Silencing of URG11 expression inhibits the proliferation and epithelial‑mesenchymal transition in benign prostatic hyperplasia cells via the RhoA/ROCK1 pathway.

abstract：:The mechanisms underlying cancer radioresistance remain unclear. Several studies have found that increased glucose transporter‑1 (GLUT‑1) expression is associated with radioresistance. Recently, the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) pathway was reported to be involved in the control of GLUT‑1...

journal_title：Molecular medicine reports

authors： Fang J,Zhou SH,Fan J,Yan SX

更新日期：2015-03-01 00:00:00

abstract：:The production of reactive oxygen species (ROS) is a common phenomenon in podocyte impairment, which leads to the irreversible progression of chronic kidney diseases, such as diabetic kidney disease (DKD). Previous research has indicated that peroxisome proliferator‑activated receptor γ (PPARγ) coactivator‑1α (PGC‑1α)...

journal_title：Molecular medicine reports

authors： Zhang L,Liu J,Zhou F,Wang W,Chen N

更新日期：2018-03-01 00:00:00

abstract：:Prostate cancer (PCa) poses a high risk to older men and it is the second most common type of male malignant tumor in western developed countries. Additionally, there is a lack of effective therapies for PCa at advanced stages. Novel treatment strategies such as adenovirus‑mediated gene therapy and virotherapy involve...

journal_title：Molecular medicine reports

authors： Cai Z,Lv H,Cao W,Zhou C,Liu Q,Li H,Zhou F

更新日期：2017-11-01 00:00:00

abstract：:Peripheral artery disease (PAD) is a common manifestation of atherosclerosis. A number of emerging risk factors, including oxidative stress biomarkers, free radicals and heat shock proteins, may add to the established risk factors for cardiovascular disease (CVD). The present study assessed surrogate markers of oxidat...

journal_title：Molecular medicine reports

authors： Signorelli SS,Li Volsi G,Fiore V,Mangiafico M,Barbagallo I,Parenti R,Rizzo M,Li Volti G

更新日期：2016-10-01 00:00:00

abstract：:Physical exercise is beneficial for the functional recovery of neurons after stroke. It has been suggested that exercise regulates proliferation and differentiation of endogenous neural stem cells (NSCs); however, the underlying molecular mechanisms are still largely unknown. In the present study, the aim was to inves...

journal_title：Molecular medicine reports

authors： Liu W,Wu W,Lin G,Cheng J,Zeng Y,Shi Y

更新日期：2018-08-01 00:00:00

abstract：:Colorectal cancer (CRC) remains a primary contributor to cancer‑associated mortality. The Lin28/let‑7 axis has previously been verified to participate in numerous pathophysiological processes involved in CRC. However, the potential roles and underlying mechanisms of this axis in apoptosis during CRC remain to be fully...

journal_title：Molecular medicine reports

authors： Zhang H,Zong Y,Qiu G,Jia R,Xu X,Wang F,Wu D

更新日期：2018-04-01 00:00:00

abstract：:Owing to an oversight during the proof checking stage, the above article has been published with the incorrect author listed for correspondence. The first author, Chao Huang, is listed as the corresponding author, although he was only intended to have been temporarily assigned to handle queries during the pre-press st...

journal_title：Molecular medicine reports

authors： Huang C,Liu H,Gong X,Wen B,Chen D,Liu J,Hu F

更新日期：2016-12-01 00:00:00

abstract：:Buckwheat flour is well known for its highly antioxidative ingredient, rutin. We have undertaken to examine alterations in the characteristics of rutin treated with various proteins. In this study, the radical scavenging activities of a rutin-ovalbumin complex were examined. Dissolved rutin hydrate and ovalbumin were ...

journal_title：Molecular medicine reports

authors： Awatsuhara R,Harada K,Maeda T,Nomura T,Nagao K

更新日期：2010-01-01 00:00:00

abstract：:Malignant cancer is one of the most serious diseases threatening the health of human beings. Natural plant alkaloids exhibit multiple biological functions, including inhibition of cell proliferation, and may have potential anticancer activity. However, most natural alkaloids may not be suitable for human therapies owi...

journal_title：Molecular medicine reports

authors： Liu J,He Y,Zhang D,Cai Y,Zhang C,Zhang P,Zhu H,Xu N,Liang S

更新日期：2017-09-01 00:00:00

abstract：:In the present study, the effect of glucosamine administration (1.5 or 3 g/day) on cartilage and bone metabolism was investigated in bicycle racers, using cartilage‑ and bone‑specific biomarkers, including C‑terminal cross‑linked telopeptides of type II collagen (CTX‑II), C‑terminal...

journal_title：Molecular medicine reports

authors： Momomura R,Naito K,Igarashi M,Watari T,Terakado A,Oike S,Sakamoto K,Nagaoka I,Kaneko K

更新日期：2013-03-01 00:00:00

abstract：:β-elemene, a plant-derived drug extracted from Curcuma wenyujin, has demonstrated marked antiproliferative effects on glioblastoma, while toxicity remains low. However, the underlying molecular mechanisms of the antitumor activity of β-elemene remain to be elucidated. Previously, it was identified that the glia matura...

journal_title：Molecular medicine reports

authors： Zhu TZ,Li XM,Luo LH,Xu YH,Cao P,Liu Y,Liang GB

更新日期：2014-08-01 00:00:00

abstract：:The aim of the present study was to examine the protective effects and mechanism of sika deer (Cervus nippon Temminck) velvet antler polypeptides (VAPs) against MPP+ exposure in the SH‑SY5Y human neuroblastoma cell line. MPP+ cytotoxicity and the protective effects of VAPs on the SH‑SY5Y cells were determined using an...

journal_title：Molecular medicine reports

authors： Xin JL,Zhang Y,Li Y,Zhang LZ,Lin Y,Zheng LW

更新日期：2017-10-01 00:00:00

abstract：:Emerging evidence has suggested that intermedin (IMD), a novel member of the calcitonin gene‑related peptide (CGRP) family, has a wide range of cardioprotective effects. The present study investigated the effects of long‑term administration of IMD on cardiac function and sympathetic neural remodeling in heart failure ...

journal_title：Molecular medicine reports

authors： Xu B,Xu H,Cao H,Liu X,Qin C,Zhao Y,Han X,Li H

更新日期：2017-08-01 00:00:00

abstract：:Indoxyl sulfate (IS), a typical uremic toxin, is of great importance in the development of chronic kidney disease. In addition to its nephrotoxicity, previous studies have provided increasing evidence for its cardiovascular toxicity. The mechanism underlying IS‑induced cardiovascular toxicity has been elusive to date....

journal_title：Molecular medicine reports

authors： Tan X,Cao XS,Zhang P,Xiang FF,Teng J,Zou JZ,Ding XQ

更新日期：2018-12-01 00:00:00

abstract：:Roux-en-Y gastric bypass (RYGB) has become an effective treatment for type 2 diabetes mellitus (T2DM). However, the blood glucose mechanism involved remains unclear. In this study, 60 male Goto-Kakizaki (GK) rats were randomly divided into 6 groups (each with 10 rats): the GB1/2 gro...

journal_title：Molecular medicine reports

authors： Li J,Wang Y,Zhou Y,Liu J

更新日期：2012-11-01 00:00:00

abstract：:Thymidylate synthase, as a rate-limiting step in DNA synthesis, catalyses the conversion of dUMP into dTMP using 5,10-methylenotetrahydrofolate as the methyl donor. Two polymorphisms have been described in this gene: a repeat polymorphism in the 5' promoter enhancer region (3R versus 2R) and a 6 bp deletion in the 3' ...

journal_title：Molecular medicine reports

authors： Carmona B,Guerreiro C,Cravo M,Nobre-Leitão C,Brito M

更新日期：2008-09-01 00:00:00

abstract：:Full‑thickness and large area defects of articular cartilage are unable to completely repair themselves and require surgical intervention, including microfracture, autologous or allogeneic osteochondral grafts, and autologous chondrocyte implantation. A large proportion of regenerative cartilage exists as fibrocartila...

journal_title：Molecular medicine reports

authors： Li Z,Fei H,Wang Z,Zhu T

更新日期：2017-09-01 00:00:00

abstract：:p53 is a tumor suppressor gene whose mutation is highly associated with tumorigenesis. The present study investigated the role of p53β in the inhibition of proliferation of gastric cancer cell lines expressing wild-type or mutated p53. Wild-type p53 is expressed in MKN45 cells, but deleted in KATOIII cells, whereas mu...

journal_title：Molecular medicine reports

authors： Ji W,Ma J,Zhang H,Zhong H,Li L,Ding N,Jiao J,Gao Z

更新日期：2015-07-01 00:00:00

abstract：:The present study aimed to investigate the effects of cinobufacini injection on the proliferation and expression of topoisomerases in human HepG-2 hepatocarcinoma cells. The cells were divided into a control group and an experimental group, in which 0.105, 0.21, 0.42 mg/l cinobufacini was injected. Cell proliferation ...

journal_title：Molecular medicine reports

authors： Liu Y,Ban LY,Su X,Gao S,Liu JW,Cui XN

更新日期：2015-07-01 00:00:00

abstract：:Several studies have noted benign thecoma‑fibroma tumors with positive F‑18 fluorodeoxyglucose (FDG) accumulation mimicking malignant ovarian tumors following F‑18 FDG positron emission tomography (PET). The present study analyzed four cases with false‑positive F‑18 FDG PET/computed tomography (CT) diagnoses of thecom...

journal_title：Molecular medicine reports

authors： Seino H,Ono S,Miura H,Morohashi S,Wu Y,Tsushima F,Takai Y,Kijima H

更新日期：2016-05-01 00:00:00

abstract：:Advanced glycosylation end-product specific receptor (AGER) is a multi-ligand cell surface receptor abnormally expressed in lung cancer, and is a member of the immunoglobulin superfamily. Therefore, this study aimed to explore the effect of AGER on the biological behavior of non‑small cell lung cancer (NSCLC) H1299 ce...

journal_title：Molecular medicine reports

authors： Wang Q,Zhu W,Xiao G,Ding M,Chang J,Liao H

更新日期：2020-08-01 00:00:00

abstract：:Cyclin-dependent kinase inhibitor 3 (CDKN3) belongs to the dual-specificity protein phosphatase family, which is hypothesized to regulate cell cycle progression in tumor cells. However, whether CDKN3 is a potential therapeutic target for breast cancer remains to be elucidated. The present in vitro study aimed to inves...

journal_title：Molecular medicine reports

authors： Deng M,Wang J,Chen Y,Zhang L,Xie G,Liu Q,Zhang T,Yuan P,Liu D

更新日期：2016-08-01 00:00:00

abstract：:The thioredoxin (Trx) and peroxiredoxin (Prx) redox system is associated with neuronal damage and neuroprotective effects via the regulation of oxidative stress in brain ischemia. In the present study, ischemia-induced changes in the protein expression levels of Trx2 and Prx3 in the stratum pyramidale (SP) of the hipp...

journal_title：Molecular medicine reports

authors： Lee CH,Park JH,Cho JH,Ahn JH,Bae EJ,Won MH

更新日期：2015-08-01 00:00:00

abstract：:Hypertrophic cardiomyopathy (HCM) is a complex inherited cardiovascular disease. The present study investigated the long noncoding (lnc)RNA/microRNA (mi)RNA/mRNA expression pattern of patients with HCM and aimed to identify key molecules involved in the development of this condition. An integrated strategy was conduct...

journal_title：Molecular medicine reports

authors： Li J,Wu Z,Zheng D,Sun Y,Wang S,Yan Y

更新日期：2019-07-01 00:00:00

abstract：:Atorvastatin (Lipitor™) is a lipid‑lowering agent that is widely used in the treatment of cardiovascular diseases. Previous research has largely focused on its cholesterol‑lowering effects; however, a limited number of studies have investigated the actions of atorvastatin on vascular endothelial cells. In the present ...

journal_title：Molecular medicine reports

authors： Zhao WB,Fu H,Chang F,Liu J,Wang J,Li F,Zhao J

更新日期：2019-03-01 00:00:00

abstract：:Autophagy is a highly conserved pathway that permits recycling of nutrients within the cell and is rapidly upregulated during starvation or cell stress. Autophagy has been implicated in the pathophysiological process of warm ischemia‑reperfusion injury in the rat lung. Cold ischemia (CI) preservation for lung transpla...

journal_title：Molecular medicine reports

authors： Chen X,Wu JX,You XJ,Zhu HW,Wei JL,Xu MY

更新日期：2015-04-01 00:00:00

abstract：:Reactive oxygen species (ROS) are important in the development of diabetic testicular dysfunction. Overproduction of ROS promotes the process of apoptosis, which shows that there is a crosstalk between oxidative stress and apoptosis. Recent research has suggested that NADPH oxidase is the main source of ROS. In this s...

journal_title：Molecular medicine reports

authors： Li M,Liu Z,Zhuan L,Wang T,Guo S,Wang S,Liu J,Ye Z

更新日期：2013-01-01 00:00:00

abstract：:Saikosaponin‑d (SSd) the primary active component of triterpene saponin derived from Bupleurum falcatum L., possesses anti‑inflammatory and antioxidant properties. The present study aimed to examine the potential therapeutic effects of SSd on carbon tetrachloride (CCl4)‑induced acute hepatocellular injury in the HL‑77...

journal_title：Molecular medicine reports

authors： Lin L,Que R,Shen Y,Chen Y,Yan N,Li Y

更新日期：2018-06-01 00:00:00

abstract：:Oxidative stress is known to play a key role in the progression of liver disease, including non-alcoholic steatohepatitis (NASH), which is often accompanied by hyperglycemia. This study examined the influence of high glucose on oxidative stress-induced hepatic cell death. Hc cells, a normal human hepatocyte-derived ce...

journal_title：Molecular medicine reports

authors： Shibata H,Ichikawa T,Nakao K,Miyaaki H,Takeshita S,Akiyama M,Fujimoto M,Miuma S,Kanda S,Yamasaki H,Eguchi K

更新日期：2008-05-01 00:00:00

abstract：:MicroRNAs (miRNAs) are non‑coding RNAs of ~22 nucleotides in length, which serve an important role in numerous diseases. Asthma is a chronic airway inflammatory disease, which is the most common chronic disease among children. The role of miRNA (miR)‑16 in asthma is unclear. The objective of the present study was to e...

journal_title：Molecular medicine reports

authors： Yu B,Yao L,Liu C,Tang L,Xing T

更新日期：2019-05-01 00:00:00