Inhibition of aldose reductase ameliorates diet-induced nonalcoholic steatohepatitis in mice via modulating the phosphorylation of hepatic peroxisome proliferator-activated receptor α.

abstract：:In the present study, the effect of fatty acid synthase (FASN) inhibition on cell invasion and migration in vitro was investigated. A recombinant plasmid containing a microRNA targeting the FASN gene was used to inhibit FASN expression in U2‑OS cells. Cell migration and invasion were investigated using wound healing a...

journal_title：Molecular medicine reports

authors： Liu ZL,Mao JH,Peng AF,Yin QS,Zhou Y,Long XH,Huang SH

更新日期：2013-02-01 00:00:00

abstract：:B cells are critically important for the pathogenesis of IgA nephropathy (IgAN). The present study aimed to investigate the abundance of B cell activating factor (BAFF), which belongs to the tumor necrosis factor superfamily, in the peripheral blood of patients with IgAN. The different forms of BAFF in peripheral bloo...

journal_title：Molecular medicine reports

authors： Zheng N,Fan J,Wang B,Wang D,Feng P,Yang Q,Yu X

更新日期：2017-04-01 00:00:00

abstract：:The presence of excess glutamate in the brain interstitial fluid characterizes several acute pathological conditions of the brain, including traumatic brain injury and stroke. It has been demonstrated that it is possible to eliminate excess glutamate in the brain by decreasing blood glutamate levels and, accordingly, ...

journal_title：Molecular medicine reports

authors： Li Y,Hou X,Qi Q,Wang L,Luo L,Yang S,Zhang Y,Miao Z,Zhang Y,Wang F,Wang H,Huang W,Wang Z,Shen Y,Wang Y

更新日期：2014-01-01 00:00:00

abstract：:Aloperine (Alo), as a quinolizidine alkaloid extracted from S. alopecuroide, has the positive activities of anti-inflammatory, anti-allergenic, antitumor and anti-viral. However, the role and mechanism of Alo in breast cancer have not been studied yet. In the present study, Alo markedly inhibited the proliferation and...

journal_title：Molecular medicine reports

authors： Tian D,Li Y,Li X,Tian Z

更新日期：2018-10-01 00:00:00

abstract：:Prostate cancer (PCa) is one of the most common types of cancer in the urinary system in men. Zeylenone (Zey), a naturally occurring cyclohexene oxide, has an anticancer effect. In the present study, the role and potential mechanism of Zey in PCa were examined. The proliferative, invasive and migratory capacities of D...

journal_title：Molecular medicine reports

authors： Zeng S,Zhu B,Zeng J,Wu W,Jiang C

更新日期：2018-12-01 00:00:00

abstract：:The PTEN induced putative kinase 1 (PINK1) mutation is the second most common cause of autosomal recessive adolescent Parkinson's disease (PD). Furthermore, mitochondrial disorders and oxidative stress are important mechanisms in the pathogenesis of PD. Numerous members of the Wnt family have been found to be associat...

journal_title：Molecular medicine reports

authors： Xia SR,Wen XY,Fan XL,Chen XR,Wei ZW,Li QH,Sun L

更新日期：2020-06-01 00:00:00

abstract：:Interleukin 17A (IL‑17A) exerts pleiotropic effects on periodontitis, partially through enhancement of alveolar bone loss. Osteoclasts are the main culprits that absorb alveolar bone. However, studies describing the correlation between IL‑17A and osteoclasts are not conclusive. Previously, autophagy was revealed to be...

journal_title：Molecular medicine reports

authors： Song L,Tan J,Wang Z,Ding P,Tang Q,Xia M,Wei Y,Chen L

更新日期：2019-06-01 00:00:00

abstract：:Oxidative stress serves important roles in cardiac injury during the process of ischemia/reperfusion (I/R). Y‑box protein 1 (YB1), a member of the highly conserved Y‑box protein family, is closely associated with inflammation and stress responses by regulating gene transcription, RNA splicing and mRNA translation. How...

journal_title：Molecular medicine reports

authors： Wang S,He F,Li Z,Hu Y,Huangfu N,Chen X

更新日期：2019-06-01 00:00:00

abstract：:Adoptive transfer of bone marrow‑derived mesenchymal stem cells (BMSCs) significantly alleviates smoking‑induced chronic obstructive pulmonary disease (COPD) in rats. Considering the critical roles of T cells during COPD development, the present study aimed to further identify the molecular mechanisms underlying the a...

journal_title：Molecular medicine reports

authors： Li X,Xu J,Li P

更新日期：2020-05-01 00:00:00

abstract：:The apoptosis of alveolar epithelial cells is important in seawater aspiration‑induced acute lung injury (ALI). The present study aimed to investigate whether epigallocatechin-3-gallate (EGCG) is able to suppress apoptosis in alveolar epithelial cells in seawater aspiration‑induced ALI in vivo and in vitro, and the po...

journal_title：Molecular medicine reports

authors： Liu W,Dong M,Bo L,Li C,Liu Q,Li Z,Jin F

更新日期：2016-01-01 00:00:00

abstract：:Glucocorticoid receptor (GR) function is essential for glucocorticoid action on various effector cells. The aim of the present study was to investigate the mRNA expression profiles of GRα and GRβ in peripheral blood mononuclear cells (PBMC) and examine the association between the expression levels of the GR isoforms a...

journal_title：Molecular medicine reports

authors： Mei B,Chen Y,Liu W,Li L,Wang C

更新日期：2015-03-01 00:00:00

abstract：:Dilated cardiomyopathy (DCM) is the most prevalent form of primary cardiomyopathy in humans and is a leading cause of heart failure and sudden cardiac death. Genetic abnormalities have been demonstrated to be a major contributor to the development of DCM. However, DCM is a genetically heterogeneous disease, and the ge...

journal_title：Molecular medicine reports

authors： Zhou YM,Dai XY,Huang RT,Xue S,Xu YJ,Qiu XB,Yang YQ

更新日期：2016-10-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most common type of brain cancer; it usually recurs and patients have a short survival time. The present study aimed to construct a gene expression classifier and to screen key genes associated with GBM prognosis. GSE7696 microarray data set included samples from 10 recurrent GBM t...

journal_title：Molecular medicine reports

authors： Yang H,Jin L,Sun X

更新日期：2019-03-01 00:00:00

abstract：:The identification of tumor biomarkers to support early diagnosis and tumor progression monitoring may potentially reduce the mortality of gastric cancer (GC). The present study aimed to detect novel tumor‑associated antigens from the AGS GC cell line, and to identify their associated autoantibodies in sera from patie...

journal_title：Molecular medicine reports

authors： Liu XX,Ye H,Wang P,Zhang Y,Zhang JY

更新日期：2017-11-01 00:00:00

abstract：:MicroRNAs (miRNAs) are single‑stranded RNA species that constitute a class of non‑coding RNAs, and are emerging as key regulators of gene expression. Since each miRNA is capable of regulating multiple genes, miRNAs are attractive markers for studies of coordinated gene expression. In this study, we investigated miRNA ...

journal_title：Molecular medicine reports

authors： Lee HY,Han SS,Rhee H,Park JH,Lee JS,Oh YM,Choi SS,Shin SH,Kim WJ

更新日期：2015-03-01 00:00:00

abstract：:Previous studies have confirmed that exposure to particulate matter with a diameter of ≤2.5 µm (PM2.5) is associated with inflammation. PM2.5 decreases cardiac cell viability and increases apoptosis through overproduction of reactive oxygen species (ROS). In the present study, the role of PM2.5 in ECs was investigated...

journal_title：Molecular medicine reports

authors： Chen S,Wu X,Hu J,Dai G,Rong A,Guo G

更新日期：2017-09-01 00:00:00

abstract：:Retinitis pigmentosa (RP) is a group of inherited diseases that primarily affect light‑sensitive rods and cones in the retina. Rhodopsin mutations, including the T17M mutation, are associated with the autosomal dominant form of retinitis pigmentosa (ADRP) and have been linked to abnormal protein folding. However, the ...

journal_title：Molecular medicine reports

authors： Jiang H,Xiong S,Xia X

更新日期：2014-05-01 00:00:00

abstract：:In the present study, a novel monoclonal antibody (MAb) specific for icariin (ICA) was prepared and characterized. A hybridoma‑secreting MAb against icariin was produced by fusing splenocytes immunized with an ICA‑bovine serum albumin conjugate with a hypoxanthine‑aminopterin‑thymidine‑sensitive mouse myeloma SP2/0 ce...

journal_title：Molecular medicine reports

authors： Cheng J,Zhang Y,Liu S,Qu B,Zhang M,Liu X,Zhao Y,Qu H

更新日期：2017-01-01 00:00:00

abstract：:Hydroxyapatite scaffolds (HASs) are widely studied as suitable materials for bone replacement scaffolds due to their chemical similarities to organic materials. In our previous study, a novel HAS with a 25‑30‑µm groove structure (HAS‑G) exhibited enhanced osteogenesis of bone mesenchymal stromal cells (BMSCs) compared...

journal_title：Molecular medicine reports

authors： Li C,Yang L,Ren X,Lin M,Shen D,Li Y,Zhang X,Liu C,Mu Y

更新日期：2020-10-01 00:00:00

abstract：:Pioglitazone may have potential benefits as an alternative therapeutic treatment for patients with Alzheimer's disease (AD), particularly in individuals that also have comorbid diabetes; however, the mechanisms of action remain unclear. The present study aimed to explore the effects of pioglitazone on amyloid β, isofo...

journal_title：Molecular medicine reports

authors： Yang S,Chen Z,Cao M,Li R,Wang Z,Zhang M

更新日期：2017-05-01 00:00:00

abstract：:The aim of the present study was to explore the survival of pig-rhesus corneal xenografts following donor bone marrow transplantation (BMT). Wuzhishan pigs were used as donors and rhesus monkeys as recipients for corneal xenotransplantation. Twelve rhesus monkeys were divided into t...

journal_title：Molecular medicine reports

authors： Jie Y,Liu L,Pan Z,Wang L

更新日期：2013-03-01 00:00:00

abstract：:Stem cells from apical papilla (SCAP) possess clear osteo‑/odontogenic differentiation capabilities, and are regarded as the major cellular source for root dentin development. Bone morphogenetic protein 2 (BMP2) and vascular endothelial growth factor (VEGF) serve pivotal roles in the modulation of tooth development an...

journal_title：Molecular medicine reports

authors： Zhang W,Zhang X,Ling J,Wei X,Jian Y

更新日期：2016-05-01 00:00:00

abstract：:Parkinson's disease (PD) is a type of movement disorder caused by loss of dopamine‑producing neurons in the midbrain. In order to identify the synergistic microRNA (miRNA) pattern in PD, miRNA and mRNA double expression profiles of PD were downloaded. Differentially expressed miRNA and mRNA were identified [P<0.01, fo...

journal_title：Molecular medicine reports

authors： Hao B,Chen X,Dai D,Zou C,Wu X,Chen J

更新日期：2015-02-01 00:00:00

abstract：:An effective therapeutic strategy for suppressing liver fibrosis should improve the overall prognosis of patients with chronic liver diseases. Although enormous efforts are ongoing to develop anti-fibrotic agents, no drugs have yet been approved as anti-fibrotic agents for humans. Insulin resistance (IR) is reportedly...

journal_title：Molecular medicine reports

authors： Yoshiji H,Noguchi R,Ikenaka Y,Kaji K,Aihara Y,Douhara A,Yamao J,Toyohara M,Mitoro A,Sawai M,Yoshida M,Morioka C,Fujimoto M,Uemura M,Fukui H

更新日期：2012-02-01 00:00:00

abstract：:Physical exercise is beneficial for the functional recovery of neurons after stroke. It has been suggested that exercise regulates proliferation and differentiation of endogenous neural stem cells (NSCs); however, the underlying molecular mechanisms are still largely unknown. In the present study, the aim was to inves...

journal_title：Molecular medicine reports

authors： Liu W,Wu W,Lin G,Cheng J,Zeng Y,Shi Y

更新日期：2018-08-01 00:00:00

abstract：:Pancreatic cancer (PC) is associated with high mortality rates and poor prognoses. Pancreatic adenocarcinoma is the most common type of PC, and almost all cases of pancreatic adenocarcinoma are pancreatic ductal adenocarcinoma (PDAC). The aim of the current study was to reveal the genes involved in the prognosis of PD...

journal_title：Molecular medicine reports

authors： Zheng B,Peng J,Mollayup A,Bakri A,Guo L,Zheng J,Xu H

更新日期：2018-01-01 00:00:00

abstract：:Interleukin-33 (IL-33) promotes migration of cancer cells through downregulating the expression of E-cadherin. Previous studies have demonstrated that IL‑33 stimulates the proliferation of trophoblasts. However, the effect of IL‑33 on the adhesion and invasion of trophoblasts has not been investigated in detail. In th...

journal_title：Molecular medicine reports

authors： Wang XH,Liu W,Fan DX,Hu WT,Li MQ,Zhu XY,Jin LP

更新日期：2017-10-01 00:00:00

abstract：:Artemisinin, the active ingredient of the Chinese medicinal herb Artemisia annua L., and its derivatives (ARTs) are currently widely used as anti-malarial drugs around the world. In this study, we found that dihydroartemisinin (DHA), one of the main active metabolites of ARTs, inhibited the proliferation of human hepa...

journal_title：Molecular medicine reports

authors： Lu JJ,Yang Z,Lu DZ,Wo XD,Shi JJ,Lin TQ,Wang MM,Li Y,Tang LH

更新日期：2012-08-01 00:00:00

abstract：:Abnormal migration of vascular smooth muscle cells (VSMCs) serves an important role in hypertension, atherosclerosis and restenosis following angioplasty, which is regulated numerous hormonal and humoral factors, including neuropeptide Y (NPY) and dopamine. Dopamine and NPY are both sympathetic neurotransmitters, and ...

journal_title：Molecular medicine reports

authors： Xia XW,Zhou YQ,Luo H,Zeng C

更新日期：2017-10-01 00:00:00

abstract：:Inflammatory responses are vital in lung injury diseases, particularly acute respiratory distress syndrome (ARDS). Recombinant human brain natriuretic peptide (rhBNP) has been shown to exhibit anti‑inflammatory effects in vivo in our previous studies. The present study aimed to investigate the mechanisms underlying th...

journal_title：Molecular medicine reports

authors： Song Z,Zhao X,Liu M,Jin H,Cui Y,Hou M,Gao Y

更新日期：2016-08-01 00:00:00