Role of hypoxia inducible factor-1 in cancer stem cells (Review).

abstract：:Recent studies have reported structural and functional abnormalities in multiple brain regions of classical trigeminal neuralgia (CTN) patients. Differences in spontaneous neuronal activity between CTN patients and healthy subjects, however, remain unknown. The aim of the present study was to investigate alterations i...

journal_title：Molecular medicine reports

authors： Chen Y,Xiang CQ,Liu WF,Jiang N,Zhu PW,Ye L,Li B,Lin Q,Min YL,Su T,He LC,Shao Y

更新日期：2019-08-01 00:00:00

abstract：:Pneumonia accounts for ~1.3 million mortalities in children per year worldwide. MicroRNAs are implicated in several diseases, including cancer and pneumonia; however, the role of let7f‑5p in pneumonia is not completely understood. In the present study, lipopolysaccharide (LPS) was used to establish an in vitro pneumon...

journal_title：Molecular medicine reports

authors： Xu L,Song Q,Ouyang Z,Zhang X,Zhang C

更新日期：2021-02-01 00:00:00

abstract：:Hemophagocytic lymphohistiocytosis (HLH) is a rare but severe disease characterized by immune hyperactivation and cytokine storm. Given the high mortality rate of HLH, there is a need for more effective diagnostic tools and treatments. The present study developed a dendrimer‑based protein biochip for rapid, sensitive ...

journal_title：Molecular medicine reports

authors： Du YX,Ye L,Song ZJ,Lv H,Liu Q,Li SG,Liu SS,Hong J,Gao Y,Schneider ME,Du WD

更新日期：2020-12-01 00:00:00

abstract：:Cardiac stem cells (CSCs) can differentiate into cardiac muscle‑like cells; however, it remains unknown whether CSCs may possess the ability to differentiate into pacemaker cells. The aim of the present study was to determine whether angiotensin II (Ang II) could promote the specialization of CSCs into pacemaker‑like ...

journal_title：Molecular medicine reports

authors： Xue C,Zhang J,Lv Z,Liu H,Huang C,Yang J,Wang T

更新日期：2015-05-01 00:00:00

abstract：:The present study aimed to investigate the functional effects of microRNA‑195 on ovarian cancer cells and the underling mechanism involved. Reverse transcription‑quantitative polymerase chain reaction was used to measure the expression of microRNA‑195 in patients with ovarian cancer. Cell proliferation and apoptosis w...

journal_title：Molecular medicine reports

authors： Chen J

更新日期：2018-08-01 00:00:00

abstract：:Metabolic syndrome based on insulin resistance (IR) and hypertension is a risk factor for advanced liver disease and cardiovascular disease in patients with nonalcoholic steatohepatitis (NASH). The present study investigated the effects of severe hypertension induced by a high‑salt (HS) diet and antihypertensive thera...

journal_title：Molecular medicine reports

authors： Kozono M,Uto H,Ibusuki R,Arima S,Oda K,Taguchi H,Sasaki F,Nasu Y,Hashimoto S,Setoyama H,Kanmura S,Numata M,Tsubouchi H,Ido A

更新日期：2016-12-01 00:00:00

abstract：:Ginsenosides exhibit various neuroprotective effects against oxidative stress. However, which ginsenoside provides optimal effects for the treatment of neurological disorders as a potent antioxidant remains to be elucidated. Therefore, the present study investigated and compared the neuroprotective effects of the Rb1,...

journal_title：Molecular medicine reports

authors： Ye J,Yao JP,Wang X,Zheng M,Li P,He C,Wan JB,Yao X,Su H

更新日期：2016-04-01 00:00:00

abstract：:Endoplasmic reticulum (ER) stress plays a key role in the development of neurodegenerative diseases, including Parkinson's disease (PD). Sulforaphane (SF) is a natural drug derived from isothiocyanate found in cruciferous vegetables. Although there are reports indicating that SF is ...

journal_title：Molecular medicine reports

authors： Deng C,Tao R,Yu SZ,Jin H

更新日期：2012-07-01 00:00:00

abstract：:Portal hypertension (PHT) is one of the most severe consequences of liver cirrhosis. Carvedilol is a first‑line pharmacological treatment of PHT. However, the antifibrogenic effects of carvedilol on liver cirrhosis and the intrinsic mechanisms underlying these effects have not been thoroughly investigated. The present...

journal_title：Molecular medicine reports

authors： Ling L,Li G,Wang G,Meng D,Li Z,Zhang C

更新日期：2019-08-01 00:00:00

abstract：:Lung adenocarcinoma (AC) is one of the most deadly malignancies. The disease has a low five-year survival rate; therefore, the identification of novel therapeutic agents is required. This study aimed to investigate the effect of small interfering RNA (siRNA) targeting hypoxia‑inducible factor 1α (HIF‑1α) on the growth...

journal_title：Molecular medicine reports

authors： Liao HY,Wang GP,Huang SH,Li Y,Cai SW,Zhang J,Chen HG,Wu WB

更新日期：2014-03-01 00:00:00

abstract：:Autophagy is an evolutionarily conserved, multi-step lysosomal degradation process in which a cell degrades its own long-lived proteins and damaged organelles. Ataxia telangiectasia mutated (ATM) has recently been shown to upregulate the process of autophagy. Previous studies showed...

journal_title：Molecular medicine reports

authors： Qased AB,Yi H,Liang N,Ma S,Qiao S,Liu X

更新日期：2013-02-01 00:00:00

abstract：:Non‑alcoholic fatty liver disease (NAFLD) is the most common fatty liver disease in developed countries, in which fat accumulation in the liver is induced by non‑alcoholic factors. The present study was conducted to identify NAFLD‑associated long non‑coding RNAs (lncRNAs), mRNAs and microRNAs (miRNAs). The microarray ...

journal_title：Molecular medicine reports

authors： Wu H,Song X,Ling Y,Zhou J,Tao Z,Shen Y

更新日期：2019-04-01 00:00:00

abstract：:Recent evidence has suggested that microRNAs (miRs), which are a class of non-coding RNAs, serve diverse roles in tumorigenesis. However, the role of miR‑635 in osteosarcoma (OS) remains unknown. The present study revealed that miR‑635 may be a tumor suppressive miR. The expression of miR‑635 was significantly decreas...

journal_title：Molecular medicine reports

authors： Tian L,Guo Z,Wang H,Liu X

更新日期：2017-10-01 00:00:00

abstract：:The interaction between the host and human cytomegalovirus (HCMV) is important in determining the outcome of a viral infection. The HCMV RL13 gene product exerts independent, inhibitory effects on viral growth in fibroblasts and epithelial cells. At present, there are few reports on the interactions between the HCMV R...

journal_title：Molecular medicine reports

authors： Wang G,Ren G,Cui X,Lu Z,Ma Y,Qi Y,Huang Y,Liu Z,Sun Z,Ruan Q

更新日期：2016-03-01 00:00:00

abstract：:Deoxyribonuclease I (DNase I) is an endonuclease responsible for the destruction of chromatin during apoptosis. However, its role in diabetes remains unclear. The aim of the current study was to investigate the role of DNase I combined with high glucose levels in β‑cell apoptosis. Human samples were collected and the ...

journal_title：Molecular medicine reports

authors： Zhu B,Zhang L,Zhang YY,Wang L,Li XG,Liu T,Fu YK,Zheng YF,Li P,Zhao ZG

更新日期：2016-06-01 00:00:00

abstract：:Paraquat (PQ) poisoning‑induced pulmonary fibrosis is one of the primary causes of mortality in patients with PQ poisoning. The potential mechanism of PQ‑induced pulmonary fibrosis was thought to be mediated by inflammation. Recently, bone marrow‑derived mesenchymal stem cells (BMSCs) have been considered as a potenti...

journal_title：Molecular medicine reports

authors： Chen J,Si L,Zhou L,Deng Y

更新日期：2019-04-01 00:00:00

abstract：:The present study observed and compared the biological behaviour of HepG2 cells prior and subsequent to the overexpression of activating transcription factor 3 (ATF3). Experiments investigating the cytological function by which ATF3 affects liver cancer cells were also performed. MTT, Transwell and flow cytometry assa...

journal_title：Molecular medicine reports

authors： Li X,Zang S,Cheng H,Li J,Huang A

更新日期：2019-02-01 00:00:00

abstract：:B7-H4 is a co‑inhibitory molecule of the B7 family, which is expressed on antigen‑presenting cells (APCs) and is able to limit the T‑cell immune response. Macrophages act as professional APCs and are important for immunoregulation of the tumor microenvironment in breast cancer. In order to identify the association bet...

journal_title：Molecular medicine reports

authors： Liu L,Li D,Chen S,Zhao R,Pang D,Li D,Fu Z

更新日期：2016-09-01 00:00:00

abstract：:Lung fibrosis is associated with inflammation, apoptosis and oxidative damage. The transcription factor nuclear factor erythroid 2‑related factor‑2 (Nrf2) prevents damage to cells from oxidative stress by regulating the expression of antioxidant proteins. Sulforaphane (SFN), an Nrf2 activator, additionally regulates e...

journal_title：Molecular medicine reports

authors： Yan B,Ma Z,Shi S,Hu Y,Ma T,Rong G,Yang J

更新日期：2017-06-01 00:00:00

abstract：:Exploring the genetic basis for idiopathic congenital nystagmus is critical for improving our understanding of its molecular pathogenesis. In the present study, direct sequencing using gene specific primers was performed in order to identify the causative mutations in two brothers from a Chinese family who had been di...

journal_title：Molecular medicine reports

authors： Xiu Y,Yao Y,Yang T,Pan M,Yang H,Fang W,Gu F,Zhao J,Zhu Y

更新日期：2018-09-01 00:00:00

abstract：:Chronic myeloid leukemia (CML) was the first hematological malignancy to be associated with a specific genetic lesion. The Philadelphia translocation, producing a BCR‑ABL hybrid oncogene, is the most common mechanism of CML development. However, in the present study, b3a2, b2a2 and ela2 fusion junctions of the breakpo...

journal_title：Molecular medicine reports

authors： Zhou JB,Zhang T,Wang BF,Gao HZ,Xu X

更新日期：2013-02-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is a life‑threatening disease induced by the excessive proliferation and reduced apoptosis of pulmonary artery smooth muscle cells (PASMCs). Formononetin (FMN) is a natural isoflavone with numerous cardioprotective properties, which can inhibit the proliferation and induce the apo...

journal_title：Molecular medicine reports

authors： Cai C,Xiang Y,Wu Y,Zhu N,Zhao H,Xu J,Lin W,Zeng C

更新日期：2019-12-01 00:00:00

abstract：:Tongue squamous cell carcinoma (TSCC) is the most frequent type of oral cancer associated with high malignancy. Circular RNAs (circRNAs) are a form of non‑coding RNA with stable and conserved expression in mammalian cells. The aim of the present study was to investigate circRNAs expression profiles in TSCC, and examin...

journal_title：Molecular medicine reports

authors： Wei T,Ye P,Yu GY,Zhang ZY

更新日期：2020-04-01 00:00:00

abstract：:In contrast with mature brain‑derived neurotrophic factor (mBDNF), proBDNF induces cell apoptosis. However, the function of proBDNF in oligodendrocytes remains unclear. In the present study, the OLN‑93 oligodendroglia cell line was utilized as an in vitro model to analyse the functions of proBDNF in oligodendroglia. p...

journal_title：Molecular medicine reports

authors： Liu S,Guo W,Zhou H,Tang L,Feng S,Zhong JH,Zhou XF

更新日期：2018-10-01 00:00:00

abstract：:Constitutive photomorphogenic 1 (COP1) belongs to the COP‑de-etiolated (DET)‑fusca (FUS) protein family and has been demonstrated to suppress prostate adenocarcinomas and other types of tumor, such as liver and gastric cancer. The present study investigated the expression of COP1 and its downstream factor, ets variant...

journal_title：Molecular medicine reports

authors： Ta L,Xuan C,Xing N,Zhu X

更新日期：2016-08-01 00:00:00

abstract：:Through searching for anti‑neuroinflammatory metabolites from Nardostachys jatamansi extracts, nardostachin was revealed to exert anti‑neuroinflammatory effects against lipopolysaccharide (LPS)‑induced overproduction of nitric oxide and prostaglandin E2 in BV2 and rat primary microglial cells. Furthermore, nardostachi...

journal_title：Molecular medicine reports

authors： Kim DC,Park JS,Yoon CS,Kim YC,Oh H

更新日期：2021-01-01 00:00:00

abstract：:Wear particles serve a central role in periprosthetic osteolysis, which leads to the aseptic loosening of prostheses. In the present study a lentiviral vector was constructed to silence macrophage colony stimulating factor (M‑CSF) and receptor activator of nuclear factor κ‑B ligand (RANKL) genes, which synergistically...

journal_title：Molecular medicine reports

authors： Zhang Y,Jiang P,Li W,Liu X,Lu Y,Huang Z,Song K

更新日期：2017-12-01 00:00:00

abstract：:Heat shock protein 70 (HSP70) protects cardiac function against ischemia-reperfusion injury through gene transfection, although it is not a clinically practical and economical method. This study investigated whether heat stress-induced HSP70 protects heterotopically transplanted donor hearts. A total of 60 donor rats ...

journal_title：Molecular medicine reports

authors： Diao LW,Zhao LL,Qi F,Sun ZD,Zhang QH,Wu NS

更新日期：2012-10-01 00:00:00

abstract：:Pancreatic adenocarcinoma (PA) is a leading cause of adult cancer mortality, and surgery is still the best available treatment strategy. However, PA can recur at any time and has limited prognosis. It is therefore necessary to explore novel serum biomarkers of PA to allow the early diagnosis of PA. Soluble a-prolifera...

journal_title：Molecular medicine reports

authors： Han L,Zhang W,Song F,Guo Y,Guo K,Zhou W

更新日期：2014-10-01 00:00:00

abstract：:Acute lung injury (ALI) is a common complication following intestinal ischemia/reperfusion (I/R) and is a major contributing factor to its high mortality rate. Sirtuin 1 (SIRT1), a NAD+-dependent deacetylase, has been reported to have an important role in apoptosis inhibition, oxidative stress resistance and cell life...

journal_title：Molecular medicine reports

authors： Zhang F,Li ZL,Xu XM,Hu Y,Yao JH,Xu W,Jing HR,Wang S,Ning SL,Tian XF

更新日期：2015-01-01 00:00:00