The antibacterial effect of topical ozone on the treatment of MRSA skin infection.

abstract：:The present study investigated the correlation between four serum biomarkers of liver fibrosis, liver function and pathological hepatic fibrosis grade in neonatal cholestatic rats. A total of 38 Sprague‑Dawley rats, aged 3 weeks, were randomly assigned to the experimental group (EG), control group (CG) and the blank c...

journal_title：Molecular medicine reports

authors： Tang N,Zhang Y,Liu Z,Ai X,Liang Q

更新日期：2017-07-01 00:00:00

abstract：:Diabetic retinopathy is one of the most common complications in patients with diabetes and affects ~75% of them within 15 years of the onset of the disease. Activation of protein kinase C (PKC) is a key feature of diabetes mellitus and may be involved in the pathogenesis of diabetic retinopathy. The present study aime...

journal_title：Molecular medicine reports

authors： Liu ZC,Yu EH,Liu W,Liu XC,Tang SB,Zhu BH

更新日期：2014-05-01 00:00:00

abstract：:Long non‑coding RNAs (lncRNAs) play critical roles in the development and progression of cancers. The present study aimed to identify novel lncRNAs and associated microRNAs (miRNAs or miRs) and mRNAs in gastric cancer. Differentially expressed lncRNAs (DElncRNAs) and differentially expressed mRNAs (DEmRNAs) of 6 paire...

journal_title：Molecular medicine reports

authors： Gu W,Ren JH,Zheng X,Hu XY,Hu MJ

更新日期：2019-09-01 00:00:00

abstract：:BCL6ZF is a novel transcript of BCL6, which lacks the first two zinc fingers of BCL6. It has been established that BCL6 acts as a sequence‑specific transcriptional repressor, however, the functions of BCL6ZF remain undefined. By generating stably overexpressed BCL6 and BCL6ZF in NCI‑H1299 lung cancer cells, it was fou...

journal_title：Molecular medicine reports

authors： Fu X,Hao Y,Mao Y,Qian Y,Qian Z,Li T,He D,Xiao X

更新日期：2015-05-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) is important for the proliferation and differentiation of gastric mucosal cells. Betacellulin (BTC) is a novel ligand for EGFR Since their role is unclear in the ulcer healing process, we investigated their expression. Gastric ulcers in 30 Sprague-Dawley rats were induced by ace...

journal_title：Molecular medicine reports

authors： Choi GH,Park HS,Kim KR,Choi HN,Jang KY,Chung MJ,Kang MJ,Lee DG,Moon WS

更新日期：2008-07-01 00:00:00

abstract：:One of the major reasons for failure after total joint arthroplasty is aseptic loosening of the implant. At articulating surfaces, defined as the interface between implant and surrounding bone cement, wear particles can be generated and released into the periprosthetic tissue, resulting in inflammation and osteolysis....

journal_title：Molecular medicine reports

authors： Jonitz-Heincke A,Lochner K,Schulze C,Pohle D,Pustlauk W,Hansmann D,Bader R

更新日期：2016-08-01 00:00:00

abstract：:In Crohn's disease (CD), clinical symptoms correspond poorly to inflammatory disease activity. Biomarkers, which reflect the level of intestinal inflammation are considered to enable effective monitoring of disease activity. The present study evaluated the role of serum pentraxin 3 (PTX3) as a marker of disease activi...

journal_title：Molecular medicine reports

authors： Chen J,Xu X,Xia L,Xi X,Liu B,Yang M

更新日期：2015-07-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have been investigated in the treatment of numerous autoimmune diseases. However, the immune properties of MSCs on the development of asthma have remained to be fully elucidated. Airway dendritic cells (DCs) have an important role in the pathogenesis of allergic asthma, and disrupting the...

journal_title：Molecular medicine reports

authors： Zeng SL,Wang LH,Li P,Wang W,Yang J

更新日期：2015-08-01 00:00:00

abstract：:The aim of the present study was to identify differentially expressed genes and biological processes associated with periodontitis. In this study, the most significant 200 differentially expressed genes associated with periodontitis were identified using integrated analysis of multiple microarray data in combination w...

journal_title：Molecular medicine reports

authors： Guo X,Wang Y,Wang C,Chen J

更新日期：2015-04-01 00:00:00

abstract：:Following the publication of this article, the authors have realized that an error was made with the description of the first and fourth listed affiliation addresses: "North China University of Science and of Technology", should have been written as "North China University of Science and Technology". This error also a...

journal_title：Molecular medicine reports

authors： Bao Z,Hao J,Li Y,Feng F

更新日期：2020-06-01 00:00:00

abstract：:Gestational diabetes mellitus (GDM) is a type of diabetes mellitus (DM) that occurs during pregnancy. The present study aimed to investigate the roles of microRNA (miR)‑195‑5p and enhancer of zeste homolog 2 (EZH2) in GDM, and their potential association. Human umbilical vein endothelial cells (HUVECs) were collected ...

journal_title：Molecular medicine reports

authors： Liao X,Zhou Z,Zhang X

更新日期：2020-08-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the third most common cause of cancer mortality worldwide, which is partially due to the lack of appropriate therapeutic options. The development of HCC is accompanied with unique and continuous genomic and epigenetic modifications. Therefore, the absence of a personalized and reprodu...

journal_title：Molecular medicine reports

authors： Wang Z,Bi B,Song H,Liu L,Zheng H,Wang S,Shen Z

更新日期：2019-06-01 00:00:00

abstract：:Apoptosis serves a pivotal role in the pathogenesis of osteoarthritis (OA). Increasing evidence has demonstrated that paeoniflorin exerts key properties (including anticancer, anti-inflammation and neuroprotective) for clinical applications. However, the precise role of paeoniflorin in articular cartilage apoptosis re...

journal_title：Molecular medicine reports

authors： Hu PF,Chen WP,Bao JP,Wu LD

更新日期：2018-04-01 00:00:00

abstract：:Pioglitazone may have potential benefits as an alternative therapeutic treatment for patients with Alzheimer's disease (AD), particularly in individuals that also have comorbid diabetes; however, the mechanisms of action remain unclear. The present study aimed to explore the effects of pioglitazone on amyloid β, isofo...

journal_title：Molecular medicine reports

authors： Yang S,Chen Z,Cao M,Li R,Wang Z,Zhang M

更新日期：2017-05-01 00:00:00

abstract：:Liver cirrhosis is frequently accompanied by malnutrition and hypoalbuminemia, which in turn commonly induces ascites in patients with liver cirrhosis. Ascites leads to abdominal distention and appetite loss, resulting in a deteriorated quality of life (QOL). Administration of branched-chain amino acid (BCAA)-rich sup...

journal_title：Molecular medicine reports

authors： Itou M,Kawaguchi T,Taniguchi E,Oku Y,Fukushima N,Ando E,Oriishi T,Uchida Y,Otsuka M,Tanaka S,Iwasaki S,Torii M,Yoshida K,Adachi Y,Suga M,Yoshiyama M,Ibi R,Akiyama Y,Takakura M,Mitsuyama K,Tsuruta O,Sata M

更新日期：2009-11-01 00:00:00

abstract：:Metastasis is the most lethal stage of cancer progression. The present study aimed to investigate the underlying molecular mechanisms of melanoma metastasis using bioinformatics. Using the microarray dataset GSE8401 from the Gene Expression Omnibus database, which included 52 biopsy specimens from patients with melano...

journal_title：Molecular medicine reports

authors： Chen J,Wu F,Shi Y,Yang D,Xu M,Lai Y,Liu Y

更新日期：2019-08-01 00:00:00

abstract：:Non‑alcoholic fatty liver disease (NAFLD) is the most common fatty liver disease in developed countries, in which fat accumulation in the liver is induced by non‑alcoholic factors. The present study was conducted to identify NAFLD‑associated long non‑coding RNAs (lncRNAs), mRNAs and microRNAs (miRNAs). The microarray ...

journal_title：Molecular medicine reports

authors： Wu H,Song X,Ling Y,Zhou J,Tao Z,Shen Y

更新日期：2019-04-01 00:00:00

abstract：:Stem cells from apical papilla (SCAP) possess clear osteo‑/odontogenic differentiation capabilities, and are regarded as the major cellular source for root dentin development. Bone morphogenetic protein 2 (BMP2) and vascular endothelial growth factor (VEGF) serve pivotal roles in the modulation of tooth development an...

journal_title：Molecular medicine reports

authors： Zhang W,Zhang X,Ling J,Wei X,Jian Y

更新日期：2016-05-01 00:00:00

abstract：:Leukemia inhibitory factor (LIF) modulates various biological processes. Although previous studies have described the effects of LIF on adipocyte differentiation, the role of LIF receptor (LIFR) on adipocyte differentiation remains unclear. Using reverse transcription‑quantitative PCR (RT‑qPCR), LIFR expression was de...

journal_title：Molecular medicine reports

authors： Wang T,Yan R,Xu X,Yu H,Wu J,Yang Y,Li W

更新日期：2019-06-01 00:00:00

abstract：:Identification of novel risk factors that are critical to the initiation of lung cancer will be key for its prevention. Recently, it has been reported that glycine dehydrogenase (GLDC) can drive the formation of lung cancer initiating cells. However, there have been no perspective studies on the association between ci...

journal_title：Molecular medicine reports

authors： Wei HY,Feng R,Shao H,Feng B,Liu HQ,Men JL,Zou W

更新日期：2018-08-01 00:00:00

abstract：:Galgeun-tang (GT) prior to and following fermentation with Lactobacillus plantarum was analyzed to determine the total polyphenol and flavonoid contents and the antioxidant activity. GT, fermented GT (FGT) and their three solvent-partitioned fractions, which were prepared by successive partitioning with ethyl acetate ...

journal_title：Molecular medicine reports

authors： Kim DS,Um YR,Ma JY

更新日期：2014-11-01 00:00:00

abstract：:Uveal melanoma (UM) is characterized by high metastasis and poor prognosis. A more improved understanding of the metastatic mechanism in UM cells is essential for the design of molecular therapy. Grb2‑associated binder 2 (Gab2) has been reported to serve important roles in the progression of various types of human can...

journal_title：Molecular medicine reports

authors： Chen M,Li Y,Sun X,Zhang B,Li W,Wang S,Zhu X,Li F,Shi L

更新日期：2017-10-01 00:00:00

abstract：:Endothelial microparticles (EMPs) and endothelial cells (ECs) are involved in the pathophysiological mechanisms of sepsis and septic shock. EMPs are small vesicles released by ECs and are considered biomarkers for endothelial cell function and mediators for intercellular information exchange. However, the effect of EM...

journal_title：Molecular medicine reports

authors： Liu Y,Zhang R,Qu H,Wu J,Li L,Tang Y

更新日期：2017-03-01 00:00:00

abstract：:The zinc-fingers and homeoboxes protein 1 (ZHX1) consists of 873 amino acid residues, is localized in the cell nucleus and appears to act as a transcriptional repressor. Previous studies have shown that ZHX1 interacts with nuclear factor Y subunit α (NF-YA), DNA methyltransferases (DNMT) 3B and ZHX2, all of which are ...

journal_title：Molecular medicine reports

authors： Wang J,Liu D,Liang X,Gao L,Yue X,Yang Y,Ma C,Liu J

更新日期：2013-11-01 00:00:00

abstract：:Advanced glycation end products (AGEs) are a contributing factor in the angiogenesis that is characteristic of proliferative diabetic retinopathy. However, a previous study made a promising observation that domain I‑IV of β2‑glycoprotein I (DI‑IV) inhibits angiogenesis in human umbilical vein cells. The present study ...

journal_title：Molecular medicine reports

authors： Wang QQ,Zhou SJ,Meng ZX,Wang J,Chen R,Lv L,Li CJ,Yu DM,Yu P

更新日期：2015-03-01 00:00:00

abstract：:The objective of the present study was to evaluate the influence of TAAAA repeat allele length on the levels of serum sex hormone binding globulin (SHBG) and cardiovascular risk factors in patients with polycystic ovary syndrome (PCOS). The study included 91 females with PCOS and 99 healthy controls. Phenotypic hypera...

journal_title：Molecular medicine reports

authors： Baldani DP,Skrgatic L,Cerne JZ,Oguic SK,Gersak BM,Gersak K

更新日期：2015-05-01 00:00:00

abstract：:Vascular smooth muscle cell (VSMC) proliferation is a primary pathological event in the development of atherosclerosis (AS), and the presence of homocysteine (Hcy) acts as an independent risk factor for AS. However, the underlying mechanisms remain to be elucidated. Phosphatase and tensin homologue on chromosome 10 (P...

journal_title：Molecular medicine reports

authors： Ma SC,Zhang HP,Jiao Y,Wang YH,Zhang H,Yang XL,Yang AN,Jiang YD

更新日期：2018-04-01 00:00:00

abstract：:The present study investigated the role of microRNA (miR)‑146a in a diabetic nephropathy (DN) model, and its molecular mechanism. DN mice were given intraperitoneal injections of streptozotocin (55 mg/kg/day) for 5 consecutive days as an in vivo DN model. The HK‑2 human kidney cell line were exposed to 45% D‑glucose a...

journal_title：Molecular medicine reports

authors： Wan RJ,Li YH

更新日期：2018-03-01 00:00:00

abstract：:The aim of the present study was to determine the role of interleukin-6 (IL-6) in the epithelial-mesenchymal transition (EMT) of human intrahepatic biliary epithelial cell (HIBEC) lines in vitro. HIBECs were stimulated with IL-6 at concentrations of 0, 10, 20, 50 and 100 µg/l for 24 h. A wound healing and Transwell as...

journal_title：Molecular medicine reports

authors： Jiang GX,Cao LP,Kang PC,Zhong XY,Lin TY,Cui YF

更新日期：2016-02-01 00:00:00

abstract：:A limited number of studies have revealed that adding kidneys to liver perfusion may maintain an improved physiological balance; however, the underlying mechanism remains to be elucidated. The preset study confirmed the protective role of this new model and investigated the underlying mechanisms. Methods: A total of 1...

journal_title：Molecular medicine reports

authors： Li J,Jia J,He N,Jiang L,Yu H,Li H,Peng Y,Xie H,Zhou L,Zheng S

更新日期：2019-08-01 00:00:00