Association between ezrin protein expression and the prognosis of colorectal adenocarcinoma.

Abstract:

:Ezrin is involved in maintaining cell structure and cell motility. Expression levels of the ezrin gene correlate with numerous human malignancies. The aim of this study was to explore the role of ezrin in tumor progression and the prognostic evaluation of colorectal adenocarcinoma (CRA). The levels of ezrin protein in 186 CRA samples were evaluated using immunohistochemistry. Furthermore, the correlation between the expression of ezrin and the clinicopathological features of CRA was evaluated with the χ2 and Fisher's exact tests, survival rates were calculated using the Kaplan-Meier method, and the correlation between prognostic factors and patient survival was calculated by Cox analysis. Ezrin protein expression demonstrated an immunohistochemical cytoplasmic staining pattern in CRA. The difference between the positive rate of ezrin expression in CRA (38.7%, 72/186) and the adjacent normal mucosal tissues was deemed to be statistically significant (91.9%, 171/186; P=0.000). The positive rate of ezrin expression in cases with a large tumor, serosal invasion, lymph node (LN) metastasis, high LN ratio (LNR) and at a late tumor stage was significantly lower than in cases without these factors (P=0.044, P=0.032, P=0.002, P=0.011 and P=0.000, respectively). The 5-year survival rate of CRA without ezrin expression was lower than CRA with expression (P=0.000). Furthermore, analysis by Kaplan-Meier demonstrated that CRA cases with poor differentiation, serosal invasion and at a late tumor stage combined with no ezrin expression had a lower survival rate than cases that had these factors plus ezrin expression (P=0.000, respectively). Additionally, the non-expression of ezrin emerged as a significant independent prognostic factor in CRA prognosis (HR, 0.562; 95% CI, 0.404-0.783; P=0.001), in addition to the LNR (HR, 0.589; 95% CI, 0.369-0.939; P=0.026) and tumor stage (HR, 0.655; 95% CI, 0.487-0.880; P=0.005). This study demonstrated that ezrin may be useful to identify at-risk patients who may benefit from a more aggressive adjuvant therapy following tumor resection. Ezrin may serve as a useful therapeutic biomarker.

journal_name

Mol Med Rep

authors

Lin LJ,Chen LT

doi

10.3892/mmr.2013.1490

subject

Has Abstract

pub_date

2013-07-01 00:00:00

pages

61-6

issue

1

eissn

1791-2997

issn

1791-3004

journal_volume

8

pub_type

杂志文章
  • Silencing of long‑chain non‑coding RNA GAS5 in osteoarthritic chondrocytes is mediated by targeting the miR‑34a/Bcl‑2 axis.

    abstract::The present study aimed to investigate the effects of the long non‑coding RNA (lncRNA) growth arrest‑specific transcript 5 (GAS5) on proliferation, apoptosis and the inflammatory response of osteoarthritic chondrocytes (OACs) and its associated mechanism of action. Primary chondrocytes were isolated from cartilage tis...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2019.10900

    authors: Ji Q,Qiao X,Liu Y,Wang D,Yan J

    更新日期:2020-03-01 00:00:00

  • MicroRNA-26a-modified adipose-derived stem cells incorporated with a porous hydroxyapatite scaffold improve the repair of bone defects.

    abstract::Tissue-engineered bone substitutes are frequently used to repair bone defects. Adipose-derived stem cells (ASCs) are a promising source of cells for repairing bone tissue, however, insufficient osteogenic potency remains the main obstacle for their application. The present study aimed to enhance the osteogenic potency...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2015.3795

    authors: Wang Z,Zhang D,Hu Z,Cheng J,Zhuo C,Fang X,Xing Y

    更新日期:2015-09-01 00:00:00

  • MicroRNA-19a mediates gastric carcinoma cell proliferation through the activation of nuclear factor-κB.

    abstract::In gastric carcinoma, the nuclear factor‑κB (NF‑κB) signaling pathway is highly active, and the constitutive activation of NF‑κB prompts malignant cell proliferation. MicroRNAs are considered to be important mediators in the regulation of the NF‑κB signaling pathway. The present study predominantly focussed on the eff...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2015.4151

    authors: Yang F,Wang H,Jiang Z,Hu A,Chu L,Sun Y,Han J

    更新日期:2015-10-01 00:00:00

  • Electrical stimulation by semi-implantable electrodes decreases the levels of proteins associated with sciatic nerve injury-induced muscle atrophy.

    abstract::Muscle atrophy is a disease that is usually caused by denervation. The aim of the present study was to determine whether electrical stimulation by semi-implantable electrodes is capable of decreasing the levels of specific proteins associated with sciatic nerve injury-induced muscle atrophy. Male Sprague Dawley (SD) r...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2013.1487

    authors: Liu J,Li K,Huang X,Xie J,Huang X

    更新日期:2013-07-01 00:00:00

  • Protective effects of camel milk against pathogenicity induced by Escherichia coli and Staphylococcus aureus in Wistar rats.

    abstract::The aim of the present study was to investigate the protective effects of camel milk on hepatic pathogenicity induced by experimental infection with Escherichia (E. coli) and Staphylococcus aureus (S. aureus) in Wistar rats. The rats were divided into six groups: The control and camel milk groups received water and ca...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2015.4486

    authors: Soliman MM,Hassan MY,Mostafa SA,Ali HA,Saleh OM

    更新日期:2015-12-01 00:00:00

  • Prognostic factors for renal allograft survival in patients with immunoglobulin A nephropathy: a case control study.

    abstract::The renal allograft survival rates of patients with immunoglobulin A nephropathy (IgAN), and patients with or without other glomerular diseases, have yet to be fully elucidated. In this study, the clinicopathological factors associated with long-term allograft survival for the prognosis of renal allograft recipients w...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2014.1954

    authors: Guo JQ,Song BL,Wu ZX,Wu WZ,Luo LT,Chen XW,He FQ,Zheng ZY,Yang SL,Tan JM

    更新日期:2014-04-01 00:00:00

  • TGF‑β signaling: A complex role in tumorigenesis (Review).

    abstract::Tumor progression can be affected by various cellular components of tumor cells and/or by tumor microenvironmental factors. The tumor microenvironment comprises a variety of nonmalignant stromal cells and inflammatory cytokines, which are pivotal in tumor promotion and progression. The transforming growth factor‑β (TG...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章,评审

    doi:10.3892/mmr.2017.7970

    authors: Liu S,Chen S,Zeng J

    更新日期:2018-01-01 00:00:00

  • Von Hippel-Lindau gene expression in human endometrium during menstrual cycle.

    abstract::The von Hippel‑Lindau (VHL) gene is a tumor suppressor gene, which is widely expressed in the kidney, lung, breast, eye, ovary and cervix. Mutations of the VHL gene are able to induce VHL disease and tumorigenesis. However, it has yet to be evaluated whether the VHL gene is expressed in the human endometrium. The obje...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2014.1962

    authors: Lu YY,Zhu WJ,Xie BG

    更新日期:2014-04-01 00:00:00

  • Protective effects of ginsenoside Rg1 on aging Sca-1⁺ hematopoietic cells.

    abstract::In adults, bone hematopoietic cells are responsible for the lifelong production of all blood cells. It is affected in aging, with progressive loss of physiological integrity leading to impaired function by cellular intrinsic and extrinsic factors. However, intervention measures, which directly inhibit the aging of hem...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2015.3884

    authors: Zhou Y,Liu J,Cai S,Liu D,Jiang R,Wang Y

    更新日期:2015-09-01 00:00:00

  • Pathological features and prognosis of different molecular subtypes of breast cancer.

    abstract::To examine the pathological features and prognosis of different molecular subtypes of breast cancer, the clinical data of 892 breast cancer patients were retrospectively analyzed and divided into four subtypes according to hormone receptor expression in breast cancer tissue: Her-2 overexpression, luminal A, luminal B ...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2012.981

    authors: Wang GS,Zhu H,Bi SJ

    更新日期:2012-10-01 00:00:00

  • Pulsed electromagnetic fields alleviate streptozotocin‑induced diabetic muscle atrophy.

    abstract::Diabetic muscle atrophy causes a reduction of skeletal muscle size and strength, which affects normal daily activities. However, pulsed electromagnetic fields (PEMFs) can retard the atrophy of type II fibers (ActRIIB) in denervated muscles. Therefore, the purpose of the present study was to determine whether PEMFs can...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2018.9067

    authors: Yang J,Sun L,Fan X,Yin B,Kang Y,An S,Tang L

    更新日期:2018-07-01 00:00:00

  • Toll‑like receptor 2 mediates deposition of collagen I in adipose tissue of high fat diet‑induced obese mice.

    abstract::Obesity is marked by deposition of collagen I in adipose tissue. Toll like receptor (TLR)2 is involved in lipid metabolism, however the association between TLR2 and collagen I remains unclear. The present study was designed to investigate the effect of TLR2 knockout on collagen I in adipose tissue in obese mice. TLR2 ...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2018.8590

    authors: Song B,Zhang H,Zhang S

    更新日期:2018-04-01 00:00:00

  • Correlation of four potential biomarkers of liver fibrosis with liver function and grade of hepatic fibrosis in a neonatal cholestatic rat model.

    abstract::The present study investigated the correlation between four serum biomarkers of liver fibrosis, liver function and pathological hepatic fibrosis grade in neonatal cholestatic rats. A total of 38 Sprague‑Dawley rats, aged 3 weeks, were randomly assigned to the experimental group (EG), control group (CG) and the blank c...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2017.6588

    authors: Tang N,Zhang Y,Liu Z,Ai X,Liang Q

    更新日期:2017-07-01 00:00:00

  • Baicalein inhibits migration and invasion of gastric cancer cells through suppression of the TGF-β signaling pathway.

    abstract::The transforming growth factor-β (TGF-β) signaling pathway exhibits an important role in cancer invasion and metastasis. Excessive expression of TGF-β activates Smad4, leading to the upregulation of downstream metastasis-associated genes. Thus, the inhibition of the TGF-β/Smad4 signaling pathway may be a novel strateg...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2014.2452

    authors: Chen F,Zhuang M,Peng J,Wang X,Huang T,Li S,Lin M,Lin H,Xu Y,Li J,Chen Z,Huang Y

    更新日期:2014-10-01 00:00:00

  • Pharmacological basis for application of scutellarin in Alzheimer's disease: Antioxidation and antiapoptosis.

    abstract::Scutellarin (SC), mainly extracted from the Chinese herb Erigeron breviscapus (vant.), has been reported to possess various pharmacological activities; however, its effects on Alzheimer's disease (AD) have not been systemically reported. The protective effects of SC on AD were investigated using an L‑glutamic acid (L‑...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2018.9482

    authors: Hu X,Teng S,He J,Sun X,Du M,Kou L,Wang X

    更新日期:2018-11-01 00:00:00

  • Reconstruction and analysis of competitive endogenous RNA network reveals regulatory role of long non‑coding RNAs in hepatic fibrosis.

    abstract::Hepatic fibrosis (HF), one of the leading global health problems, is defined as aberrant and excess production of extracellular matrix components. The pathogenesis of HF is complex and poorly understood. Long non‑coding RNAs (LncRNAs) can interact with microRNAs (miRNAs) as competing endogenous RNAs (ceRNAs) to regula...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2019.10682

    authors: Jiang H,Wu F,Jiang N,Gao J,Zhang J

    更新日期:2019-11-01 00:00:00

  • Effect of IL‑7 on Th17 cell responses in a mouse model of neutrophilic asthma.

    abstract::Neutrophilic asthma (NA) is characterized by neutrophil‑mediated inflammation and the presence of Th17 cells. However, the mechanisms underlying Th17 cell responses in NA remain unknown. The aim of the present study was to examine the effects of interleukin (IL)‑7 on Th17 cell responses in NA. A NA mouse model was sen...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2020.11191

    authors: Zhang X,Zhang M,Jiang M,Nong G

    更新日期:2020-08-01 00:00:00

  • Poor permeability and absorption affect the activity of four alkaloids from Coptis.

    abstract::Coptidis rhizoma (Coptis) and its alkaloids exert various pharmacological functions in cells and tissues; however, the oral absorption of these alkaloids requires further elucidation. The present study aimed to examine the mechanism underlying the poor absorption of alkaloids, including berberine (BER), coptisine (COP...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2015.4288

    authors: Cui HM,Zhang QY,Wang JL,Chen JL,Zhang YL,Tong XL

    更新日期:2015-11-01 00:00:00

  • Targeted next‑generation sequencing for research and diagnostics in congenital heart disease, and cleft lip and/or palate.

    abstract::Congenital heart disease (CHD), and cleft lip and palate (CLP) are currently the most common types of structural malformation in infants. Various methods have been used to identify the disease‑associated genes. However, targeted next‑generation sequencing (NGS) is not yet considered an option for routine use. Thus, th...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2019.10043

    authors: Bu H,Liu L,Hu S,Tan Z,Zhao T

    更新日期:2019-05-01 00:00:00

  • c‑Jun N‑terminal kinase/transforming growth factor‑β/Smad3 pathway: Is it associated with endoplasmic reticulum stress‑mediated renal interstitial fibrosis?

    abstract::The present study investigated the role of the c‑Jun N‑terminal kinase (JNK)/transforming growth factor‑β (TGF‑β)/Smad3 pathway in endoplasmic reticulum stress (ERS)‑mediated renal interstitial fibrosis, which would be beneficial for chronic kidney disease (CKD) therapy. In human renal biopsy tissue, the expression le...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2019.10276

    authors: Liu Y,Shen P,Zhou Y,Tang L,Chai H

    更新日期:2019-07-01 00:00:00

  • Mild microwave ablation combined with HSP90 and TGF‑β1 inhibitors enhances the therapeutic effect on osteosarcoma.

    abstract::Osteosarcoma is the most common malignant bone tumour and the second leading cause of cancer‑related death in children and adolescents. Microwave ablation has an excellent therapeutic effect on bone tumours by instantaneously increasing the temperature in the tumour; however, there is a risk of damaging the surroundin...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2020.11173

    authors: Chen L,Wang M,Lin Z,Yao M,Wang W,Cheng S,Li B,Zhang Y,Yin Q

    更新日期:2020-08-01 00:00:00

  • IL‑33 and kidney disease (Review).

    abstract::Interleukin (IL)-33, is a novel member of the IL-1 superfamily, and act as a dual-function molecule as a nuclear factor and cytokine. The expression of IL-33 can be detected in several tissues and cells in humans and in mice. In addition to the conventional secretion approach for cytokines, full-length IL-33 can also ...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章,评审

    doi:10.3892/mmr.2015.4516

    authors: Yang F,Zhu P,Duan L,Yang L,Wang J

    更新日期:2016-01-01 00:00:00

  • Anti-proliferative effects of cucurmosin on human hepatoma HepG2 cells.

    abstract::We extracted cucurmosin (CUS) from the sarcocarp of Cucrubita moschata (pumpkin). Recently, a number of studies have indicated that CUS has cytotoxic properties and induces apoptosis in a number of human tumor cells. However, the detailed mechanisms are largely unknown. The aim of this study was to confirm CUS's antic...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2011.605

    authors: Xie J,Que W,Liu H,Liu M,Yang A,Chen M

    更新日期:2012-01-01 00:00:00

  • A high glucose condition sensitizes human hepatocytes to hydrogen peroxide-induced cell death.

    abstract::Oxidative stress is known to play a key role in the progression of liver disease, including non-alcoholic steatohepatitis (NASH), which is often accompanied by hyperglycemia. This study examined the influence of high glucose on oxidative stress-induced hepatic cell death. Hc cells, a normal human hepatocyte-derived ce...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:

    authors: Shibata H,Ichikawa T,Nakao K,Miyaaki H,Takeshita S,Akiyama M,Fujimoto M,Miuma S,Kanda S,Yamasaki H,Eguchi K

    更新日期:2008-05-01 00:00:00

  • MicroRNA‑542‑3p represses OTUB1 expression to inhibit migration and invasion of esophageal cancer cells.

    abstract::Dysregulation of microRNAs (miRNAs) is involved in the pathogenesis of esophageal cancer. miRNA (miR)‑542‑3p is a tumor suppressor in multiple types of cancer. However, whether and how miR‑542‑3p contributes to the progression of esophageal cancer remains unknown, and this is the aim of the present study. In the curre...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2019.10836

    authors: Sun J,Deng Y,Shi J,Yang W

    更新日期:2020-01-01 00:00:00

  • Effect of bisphenol A on the EGFR-STAT3 pathway in MCF-7 breast cancer cells.

    abstract::The aim of this study was to explore the effect of bisphenol A (BPA) on the EGFR-STAT3 pathway in breast cancer. We applied 3-(4,5-dimethylthiazol-2-yl)2,5-diphenyl tetrazolium bromide (MTT) cytotoxicity assay to the analysis of the responsiveness of MCF-7 cells to BPA. Gene expression was assayed at the transcription...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2011.583

    authors: Zhang W,Fang Y,Shi X,Zhang M,Wang X,Tan Y

    更新日期:2012-01-01 00:00:00

  • Overexpression of CKS2 is associated with a poor prognosis and promotes cell proliferation and invasion in breast cancer.

    abstract::Growing evidence indicates that cyclin dependent kinases regulatory subunit 2 (CKS2) serves an essential role in the regulation of multiple cellular processes in diverse human cancer types. The present study investigated the contribution of CKS2 to breast cancer (BC) progression. In the present study, CKS2 expression ...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2019.10134

    authors: Huang N,Wu Z,Hong H,Wang X,Yang F,Li H

    更新日期:2019-06-01 00:00:00

  • Dimethylation of Histone 3 Lysine 9 is sensitive to the epileptic activity, and affects the transcriptional regulation of the potassium channel Kcnj10 gene in epileptic rats.

    abstract::Potassium channels can be affected by epileptic seizures and serve a crucial role in the pathophysiology of epilepsy. Dimethylation of histone 3 lysine 9 (H3K9me2) and its enzyme euchromatic histone‑lysine N‑methyltransferase 2 (G9a) are the major epigenetic modulators and are associated with gene silencing. Insight i...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2017.7942

    authors: Zhang SP,Zhang M,Tao H,Luo Y,He T,Wang CH,Li XC,Chen L,Zhang LN,Sun T,Hu QK

    更新日期:2018-01-01 00:00:00

  • Effects of Paeoniflorin on the activity of muscle strips, intracellular calcium ion concentration and L‑type voltage‑sensitive calcium ion channels in the sphincter of Oddi of hypercholesterolemic rabbits.

    abstract::Sphincter of Oddi dysfunction (SOD) is a benign obstructive disorder predominantly resulting from spasms of the SO. Pharmacological therapies aim to induce SO relaxation; the hypercholesterolemic (HC) rabbit is the only SOD model available for study. In the present study, SO muscle strips, intracellular calcium ion co...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2019.10183

    authors: Wang F,Yang Y,Ji X,Tao X,Wang Y,Wang C

    更新日期:2019-06-01 00:00:00

  • Mechanism and therapeutic effects of Saccharomyces boulardii on experimental colitis in mice.

    abstract::Inflammatory bowel disease (IBD) is a type of chronic inflammatory disturbance that affects a number of individuals worldwide; the precise mechanism is unclear and treatment is frequently insufficient to maintain patients in remission. Saccharomyces boulardii is a thermophilic, non‑pathogenic yeast that may be adminis...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2018.9612

    authors: Zhou H,Zhang HJ,Guan L,Zhang YN,Li Y,Sun MJ

    更新日期:2018-12-01 00:00:00