Intermittent fasting increases SOD2 and catalase immunoreactivities in the hippocampus but does not protect from neuronal death following transient ischemia in gerbils.

abstract：:Aloperine (Alo), as a quinolizidine alkaloid extracted from S. alopecuroide, has the positive activities of anti-inflammatory, anti-allergenic, antitumor and anti-viral. However, the role and mechanism of Alo in breast cancer have not been studied yet. In the present study, Alo markedly inhibited the proliferation and...

journal_title：Molecular medicine reports

authors： Tian D,Li Y,Li X,Tian Z

更新日期：2018-10-01 00:00:00

abstract：:It is well known that the local renin-angiotensin system (RAS) is activated in the diabetic state, which results in an increase in the level of oxidative stress injury to pancreatic β cells. The angiotensin‑converting enzyme 2 (ACE2)/angiotensin (1‑7) [Ang (1‑7)]/Mas axis is a negative regulator of the classical renin...

journal_title：Molecular medicine reports

authors： Zhang F,Liu C,Wang L,Cao X,Wang YY,Yang JK

更新日期：2016-09-01 00:00:00

abstract：:Inflammatory and immune responses, as well as melatonin secretion, are affected by circadian regulation. Abnormal circadian rhythm of melatonin release has been reported to be associated with the later stages of sepsis; however, its role in the early stages of sepsis is unclear. We studied 11 septic and 11 non-septic ...

journal_title：Molecular medicine reports

authors： Li CX,Liang DD,Xie GH,Cheng BL,Chen QX,Wu SJ,Wang JL,Cho W,Fang XM

更新日期：2013-04-01 00:00:00

abstract：:The present study aimed to screen several differentially expressed genes (DEGs) and differentially expressed microRNAs (miRNAs) for two types of mesenchymal stem cell (MSC) differentiation. Bone morphogenetic protein 6 (BMP‑6) and dexamethasone were used to induce MSCs towards osteoblastic differentiation or adipocyti...

journal_title：Molecular medicine reports

authors： Xu X,Jiang H,Li X,Wu P,Liu J,Wang T,Zhou X,Xiong J,Li W

更新日期：2017-04-01 00:00:00

abstract：:Moscatilin is a bibenzyl derivative extracted from the Dendrobium aurantiacum var. denneanum, which has traditionally been used as an immunomodulatory treatment in China. The present study was designed to determine whether moscatilin is a pro‑apoptotic agent in pancreatic cancer, and to elucidate the underlying mechan...

journal_title：Molecular medicine reports

authors： Zhang L,Fang Y,Xu XF,Jin DY

更新日期：2017-03-01 00:00:00

abstract：:Currently, the role of tumor endothelial marker 8 (TEM8) in the occurrence, development, invasion and metastasis of lung cancer and its mechanism are poorly understood. The present study aimed to investigate the effects of TEM8 on proliferation, apoptosis, migration and invasion of XWLC‑05 lung cancer cells. The expre...

journal_title：Molecular medicine reports

authors： Gong Q,Liu C,Wang C,Zhuang L,Zhang L,Wang X

更新日期：2018-01-01 00:00:00

abstract：:Hemophagocytic lymphohistiocytosis (HLH) is a rare but severe disease characterized by immune hyperactivation and cytokine storm. Given the high mortality rate of HLH, there is a need for more effective diagnostic tools and treatments. The present study developed a dendrimer‑based protein biochip for rapid, sensitive ...

journal_title：Molecular medicine reports

authors： Du YX,Ye L,Song ZJ,Lv H,Liu Q,Li SG,Liu SS,Hong J,Gao Y,Schneider ME,Du WD

更新日期：2020-12-01 00:00:00

abstract：:Endothelial microparticles (EMPs) and endothelial cells (ECs) are involved in the pathophysiological mechanisms of sepsis and septic shock. EMPs are small vesicles released by ECs and are considered biomarkers for endothelial cell function and mediators for intercellular information exchange. However, the effect of EM...

journal_title：Molecular medicine reports

authors： Liu Y,Zhang R,Qu H,Wu J,Li L,Tang Y

更新日期：2017-03-01 00:00:00

abstract：:Doxorubicin (Dox)-induced cardiotoxicity has been a well‑known phenomenon to clinicians and scientists for decades. It has been confirmed that Dox‑dependent cardiotoxicity is accompanied by cardiac cellular senescence. However, the molecular mechanisms underlying Dox cardiotoxicity remains to be fully elucidated. Long...

journal_title：Molecular medicine reports

authors： Xie Z,Xia W,Hou M

更新日期：2018-02-01 00:00:00

abstract：:MicroRNAs (miRNAs) are single‑stranded RNA species that constitute a class of non‑coding RNAs, and are emerging as key regulators of gene expression. Since each miRNA is capable of regulating multiple genes, miRNAs are attractive markers for studies of coordinated gene expression. In this study, we investigated miRNA ...

journal_title：Molecular medicine reports

authors： Lee HY,Han SS,Rhee H,Park JH,Lee JS,Oh YM,Choi SS,Shin SH,Kim WJ

更新日期：2015-03-01 00:00:00

abstract：:Androgens are essential for the development of the prostate and prostate cancer. We examined androgen-regulated gene expression in the human prostate. Samples from benign and malignant prostate tissue and samples containing prostate tissue obtained from prostate cancer patients thre...

journal_title：Molecular medicine reports

authors： Vaarala MH,Hirvikoski P,Kauppila S,Paavonen TK

更新日期：2012-09-01 00:00:00

abstract：:As well-known regulators of gene expression, microRNAs (miRNAs) are important not only in cell proliferation and differentiation, but also in tumorigenesis and organ development. It has been estimated that miRNAs may be responsible for regulating the expression of almost one third of the human genome. Simultaneously, ...

journal_title：Molecular medicine reports

authors： Kan Q,Ding S,Yang Y,Zhou X

更新日期：2015-08-01 00:00:00

abstract：:Metabolic syndrome is a combination of medical disorders including hypertension, dyslipidemia, hyperglycemia, insulin resistance and increased waist circumference, and is associated with a higher risk of cardiovascular disease. An increase in adipose tissue mass is associated with t...

journal_title：Molecular medicine reports

authors： Pérez PM,Moore-Carrasco R,González DR,Fuentes EQ,Palomo IG

更新日期：2012-05-01 00:00:00

abstract：:Medulloblastoma is the most common malignant brain tumor of the central nervous system among children. Medulloblastoma is an embryonal tumor, of which little is known about the pathogenesis. Several efforts have been made to understand the molecular aspects of its tumorigenic pathways; however, these are poorly unders...

journal_title：Molecular medicine reports

authors： Dai J,Li Q,Bing Z,Zhang Y,Niu L,Yin H,Yuan G,Pan Y

更新日期：2017-06-01 00:00:00

abstract：:The aim of the current study was to implement whole transcriptome massively parallel sequencing (RNASeq) and copy number analysis to investigate the molecular biology of pancreatic ductal adenocarcinoma (PDAC). Samples from 16 patients with PDAC were collected by ultrasound‑guided biopsy or from surgical specimens for...

journal_title：Molecular medicine reports

authors： Di Marco M,Astolfi A,Grassi E,Vecchiarelli S,Macchini M,Indio V,Casadei R,Ricci C,D'Ambra M,Taffurelli G,Serra C,Ercolani G,Santini D,D'Errico A,Pinna AD,Minni F,Durante S,Martella LR,Biasco G

更新日期：2015-11-01 00:00:00

abstract：:Promoter hypermethylation is a marginal approach to inactivating tumor suppressor genes in cancer. DNA hypermethylation is a well-recognized epigenetic malfunction observed in several malignancies, most predominantly in prostate cancer. Aberrant DNA methylation patterns are considered to be the earliest somatic genome...

journal_title：Molecular medicine reports

authors： Syeed N,Syed Sameer A,Hamid A,Shah ZA,Afroze D,Rasool R,Siddiqi MA

更新日期：2010-09-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most malignant types of tumor worldwide with a high rate of mortality. Diosmetin (DIOS) exhibits various activities, including anticancer activities. However, the role of DIOS in the metastasis of HCC, and its underlying molecular mechanism, remain to be fully elucidated. I...

journal_title：Molecular medicine reports

authors： Liu J,Wen X,Liu B,Zhang Q,Zhang J,Miao H,Zhu R

更新日期：2016-03-01 00:00:00

abstract：:Osteosarcoma is the most common type of primary malignant tumor of the bone. However, mechanisms underlying osteosarcoma cell proliferation are poorly understood. The present study shows that RBEL1, a newly identified Rab-like GTPase, may be a key regulator of osteosarcoma cell proliferation. Knockdown of RBEL1 in ost...

journal_title：Molecular medicine reports

authors： Tang H,Ji F,Sun J,Xie Y,Xu Y,Yue H

更新日期：2016-02-01 00:00:00

abstract：:Chronic hepatitis B virus (HBV) infection is commonly considered to occur as a result of disturbance of the immune system. T-box expressed in T cells (T-bet) is an essential transcription factor for T helper (Th) cell differentiation and function. The aim of this study was to investigate the effect of T-bet overexpres...

journal_title：Molecular medicine reports

authors： Liu X,Tang Z,Zhang Y,Hu J,Li D,Zang G,Yu Y

更新日期：2012-08-01 00:00:00

abstract：:The co-delivery of a drug and a target gene has become a primary strategy in cancer therapy. Based on our previous study, a synthesized star‑shaped co‑polymer consisting of β‑cyclodextrin (CD) and a poly(L‑lysine) dendron (PLLD) was used to co-deliver docetaxel (DOC) and matrix metalloproteinase 9 (MMP‑9) small interf...

journal_title：Molecular medicine reports

authors： Liu T,Wu X,Wang Y,Hou X,Jiang G,Wu T,Xie H,Xie M

更新日期：2017-08-01 00:00:00

abstract：:Cardiac fibrosis is one of the pathological characteristics of diabetic cardiomyopathy (DbCM). Matrine treatment has proven to be effective in cases of organ fibrosis and cardiovascular diseases. In the present study, the anti-fibrosis-associated cardioprotective effects of matrine on DbCM were investigated. Rats with...

journal_title：Molecular medicine reports

authors： Zhang Y,Cui L,Guan G,Wang J,Qiu C,Yang T,Guo Y,Liu Z

更新日期：2018-01-01 00:00:00

abstract：:The present study was conducted to determine whether the activation of TRESK in the dorsal root ganglion (DRG) by the TRESK gene recombinant adenovirus vector inhibits the capsaicin-evoked substance P (SP) release using a radioimmunoassay. TRESK is an outwardly rectifying K+ current...

journal_title：Molecular medicine reports

authors： Zhou J,Yao SL,Yang CX,Zhong JY,Wang HB,Zhang Y

更新日期：2012-04-01 00:00:00

abstract：:Ovarian cancer is the most frequent cause of death among gynecological cancers. In the present study, the anti‑cancer effect of liriopesides B, a steroidal saponin from Liriope spicata var. prolifera, against A2780 cells was investigated. Transwell chambers were adopted to assess its effect on cell invasion and chemot...

journal_title：Molecular medicine reports

authors： Yu H,Wang H,Yin Y,Wang Z

更新日期：2020-09-01 00:00:00

abstract：:The synergistic mechanism underlying the effects of multi‑component combined drug use for complex diseases remains to be fully elucidated. Microglial activation following ischemia can either affect neural survival or cause neuronal injury. The aim of the present study was to determine the synergistic effect of genipos...

journal_title：Molecular medicine reports

authors： Wang J,Hou J,Lei H,Fu J,Pan Y,Liu J

更新日期：2015-10-01 00:00:00

abstract：:Brain metabolism is closely associated with neuronal activity and enables the accurate synthesis and function of neurotransmitters. Although previous studies have demonstrated that chronic stress is associated with the overproduction of reactive oxygen species (ROS), which leads to oxidative stress and the disruption ...

journal_title：Molecular medicine reports

authors： Herbet M,Natorska-Chomicka D,Korga A,Ostrowska M,Izdebska M,Gawrońska-Grzywacz M,Piątkowska-Chmiel I,Pawłowski K,Ślaska B,Poleszak E,Dudka J

更新日期：2019-03-01 00:00:00

abstract：:Although microRNA-296 (miR-296) has been studied in various types of human cancer, its expression, biological role and mechanism of action in pancreatic cancer remains to be elucidated. The aim of the current study was to investigate the expression level, possible roles and underlying molecular mechanisms of miR‑296 i...

journal_title：Molecular medicine reports

authors： Li H,Li J,Shi B,Chen F

更新日期：2017-07-01 00:00:00

abstract：:Physical exercise is beneficial for the functional recovery of neurons after stroke. It has been suggested that exercise regulates proliferation and differentiation of endogenous neural stem cells (NSCs); however, the underlying molecular mechanisms are still largely unknown. In the present study, the aim was to inves...

journal_title：Molecular medicine reports

authors： Liu W,Wu W,Lin G,Cheng J,Zeng Y,Shi Y

更新日期：2018-08-01 00:00:00

abstract：:Methylglyoxal (MGO)-induced carbonyl stress and pro-inflammatory responses have been suggested to contribute to endothelial dysfunction. Curcumin (Cur), a polyphenolic compound from Curcuma longa L., may protect endothelial cells against carbonyl stress-induced damage by trapping dicarbonyl compounds such as MGO. Howe...

journal_title：Molecular medicine reports

authors： Sun YP,Gu JF,Tan XB,Wang CF,Jia XB,Feng L,Liu JP

更新日期：2016-02-01 00:00:00

abstract：:Previous studies have shown that (GM3), a ganglioside, suppresses hepatoma cell motility and migration by inhibiting phosphorylation of EGFR and the activity of the PI3K/AKT signaling pathway. Therefore, the aim of the present study was to investigate whether the combined treatment of CD82 with gangliosides can exert ...

journal_title：Molecular medicine reports

authors： Huang X,Li Y,He X,Chen Y,Wei W,Yang X,Ma K

更新日期：2020-11-01 00:00:00

abstract：:Interleukin (IL)-1β-induced chondrocyte apoptosis is associated with the pathogenesis of arthritis. Platelet‑rich plasma (PRP), which is derived from the patient's own blood and contains numerous growth factors, has the potential for arthritis treatment. Therefore, the present study aimed to determine the effects of P...

journal_title：Molecular medicine reports

authors： Yang J,Lu Y,Guo A

更新日期：2016-11-01 00:00:00