Low‑dose halofuginone inhibits the synthesis of type I collagen without influencing type II collagen in the extracellular matrix of chondrocytes.

abstract：:Advanced glycation end products (AGEs) are a contributing factor in the angiogenesis that is characteristic of proliferative diabetic retinopathy. However, a previous study made a promising observation that domain I‑IV of β2‑glycoprotein I (DI‑IV) inhibits angiogenesis in human umbilical vein cells. The present study ...

journal_title：Molecular medicine reports

authors： Wang QQ,Zhou SJ,Meng ZX,Wang J,Chen R,Lv L,Li CJ,Yu DM,Yu P

更新日期：2015-03-01 00:00:00

abstract：:Galectin‑3, a galactoside‑binding protein, is highly expressed in carotid plaques and plays an important role in the atherosclerotic lesions. The phenotype transformation of vascular smooth muscle cells is the basic pathological change of atherosclerosis. This study investigated the effects of exogenous galectin‑3 on ...

journal_title：Molecular medicine reports

authors： Tian L,Chen K,Cao J,Han Z,Wang Y,Gao L,Fan Y,Wang C

更新日期：2017-06-01 00:00:00

abstract：:In this study, we aimed to explore the radio-sensitization of the SHG44 glioma cell line by Aidi injection and the possible mechanisms involved. The growth curve, cloning efficiency and divisional index of the SHG44 cell line were observed. The inhibition ratio was determined by MTT assay, the change in the cell cycle...

journal_title：Molecular medicine reports

authors： Xu XT,Song Y,Qin S,Wang LL,Zhou JY

更新日期：2012-06-01 00:00:00

abstract：:Macrophages can be polarized into the inflammatory M1 lineage or the immunomodulatory M2 lineage, depending on the differential tissue microenvironment signaling, specific pathogens or cytokine stimulation. Tumor necrosis factor α‑induced protein 8‑like protein 2 (TIPE2) has been demonstrated to negatively regulate in...

journal_title：Molecular medicine reports

authors： Jiang Y,Li Q,Zhang Y,Gao Y,Jiang L,Chen Z

更新日期：2018-01-01 00:00:00

abstract：:Schizophrenia (SZ) and cancer (Ca) have a broad spectrum of clinical phenotypes and a complex biological background, implicating a large number of genetic and epigenetic factors. SZ is a chronic neurodevelopmental disorder signified by an increase in the expression of apoptotic molecular signals, whereas Ca is convers...

journal_title：Molecular medicine reports

authors： Rizos E,Siafakas N,Skourti E,Papageorgiou C,Tsoporis J,Parker TH,Christodoulou DI,Spandidos DA,Katsantoni E,Zoumpourlis V

更新日期：2016-12-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most common type of brain cancer; it usually recurs and patients have a short survival time. The present study aimed to construct a gene expression classifier and to screen key genes associated with GBM prognosis. GSE7696 microarray data set included samples from 10 recurrent GBM t...

journal_title：Molecular medicine reports

authors： Yang H,Jin L,Sun X

更新日期：2019-03-01 00:00:00

abstract：:The hypoxic state of the brain tissue surrounding craniocerebral injury induces an increase in the secretion of HIF‑1α during the healing process. HIF‑1α can promote mesenchymal stem cell (MSC) migration to ischemic and hypoxic sites by regulating the expression levels of molecules such as stromal cell‑derived factor‑...

journal_title：Molecular medicine reports

authors： Xue Y,Li Z,Wang Y,Zhu X,Hu R,Xu W

更新日期：2020-10-01 00:00:00

abstract：:Gastric cancer (GC) has one of the highest mortality rates among all types of cancer in the world. At present, an efficient treatment for GC remains elusive. Studies have demonstrated that microRNAs (miRs) are abnormally expressed in cancer, and that these serve important roles in the development and metastasis of var...

journal_title：Molecular medicine reports

authors： Yin Y,Li X,Guo Z,Zhou F

更新日期：2019-11-01 00:00:00

abstract：:The aim of this study was to investigate the protective effect of erythropoietin (EPO) against acute myocardial injury and its underlying mechanisms. Mice (n=146) were randomly divided in a double‑blind manner into four groups, sham, Rocephin, EPO and sepsis, and mortality was observed on the seventh day after cecal l...

journal_title：Molecular medicine reports

authors： Zhang X,Dong S,Qin Y,Bian X

更新日期：2015-05-01 00:00:00

abstract：:The authors of the above article wish to retract their paper. Subsequently to its publication, in addition to certain irreconcilable differences in opinion shared among the authors, they have realized that, in their analysis of the role of peroxisome proliferator‑activated receptor γ in brain microvascular endothelial...

journal_title：Molecular medicine reports

authors： Xu M,Yang X,Zeng Q,He H,Lu P,Huang G

更新日期：2018-11-01 00:00:00

abstract：:Human amniotic epithelial cells (hAECs) have recently been recognized as a potential source of stem cells. The present study was designed to investigate the effects of mechanical stretch on the osteogenic differentiation of hAECs. As it has been previously reported that the physical environment is an important factor ...

journal_title：Molecular medicine reports

authors： Luan F,Ma K,Mao J,Yang F,Zhang M,Luan H

更新日期：2018-12-01 00:00:00

abstract：:Colorectal cancer (CRC) is one of the primary causes of cancer‑associated mortality worldwide. However, the potential molecular mechanism of CRC progression remains unknown. Long non‑coding RNA small nucleolar RNA host gene 20 (SNHG20) has been demonstrated to be involved in the development and progression of a variet...

journal_title：Molecular medicine reports

authors： Wang Y,Fu J,Yang L,Liang Z

更新日期：2021-01-01 00:00:00

abstract：:The present study characterizes the effects of resveratrol (Res) on vascular endothelial growth factor (VEGF) secretion in retinal pigment epithelial (RPE) cells. ARPE-19 cells were treated with CoCl2, a hypoxia mimetic agent. CoCl2 treatment increased protein levels of hypoxia inducible factor-1α (HIF-1α) and CXC-che...

journal_title：Molecular medicine reports

authors： Seong H,Ryu J,Jeong JY,Chung IY,Han YS,Hwang SH,Park JM,Kang SS,Seo SW

更新日期：2015-07-01 00:00:00

abstract：:MicroRNA (miR)-22 has previously been reported to be frequently downregulated in certain types of cancer. The present study examined the expression and effects of miR-22 in renal cell carcinoma (RCC). The results indicated that miR‑22 was downregulated in tumor tissue from patients with RCC. In addition, lower miR‑22 ...

journal_title：Molecular medicine reports

authors： Fan W,Huang J,Xiao H,Liang Z

更新日期：2016-06-01 00:00:00

abstract：:Growth arrest‑specific 5 (GAS5) is a known tumor suppressor which negatively regulates cell survival and malignancy in several cancer cell types. The present study aimed to establish the correlation between GAS5 and unc‑51 like autophagy activating kinase (ULK)1/2, two key regulators of autophagy initiation in breast ...

journal_title：Molecular medicine reports

authors： Li G,Qian L,Tang X,Chen Y,Zhao Z,Zhang C

更新日期：2020-09-01 00:00:00

abstract：:Potassium channels can be affected by epileptic seizures and serve a crucial role in the pathophysiology of epilepsy. Dimethylation of histone 3 lysine 9 (H3K9me2) and its enzyme euchromatic histone‑lysine N‑methyltransferase 2 (G9a) are the major epigenetic modulators and are associated with gene silencing. Insight i...

journal_title：Molecular medicine reports

authors： Zhang SP,Zhang M,Tao H,Luo Y,He T,Wang CH,Li XC,Chen L,Zhang LN,Sun T,Hu QK

更新日期：2018-01-01 00:00:00

abstract：:Intermittent fasting has been shown to have neuroprotective effects against transient focal cerebral ischemic insults. However, the effects of intermittent fasting on transient global ischemic insult has not been studied much yet. The present study examined effects of intermittent fasting on endogenous antioxidant enz...

journal_title：Molecular medicine reports

authors： Ahn JH,Noh Y,Shin BN,Kim SS,Park JH,Lee TK,Song M,Kim H,Lee JC,Yong JH,Kang IJ,Lee YL,Won MH,Kim JD

更新日期：2018-12-01 00:00:00

abstract：:Graft‑vs.‑host disease (GvHD) is a major and lethal complication of allogeneic bone marrow transplantation (allo‑BMT). Although great development has been made, the treatment progress of this disorder is slow. Research has illustrated that STAT3 was critical for T cell alloactivation in GvHD. In the present study, the...

journal_title：Molecular medicine reports

authors： Jia H,Cui J,Jia X,Zhao J,Feng Y,Zhao P,Zang D,Yu J,Zhao T,Wang H,Xu K

更新日期：2017-12-01 00:00:00

abstract：:Embryonic stem cells (ESCs) are pluripotent stem cells derived from early stage embryos. It remains unclear whether inhibiting the Wnt/β‑catenin signaling pathway using dickkopf Wnt signaling pathway inhibitor 1 (DKK1) impacts on the differentiation potential of mouse ESCs in vitro and in vivo. In the present study, i...

journal_title：Molecular medicine reports

authors： Ou L,Fang L,Tang H,Qiao H,Zhang X,Wang Z

更新日期：2016-01-01 00:00:00

abstract：:The baseline concentration of C-reactive protein (CRP) has been associated with a wide array of human diseases. In epidemiological studies and in the clinic, CRP is typically measured as a pentamer, composed of 5 identical CRP subunits. The present study aimed to determine whether other isoforms were present in the bl...

journal_title：Molecular medicine reports

authors： Li Q,Xu W,Xue X,Wang Q,Han L,Li W,Lv S,Liu D,Richards J,Shen Z,Ma L,Song Q

更新日期：2016-12-01 00:00:00

abstract：:Even though standard treatment options are available for prostate cancer patients, prostate cancer is still a leading cause of death in many Western countries due to drug resistance and recurrence. Immune checkpoint blockade therapy has been proved to be very effective in some melanoma patients, which might dependent ...

journal_title：Molecular medicine reports

authors： Zhou J,Yang T,Liu L,Lu B

更新日期：2017-09-01 00:00:00

abstract：:P-glycoprotein (P-gp) overexpression and tumor stem cells are thought to be important factors in the cross-resistance of cancer cells. There have been no studies on whether diallyl trisulfide (DATS) can reverse drug resistance in human osteosarcoma cells. In the present study, we demonstrated that DATS down-regulated ...

journal_title：Molecular medicine reports

authors： Li J,Liu W,Zhao K,Zhang Y,Li X,Yang Q,Li Z,Li J

更新日期：2009-03-01 00:00:00

abstract：:Theaflavin has been proven to own strong antioxidative capacity; however, the molecular mechanism underlying its protective effect against cerebral ischemia‑reperfusion (I/R) injury remains unclear. Therefore, the present study was designed to elucidate the neuroprotective effects of theaflavin on cerebral I/R injury ...

journal_title：Molecular medicine reports

authors： Li R,Li X,Wu H,Yang Z,Fei L,Zhu J

更新日期：2019-12-01 00:00:00

abstract：:The present study aimed to determine the intracellular localization of Cpn0425 in Chlamydophila pneumoniae-infected cells. The recombinant plasmid pGEX-6p/Cpn0425 was transformed into E.coli Bl21 cells to express the fusion protein. Following purification with glutathione S-transfer...

journal_title：Molecular medicine reports

authors： Liu L,You X,Chen L,Zeng Y,Tang S,Yu M,Wu Y,Xhen X

更新日期：2012-12-01 00:00:00

abstract：:Oxyresveratrol (ORES) is a natural phenolic compound with multiple biological functions including antioxidation, anti‑inflammation and neuroprotection; however, the inhibitory effect of ORES on osteosarcoma remains largely unknown. The present study aimed to determine the effects of ORES on osteosarcoma cell Saos‑2. C...

journal_title：Molecular medicine reports

authors： Lv T,Jian Z,Li D,Ao R,Zhang X,Yu B

更新日期：2020-12-01 00:00:00

abstract：:Previous studies have shown that long non‑coding RNAs (lncRNAs) serve important roles in necrotizing enterocolitis (NEC). However, the underlying mechanisms remain largely unknown. In order to examine the potential role of lncRNAs in NEC, the present study investigated lncRNA and mRNA expression profiles in NEC lesion...

journal_title：Molecular medicine reports

authors： Chen W,Yan X,Tian T,Yan R,Wang X,Yu Z,Li Y,Zhang L,Han S

更新日期：2020-07-01 00:00:00

abstract：:Plesiomonas shigelloides (P. shigelloides) is implicated as an aetiological agent of human gastroenteritis in humans, for which reliable laboratory detection of P. shigelloides is clinically and epidemiologically desirable. A simple molecular method for rapid detection of P. shigelloides using cross‑priming amplificat...

journal_title：Molecular medicine reports

authors： Meng S,Wang Y,Wang Y,Ye C

更新日期：2016-12-01 00:00:00

abstract：:Wilms tumor (WT) is the most common type of renal malignancy in children. Survival rates are low and high‑risk WT generally still carries a poor prognosis. To better elucidate the pathogenesis and tumorigenic pathways of high‑risk WT, the present study presents an integrated analysis of RNA expression profiles of high...

journal_title：Molecular medicine reports

authors： Wang X,Song P,Huang C,Yuan N,Zhao X,Xu C

更新日期：2019-03-01 00:00:00

abstract：:As demonstrated in previous studies, the phosphorylated form of 4E‑binding protein 1 (p‑4E‑BP1) may be a suitable tumor biomarker. The aim of the current study was to examine the expression status of p‑4E‑BP1 in colorectal cancer (CRC), in order to determine its clinical significance. The present study enrolled 89 pat...

journal_title：Molecular medicine reports

authors： Miao Y,Chen L,Shi C,Fan R,Chen P,Liu H,Xia A,Qian H

更新日期：2017-05-01 00:00:00

abstract：:Interleukin 17A (IL‑17A) exerts pleiotropic effects on periodontitis, partially through enhancement of alveolar bone loss. Osteoclasts are the main culprits that absorb alveolar bone. However, studies describing the correlation between IL‑17A and osteoclasts are not conclusive. Previously, autophagy was revealed to be...

journal_title：Molecular medicine reports

authors： Song L,Tan J,Wang Z,Ding P,Tang Q,Xia M,Wei Y,Chen L

更新日期：2019-06-01 00:00:00