Expression of aquaporin-4 and pathological characteristics of brain injury in a rat model of traumatic brain injury.

abstract：:Artemisinin, the active ingredient of the Chinese medicinal herb Artemisia annua L., and its derivatives (ARTs) are currently widely used as anti-malarial drugs around the world. In this study, we found that dihydroartemisinin (DHA), one of the main active metabolites of ARTs, inhibited the proliferation of human hepa...

journal_title：Molecular medicine reports

authors： Lu JJ,Yang Z,Lu DZ,Wo XD,Shi JJ,Lin TQ,Wang MM,Li Y,Tang LH

更新日期：2012-08-01 00:00:00

abstract：:Dermal papilla (DP) cells function as important regulators of the hair growth cycle. The loss of these cells is a primary cause of diseases characterized by hair loss, including alopecia, and evidence has revealed significantly increased levels of reactive oxygen species (ROS) in hair tissue and DP cells in the baldin...

journal_title：Molecular medicine reports

authors： Lim KM,An S,Lee OK,Lee MJ,Lee JP,Lee KS,Lee GT,Lee KK,Bae S

更新日期：2015-08-01 00:00:00

abstract：:The aim of the present study was to investigate the potential effect of hematoporphyrin monomethyl ether-sonodynamic therapy (HMME-SDT) on MG-63 osteosarcoma cells. The HMME concentration was kept constant at 20 µg/ml and the MG-63 osteosarcoma cell line was exposed to ultrasound with an intensity of 1.0 W/cm2 for 30 ...

journal_title：Molecular medicine reports

authors： Liu X,Li W,Geng S,Meng QG,Bi ZG

更新日期：2015-07-01 00:00:00

abstract：:Prostate cancer (PCa) is the second most common cancer amongst males worldwide. In the current study, microarray datasets GSE3325 and GSE6919 from the Gene Expression Omnibus database were screened to identify candidate genes that are associated with the progression of PCa. A total of 273 differentially expressed gene...

journal_title：Molecular medicine reports

authors： Li S,Hou J,Xu W

更新日期：2020-01-01 00:00:00

abstract：:Metastasis is the most lethal stage of cancer progression. The present study aimed to investigate the underlying molecular mechanisms of melanoma metastasis using bioinformatics. Using the microarray dataset GSE8401 from the Gene Expression Omnibus database, which included 52 biopsy specimens from patients with melano...

journal_title：Molecular medicine reports

authors： Chen J,Wu F,Shi Y,Yang D,Xu M,Lai Y,Liu Y

更新日期：2019-08-01 00:00:00

abstract：:Plesiomonas shigelloides (P. shigelloides) is implicated as an aetiological agent of human gastroenteritis in humans, for which reliable laboratory detection of P. shigelloides is clinically and epidemiologically desirable. A simple molecular method for rapid detection of P. shigelloides using cross‑priming amplificat...

journal_title：Molecular medicine reports

authors： Meng S,Wang Y,Wang Y,Ye C

更新日期：2016-12-01 00:00:00

abstract：:MicroRNAs (miRNAs/miRs) are a class of non‑coding RNAs that serve crucial roles in liver cancer and other liver injury diseases. However, the expression profile and mechanisms underlying miRNAs in liver fibrosis are not completely understood. The present study identified the novel miR‑375/Rac family small GTPase 1 (RA...

journal_title：Molecular medicine reports

authors： Liang Z,Li J,Zhao L,Deng Y

更新日期：2021-03-01 00:00:00

abstract：:Soy sauce is a traditional fermented seasoning of Japan and is available throughout the world. The two main raw ingredients of soy sauce are soybean and wheat, both of which are established food allergens. The present study examined the degradation and removal of soybean allergens in soy sauce by immunoblotting with a...

journal_title：Molecular medicine reports

authors： Magishi N,Yuikawa N,Kobayashi M,Taniuchi S

更新日期：2017-08-01 00:00:00

abstract：:The primary aim of the present study was to examine the effects of microRNA‑21 (miR‑21) on the proliferation and differentiation of rat primary neural stem cells (NSCs) in vitro. miR‑21 was overexpressed in NSCs by transfection with a miR‑21 mimic. The effects of miR‑21 overexpression on NSC proliferation were reveale...

journal_title：Molecular medicine reports

authors： Zhang WM,Zhang ZR,Yang XT,Zhang YG,Gao YS

更新日期：2018-01-01 00:00:00

abstract：:Electroacupuncture (EA) has been documented as a form of therapy for chronic sinusitis (CRS). The present study aimed to assess the effects of EA combined with interleukin‑10 (IL‑10) overexpression on CRS in mice, and to investigate the associated mechanisms. A mouse model of CRS was established by the administration ...

journal_title：Molecular medicine reports

authors： Zhou L,Hong J,Wan Z,Lu X,Shao Y

更新日期：2019-08-01 00:00:00

abstract：:Osteosarcoma is a malignant bone tumor which is found most commonly in adolescents and young adults. Local perfusion thermochemotherapy has long been proposed as an alternative strategy for the treatment of osteosarcoma. As a standard anticancer drug, paclitaxel plays a significant ...

journal_title：Molecular medicine reports

authors： Huang T,Gong WH,Li XC,Zou CP,Jiang GJ,Li XH,Feng DP

更新日期：2012-11-01 00:00:00

abstract：:Pancreatic cancer (PC) is associated with high mortality rates and poor prognoses. Pancreatic adenocarcinoma is the most common type of PC, and almost all cases of pancreatic adenocarcinoma are pancreatic ductal adenocarcinoma (PDAC). The aim of the current study was to reveal the genes involved in the prognosis of PD...

journal_title：Molecular medicine reports

authors： Zheng B,Peng J,Mollayup A,Bakri A,Guo L,Zheng J,Xu H

更新日期：2018-01-01 00:00:00

abstract：:Lung cancer is a leading cause of cancer mortality worldwide and patients occasionally develop local recurrence or distant metastasis soon after curative resection. Reports of new therapeutic strategies for lung squamous cell carcinoma (SqCC) are extremely rare, while selective anti...

journal_title：Molecular medicine reports

authors： Masuda R,Kijima H,Imamura N,Aruga N,Nakamura Y,Masuda D,Takeichi H,Kato N,Nakagawa T,Tanaka M,Inokuchi S,Iwazaki M

更新日期：2012-11-01 00:00:00

abstract：:The present study aimed to identify the genes directly or indirectly correlated with the amplification of MYCN in neuroblastoma (NB). Microarray data (GSE53371) were downloaded from Gene Expression Omnibus, and included 10 NB cell lines with MYCN amplification and 10 NB cell lines with normal MYCN copy numbers. Differ...

journal_title：Molecular medicine reports

authors： Bao J,Qin L,Cui L,Wang X,Meng Q,Zhu L,Zhang S

更新日期：2015-11-01 00:00:00

abstract：:Ephrin type‑A receptor 2 (EphA2) is a receptor tyrosine kinase that is associated with cancer cell metastasis. There has been little investigation into its impact on the regulation of sensitivity to paclitaxel in nasopharyngeal carcinoma (NPC). In the present study, upregulation of EphA2 expression enhanced the surviv...

journal_title：Molecular medicine reports

authors： Wang Y,Liu Y,Li G,Su Z,Ren S,Tan P,Zhang X,Qiu Y,Tian Y

更新日期：2015-02-01 00:00:00

abstract：:The present study aimed to investigate the effect of Dickkopf-related protein 3 (DKK3) on osteogenic differentiation of rat dental follicle cells (DFCs). A PCR array analysis of Wnt pathway activation in DFCs identified genes dysregulated by mineral induction. Among them, DKK3expression levels were decreased, and furt...

journal_title：Molecular medicine reports

authors： Zhang X,Du Y,Ling J,Li W,Liao Y,Wei X

更新日期：2017-04-01 00:00:00

abstract：:Partial splenic embolization (PSE) or splenectomy is widely performed to increase platelet counts for interferon (IFN) therapy. The aim of the present study was to evaluate the long-term effects of splenectomy and subsequent IFN therapy in patients with hepatitis C virus (HCV)-related liver cirrhosis (LC). The present...

journal_title：Molecular medicine reports

authors： Inagaki Y,Sugimoto K,Shiraki K,Tameda M,Kusagawa S,Nojiri K,Ogura S,Yamamoto N,Takei Y,Ito M,Mizuno S,Usui M,Sakurai H,Isaji S

更新日期：2014-02-01 00:00:00

abstract：:Ilexonin A is a compound isolated from the root of a plant commonly used in traditional Chinese medicine. The aim of the present study was to investigate the possible protective mechanism of Ilexonin A in rats subjected to occlusion of the middle cerebral artery (MCAO). Transient focal cerebral ischemia was induced by...

journal_title：Molecular medicine reports

authors： Xu AL,Zheng GY,Wang ZJ,Chen XD,Jiang Q

更新日期：2016-04-01 00:00:00

abstract：:The renal allograft survival rates of patients with immunoglobulin A nephropathy (IgAN), and patients with or without other glomerular diseases, have yet to be fully elucidated. In this study, the clinicopathological factors associated with long-term allograft survival for the prognosis of renal allograft recipients w...

journal_title：Molecular medicine reports

authors： Guo JQ,Song BL,Wu ZX,Wu WZ,Luo LT,Chen XW,He FQ,Zheng ZY,Yang SL,Tan JM

更新日期：2014-04-01 00:00:00

abstract：:The present study aimed to investigate the effects of cinobufacini injection on the proliferation and expression of topoisomerases in human HepG-2 hepatocarcinoma cells. The cells were divided into a control group and an experimental group, in which 0.105, 0.21, 0.42 mg/l cinobufacini was injected. Cell proliferation ...

journal_title：Molecular medicine reports

authors： Liu Y,Ban LY,Su X,Gao S,Liu JW,Cui XN

更新日期：2015-07-01 00:00:00

abstract：:Diabetic nephropathy (DN) is one of the most important causes of end‑stage renal disease. Astragaloside IV (AS-IV) is a saponin isolated from Astragalus membranaceus, which possesses various pharmacological activities. AS‑IV prevents podocyte apoptosis and ameliorates renal injury in DN; however, few studies have focu...

journal_title：Molecular medicine reports

authors： Yao XM,Liu YJ,Wang YM,Wang H,Zhu BB,Liang YP,Yao WG,Yu H,Wang NS,Zhang XM,Peng W

更新日期：2016-06-01 00:00:00

abstract：:Doxorubicin (Dox)-induced cardiotoxicity has been a well‑known phenomenon to clinicians and scientists for decades. It has been confirmed that Dox‑dependent cardiotoxicity is accompanied by cardiac cellular senescence. However, the molecular mechanisms underlying Dox cardiotoxicity remains to be fully elucidated. Long...

journal_title：Molecular medicine reports

authors： Xie Z,Xia W,Hou M

更新日期：2018-02-01 00:00:00

abstract：:Nuclear respiratory factor 1 (NRF-1) has important roles in the regulation of several key metabolic genes required for cellular growth and respiration. A previous study by our group indicated that NRF‑1 is involved in mitochondrial dysfunction induced by the environmental pollutant benzo[a]pyrene in the 16HBE human br...

journal_title：Molecular medicine reports

authors： Wu J,Wang Y,Wo D,Zhang L,Li J

更新日期：2016-05-01 00:00:00

abstract：:Serious diabetic complications affect millions of patients worldwide. Skeletal muscle represents the largest insulin-regulated glucose sink in the body, making insulin resistance and abnormal glucose disposal in muscle fibres a critical aspect of diabetes mellitus. Advances in the biomedical analysis of the molecular ...

journal_title：Molecular medicine reports

authors： Mulvey C,Mullen E,Ohlendieck K

更新日期：2008-05-01 00:00:00

abstract：:The thioredoxin (Trx) and peroxiredoxin (Prx) redox system is associated with neuronal damage and neuroprotective effects via the regulation of oxidative stress in brain ischemia. In the present study, ischemia-induced changes in the protein expression levels of Trx2 and Prx3 in the stratum pyramidale (SP) of the hipp...

journal_title：Molecular medicine reports

authors： Lee CH,Park JH,Cho JH,Ahn JH,Bae EJ,Won MH

更新日期：2015-08-01 00:00:00

abstract：:Cyclin-dependent kinase inhibitor 3 (CDKN3) belongs to the dual-specificity protein phosphatase family, which is hypothesized to regulate cell cycle progression in tumor cells. However, whether CDKN3 is a potential therapeutic target for breast cancer remains to be elucidated. The present in vitro study aimed to inves...

journal_title：Molecular medicine reports

authors： Deng M,Wang J,Chen Y,Zhang L,Xie G,Liu Q,Zhang T,Yuan P,Liu D

更新日期：2016-08-01 00:00:00

abstract：:Osteosarcoma (OS) is the most frequent malignant primary bone tumor arising from primitive bone‑forming mesenchymal cells in children and adolescents. The dysregulation of microRNAs (miRNAs) has been reported in OS, and these aberrantly expressed miRNAs are involved in the initiation and progression of OS. The aim of ...

journal_title：Molecular medicine reports

authors： Yang X,Cui Y,Yang F,Sun C,Gao X

更新日期：2017-09-01 00:00:00

abstract：:In this study, we aimed to explore the radio-sensitization of the SHG44 glioma cell line by Aidi injection and the possible mechanisms involved. The growth curve, cloning efficiency and divisional index of the SHG44 cell line were observed. The inhibition ratio was determined by MTT assay, the change in the cell cycle...

journal_title：Molecular medicine reports

authors： Xu XT,Song Y,Qin S,Wang LL,Zhou JY

更新日期：2012-06-01 00:00:00

abstract：:The aim of the present study was to identify key genes and signaling pathways associated with the pathogenesis of juvenile spondyloarthritis (JSA). The gene expression profile dataset GSE58667, including data from 15 human whole blood samples collected from 11 patients with JSA and four healthy controls, was analyzed ...

journal_title：Molecular medicine reports

authors： Wang Z,Han Y,Zhang Z,Jia C,Zhao Q,Song W,Chen T,Zhang Y,Wang X

更新日期：2018-08-01 00:00:00

abstract：:Daikenchuto (TU‑100) is a traditional Japanese medicine that is widely used to treat intestinal symptoms. The mechanisms underlying it effects on the circulating levels of adrenomedullin (ADM) are of interest. In addition, the effect of TU‑100 in the treatment of Crohn's disease (CD) in humans remains to be elucidated...

journal_title：Molecular medicine reports

authors： Kominato K,Yamasaki H,Mitsuyama K,Takedatsu H,Yoshioka S,Kuwaki K,Kobayashi T,Yamauchi R,Fukunaga S,Tsuruta O,Torimura T

更新日期：2016-09-01 00:00:00