung and intestinal injury. Sprague-Dawley rats were randomly allocated to control (n=...

journal_title：Molecular medicine reports

authors： Hu HL,Zhang Q,Kong B,Shi X

更新日期：2013-02-01 00:00:00

abstract：:The increasing burden of diabetes in low and middle‑income countries is attributable to both genetic and epigenetic factors. Environmental‑ and lifestyle‑associated changes are also considered to be important contributors to this disease. The resultant co‑morbidities arising from micro‑and macrovascular changes in dia...

journal_title：Molecular medicine reports

authors： Yu Z,Zhang W,Zhang X,Xu D,Wang N

更新日期：2020-08-01 00:00:00