Chloride intracellular channel 1 regulates migration and invasion in gastric cancer by triggering the ROS-mediated p38 MAPK signaling pathway.


:Chloride intracellular channel 1 (CLIC1) has been demonstrated to be overexpressed in gastric cancer, and elevated CLIC1 expression levels are markedly associated with the processes of tumor cell migration and invasion. However, the regulatory mechanism and signaling pathway underlying these processes have remained to be elucidated. The present study examined the impact of N-acetyl cysteine (NAC), indanyloxyacetic acid (IAA)-94 and SB203580, inhibitors of reactive oxygen species (ROS), as well as CLIC1 and p38 mitogen-activated protein kinase (MAPK) on the migration and invasion of SGC-7901 gastric cancer cells in a hypoxia‑reoxygenation (H-R) microenvironment. The results demonstrated that intracellular ROS and CLIC1 levels were increased under H‑R conditions, and that functional inhibition of CLIC1 significantly decreased the H‑R‑elevated ROS generation and p‑p38 MAPK levels in SGC‑7901 cells, as well as inhibited the migration and invasion of SGC‑7901 cells. In addition, the expression levels of MMP‑2 and MMP‑9 were inhibited by NAC, IAA‑94 and SB203580. These results indicated that CLIC1 regulates gastric cancer-cell migration and invasion via the ROS-mediated p38 MAPK signaling pathway.


Mol Med Rep


Zhao W,Lu M,Zhang Q




Has Abstract


2015-12-01 00:00:00












  • Tumor budding is a significant indicator of a poor prognosis in lung squamous cell carcinoma patients.

    abstract::Lung cancer is a leading cause of cancer mortality worldwide and patients occasionally develop local recurrence or distant metastasis soon after curative resection. Reports of new therapeutic strategies for lung squamous cell carcinoma (SqCC) are extremely rare, while selective anti...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Masuda R,Kijima H,Imamura N,Aruga N,Nakamura Y,Masuda D,Takeichi H,Kato N,Nakagawa T,Tanaka M,Inokuchi S,Iwazaki M

    更新日期:2012-11-01 00:00:00

  • MicroRNA expression profiles of LO2 cells expressing the wild-type and mutant HBx gene.

    abstract::Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. Although numerous studies have suggested the potentially oncogenic roles of wild‑type or mutant hepatitis B virus X (HBx) protein in hepatocarcinogenesis, their exact mechanism remains unclear. Increasing evidence suggests that microRNAs ...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Fu X,Tan D,Hou Z,Hu Z,Liu G,Ouyang Y,Liu F

    更新日期:2013-02-01 00:00:00

  • Overexpression of CKS2 is associated with a poor prognosis and promotes cell proliferation and invasion in breast cancer.

    abstract::Growing evidence indicates that cyclin dependent kinases regulatory subunit 2 (CKS2) serves an essential role in the regulation of multiple cellular processes in diverse human cancer types. The present study investigated the contribution of CKS2 to breast cancer (BC) progression. In the present study, CKS2 expression ...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Huang N,Wu Z,Hong H,Wang X,Yang F,Li H

    更新日期:2019-06-01 00:00:00

  • Individualized drug screening based on next generation sequencing and patient derived xenograft model for pancreatic cancer with bone metastasis.

    abstract::The efficacy of traditional chemoradiotherapies for pancreatic cancer remains limited, and no effective targeted therapies or screening tests are currently available. Therefore more individualized drug screening is warranted for the clinical treatment of pancreatic cancer. A patient‑derived xenograft (PDX) model of pa...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Guan Z,Lan H,Chen X,Jiang X,Wang X,Jin K

    更新日期:2017-10-01 00:00:00

  • Physical exercise promotes proliferation and differentiation of endogenous neural stem cells via ERK in rats with cerebral infarction.

    abstract::Physical exercise is beneficial for the functional recovery of neurons after stroke. It has been suggested that exercise regulates proliferation and differentiation of endogenous neural stem cells (NSCs); however, the underlying molecular mechanisms are still largely unknown. In the present study, the aim was to inves...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Liu W,Wu W,Lin G,Cheng J,Zeng Y,Shi Y

    更新日期:2018-08-01 00:00:00

  • Transforming growth factor-β1 gene mutations and phenotypes in pediatric patients with Camurati‑Engelmann disease.

    abstract::The aim of the present study was to investigate the clinical characteristics and major causative gene in pediatric patients with Camurati‑Engelmann disease (CED). Biochemical and radiographic examinations, bone scintigraphy and genetic analyses were performed in two affected males and their parents. The two patients e...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Wang C,Zhang BH,Liu YJ,Hu YQ,He JW,Zhang ZL

    更新日期:2013-05-01 00:00:00

  • Increased expression of epidermal growth factor receptor and betacellulin during the early stage of gastric ulcer healing.

    abstract::Epidermal growth factor receptor (EGFR) is important for the proliferation and differentiation of gastric mucosal cells. Betacellulin (BTC) is a novel ligand for EGFR Since their role is unclear in the ulcer healing process, we investigated their expression. Gastric ulcers in 30 Sprague-Dawley rats were induced by ace...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Choi GH,Park HS,Kim KR,Choi HN,Jang KY,Chung MJ,Kang MJ,Lee DG,Moon WS

    更新日期:2008-07-01 00:00:00

  • A study on the correlation between STAT‑1 and mutant p53 expression in glioma.

    abstract::Glioma is the most common primary brain tumor in adults and the second most common malignant tumor in children. Aberrant expression of signal transducer and activator of transcription 1 (STAT‑1) and p53 are known to affect the occurrence and progression of malignant tumors. The aim of the present study was to investig...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Yang W,Wang H,Ju H,Dou C

    更新日期:2018-06-01 00:00:00

  • Expression and clinical significance of ubiquitin‑specific‑processing protease 34 in diffuse large B‑cell lymphoma.

    abstract::Ubiquitin‑specific‑processing protease 34 (USP34) is a deubiquitinase that is involved in the pathogenesis of various cancers. Its roles in diffuse large B‑cell lymphoma (DLBCL) are unknown. The present study aimed to determine the level of USP34 expression and to explore its association with clinicopathological featu...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Li C,Huang L,Lu H,Wang W,Chen G,Gu Y,Zhou Q,Peng Z,Feng Z

    更新日期:2018-11-01 00:00:00

  • Upregulation of centromere protein M promotes tumorigenesis: A potential predictive target for cancer in humans.

    abstract::Centromere protein M (CENPM), a protein required for chromosome separation, is involved in in mitosis. However, little has been reported about the roles of CENPM in various types of cancer. The present study identified that the mRNA expression levels of CENPM were significantly upregulated in 14 types of human cancer ...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Liu Y,Yu W,Ren P,Zhang T

    更新日期:2020-11-01 00:00:00

  • Use of data mining to determine changes in the gene expression profiles of rat embryos following prenatal exposure to inflammatory stimulants.

    abstract::Numerous clinical epidemiology and laboratory studies have demonstrated a close association between inflammation or immunity and the occurrence of hypertension. Our group has previously shown that upon intraperitoneal injection of lipopolysaccharide (LPS) or zymosan (Zym) into pregnant rats, the offspring of the exper...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Zhou J,Zhang X,Zhang H,Jia Y,Liu Y,Tang Y,Li X

    更新日期:2013-07-01 00:00:00

  • Role of ROCK expression in gallbladder smooth muscle contraction.

    abstract::Cholelithiasis is a common medical condition whose incidence rate is increasing yearly, while its pathogenesis has yet to be elucidated. The present study assessed the expression of Rho-kinase (ROCK) in gallbladder smooth muscles and its effect on the contractile function of gallbladder smooth muscles during gallstone...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Wang B,Ding YM,Wang CT,Wang WX

    更新日期:2015-08-01 00:00:00

  • D‑galactose‑induced mitochondrial DNA oxidative damage in the auditory cortex of rats.

    abstract::Chronic administration of D‑galactose (D‑gal) is a useful method for establishing a model of natural aging in the auditory system. Previous studies have demonstrated that NADPH oxidases (NOXs) may be an important source of reactive oxygen species (ROS) in the peripheral auditory system (PAS) and cause an increase in m...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Du Z,Yang Q,Zhou T,Liu L,Li S,Chen S,Gao C

    更新日期:2014-12-01 00:00:00

  • Inhibitory effects of imatinib on vitamin D₃ synthesis in human keratinocytes.

    abstract::Chronic myeloid leukemia (CML) is a myeloproliferative disease characterized by the presence of the BCR‑ABL1 fusion gene, a constitutively active, oncogenic tyrosine kinase that is responsible for the clinical features of CML. Tyrosine kinase inhibitors, such as imatinib, have markedly altered the treatment of CML. Ho...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Mehlig LM,Garve C,Tauer JT,Suttorp M,Bauer A

    更新日期:2015-04-01 00:00:00

  • Dexmedetomidine attenuates sevoflurane‑induced neurocognitive impairment through α2‑adrenoceptors.

    abstract::It has been reported that sevoflurane induces neurotoxicity in the developing brain. Dexmedetomidine is an α2 adrenoceptor agonist used for the prevention of sevoflurane‑induced agitation in children in clinical practice. The aim of the present study was to determine whether dexmedetomidine could prevent sevoflurane‑i...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Zhang Y,Li M,Cui E,Zhang H,Zhu X,Zhou J,Yan M,Sun J

    更新日期:2021-01-01 00:00:00

  • Irradiation alters the differentiation potential of bone marrow mesenchymal stem cells.

    abstract::Bone injury following radiotherapy has been confirmed by epidemiological and animal studies. However, the underlying mechanism remains to be elucidated and no preventive or curative solution has been identified for this bone loss. The present study aimed to investigate the irradiation‑altered osteogenesis and adipogen...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Wang Y,Zhu G,Wang J,Chen J

    更新日期:2016-01-01 00:00:00

  • Inhibition of autophagy by berberine enhances the survival of H9C2 myocytes following hypoxia.

    abstract::Hypoxia may induce apoptosis and autophagy to promote cardiomyocyte injury. The present study investigated the effect of berberine, a natural extract of Rhizoma Coptidis, on hypoxia‑induced autophagy and apoptosis in the H9c2 rat myocardial cell line. Expression levels of apoptosis and autophagy markers were upregulat...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Jia Z,Lin L,Huang S,Zhu Z,Huang W,Huang Z

    更新日期:2017-08-01 00:00:00

  • Microarray data analysis of neuroblastoma: Expression of SOX2 downregulates the expression of MYCN.

    abstract::The present study aimed to identify the genes directly or indirectly correlated with the amplification of MYCN in neuroblastoma (NB). Microarray data (GSE53371) were downloaded from Gene Expression Omnibus, and included 10 NB cell lines with MYCN amplification and 10 NB cell lines with normal MYCN copy numbers. Differ...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Bao J,Qin L,Cui L,Wang X,Meng Q,Zhu L,Zhang S

    更新日期:2015-11-01 00:00:00

  • Resveratrol alleviates diabetic mechanical allodynia in rats by downregulating P2X3R.

    abstract::Mechanical allodynia, which develops in patients of diabetes mellitus as a neuropathic manifestation, remains without an effective treatment. The aim of the present study was to investigate the effects and potential mechanisms underlying resveratrol (RES) in a rat model of streptozocin (STZ)‑induced diabetic mechanica...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Cui Y,Li Y,Ning J,Mi Y,Wang X,Qiu Z,Li L,Gou X

    更新日期:2020-08-01 00:00:00

  • Mutation of 3β-hydroxysteroid dehydrogenase (3β-HSD) at the 3'-untranslated region is associated with adrenocortical insufficiency.

    abstract::In the present study, we report the mutation of the 3β-hydroxysteroid dehydrogenase (3β-HSD) gene in a family suffering from adrenocortical insufficiency. The index patient was clinically diagnosed with adrenocortical insufficiency. Peripheral venous blood (5 ml) was collected from ...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Pan Y,Zhong S,Hu RM,Gong W

    更新日期:2012-12-01 00:00:00

  • Inhibitory activity of Socheongryong‑tang and its constituent components against the production of RANTES, eotaxin, eotaxin‑3 and MMP‑9 from BEAS‑2B cells.

    abstract::Socheongryeong‑tang (SCRT) is a herbal formula previously used to treat pulmonary diseases primarily caused by the common cold virus, including airway inflammation, asthma and allergy. The aim of the present study was to investigate the inhibitory effect of SCRT water extract and its 13 constituent components on chemo...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Kim JH,Jeon WY,Lee MY,Seo CS,Lim HS,Shin HK

    更新日期:2014-12-01 00:00:00

  • Rapamycin promotes osteogenesis under inflammatory conditions.

    abstract::Chronic periodontitis, a common oral disease, usually results in irreversible bone resorption. Bone regeneration is a complex process between bone‑forming activity of osteoblasts and bone‑resorbing activity of osteoclasts, and still remains a challenge for physicians clinically. A previous study demonstrated that the ...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Li X,Chang B,Wang B,Bu W,Zhao L,Liu J,Meng L,Wang L,Xin Y,Wang D,Tang Q,Zheng C,Sun H

    更新日期:2017-12-01 00:00:00

  • Domain I-IV of β2-glycoprotein I inhibits advanced glycation end product-induced angiogenesis by down-regulating vascular endothelial growth factor 2 signaling.

    abstract::Advanced glycation end products (AGEs) are a contributing factor in the angiogenesis that is characteristic of proliferative diabetic retinopathy. However, a previous study made a promising observation that domain I‑IV of β2‑glycoprotein I (DI‑IV) inhibits angiogenesis in human umbilical vein cells. The present study ...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Wang QQ,Zhou SJ,Meng ZX,Wang J,Chen R,Lv L,Li CJ,Yu DM,Yu P

    更新日期:2015-03-01 00:00:00

  • MicroRNA‑376a inhibits cell proliferation and invasion in osteosarcoma via directly targeting SATB1.

    abstract::Aberrantly expressed microRNAs (miRs) are implicated in the regulation of osteosarcoma (OS) onset and development. Therefore, key miRs in OS must be identified to develop promising and effective therapeutic targets for patients with OS. In the present study, reverse transcription‑quantitative polymerase chain reaction...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Zhou G,Jiang H,Ma L

    更新日期:2018-09-01 00:00:00

  • Erythropoietin alleviates post-resuscitation myocardial dysfunction in rats potentially through increasing the expression of angiotensin II receptor type 2 in myocardial tissues.

    abstract::Activation of renin-angiotensin system (RAS) is one of the pathological mechanisms associated with myocardial ischemia-reperfusion injury following resuscitation. The present study aimed to determine whether erythropoietin (EPO) improves post‑resuscitation myocardial dysfunction and how it affects the renin‑angiotensi...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Zhou H,Huang J,Zhu L,Cao Y

    更新日期:2018-04-01 00:00:00

  • Role of the HIF‑1α/SDF‑1/CXCR4 signaling axis in accelerated fracture healing after craniocerebral injury.

    abstract::The hypoxic state of the brain tissue surrounding craniocerebral injury induces an increase in the secretion of HIF‑1α during the healing process. HIF‑1α can promote mesenchymal stem cell (MSC) migration to ischemic and hypoxic sites by regulating the expression levels of molecules such as stromal cell‑derived factor‑...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Xue Y,Li Z,Wang Y,Zhu X,Hu R,Xu W

    更新日期:2020-10-01 00:00:00

  • Influence of cytotoxic T lymphocyte-associated antigen 4 polymorphisms on the outcomes of hepatitis B virus infection.

    abstract::Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates T-cell activation and Th1/Th2 cytokine production and is involved in the immune response against Hepatitis B virus (HBV) infection. To detect the association of the CTLA-4 gene polymorphisms with susceptibility to HBV infection a hospital-based case-contro...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Chen M,Chang Y,Tang F,Xie QH,Li J,Yang H,He XX,Lin JS

    更新日期:2014-02-01 00:00:00

  • Galectin‑3 induces the phenotype transformation of human vascular smooth muscle cells via the canonical Wnt signaling.

    abstract::Galectin‑3, a galactoside‑binding protein, is highly expressed in carotid plaques and plays an important role in the atherosclerotic lesions. The phenotype transformation of vascular smooth muscle cells is the basic pathological change of atherosclerosis. This study investigated the effects of exogenous galectin‑3 on ...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Tian L,Chen K,Cao J,Han Z,Wang Y,Gao L,Fan Y,Wang C

    更新日期:2017-06-01 00:00:00

  • Gli affects the stemness and prognosis of epithelial ovarian cancer via homeobox protein NANOG.

    abstract::Gli proteins are key transcription factors of the Hedgehog (HH) signaling pathway, which is associated with tumorigenesis and drug resistance. However, the role of the HH signaling pathway in epithelial ovarian cancer (EOC) remains unclear. Studies have demonstrated that in some tumors, homeobox protein NANOG (NANOG),...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Zhao H,Li N,Pang Y,Zhao J,Wu X

    更新日期:2021-02-01 00:00:00

  • miR-194-5p serves a suppressive role in human keloid fibroblasts via targeting NR2F2.

    abstract::Keloids are a skin fibrotic disease that cause a number of problems for reconstructive surgeons. MicroRNAs (miRs) are crucial for the development of keloids. The present study aimed to investigate the function of the miR‑194‑5p/nuclear receptor subfamily 2 group F member 2 (NR2F2) interactome in human keloid fibroblas...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Xu Q,Jiang S

    更新日期:2021-01-01 00:00:00