Silencing cyclin-dependent kinase inhibitor 3 inhibits the migration of breast cancer cell lines.

abstract：:Previous studies have demonstrated that microRNAs (miRNAs), a class of single‑stranded RNA molecules that are 18‑27 nucleotides in length, serve a critical function in tumorigenesis, including in the development of colon cancer. In the current study, miR‑100 levels were demonstrated to be reduced in colon cancer tissu...

journal_title：Molecular medicine reports

authors： Zhou MK,Liu XJ,Zhao ZG,Cheng YM

更新日期：2015-04-01 00:00:00

abstract：:The present study aimed to examine whether fms‑related tyrosine kinase 3 ligand (Flt3L) protects the organs of mice with multiorgan dysfunction syndrome (MODS). Male C57BL/6 mice were randomly assigned to normal control, MODS and Flt3L treatment groups. The mouse models of MODS were established using intraperitoneal z...

journal_title：Molecular medicine reports

authors： Tian G,Lu J,Guo H,Liu Q,Wang H

更新日期：2015-06-01 00:00:00

abstract：:Dermal papilla cells (DPCs) are located at the base of hair follicles, and are known to induce hair follicle regeneration. Platelet-rich plasma (PRP) functions in hair follicle regeneration. To investigate the influence of PRP on DPCs, the present study analyzed RNA‑seq data of human hair dermal papilla cells (HHDPCs)...

journal_title：Molecular medicine reports

authors： Shen H,Cheng H,Chen H,Zhang J

更新日期：2017-01-01 00:00:00

abstract：:Peritoneal dialysis (PD)-associated peritoneal fibrosis is a serious complication in patients with chronic renal failure on dialysis maintenance. Studies have shown that patients on long‑term PD have chronic inflammation. The epithelial-to-mesenchymal transition (EMT) induced by inflammation is a major cause of perito...

journal_title：Molecular medicine reports

authors： Shi S,Zhang Y,Wen W,Zhao Y,Sun L

更新日期：2016-11-01 00:00:00

abstract：:Low molecular weight heparin (LMWH) has a structure similar to heparan sulfate, which exerts anti‑inflammatory effects via inhibiting elastase (Ela) activity. Release of Ela along the glomerular capillary wall may induce glomerular injury and proteinuria. The present study aimed to investigate the influence of LMWH on...

journal_title：Molecular medicine reports

authors： Zhai S,Hu L,Zhong L,Tao Y,Wang Z

更新日期：2017-12-01 00:00:00

abstract：:The overexpression and hypersecretion of mucus is a hallmark of several chronic pulmonary inflammatory diseases, including chronic obstructive pulmonary disease (COPD), asthma and cystic fibrosis. Mucin 5ac (MUC5AC) is a major component of airway mucus. Annexin II (ANXII) has been reported to be expressed in various c...

journal_title：Molecular medicine reports

authors： Xu R,Li Q,Zhou X,Perelman JM,Kolosov VP

更新日期：2014-01-01 00:00:00

abstract：:Isoniazid (INH) is a drug extensively used as a prophylactic and therapeutic agent for human tuberculosis (TB). INH is metabolized by the enzymatic activity of N-acetyltransferase 2 (NAT2). Human NAT2, encoded by a highly polymorphic gene, is involved in the biotransformation of xenobiotics, including drugs and certai...

journal_title：Molecular medicine reports

authors： Díaz-Molina R,Cornejo-Bravo JM,Ramos-Ibarra MA,Estrada-Guzmán JD,Morales-Arango O,Reyes-Báez R,Robinson-Navarro OM,Soria-Rodríguez CG

更新日期：2008-11-01 00:00:00

abstract：:Muscle atrophy is a disease that is usually caused by denervation. The aim of the present study was to determine whether electrical stimulation by semi-implantable electrodes is capable of decreasing the levels of specific proteins associated with sciatic nerve injury-induced muscle atrophy. Male Sprague Dawley (SD) r...

journal_title：Molecular medicine reports

authors： Liu J,Li K,Huang X,Xie J,Huang X

更新日期：2013-07-01 00:00:00

abstract：:Mutations in mitochondrial DNA (mtDNA), especially in mitochondrial 12S rRNA and transfer RNA(tRNA)Ser(UCN) genes, are important causes of non‑syndromic hearing loss. However, the molecular mechanism underlying mt‑tRNA mutations in clinical hearing impairment are not fully understood. The present study assessed the mo...

journal_title：Molecular medicine reports

authors： Peng W,Zhong Y,Zhao X,Yuan J

更新日期：2020-07-01 00:00:00

abstract：:Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic disease. MicroRNAs (miRNAs) are a group of endogenous small non‑coding RNAs that regulate target genes, and play a critical role in many biological processes. However, the underlying mechanism of specific miRNA, miR‑130a‑3p, in AS remains largely unknown....

journal_title：Molecular medicine reports

authors： Li F,Si D,Guo X,Guo N,Li D,Zhang L,Jian X,Ma J

更新日期：2019-10-01 00:00:00

abstract：:Minimally invasive aesthetic and cosmetic procedures have increased in popularity. Injectable dermal fillers provide soft tissue augmentation, improve facial rejuvenation and wrinkles, and correct tissue defects. To investigate the use of adipose‑derived stem cells integrated with a hyaluronic acid based gel as a derm...

journal_title：Molecular medicine reports

authors： Guo J,Guo S,Wang Y,Yu Y

更新日期：2017-10-01 00:00:00

abstract：:The present study aimed to investigate the effect of SOX2 on odontoblast differentiation of dental pulp stem cells (DPSCs), and to examine the potential application of DPSCs on dental restoration. SRY‑box 2 (SOX2) overexpression in human DPSCs (DPSCs‑SOX2) was established by retroviral infection. The empty vector‑infe...

journal_title：Molecular medicine reports

authors： Yang Y,Zhao Y,Liu X,Chen Y,Liu P,Zhao L

更新日期：2017-12-01 00:00:00

abstract：:Ezrin is involved in maintaining cell structure and cell motility. Expression levels of the ezrin gene correlate with numerous human malignancies. The aim of this study was to explore the role of ezrin in tumor progression and the prognostic evaluation of colorectal adenocarcinoma (CRA). The levels of ezrin protein in...

journal_title：Molecular medicine reports

authors： Lin LJ,Chen LT

更新日期：2013-07-01 00:00:00

abstract：:Pentatricopeptide repeat domain protein 3 (PTCD3) is a mitochondrial RNA‑binding protein that serves a role in mitochondrial translation. PTCD3 was originally reported as an oncogene that is involved in breast cancer and lymphoma. However, the expression and function of PTCD3 in prostate cancer (PCa) are unknown. Ther...

journal_title：Molecular medicine reports

authors： Huang Y,Jiang G,Liang X,Lan Z,Su Z,Wu H,Weng J,Jiang X

更新日期：2018-10-01 00:00:00

abstract：:Indoxyl sulfate (IS), a typical uremic toxin, is of great importance in the development of chronic kidney disease. In addition to its nephrotoxicity, previous studies have provided increasing evidence for its cardiovascular toxicity. The mechanism underlying IS‑induced cardiovascular toxicity has been elusive to date....

journal_title：Molecular medicine reports

authors： Tan X,Cao XS,Zhang P,Xiang FF,Teng J,Zou JZ,Ding XQ

更新日期：2018-12-01 00:00:00

abstract：:Lung cancer is one of the primary causes of mortality worldwide and drug resistance is the key contributing factor which results in the failure of lung cancer chemotherapy. Previous studies have shown that microRNA (miR)‑10a was involved in the reversal of cisplatin (DDP) resistance in numerous types of tumors; howeve...

journal_title：Molecular medicine reports

authors： Sun W,Ma Y,Chen P,Wang D

更新日期：2015-05-01 00:00:00

abstract：:Sepsis is a systemic inflammatory response resulting from the excessive production of pro-inflammatory cytokines, including tumor necrosis factor (TNF)‑α. Sirtuin 1 (SirT1) actively deacetylates histone proteins, and facilitates chromatin compaction and gene silencing. In the present study, a cell model of sepsis, com...

journal_title：Molecular medicine reports

authors： Chen GD,Yu WD,Chen XP

更新日期：2016-12-01 00:00:00

abstract：:An effective therapeutic strategy for suppressing liver fibrosis should improve the overall prognosis of patients with chronic liver diseases. Although enormous efforts are ongoing to develop anti-fibrotic agents, no drugs have yet been approved as anti-fibrotic agents for humans. Insulin resistance (IR) is reportedly...

journal_title：Molecular medicine reports

authors： Yoshiji H,Noguchi R,Ikenaka Y,Kaji K,Aihara Y,Douhara A,Yamao J,Toyohara M,Mitoro A,Sawai M,Yoshida M,Morioka C,Fujimoto M,Uemura M,Fukui H

更新日期：2012-02-01 00:00:00

abstract：:Methylglyoxal (MGO)-induced carbonyl stress and pro-inflammatory responses have been suggested to contribute to endothelial dysfunction. Curcumin (Cur), a polyphenolic compound from Curcuma longa L., may protect endothelial cells against carbonyl stress-induced damage by trapping dicarbonyl compounds such as MGO. Howe...

journal_title：Molecular medicine reports

authors： Sun YP,Gu JF,Tan XB,Wang CF,Jia XB,Feng L,Liu JP

更新日期：2016-02-01 00:00:00

abstract：:Long non‑coding RNAs (lncRNAs) affect atherosclerosis by regulating the physiological and pathological processes of endothelial cells; however, the role of lncRNA WEE2 antisense RNA 1 (WEE2‑AS1) in arteriosclerosis obliterans (ASO) is not completely understood. The present study aimed to explore the function of lncRNA...

journal_title：Molecular medicine reports

authors： Jiang B,Wang R,Lin Z,Ma J,Cui J,Wang M,Liu R,Wu W,Zhang C,Li W,Wang S

更新日期：2020-12-01 00:00:00

abstract：:The hyper-responsiveness of plasma cortisol to vasopressin has been reported in patients with ACTH-independent bilateral macronodular adrenocortical hyperplasia (AIMAH) and in certain cases of Cushing's adenomas with overexpression of V1a receptors in the adrenal gland. We previously reported a high prevalence of the ...

journal_title：Molecular medicine reports

authors： Suzuki S,Uchida D,Koide H,Suyama K,Tanaka T,Noguchi Y,Saito Y,Tatsuno I

更新日期：2009-01-01 00:00:00

abstract：:The aim of the present study was to investigate the hypotheses that cytomegalovirus (CMV) may trigger idiopathic pulmonary fibrosis (IPF) in a susceptible host and/or that the presence of CMV may alter IPF in response to a well-defined trigger of pulmonary fibrosis. A mouse model of murine CMV (MCMV) infection was est...

journal_title：Molecular medicine reports

authors： Li Y,Gao J,Wang G,Fei G

更新日期：2016-08-01 00:00:00

abstract：:Kallikrein-related peptidase 14 (KLK14) is a member of the tissue kallikrein family of proteases, which are associated with the pathogenesis of malignant tumors and are over-expressed in ovarian carcinoma. However, the mechanism through which KLK14 is implicated in ovarian cancer remains unclear. The aim of the presen...

journal_title：Molecular medicine reports

authors： Zhang R,Shi H,Chen Z,Feng W,Zhang H,Wu K

更新日期：2012-01-01 00:00:00

abstract：:Several environmental contaminants have been linked to the development of diabetes and increased diabetes‑associated mortality. Perfluorooctanoic acid (PFOA) is a widely used perfluoroalkane found in surfactants and lubricants, and in processing aids used in the production of polymers. Furthermore, PFOA has been detec...

journal_title：Molecular medicine reports

authors： Suh KS,Choi EM,Kim YJ,Hong SM,Park SY,Rhee SY,Oh S,Kim SW,Pak YK,Choe W,Chon S

更新日期：2017-06-01 00:00:00

abstract：:Previous studies have demonstrated the overexpression of paired basic amino acid cleaving enzyme 4 (PACE4) mRNA in prostate cancer tissues. This overexpression is correlated with higher circulating protein levels in certain patients, however, the role of PACE4 in apoptosis and the potential molecular mechanisms of pan...

journal_title：Molecular medicine reports

authors： Tian XF,Huang GM,Zang HL,Cao H

更新日期：2016-12-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic inflammatory joint disease characterized by synovial inflammation. Fibroblast‑like synoviocytes (FLS) serve a vital role in the initiation and perpetuation of the immune response in patients with RA. The present study aimed to investigate the potential role of microRNA (miR)‑34a‑...

journal_title：Molecular medicine reports

authors： Hou C,Wang D,Zhang L

更新日期：2019-09-01 00:00:00

abstract：:Cisplatin is a first generation platinum‑based chemotherapeutic agent, however, the extensive application of cisplatin inevitably results in drug resistance, which is a major obstacle in cancer chemotherapy. The aim of the present study was to investigate the efficiency of reversing cisplatin‑resistance with the use o...

journal_title：Molecular medicine reports

authors： Ma S,Tan W,Du B,Liu W,Li W,Che D,Zhang G

更新日期：2016-04-01 00:00:00

abstract：:The effects of 9 calcium antagonists on ABCG2/BCRP-mediated resistance and transport were examined in HeLa and SN-38-resistant HeLa (HeLa/SN100) cells, overexpressing ABCG2/BCRP. Sensitivity to mitoxantrone, an ABCG2/BCRP substrate, in HeLa/SN100 cells was significantly reversed by ...

journal_title：Molecular medicine reports

authors： Takara K,Matsubara M,Yamamoto K,Minegaki T,Takegami S,Takahashi M,Yokoyama T,Okumura K

更新日期：2012-03-01 00:00:00

abstract：:Chronic hypoxia can be observed in the heart under physiological or pathophysiological states, including embryonic development or cyanotic congenital heart disease. The aim of the present study was to examine gene expression profiles of chronically hypoxic myocardium and to explore the pathophysiological mechanisms by...

journal_title：Molecular medicine reports

authors： Wu F,Gao F,He S,Xiao Y

更新日期：2019-05-01 00:00:00

abstract：:In the last 30 years, the 5-year-survival rate of patients with osteosarcoma has not improved as a result of the low prevalence and large tumor heterogeneity. Therefore, the development of novel drugs for the treatment of osteosarcoma is urgently required. The present study aimed to identify potential novel drugs for ...

journal_title：Molecular medicine reports

authors： Zou Y,Yang J,Jiang D

更新日期：2015-11-01 00:00:00