Protective effect of Flt3L on organ structure during advanced multiorgan dysfunction syndrome in mice.

abstract：:Inflammation has been implicated in the pathogenesis of type 2 diabetes (T2D), which is a progressive disease characterized by pancreatic β‑cell dysfunction and apoptosis with consequential insufficient insulin secretion. Autophagy is necessary to maintain the structure, mass and function of pancreatic β‑cells. The pr...

journal_title：Molecular medicine reports

authors： Zhu LB,Cao MM,Wang J,Su Y,Jiang W,Liu GD,Li YB

更新日期：2019-06-01 00:00:00

abstract：:Dietary n‑3 polyunsaturated fatty acid (PUFA) exerts anti‑inflammatory and immunoregulatory effects via downregulation of the innate and adaptive immune responses. However, the effect of dietary n‑3 PUFA on experimental Crohn's Disease (CD) in rats and the underlying mechanisms are unclear. The present study aimed to ...

journal_title：Molecular medicine reports

authors： Yao J,Lu Y,Zhi M,Hu P,Wu W,Gao X

更新日期：2017-12-01 00:00:00

abstract：:Doxorubicin (Dox)-induced cardiotoxicity has been a well‑known phenomenon to clinicians and scientists for decades. It has been confirmed that Dox‑dependent cardiotoxicity is accompanied by cardiac cellular senescence. However, the molecular mechanisms underlying Dox cardiotoxicity remains to be fully elucidated. Long...

journal_title：Molecular medicine reports

authors： Xie Z,Xia W,Hou M

更新日期：2018-02-01 00:00:00

abstract：:Calcium oxalate stones account for >80% of urinary stones, however the mechanisms underlying their formation remains to be elucidated. Hyperoxaluria serves an important role in the pathophysiological process of stone formation. In the present study, differences in the miRNA expression profiles between experimental hyp...

journal_title：Molecular medicine reports

authors： Liu Z,Jiang H,Yang J,Wang T,Ding Y,Liu J,Wang S,Ye Z

更新日期：2016-11-01 00:00:00

abstract：:4-Hydroxy-3-methoxybenzaldehyde (vanillin), contained in a number of species of plant, has been reported to display beneficial effects against brain injuries. In the present study, the impact of vanillin on scopolamine‑induced alterations in cognition and the expression of DNA binding protein inhibitor ID‑1 (ID1), one...

journal_title：Molecular medicine reports

authors： Lee JC,Kim IH,Cho JH,Lee TK,Park JH,Ahn JH,Shin BN,Yan BC,Kim JD,Jeon YH,Lee YJ,Won MH,Kang IJ

更新日期：2018-03-01 00:00:00

abstract：:Glioma is one of the most common malignant tumors affecting the central nervous system. We screened active drugs from 12 classes to provide experimental data for the study of human glioma. Serum-free suspension clone formation was used to induce the formation of glioma stem‑like cel...

journal_title：Molecular medicine reports

authors： Feng X,Zhou Q,Liu C,Tao ML

更新日期：2012-11-01 00:00:00

abstract：:The authors initially performed reverse transcription‑quantitative polymerase chain reaction to determine the expression profile of KDM5A in ovarian cancer tissues and adjacent normal tissue. Compared with adjacent normal tissue, it was identified that KDM5A was highly expressed in ovarian cancer tissues. Moreover, hu...

journal_title：Molecular medicine reports

authors： Feng T,Wang Y,Lang Y,Zhang Y

更新日期：2017-09-01 00:00:00

abstract：:Cisplatin-induced heart damage is associated with enzymes and protein alterations. The purpose of this study was to investigate cisplatin-induced alterations in cardiac endothelin (ET)-1 and type III collagen following administration of cisplatin. Male Wistar rats were randomly divided into two groups: a control and a...

journal_title：Molecular medicine reports

authors： Huang QY,Li XF,Liu SP

更新日期：2012-03-01 00:00:00

abstract：:Various studies have investigated hepatic carcinoma cachexia, however, there is little published information regarding the effect of Chinese Medicine carcinoma cachexia. The present study was performed to investigate the effect of modified Chinese herbal compound jianpijiedu (MJPJD) on a mouse model of ascites‑induced...

journal_title：Molecular medicine reports

authors： Sun B,Luo H,Deng L,Zhang S,Chen Z

更新日期：2016-10-01 00:00:00

abstract：:A subset of cancer stem cells termed 'side population' (SP) cells has been identified in several types of solid tumor and is known to be responsible for the failure of chemotherapy and for cancer relapse. In the present study, the oral squamous cell carcinoma (OSCC) cell line SCC‑55 was used for analysis of the SP cel...

journal_title：Molecular medicine reports

authors： Liu Y,Cui P,Chen J,Li W

更新日期：2015-05-01 00:00:00

abstract：:The aim of the current study was to investigate the biological effect on T24 cells and human umbilical vein endothelial cells (HUVECs) of transfection with brain-specific angiogenesis inhibitor-1 (BAI-1). The recombinant plasmid pReceiver-M61-BAI-1 was transfected into human superficial bladder tumor cells (T24) and H...

journal_title：Molecular medicine reports

authors： Tian DW,Hu HL,Sun Y,Tang Y,Lei MD,Liu LW,Han RF,Wu CL

更新日期：2016-08-01 00:00:00

abstract：:Paraquat is a highly toxic pesticide, which often causes pulmonary interstitial fibrosis after poisoning, and there is no specific antidote. At present, limited studies have reported that tacrolimus, as an immunosuppressant, can inhibit pulmonary fibrosis, but the specific mechanism remains unknown. The aim of the pre...

journal_title：Molecular medicine reports

authors： Ren Y,Jian X,Zhang Z,Ning Q,Kan B,Kong L

更新日期：2020-11-01 00:00:00

abstract：:Neuregulin-1 (NRG-1) is a type of epidermal growth factor‑like protein primarily distributed in the nervous and cardiovascular systems. When sepsis occurs, the incidence of cardiac dysfunction in myocardial injury is high and the mechanism is complicated. It directly causes myocardial cell damage, whilst also causing ...

journal_title：Molecular medicine reports

authors： Kang W,Cheng Y,Wang X,Zhou F,Zhou C,Wang L,Zhong L

更新日期：2020-06-01 00:00:00

abstract：:The use of non‑steroidal anti‑inflammatory drugs (NSAIDs) has been associated with a reduced risk of various types of cancer, including esophageal cancer. However, the mechanisms underlying the antineoplastic effects of NSAIDs in esophageal cancer remain to be elucidated. In the present study, a significant inhibition...

journal_title：Molecular medicine reports

authors： Qin S,Xu C,Li S,Yang C,Sun X,Wang X,Tang SC,Ren H

更新日期：2015-06-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common cancer types worldwide. The signal transducer and activator of transcription 3 (STAT3) protein is a member of the STAT transcription factor family. Oncogenesis, invasion, and metastasis of HCC are associated with activation of STAT3. However, whether aberrant ex...

journal_title：Molecular medicine reports

authors： Wang X,Xin W,Zhang H,Zhang F,Gao M,Yuan L,Xu X,Hu X,Zhao M

更新日期：2014-11-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. Although numerous studies have suggested the potentially oncogenic roles of wild‑type or mutant hepatitis B virus X (HBx) protein in hepatocarcinogenesis, their exact mechanism remains unclear. Increasing evidence suggests that microRNAs ...

journal_title：Molecular medicine reports

authors： Fu X,Tan D,Hou Z,Hu Z,Liu G,Ouyang Y,Liu F

更新日期：2013-02-01 00:00:00

abstract：:Aldosterone has an important role in the progression of renal fibrosis. In the present study, the concentration of aldosterone and klotho (KL) in the serum of patients with chronic kidney disease (CKD) were analyzed. A negative correlation was observed between aldosterone and KL, suggesting that KL may serve a protect...

journal_title：Molecular medicine reports

authors： Lai L,Cheng P,Yan M,Gu Y,Xue J

更新日期：2019-03-01 00:00:00

abstract：:Autophagy is a highly conserved pathway that permits recycling of nutrients within the cell and is rapidly upregulated during starvation or cell stress. Autophagy has been implicated in the pathophysiological process of warm ischemia‑reperfusion injury in the rat lung. Cold ischemia (CI) preservation for lung transpla...

journal_title：Molecular medicine reports

authors： Chen X,Wu JX,You XJ,Zhu HW,Wei JL,Xu MY

更新日期：2015-04-01 00:00:00

abstract：:Histone deacetylases (HDACs) are enzymes that catalyze the removal of acetyl from lysine residues in histones and other proteins, which results in gene transcriptional repression and subsequent changes in signaling events. HDACs inhibitors (HDACIs) have been used to reverse the aberrant epigenetic changes associated w...

journal_title：Molecular medicine reports

authors： Han RF,Li K,Yang ZS,Chen ZG,Yang WC

更新日期：2014-12-01 00:00:00

abstract：:The present study aimed to determine the potential molecular mechanisms underlying p21 (RAC1)‑activated kinase 7 (PAK7) expression in glioblastoma (GBM) and evaluate candidate prognosis biomarkers for GBM. Gene expression data from patients with GBM, including 144 tumor samples and 5 normal brain samples, were downloa...

journal_title：Molecular medicine reports

authors： Wang X,Liu S,Shao Z,Zhang P

更新日期：2020-08-01 00:00:00

abstract：:B7-H4 is a co‑inhibitory molecule of the B7 family, which is expressed on antigen‑presenting cells (APCs) and is able to limit the T‑cell immune response. Macrophages act as professional APCs and are important for immunoregulation of the tumor microenvironment in breast cancer. In order to identify the association bet...

journal_title：Molecular medicine reports

authors： Liu L,Li D,Chen S,Zhao R,Pang D,Li D,Fu Z

更新日期：2016-09-01 00:00:00

abstract：:Vascular smooth muscle cell (VSMC) proliferation is a key event in the development of in‑stent restenosis. Evodiamine is an indole alkaloid extracted from the Chinese medicine, evodia, and has been shown to inhibit tumor cell proliferation and protect the cardiovascular system. However, whether evodiamine affects VSMC...

journal_title：Molecular medicine reports

authors： Ge X,Chen SY,Liu M,Liang TM,Liu C

更新日期：2016-11-01 00:00:00

abstract：:Cardiovascular diseases have become one of the major public health problems in many countries. The downregulation of MYBL2 was found in H9c2 and native cardiomyocytes cells after hypoxia treatment. The present study aimed to investigate the effects of MYB proto‑oncogene like 2 (MYBL2) on H9c2 injury induced by hypoxia...

journal_title：Molecular medicine reports

authors： Shao M,Ren Z,Zhang R

更新日期：2018-03-01 00:00:00

abstract：:In the present study, optically active cis and trans α-hydroxy-β-lactams were prepared by Baker's yeast reduction of a racemic α-keto-β-lactam and by the hydrolysis of a racemic α-acetoxy β-lactam with the resting cells of Bacillus Subtilis. ...

journal_title：Molecular medicine reports

authors： Banik BK,Negi M,Manhas MS,Bose AK

更新日期：2010-03-01 00:00:00

abstract：:Indoleamine 2,3‑dioxygenase (IDO), through L‑tryptophan depletion, activates general control non‑derepressible (GCN) 2 kinase and suppresses T‑cell proliferation, in addition to suppressing aerobic glycolysis and glutaminolysis, which are required for these rapidly proliferating cells. A number of, however not all of ...

journal_title：Molecular medicine reports

authors： Eleftheriadis T,Pissas G,Antoniadi G,Tsogka K,Sounidaki M,Liakopoulos V,Stefanidis I

更新日期：2016-01-01 00:00:00

abstract：:Chloride intracellular channel 1 (CLIC1) has been demonstrated to be overexpressed in gastric cancer, and elevated CLIC1 expression levels are markedly associated with the processes of tumor cell migration and invasion. However, the regulatory mechanism and signaling pathway underlying these processes have remained to...

journal_title：Molecular medicine reports

authors： Zhao W,Lu M,Zhang Q

更新日期：2015-12-01 00:00:00

abstract：:Although imatinib is effective in chronic myeloid leukemia treatment, imatinib resistance due to the T315I mutation and/or other mutations is a challenge to be overcome. However, how DNA mutation occurs, particularly the T315I mutation, remains unclear. In the current study, the mutagenesis of BCR‑ABL was analyzed via...

journal_title：Molecular medicine reports

authors： Dong Y,Gao X,Zhao Y,Wei M,Xu L,Yang G,Liu L

更新日期：2017-12-01 00:00:00

abstract：:Tissue-engineered bone substitutes are frequently used to repair bone defects. Adipose-derived stem cells (ASCs) are a promising source of cells for repairing bone tissue, however, insufficient osteogenic potency remains the main obstacle for their application. The present study aimed to enhance the osteogenic potency...

journal_title：Molecular medicine reports

authors： Wang Z,Zhang D,Hu Z,Cheng J,Zhuo C,Fang X,Xing Y

更新日期：2015-09-01 00:00:00

abstract：:Circular RNAs (circRNAs) are class of endogenous RNAs that have a role in the regulation of gene expression. The present study aimed to investigate the diagnostic value and role of circRNA in the pathogenesis of leukoaraiosis (LA). The present study performed Arraystar Human circRNA Array analysis of 6 samples from LA...

journal_title：Molecular medicine reports

authors： Mi T,Luo C,Hu Y,Qu C,Wang X,Guo S,Du Y

更新日期：2017-09-01 00:00:00

abstract：:The aim of this study was to evaluate the clinical application of 18-fluorodeoxyglucose positron emission tomography (FDG-PET) imaging for the detection of malignant lesions. A total of 132 patients with increased levels of blood tumor markers but without a prior history of malignancy were examined. The results of FDG...

journal_title：Molecular medicine reports

authors： Zhan HW,Xu W,Ye XJ,Zhao CL,Zhang H,Li J,Yao Q,Zhang LJ

更新日期：2009-09-01 00:00:00