Effect of puerarin on collagen metabolism of fibroblasts in pelvic tissue of women with pelvic organ prolapse.

abstract：:The effects of 9 calcium antagonists on ABCG2/BCRP-mediated resistance and transport were examined in HeLa and SN-38-resistant HeLa (HeLa/SN100) cells, overexpressing ABCG2/BCRP. Sensitivity to mitoxantrone, an ABCG2/BCRP substrate, in HeLa/SN100 cells was significantly reversed by ...

journal_title：Molecular medicine reports

authors： Takara K,Matsubara M,Yamamoto K,Minegaki T,Takegami S,Takahashi M,Yokoyama T,Okumura K

更新日期：2012-03-01 00:00:00

abstract：:The presence of excess glutamate in the brain interstitial fluid characterizes several acute pathological conditions of the brain, including traumatic brain injury and stroke. It has been demonstrated that it is possible to eliminate excess glutamate in the brain by decreasing blood glutamate levels and, accordingly, ...

journal_title：Molecular medicine reports

authors： Li Y,Hou X,Qi Q,Wang L,Luo L,Yang S,Zhang Y,Miao Z,Zhang Y,Wang F,Wang H,Huang W,Wang Z,Shen Y,Wang Y

更新日期：2014-01-01 00:00:00

abstract：:It is a challenge for dentists to save dental pulp in patients with pulp disease without resorting to root canal therapy. Formation of tertiary dentin to maintain pulp vitality is a key odontoblast response to dental pulp injury. Vascular endothelial growth factor (VEGF) is the most potent angiogenic and vasculogenic ...

journal_title：Molecular medicine reports

authors： Zhang J,Liu X,Yu W,Zhang Y,Shi C,Ni S,Liu Q,Li X,Sun Y,Zheng C,Sun H

更新日期：2016-01-01 00:00:00

abstract：:Upregulated gene 11 (URG11) represents a gene upregulated by hepatitis B virus X protein and is involved in the biological processes of multifarious tumors. The present study aimed to investigate the protective effects and regulatory mechanisms of URG11 in benign prostatic hyperplasia (BPH). URG11, Ras homolog family ...

journal_title：Molecular medicine reports

authors： Zhang G,Zhu F,Han G,Li Z,Yu Q,Li Z,Li J

更新日期：2018-07-01 00:00:00

abstract：:Circular RNAs (circRNAs) have been shown to be involved in the development of cancer. The aim of the present study was to investigate the role of circRNA SMARCA5 (cSMARCA5) in human cervical cancer. In the present study, cSMARCA5 expression was upregulated in cervical cancer tissues and cell lines. Furthermore, the pr...

journal_title：Molecular medicine reports

authors： Huang P,Qi B,Yao H,Zhang L,Li Y,Li Q

更新日期：2020-03-01 00:00:00

abstract：:Radix Polygalae is a traditional Chinese medicine that has been used as a sedative and to improve memory for a number of years. The impact of Radix Polygalae in patients with Alzheimer's disease has been investigated. However the mechanisms underlying its effects remain unclear. In the current study, the toxicity of v...

journal_title：Molecular medicine reports

authors： Zhao H,Wang ZC,Wang KF,Chen XY

更新日期：2015-08-01 00:00:00

abstract：:Hypoxia‑inducible factor‑1α (HIF‑1α) is key in tumor progression and aggressiveness as it regulates a series of genes involved in angiogenesis and anaerobic metabolism. Previous studies have shown that the transcriptional levels of HIF‑1α may be downregulated by endostatin. However, the molecular mechanism by which en...

journal_title：Molecular medicine reports

authors： Guo L,Chen Y,He T,Qi F,Liu G,Fu Y,Rao C,Wang J,Luo Y

更新日期：2015-05-01 00:00:00

abstract：:Cardiac stem cells (CSCs) can differentiate into cardiac muscle‑like cells; however, it remains unknown whether CSCs may possess the ability to differentiate into pacemaker cells. The aim of the present study was to determine whether angiotensin II (Ang II) could promote the specialization of CSCs into pacemaker‑like ...

journal_title：Molecular medicine reports

authors： Xue C,Zhang J,Lv Z,Liu H,Huang C,Yang J,Wang T

更新日期：2015-05-01 00:00:00

abstract：:Long non‑coding RNAs (lncRNAs) have been reported to serve a key role in a variety of cardiovascular diseases, including in cardiac fibrosis. The present study aimed to investigate the biological role and underlying mechanisms of the induction of cardiac fibroblasts by the lncRNA, RNA component of mitochondrial RNA pr...

journal_title：Molecular medicine reports

authors： Zhang SY,Huang SH,Gao SX,Wang YB,Jin P,Lu FJ

更新日期：2019-10-01 00:00:00

abstract：:Cellular prion protein (PrPC) can replace other pivotal molecules due to its interaction with several partners in performing a variety of important biological functions that may differ between embryonic and mature stem cells. Recent studies have revealed major advances in elucidating the putative role of PrPC in the r...

journal_title：Molecular medicine reports

authors： Yun SP,Han YS,Lee JH,Yoon YM,Yun CW,Rhee P,Lee SH

更新日期：2017-11-01 00:00:00

abstract：:Tongue squamous cell carcinoma (TSCC) is the most frequent type of oral cancer associated with high malignancy. Circular RNAs (circRNAs) are a form of non‑coding RNA with stable and conserved expression in mammalian cells. The aim of the present study was to investigate circRNAs expression profiles in TSCC, and examin...

journal_title：Molecular medicine reports

authors： Wei T,Ye P,Yu GY,Zhang ZY

更新日期：2020-04-01 00:00:00

abstract：:The chondrogenic differentiation of synovial mesenchymal stem cells (SMSCs) is regulated by essential transcription factors and signaling cascades. However, the precise mechanisms involved in this process remain unclear. MicroRNAs (miRs/miRNAs) are undersized non‑coding RNAs responsible for the post‑transcriptional re...

journal_title：Molecular medicine reports

authors： Cong R,Tao K,Fu P,Lou L,Zhu Y,Chen S,Cai X,Mao L

更新日期：2017-12-01 00:00:00

abstract：:High glucose (HG) in peritoneal dialysates has been demonstrated to induce extracellular matrix (ECM) synthesis by peritoneal mesothelial cells (PMCs) and to contribute to peritoneal fibrosis during continuous ambulatory peritoneal dialysis (CAPD). In the present study, we investigated the effects of pioglitazone, a p...

journal_title：Molecular medicine reports

authors： Zhou G,Su X,Ma J,Wang L,Li D

更新日期：2013-04-01 00:00:00

abstract：:Inflammatory bowel disease (IBD) is a type of chronic inflammatory disturbance that affects a number of individuals worldwide; the precise mechanism is unclear and treatment is frequently insufficient to maintain patients in remission. Saccharomyces boulardii is a thermophilic, non‑pathogenic yeast that may be adminis...

journal_title：Molecular medicine reports

authors： Zhou H,Zhang HJ,Guan L,Zhang YN,Li Y,Sun MJ

更新日期：2018-12-01 00:00:00

abstract：:The aim of the present study was to investigate the anticancer effects of resveratrol‑4‑O‑D-(2'‑galloyl)-glucopyranoside (REG) on leukemia and the mechanism underlying its effects. Three leukemia cell lines (HL‑60, Jurkat and U937) were used in this study. A Cell Counting kit‑8 assay was performed to evaluate the anti...

journal_title：Molecular medicine reports

authors： Chen P,Wang B,Pan B,Guo W

更新日期：2016-03-01 00:00:00

abstract：:Antimycin A (AMA) is an inhibitor of the electron transport chain in mitochondria. In this study, we investigated the anti-apoptotic effects of pan-caspase inhibitor (Z-VAD), superoxide dismutase (SOD) or catalase on AMA-induced HeLa cell death in relation to the cell cycle. Treatment with Z-VAD, SOD or catalase rescu...

journal_title：Molecular medicine reports

authors： Han YH,Kim SH,Kim SZ,Park WH

更新日期：2009-03-01 00:00:00

abstract：:Interleukin-33 (IL-33) promotes migration of cancer cells through downregulating the expression of E-cadherin. Previous studies have demonstrated that IL‑33 stimulates the proliferation of trophoblasts. However, the effect of IL‑33 on the adhesion and invasion of trophoblasts has not been investigated in detail. In th...

journal_title：Molecular medicine reports

authors： Wang XH,Liu W,Fan DX,Hu WT,Li MQ,Zhu XY,Jin LP

更新日期：2017-10-01 00:00:00

abstract：:Lung cancer is a leading cause of cancer-associated mortality worldwide. The cisplatin (DDP)‑based chemotherapy remains the foundation of treatment for the majority of patients affected by advanced non‑small cell lung cancer (NSCLC). However, DDP‑resistance limits the clinical utility of this drug in patients with adv...

journal_title：Molecular medicine reports

authors： Zuo Y,Yang D,Yu Y,Xiang M,Li H,Yang J,Li J,Jiang D,Zhou H,Xu Z,Yu Z

更新日期：2018-03-01 00:00:00

abstract：:The purpose of the present study was to investigate the effect of bufadienolides on the A‑375 melanoma cell line, and to delineate the underlying mechanism. A Cell Counting Kit‑8 assay was used to determine the viability of the cells, and flow cytometry was used to evaluate apoptosis. Western blot analysis was used to...

journal_title：Molecular medicine reports

authors： Li H,Cao X,Chen X,Yi X,Xia J,Chen J,Yang L

更新日期：2019-09-01 00:00:00

abstract：:Endothelial dysfunction and impaired endothelial regenerative capacity are key contributors to the high incidence of cardiovascular disease in patients with chronic kidney disease (CKD). Uremic toxins are associated with this pathogenesis. Previous studies have revealed that a uremic toxin, para‑cresol (p‑cresol), exe...

journal_title：Molecular medicine reports

authors： Pan L,Ye X,Ding J,Zhou Y

更新日期：2017-04-01 00:00:00

abstract：:OLIG1 is an oligodendrocyte (OL) transcription factor, which can contribute to the proliferation and differentiation of OLs, and the maturation of myelin. The aim of this study was to clarify the role of OLIG1 in neonatal Sprague Dawley rats with periventricular leukomalacia (PVL), induced by hypoxia‑ischemia (HI). Ne...

journal_title：Molecular medicine reports

authors： Cheng T,Xue X,Fu J

更新日期：2015-04-01 00:00:00

abstract：:The present study aimed to investigate the functional effects of microRNA‑195 on ovarian cancer cells and the underling mechanism involved. Reverse transcription‑quantitative polymerase chain reaction was used to measure the expression of microRNA‑195 in patients with ovarian cancer. Cell proliferation and apoptosis w...

journal_title：Molecular medicine reports

authors： Chen J

更新日期：2018-08-01 00:00:00

abstract：:Lung fibrosis is associated with inflammation, apoptosis and oxidative damage. The transcription factor nuclear factor erythroid 2‑related factor‑2 (Nrf2) prevents damage to cells from oxidative stress by regulating the expression of antioxidant proteins. Sulforaphane (SFN), an Nrf2 activator, additionally regulates e...

journal_title：Molecular medicine reports

authors： Yan B,Ma Z,Shi S,Hu Y,Ma T,Rong G,Yang J

更新日期：2017-06-01 00:00:00

abstract：:Wear particles serve a central role in periprosthetic osteolysis, which leads to the aseptic loosening of prostheses. In the present study a lentiviral vector was constructed to silence macrophage colony stimulating factor (M‑CSF) and receptor activator of nuclear factor κ‑B ligand (RANKL) genes, which synergistically...

journal_title：Molecular medicine reports

authors： Zhang Y,Jiang P,Li W,Liu X,Lu Y,Huang Z,Song K

更新日期：2017-12-01 00:00:00

abstract：:Liver-intestine cadherin (LI-cadherin), a novel member of the cadherin family, has been associated with the ability of a tumor to acquire an aggressive phenotype in several types of cancer. However, the exact function of LI-cadherin in the process of tumor invasion and metastasis remains predominantly unknown. To expl...

journal_title：Molecular medicine reports

authors： Yu Q,Shen W,Zhou H,Dong W,Gao D

更新日期：2016-05-01 00:00:00

abstract：:N-acetyl cysteine (NAC) has been extensively reported to exert neuroprotective effects on the central nervous system. Oxidative stress may contribute to the underlying mechanisms causing Alzheimer's disease (AD). The effect of NAC against oxidative stress injury was investigated in a cellular model of AD in the presen...

journal_title：Molecular medicine reports

authors： Wu W,Liu BH,Xie CL,Xia XD,Zhang YM

更新日期：2018-05-01 00:00:00

abstract：:Circular RNAs (circRNAs) are class of endogenous RNAs that have a role in the regulation of gene expression. The present study aimed to investigate the diagnostic value and role of circRNA in the pathogenesis of leukoaraiosis (LA). The present study performed Arraystar Human circRNA Array analysis of 6 samples from LA...

journal_title：Molecular medicine reports

authors： Mi T,Luo C,Hu Y,Qu C,Wang X,Guo S,Du Y

更新日期：2017-09-01 00:00:00

abstract：:The aim of the present study was to investigate the possible metabolic alterations in the frontal cortex and parietal white matter in patients with diabetic hypertension (DHT) using proton magnetic resonance (MR) spectroscopic imaging. A total of 33 DHT patients and 30 healthy control subjects aged between 45 and 75 w...

journal_title：Molecular medicine reports

authors： Cao Z,Ye BD,Shen ZW,Cheng XF,Yang ZX,Liu YY,Wu RH,Geng K,Xiao YY

更新日期：2015-06-01 00:00:00

abstract：:Pentatricopeptide repeat domain protein 3 (PTCD3) is a mitochondrial RNA‑binding protein that serves a role in mitochondrial translation. PTCD3 was originally reported as an oncogene that is involved in breast cancer and lymphoma. However, the expression and function of PTCD3 in prostate cancer (PCa) are unknown. Ther...

journal_title：Molecular medicine reports

authors： Huang Y,Jiang G,Liang X,Lan Z,Su Z,Wu H,Weng J,Jiang X

更新日期：2018-10-01 00:00:00

abstract：:Emerging evidence suggests that altered expression of microRNAs (miRNAs) is involved in cancer progression. However, the role of miR-125a-5p in gastric carcinogenesis remains unknown. Quantitative real-time PCR analysis revealed that the expression of miR-125a-5p was significantly decreased in >80% of gastric cancer t...

journal_title：Molecular medicine reports

authors： Xu Y,Huang Z,Liu Y

更新日期：2014-11-01 00:00:00