Neuregulin‑1: An underlying protective force of cardiac dysfunction in sepsis (Review).

abstract：:Blood stasis syndrome (BSS), additionally called Eohyul, is a basic pathological concept in Traditional Korean Medicine. Do In Seung Gi‑Tang (DISGT) is herbal medicine used for the treatment of BSS. It primarily treats metabolic diseases (MDs) including obesity, hypertension, diabetes mellitus and gynecological diseas...

journal_title：Molecular medicine reports

authors： Shim EH,Lee MS,Lee JA,Lee H

更新日期：2017-06-01 00:00:00

abstract：:In order to gain greater understanding of the mechanisms underlying the effect of epigallocatechin-3-gallate (EGCG) on DNA methylation and its chemopreventative action in oral squamous cell carcinoma (OSCC), a genome‑wide methylation and mRNA expression screen was performed in the CAL‑27 cell line with and without EGC...

journal_title：Molecular medicine reports

authors： Chen LL,Han WF,Geng Y,Su JS

更新日期：2015-10-01 00:00:00

abstract：:Skin can be infected by many types of microorganisms, most commonly by gram‑positive strains of Staphylococcus and Streptococcus spp. Treatment of Staphylococcus aureus (S. aureus) infections, particularly that of methicillin resistant Staphylococcus aureus (MRSA), is a challenge in clinical practice. Ozone therapy ha...

journal_title：Molecular medicine reports

authors： Song M,Zeng Q,Xiang Y,Gao L,Huang J,Huang J,Wu K,Lu J

更新日期：2018-02-01 00:00:00

abstract：:The aim of this study was to investigate the correlation between brain-derived neurotrophic factor (BDNF) expression and cognitive impairment in post‑stroke depression (PSD) rats and to explore the mechanism(s) involved in the process of cognitive impairment. A rat model of focal ce...

journal_title：Molecular medicine reports

authors： Zhang ZH,Wu LN,Song JG,Li WQ

更新日期：2012-10-01 00:00:00

abstract：:Mesenchymal stromal cells (MSCs) are a potential cell source for the development of therapeutic products. Recent studies have shown that the transplantation of MSCs to damaged organs, including the heart, liver and kidneys, results in the restoration of the damaged tissues. However, the mechanisms underlying this rege...

journal_title：Molecular medicine reports

authors： Cho KA,Ju SY,Ryu KH,Woo SY

更新日期：2009-01-01 00:00:00

abstract：:Partial splenic embolization (PSE) or splenectomy is widely performed to increase platelet counts for interferon (IFN) therapy. The aim of the present study was to evaluate the long-term effects of splenectomy and subsequent IFN therapy in patients with hepatitis C virus (HCV)-related liver cirrhosis (LC). The present...

journal_title：Molecular medicine reports

authors： Inagaki Y,Sugimoto K,Shiraki K,Tameda M,Kusagawa S,Nojiri K,Ogura S,Yamamoto N,Takei Y,Ito M,Mizuno S,Usui M,Sakurai H,Isaji S

更新日期：2014-02-01 00:00:00

abstract：:To determine the effect of the down-regulation of osteopontin (OPN) expression on the sensitivity of breast cancer cells to doxorubicin, a chemotherapeutic drug, OPN shRNA was used to transfect the OPN-positive breast cancer cell line MDA-MB-231. The expression of OPN mRNA and protein was analyzed by RT-PCR and Wester...

journal_title：Molecular medicine reports

authors： Yang L,Wei L,Zhao W,Wang X,Zheng G,Zheng M,Song X,Zuo W

更新日期：2012-02-01 00:00:00

abstract：:The endogenously activated rheumatoid arthritis (RA) synovial fibroblasts (RSFs) are likely to be the key to curing the disease. RSFs express Toll‑like receptors (TLRs) rendering them prone to activation by exogenous and endogenous TLR ligands, resulting in the production of chemokines and cytokines Germline deletion ...

journal_title：Molecular medicine reports

authors： Shi C,Wang Y,Zhuang G,Qi Z,Li Y,Yin P

更新日期：2017-11-01 00:00:00

abstract：:It has been previously reported that increased expression of coiled‑coil domain containing 34 (CCDC34), a member of the CCDCs family, may promote the proliferation and invasion of bladder cancer cells. However, its role in colorectal cancer (CRC) remains unclear. The present study investigated CCDC34 expression in CRC...

journal_title：Molecular medicine reports

authors： Geng W,Liang W,Fan Y,Ye Z,Zhang L

更新日期：2018-01-01 00:00:00

abstract：:Pregnancy complications are associated with abnormal cytotrophoblast differentiation and invasion. Hydrogen peroxide (H2O2) is an important mediator of oxidative ischemia/reperfusion stress in the placenta. Lycium barbarum polysaccharides (LBP) have been demonstrated to counteract oxidative free radicals. The effects ...

journal_title：Molecular medicine reports

authors： Li J,Ding Z,Yang Y,Mao B,Wang Y,Xu X

更新日期：2018-09-01 00:00:00

abstract：:Scutellarin (SC), mainly extracted from the Chinese herb Erigeron breviscapus (vant.), has been reported to possess various pharmacological activities; however, its effects on Alzheimer's disease (AD) have not been systemically reported. The protective effects of SC on AD were investigated using an L‑glutamic acid (L‑...

journal_title：Molecular medicine reports

authors： Hu X,Teng S,He J,Sun X,Du M,Kou L,Wang X

更新日期：2018-11-01 00:00:00

abstract：:Intermittent fasting has been shown to have neuroprotective effects against transient focal cerebral ischemic insults. However, the effects of intermittent fasting on transient global ischemic insult has not been studied much yet. The present study examined effects of intermittent fasting on endogenous antioxidant enz...

journal_title：Molecular medicine reports

authors： Ahn JH,Noh Y,Shin BN,Kim SS,Park JH,Lee TK,Song M,Kim H,Lee JC,Yong JH,Kang IJ,Lee YL,Won MH,Kim JD

更新日期：2018-12-01 00:00:00

abstract：:Glucosamine is a possible cause of vascular endothelial injury in the initial stages of atherosclerosis, through endoplasmic reticulum (ER) stress resulting in fatty streaks in the vascular wall. Quercetin is an anti‑diabetic and cardiovascular protective agent that has previously been demonstrated to reduce ER stress...

journal_title：Molecular medicine reports

authors： Cai X,Bao L,Ding Y,Dai X,Zhang Z,Li Y

更新日期：2017-02-01 00:00:00

abstract：:CXC195 exhibits strong protective effects against neuronal apoptosis by exerting antioxidant activity. However, the pharmacological function of CXC195 in cancer remains to be elucidated. The present study demonstrated that CXC195 exhibited significant cytotoxic effects, and induced cell cycle arrest and apoptosis in H...

journal_title：Molecular medicine reports

authors： Chen XL,Fu JP,Shi J,Wan P,Cao H,Tang ZM

更新日期：2015-12-01 00:00:00

abstract：:NOVA alternative splicing regulator 1 (NOVA1) dysregulation has been detected in the gastric cancer microenvironment. Decreased NOVA1 expression has been linked to the progression and poor prognosis of gastric cancer; however, the role of NOVA1 in regulating epithelial‑mesenchymal transition (EMT) remains unclear in t...

journal_title：Molecular medicine reports

authors： Li K,Zhu X,Chen X,Wang X

更新日期：2020-03-01 00:00:00

abstract：:Dexamethasone (Dex) and other glucocorticoids are widely used to treat serious infections and immunological diseases, however they may cause steroid‑induced avascular necrosis of the femoral head (SANFH). Salidroside (Sal) has demonstrated an anti‑apoptotic effect on neurocytes by activating the phosphoinositide 3‑kin...

journal_title：Molecular medicine reports

authors： Xue XH,Feng ZH,Li ZX,Pan XY

更新日期：2018-03-01 00:00:00

abstract：:Little is known regarding the expression or clinical significance of δ-catenin, a member of the catenin family, in colorectal cancer (CRC). The present study examined the expression of δ-catenin using immunohistochemistry in 110 cases of CRC, including 70 cases with complete follow‑up records and 40 cases with paired ...

journal_title：Molecular medicine reports

authors： Zhang H,Dai SD,Liu SL,Zhang FY,Dai CL

更新日期：2015-09-01 00:00:00

abstract：:In order to evaluate SCN2A as a candidate gene for epileptic susceptibility and the use of a Cu-Zn superoxide dismutase (SOD) supplement as a potential therapy for epilepsy, SCN2A expression in the cortex and the correlation between SCN2A and Cu-Zn SOD in SH-SY5Y cells were examined. SCN2A expression and the concentra...

journal_title：Molecular medicine reports

authors： Xiang J,Jiang Y

更新日期：2014-01-01 00:00:00

abstract：:Alzheimer's disease is one of the most common age‑associated diseases that frequently leads to memory disorders, cognitive decline and dementia. Evidence suggests that nicergoline serves an important role in the apoptosis of hippocampal cells, memory recovery, cognitive function and neuronal survival. However, the sig...

journal_title：Molecular medicine reports

authors： Zang G,Fang L,Chen L,Wang C

更新日期：2018-05-01 00:00:00

abstract：:The aim of the present study was to report on a complete synthetic approach, namely benzylation-hydrolysis-acylation‑hydrogenation, to the synthesis of regioselectively acylated quercetin analogues using low‑cost rutin as a starting material. Three quercetin analogues, quercetin‑3‑O‑propionate (Q‑pr), quercetin‑3‑O‑bu...

journal_title：Molecular medicine reports

authors： Duan Y,Sun N,Xue M,Wang X,Yang H

更新日期：2017-12-01 00:00:00

abstract：:Cardiac stem cells (CSCs) can differentiate into cardiac muscle‑like cells; however, it remains unknown whether CSCs may possess the ability to differentiate into pacemaker cells. The aim of the present study was to determine whether angiotensin II (Ang II) could promote the specialization of CSCs into pacemaker‑like ...

journal_title：Molecular medicine reports

authors： Xue C,Zhang J,Lv Z,Liu H,Huang C,Yang J,Wang T

更新日期：2015-05-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis is a chronic pulmonary disease that is characterized by formation of scar tissue in lungs. Transforming growth factor-β (TGF-β) is considered an important cytokine in the pathogenesis of this disease. Hence, the antifibrotic effect of an inhibitor of the TGF-β type I receptor, namely, SB ...

journal_title：Molecular medicine reports

authors： Koh RY,Lim CL,Uhal BD,Abdullah M,Vidyadaran S,Ho CC,Seow HF

更新日期：2015-05-01 00:00:00

abstract：:Bone morphogenetic protein 2 (BMP2) is a growth factor that is involved in the development and progression of various types of cancer. However, the epigenetic regulation of the expression of BMP2 and the association between BMP2 expression and drug resistance in breast cancer remains to be elucidated. The present stud...

journal_title：Molecular medicine reports

authors： Du M,Su XM,Zhang T,Xing YJ

更新日期：2014-08-01 00:00:00

abstract：:Myocyte apoptosis and oxidative stress key critical roles in the process of doxorubicin (DOX)‑induced cardiotoxicity. However, how apoptosis and oxidative stress arise in DOX‑induced heart injury remains largely unknown. Cathepsin B (CTSB) is a typical lysosomal cysteine protease that is associated with apoptosis, inf...

journal_title：Molecular medicine reports

authors： Liu C,Cai Z,Hu T,Yao Q,Zhang L

更新日期：2020-12-01 00:00:00

abstract：:β-crystallin B2 (CRYBB2) knockout mice exhibit morphological and functional abnormalities in the ovary. Long non‑coding RNAs (lncRNAs) regulate gene transcription and translation, and epigenetic modification of genomic DNA. The present study investigated the role of lncRNAs in mediating the effects of CRYBB2 in the re...

journal_title：Molecular medicine reports

authors： Gao Q,Ren H,Chen M,Niu Z,Tao H,Jia Y,Zhang J,Li W

更新日期：2016-11-01 00:00:00

abstract：:Socheongryeong‑tang (SCRT) is a herbal formula previously used to treat pulmonary diseases primarily caused by the common cold virus, including airway inflammation, asthma and allergy. The aim of the present study was to investigate the inhibitory effect of SCRT water extract and its 13 constituent components on chemo...

journal_title：Molecular medicine reports

authors： Kim JH,Jeon WY,Lee MY,Seo CS,Lim HS,Shin HK

更新日期：2014-12-01 00:00:00

abstract：:Hepatitis C virus (HCV) infection induces not only chronic liver disease, but also extrahepatic manifestations such as thyroid disease and oral cancer. Thyroid dysfunction is also a complication known to be associated with interferon (IFN) therapy for HCV infection. We report on a 69-year-old Japanese man who develope...

journal_title：Molecular medicine reports

authors： Nagao Y,Hiromatsu Y,Nakashima T,Sata M

更新日期：2008-09-01 00:00:00

abstract：:Lumbar disc disease (LDD) is common in aged populations, and it is primarily caused by intervertebral disc degeneration (IDD). Cartilage intermediate layer protein (CILP), which is specifically expressed in intervertebral discs (IVDs), is suspected to be associated with IDD. However, it remains unclear whether CILP co...

journal_title：Molecular medicine reports

authors： He J,Feng C,Sun J,Lu K,Chu T,Zhou Y,Pan Y

更新日期：2018-04-01 00:00:00

abstract：:Dermal papilla (DP) cells function as important regulators of the hair growth cycle. The loss of these cells is a primary cause of diseases characterized by hair loss, including alopecia, and evidence has revealed significantly increased levels of reactive oxygen species (ROS) in hair tissue and DP cells in the baldin...

journal_title：Molecular medicine reports

authors： Lim KM,An S,Lee OK,Lee MJ,Lee JP,Lee KS,Lee GT,Lee KK,Bae S

更新日期：2015-08-01 00:00:00

abstract：:Interleukin (IL)-35 is the latest member of IL-12 family, which plays an important role in other autoimmune diseases. Bone marrow mononuclear cells Coombs test‑positive hemocytopenia, also termed immunorelated hemocytopenia (IRH) is a type of autoimmune-associated diseases. The present study investigated the relations...

journal_title：Molecular medicine reports

authors： Li Y,Wang Y,Liu H,Ding K,Hao S,Shao Y,Wang H,Chen J,Huang L,Shao Z,Fu R

更新日期：2018-02-01 00:00:00