Increased expression of epidermal growth factor receptor and betacellulin during the early stage of gastric ulcer healing.

abstract：:Moutan cortex, the root bark of Paeonia suffruticosa Andrews (Paeoniaceae), is a traditional Chinese medicine widely used for the treatment of various diseases. In the present study, we examined the antiproliferative effect and apoptosis-inducing activity of paeonol and the crude total glycosides (CTG) extracted from ...

journal_title：Molecular medicine reports

authors： Xing G,Zhang Z,Liu J,Hu H,Sugiura N

更新日期：2010-01-01 00:00:00

abstract：:Diabetic cardiomyopathy (DCM) is a major cause of mortality in patients with diabetes, particularly those with type 2 diabetes. Long non‑coding RNAs (lncRNAs), including terminal differentiation‑induced lncRNA (TINCR), myocardial infarction‑associated transcript (MIAT) and H19, serve a key role in the regulation of DC...

journal_title：Molecular medicine reports

authors： Chen K,Ma Y,Wu S,Zhuang Y,Liu X,Lv L,Zhang G

更新日期：2019-08-01 00:00:00

abstract：:Derivatives of caffeoylquinic acid (CQA) have been studied and reported as potent bioactive molecules possessing various health benefits including antioxidant and anti‑inflammatory activities. In the present study, the protective effect of 3,5‑dicaffeoyl‑epi‑quinic acid (DCEQA) isolated from Atriplex gmelinii on UVB‑i...

journal_title：Molecular medicine reports

authors： Oh JH,Karadeniz F,Lee JI,Seo Y,Kong CS

更新日期：2019-07-01 00:00:00

abstract：:Radiotherapy is commonly used to treat thoracic malignancies, but often causes severe lung injury. Currently there are no effective protective strategies against radiation-induced lung injury (RILI). This study aimed to evaluate the ability of an angiogenesis antagonist, Endostar, against RILI, and the underlying mech...

journal_title：Molecular medicine reports

authors： Zhang K,Yang S,Zhu Y,Mo A,Zhang D,Liu L

更新日期：2012-08-01 00:00:00

abstract：:Systemic lupus erythematosus is a connective tissue disease characterized by autoimmune inflammation, which leads to specific and nonspecific immune disorders with the formation of various autoantibodies by activated B cells. B‑cell‑activating factor (BAFF) is secreted by macrophages and activated T cells, and is resp...

journal_title：Molecular medicine reports

authors： Ge F,Wang F,Yan X,Li Z,Wang X

更新日期：2017-11-01 00:00:00

abstract：:Adrenomedullin (ADM), initially identified in human pheochromocytoma, participates in a wide range of physiological and pathological processes, including vasorelaxation, angiogenesis and apoptosis. Recent studies have reported that ADM protected tumor cells against apoptotic cell de...

journal_title：Molecular medicine reports

authors： Kim JY,Park WD,Lee S,Park JH

更新日期：2012-11-01 00:00:00

abstract：:Cancer stem cells (CSCs) have been found to play a decisive role in cancer recurrence, metastasis, and chemo‑, radio‑ and immuno‑resistance. Understanding the mechanism of CSC self‑renewal and proliferation may help overcome the limitations of clinical treatment. The microenvironment of tumor growth consists of a lack...

journal_title：Molecular medicine reports

authors： Zhang Q,Han Z,Zhu Y,Chen J,Li W

更新日期：2021-01-01 00:00:00

abstract：:Prostate cancer is the second most common disease of the male reproductive system. Berberine is a quaternary ammonium salt that is extracted from plants. The aim of the current study was to explore the antitumor activity of berberine in prostate cancer cells and identify the underlying mechanism of its effects. PC3 hu...

journal_title：Molecular medicine reports

authors： Lu W,Du S,Wang J

更新日期：2015-05-01 00:00:00

abstract：:Low shear stress serves an important role in the initiation and progression of atherosclerotic lesions, with an impact on progression, but its detailed mechanisms are .not yet fully known. The present study aimed to investigate endothelial cell (EC) apoptosis, as well as monocyte adhesion induced by low shear stress a...

journal_title：Molecular medicine reports

authors： Xie X,Wang F,Zhu L,Yang H,Pan D,Liu Y,Qu X,Gu Y,Li X,Chen S

更新日期：2020-06-01 00:00:00

abstract：:The aim of the present study was to investigate the protective effect of puerarin on pelvic organ prolapse (POP) and the underlying mechanisms that regulate the metabolism of human parametrial ligament fibroblasts (HPLFs). HPLFs obtained from the pelvic tissue of patients with (n=10) or without (n=8) POP during hyster...

journal_title：Molecular medicine reports

authors： Li Y,Hong L,Liu C,Min J,Hong S,Hu M,Zhao Y,Yang Q,Tang J,He S

更新日期：2018-02-01 00:00:00

abstract：:Cytokines and their intercellular signals regulate the multipotency of mesenchymal stem cells (MSCs). The present study established the MSC lines SG‑2, ‑3, and ‑5 from the bone marrow of green fluorescent protein (GFP)‑transgenic mice. These cell lines clearly expressed mouse MSC markers Sca‑1 and CD44, and SG‑2 and ‑...

journal_title：Molecular medicine reports

authors： Sawada S,Chosa N,Takizawa N,Yokota J,Igarashi Y,Tomoda K,Kondo H,Yaegashi T,Ishisaki A

更新日期：2016-03-01 00:00:00

abstract：:The advanced glycosylation end product-specific receptor (RAGE) has been demonstrated to be an important mediator of asthma pathogenesis. The soluble isoform of RAGE (sRAGE) acts as a 'decoy' to sequester RAGE ligands, and thus prevents their binding to the receptor. A number of reports have linked deficiency of sRAGE...

journal_title：Molecular medicine reports

authors： Lyu Y,Zhao H,Ye Y,Liu L,Zhu S,Xia Y,Zou F,Cai S

更新日期：2018-03-01 00:00:00

abstract：:The pathogenesis and therapy of hypertrophic scars (HS) have not yet been established. The aim of the present study was to investigate the potential effect of naringenin on HS and its underlying mechanisms. The mouse model of HS was prepared by a mechanical stretch device and then treated with naringenin at various co...

journal_title：Molecular medicine reports

authors： Shan S,Zhang Y,Wu M,Yi B,Wang J,Li Q

更新日期：2017-10-01 00:00:00

abstract：:Abnormal paired box 9 (PAX9) expression is associated with tumorigenesis, cancer development, invasion and metastasis. The present study investigated the prognostic significance of PAX9 in esophageal squamous cell carcinoma (ESCC) and its role in predicting radiation sensitivity. A total of 52.8% (121/229) ESCC tissue...

journal_title：Molecular medicine reports

authors： Tan B,Wang J,Song Q,Wang N,Jia Y,Wang C,Yao B,Liu Z,Zhang X,Cheng Y

更新日期：2017-07-01 00:00:00

abstract：:A coma is a serious complication, which can occur following traumatic brain injury (TBI), for which no effective treatment has been established. Previous studies have suggested that neural electrical stimulation, including median nerve stimulation (MNS), may be an effective method for treating patients in a coma, and ...

journal_title：Molecular medicine reports

authors： Zhong YJ,Feng Z,Wang L,Wei TQ

更新日期：2015-09-01 00:00:00

abstract：:The aim of the current study was to investigate the biological effect on T24 cells and human umbilical vein endothelial cells (HUVECs) of transfection with brain-specific angiogenesis inhibitor-1 (BAI-1). The recombinant plasmid pReceiver-M61-BAI-1 was transfected into human superficial bladder tumor cells (T24) and H...

journal_title：Molecular medicine reports

authors： Tian DW,Hu HL,Sun Y,Tang Y,Lei MD,Liu LW,Han RF,Wu CL

更新日期：2016-08-01 00:00:00

abstract：:The echinoderm microtubule associated protein like 4‑anaplastic lymphoma kinase (EML4‑ALK) fusion is almost mutually exclusive to epidermal growth factor receptor (EGFR) or K‑RAS mutation in non‑small cell lung cancer (NSCLC), and it is extremely rare for patients to exhibit both mutations. The present study reported ...

journal_title：Molecular medicine reports

authors： Xu CW,Cai XY,Shao Y,Li Y,Shi MW,Zhang LY,Wang L,Zhang YP,Wang LP,Tian YW

更新日期：2015-09-01 00:00:00

abstract：:The aim of the present study was to examine the protective effects and mechanism of sika deer (Cervus nippon Temminck) velvet antler polypeptides (VAPs) against MPP+ exposure in the SH‑SY5Y human neuroblastoma cell line. MPP+ cytotoxicity and the protective effects of VAPs on the SH‑SY5Y cells were determined using an...

journal_title：Molecular medicine reports

authors： Xin JL,Zhang Y,Li Y,Zhang LZ,Lin Y,Zheng LW

更新日期：2017-10-01 00:00:00

abstract：:Obesity may induce end‑organ damage through metabolic syndrome, and autophagy serves a vital role in the pathogenesis of metabolic syndrome. The purpose of the present study was to define the roles of autophagy and mitophagy in high fat diet (HFD)‑induced cardiomyopathy. Male, 8 week‑old C57BL/6 mice were fed either a...

journal_title：Molecular medicine reports

authors： Che Y,Wang ZP,Yuan Y,Zhang N,Jin YG,Wan CX,Tang QZ

更新日期：2018-09-01 00:00:00

abstract：:Cochlear progenitor cells are considered as one of the best candidates for hair cell regeneration, thus, the regulation of cochlear progenitor cell proliferation has become a focus in this field. Several genes expressed in the inner ear during postnatal development have been demonstrated to be involved in maintaining ...

journal_title：Molecular medicine reports

authors： Song YL,Tian KY,Mi WJ,Ding ZJ,Qiu Y,Chen FQ,Zha DJ,Qiu JH

更新日期：2018-04-01 00:00:00

abstract：:The present study aimed to identify the mutation causing an atypical syndrome. High-resolution single nucleotide polymorphism (SNP) arrays are considered to be a major detection method for submicroscopic chromosomal rearrangements smaller than 5 Mb in size. Genomic DNA samples of the patient and his parents were conve...

journal_title：Molecular medicine reports

authors： Hu S,Yang Y,Liu L,Tan Z,Zhao T

更新日期：2017-05-01 00:00:00

abstract：:Gli proteins are key transcription factors of the Hedgehog (HH) signaling pathway, which is associated with tumorigenesis and drug resistance. However, the role of the HH signaling pathway in epithelial ovarian cancer (EOC) remains unclear. Studies have demonstrated that in some tumors, homeobox protein NANOG (NANOG),...

journal_title：Molecular medicine reports

authors： Zhao H,Li N,Pang Y,Zhao J,Wu X

更新日期：2021-02-01 00:00:00

abstract：:The aim of this study was to explore the effect of bisphenol A (BPA) on the EGFR-STAT3 pathway in breast cancer. We applied 3-(4,5-dimethylthiazol-2-yl)2,5-diphenyl tetrazolium bromide (MTT) cytotoxicity assay to the analysis of the responsiveness of MCF-7 cells to BPA. Gene expression was assayed at the transcription...

journal_title：Molecular medicine reports

authors： Zhang W,Fang Y,Shi X,Zhang M,Wang X,Tan Y

更新日期：2012-01-01 00:00:00

abstract：:Hemophagocytic lymphohistiocytosis (HLH) is a rare but severe disease characterized by immune hyperactivation and cytokine storm. Given the high mortality rate of HLH, there is a need for more effective diagnostic tools and treatments. The present study developed a dendrimer‑based protein biochip for rapid, sensitive ...

journal_title：Molecular medicine reports

authors： Du YX,Ye L,Song ZJ,Lv H,Liu Q,Li SG,Liu SS,Hong J,Gao Y,Schneider ME,Du WD

更新日期：2020-12-01 00:00:00

abstract：:GGsTOP is a novel and selective inhibitor of gamma-glutamyl transferase (GGT), a cell-surface enzyme that has a key role in glutathione homeostasis and the maintenance of cellular reactive oxygen species (ROS). ROS are essential for wound healing. However, little is known about the molecular mechanisms underlying the ...

journal_title：Molecular medicine reports

authors： Jiang Y,Wang X,Li Y,Mu S,Zhou S,Liu Y,Zhang B

更新日期：2016-05-01 00:00:00

abstract：:Obesity is marked by deposition of collagen I in adipose tissue. Toll like receptor (TLR)2 is involved in lipid metabolism, however the association between TLR2 and collagen I remains unclear. The present study was designed to investigate the effect of TLR2 knockout on collagen I in adipose tissue in obese mice. TLR2 ...

journal_title：Molecular medicine reports

authors： Song B,Zhang H,Zhang S

更新日期：2018-04-01 00:00:00

abstract：:Previous studies have reported that the Rho-associated coiled-coil containing protein kinase 2 (ROCKII) and glycogen synthase kinase‑3β (GSK)‑3β signaling pathways are involved in axonal regeneration. The present study investigated the effects of the combined application of Y27632 (a ROCKII inhibitor) and 4-benzyl-2‑m...

journal_title：Molecular medicine reports

authors： Zhang G,Lei F,Zhou Q,Feng D,Bai Y

更新日期：2016-12-01 00:00:00

abstract：:Spinal cord injury (SCI) is a cause of disability. The present study aimed to investigate the molecular mechanisms involved in traumatic SCI. Transcriptome data under accession no. GSE5296, including 96 chips, were downloaded from the Gene Expression Omnibus database. The raw data were normalized and differentially ex...

journal_title：Molecular medicine reports

authors： Zhao SJ,Zhou W,Chen J,Luo YJ,Yin GY

更新日期：2018-06-01 00:00:00

abstract：:Ectomesenchymal stem cells (EMSCs) represent a type of adult stem cells derived from the cranial neural crest. These cells are capable of self‑renewal and have the potential for multidirectional differentiation. Tissue transglutaminase type 2 (TG2) is a ubiquitously expressed member of the transglutaminase family of C...

journal_title：Molecular medicine reports

authors： Shi W,Que Y,Lv D,Bi S,Xu Z,Wang D,Zhang Z

更新日期：2019-09-01 00:00:00

abstract：:Cip1-interacting zinc finger protein 1 (CIZ1) is a nuclear protein that was observed to bind to p21Cip1/Waf1. p21Cip1/Waf1 regulates the cell cycle and is associated with colorectal cancer (CRC) progression. However, the effect of CIZ1 on CRC cells remains unclear. In the present study, CIZ1 was observed to be highly ...

journal_title：Molecular medicine reports

authors： Yin J,Wang C,Tang X,Sun H,Shao Q,Yang X,Qu X

更新日期：2013-12-01 00:00:00