Abstract:
:Pentatricopeptide repeat domain protein 3 (PTCD3) is a mitochondrial RNA‑binding protein that serves a role in mitochondrial translation. PTCD3 was originally reported as an oncogene that is involved in breast cancer and lymphoma. However, the expression and function of PTCD3 in prostate cancer (PCa) are unknown. Therefore, the aim of the present study was to investigate the expression of PTCD3 and its clinical significance in PCa. Immunohistochemistry and dataset analyses revealed that PTCD3 protein expression levels were enhanced in human PCa tissues and mouse PCa models. PTCD3 expression levels were positively correlated with advanced PCa pathological grade and clinical stage. Additionally, PTCD3 mRNA expression was positively correlated with tissue malignancy, high Gleason score and distant metastasis in The Cancer Genome Atlas dataset. Kaplan‑Meier analysis revealed that high PTCD3 levels can predict the increased biochemical recurrence (BCR)‑free survival in all patients with or without metastasis. The overexpression of PTCD3 could be used as an independent prognostic marker of poor BCR‑free survival. Immunofluorescence and western blot analysis in human PCa cell lines further confirmed that PTCD3 levels were associated with the hormone independence of PCa. Therefore, the present study revealed that PTCD3 levels may serve as a novel biomarker for PCa prognosis.
journal_name
Mol Med Repjournal_title
Molecular medicine reportsauthors
Huang Y,Jiang G,Liang X,Lan Z,Su Z,Wu H,Weng J,Jiang Xdoi
10.3892/mmr.2018.9402subject
Has Abstractpub_date
2018-10-01 00:00:00pages
3914-3922issue
4eissn
1791-2997issn
1791-3004journal_volume
18pub_type
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