Long non‑coding RNA SNHG20 promotes colorectal cancer cell proliferation, migration and invasion via miR‑495/STAT3 axis.

abstract：:Macrophages are involved in the progression of atherosclerosis by releasing pro-inflammatory cytokines. High levels of interleukin (IL)-18 are associated with an increased risk of developing diabetes and atherosclerosis. The present study aimed to investigate the association between IL-18, and high and fluctuating glu...

journal_title：Molecular medicine reports

authors： Zhang C,Bi Y,Jin G,Gan H,Yu L

更新日期：2015-08-01 00:00:00

abstract：:LEOPARD syndrome (LS) is an autosomal dominant inherited disorder primarily caused by mutations in the PTPN11, RAF1 and BRAF genes. Characteristic features include lentigines, craniofacial dysmorphism, myocardium or valve abnormalities, eletrocardiographic conduction defects and deafness. LS, neurofibromatosis type 1,...

journal_title：Molecular medicine reports

authors： Zhang J,Shen J,Cheng R,Ni C,Liang J,Li M,Yao Z

更新日期：2016-09-01 00:00:00

abstract：:Activation of renin-angiotensin system (RAS) is one of the pathological mechanisms associated with myocardial ischemia-reperfusion injury following resuscitation. The present study aimed to determine whether erythropoietin (EPO) improves post‑resuscitation myocardial dysfunction and how it affects the renin‑angiotensi...

journal_title：Molecular medicine reports

authors： Zhou H,Huang J,Zhu L,Cao Y

更新日期：2018-04-01 00:00:00

abstract：:Diabetic nephropathy (DN) is by far the most common cause of end‑stage renal disease (ESRD) in industrial countries, accounting for ~45% of all new ESRD cases in the United States. Grape seed proanthocyanidin extracts (GSPE) are powerful antioxidants, with an antioxidant ability 50‑fold greater than that of vitamin E ...

journal_title：Molecular medicine reports

authors： Gao Z,Liu G,Hu Z,Shi W,Chen B,Zou P,Li X

更新日期：2018-08-01 00:00:00

abstract：:Calcium is an important second messenger and it is widely recognized that acute lung injury (ALI) is often caused by oscillations of cytosolic free Ca2+. Previous studies have indicated that the activation of transient receptor potential‑vanilloid (TRPV) channels and subsequent Ca2+ entry initiates an acute calcium‑de...

journal_title：Molecular medicine reports

authors： Li C,Bo L,Liu Q,Liu W,Chen X,Xu D,Jin F

更新日期：2016-03-01 00:00:00

abstract：:Cardiac fibrosis is a deleterious effect of many cardiovascular diseases. Previous studies have shown that curcumin has exhibited protective effects on cardiovascular diseases. The aim of the present study was to evaluate the effects of curcumin on the activity of human cardiac fibroblasts (CFs) and to elucidate the u...

journal_title：Molecular medicine reports

authors： Fang G,Chen S,Huang Q,Chen L,Liao D

更新日期：2018-08-01 00:00:00

abstract：:Aldosterone has an important role in the progression of renal fibrosis. In the present study, the concentration of aldosterone and klotho (KL) in the serum of patients with chronic kidney disease (CKD) were analyzed. A negative correlation was observed between aldosterone and KL, suggesting that KL may serve a protect...

journal_title：Molecular medicine reports

authors： Lai L,Cheng P,Yan M,Gu Y,Xue J

更新日期：2019-03-01 00:00:00

abstract：:The aim of the current study was to investigate the role of phospholipase C (PLC)γ/protein kinase C (PKC)/C‑kinase‑activated protein phosphatase‑1 (CPI‑17) signaling pathways in uterine smooth muscle during parturition. Samples of uterine tissue were collected from pregnant patients who underwent a caesarean section f...

journal_title：Molecular medicine reports

authors： Chen J,Zheng D,Cui H,Liu S,Zhang L,Liu C

更新日期：2018-01-01 00:00:00

abstract：:Dengue virus (DENV) causes self‑limiting dengue fever (DF), severe dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). It is generally considered that cytokine storm leads to the increased plasma leakage characteristic of DHF/DSS. In the present study, peripheral blood m...

journal_title：Molecular medicine reports

authors： Qi Y,Li Y,Zhang L,Huang J

更新日期：2013-03-01 00:00:00

abstract：:Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates T-cell activation and Th1/Th2 cytokine production and is involved in the immune response against Hepatitis B virus (HBV) infection. To detect the association of the CTLA-4 gene polymorphisms with susceptibility to HBV infection a hospital-based case-contro...

journal_title：Molecular medicine reports

authors： Chen M,Chang Y,Tang F,Xie QH,Li J,Yang H,He XX,Lin JS

更新日期：2014-02-01 00:00:00

abstract：:Cerebral infarction is a cerebrovascular disease caused by local brain ischemic necrosis or softening, which is associated with diabetes, obesity, hypertension and rheumatic heart arrhythmia. Previous studies have indicated that aspirin is a potential oral anticoagulant in the treatment of cerebral ischemic stroke. Ho...

journal_title：Molecular medicine reports

authors： Wang X,Shen B,Sun D,Cui X

更新日期：2018-01-01 00:00:00

abstract：:To identify the key genes and pathways in the development of hepatocellular carcinoma (HCC) from hepatitis B virus (HBV)‑positive liver cirrhosis, differentially expressed genes (DEGs) between HCC and liver cirrhosis tissue samples from the GSE17548 gene expression profile dataset were screened. A total of 1,845 DEGs ...

journal_title：Molecular medicine reports

authors： Chen QF,Xia JG,Li W,Shen LJ,Huang T,Wu P

更新日期：2018-12-01 00:00:00

abstract：:Previous studies have demonstrated the overexpression of paired basic amino acid cleaving enzyme 4 (PACE4) mRNA in prostate cancer tissues. This overexpression is correlated with higher circulating protein levels in certain patients, however, the role of PACE4 in apoptosis and the potential molecular mechanisms of pan...

journal_title：Molecular medicine reports

authors： Tian XF,Huang GM,Zang HL,Cao H

更新日期：2016-12-01 00:00:00

abstract：:Sepsis is a leading killer of children worldwide with numerous differentially expressed genes reported to be associated with sepsis. Identifying core pathways in an individual is important for understanding septic mechanisms and for the future application of custom therapeutic decisions. Samples used in the study were...

journal_title：Molecular medicine reports

authors： Li B,Zeng Q

更新日期：2017-10-01 00:00:00

abstract：:Bone cancer pain (BCP) is a severe complication of advanced bone cancer. Although cannabinoid receptor 2 (CB2) agonists may have an analgesic effect, the underlying mechanism remains unclear. CB2 serves a protective role in various pathological states through the activation of autophagy. Therefore, the present study a...

journal_title：Molecular medicine reports

authors： Mao Y,Huang Y,Zhang Y,Wang C,Wu H,Tian X,Liu Y,Hou B,Liang Y,Rong H,Gu X,Ma Z

更新日期：2019-12-01 00:00:00

abstract：:Complement factor H‑related 3 (CFHR3) belongs to the human factor H protein family and is associated with various human diseases, including nephropathy, age‑related macular degeneration and atypical hemolytic uremic syndrome. However, to the best of our knowledge, the role of CFHR3 in hepatocellular carcinoma (HCC) re...

journal_title：Molecular medicine reports

authors： Liu H,Zhang L,Wang P

更新日期：2019-09-01 00:00:00

abstract：:The aim of the present was to evaluate the effects of DNA methylation and histone acetylation on 2,3,7,8‑tetrachlorodibenzo‑p‑dioxin (TCDD)‑induced cleft palate in fetal mice. Pregnant mice (n=10) were randomly divided into two groups: i) TCDD group, mice were treated with 28 µg/kg TCDD on gestation day (GD) 10 by ora...

journal_title：Molecular medicine reports

authors： Yuan X,Qiu L,Pu Y,Liu C,Zhang X,Wang C,Pu W,Fu Y

更新日期：2016-08-01 00:00:00

abstract：:Gastric cancer (GC) has one of the highest mortality rates among all types of cancer in the world. At present, an efficient treatment for GC remains elusive. Studies have demonstrated that microRNAs (miRs) are abnormally expressed in cancer, and that these serve important roles in the development and metastasis of var...

journal_title：Molecular medicine reports

authors： Yin Y,Li X,Guo Z,Zhou F

更新日期：2019-11-01 00:00:00

abstract：:Metastasis is the most lethal stage of cancer progression. The present study aimed to investigate the underlying molecular mechanisms of melanoma metastasis using bioinformatics. Using the microarray dataset GSE8401 from the Gene Expression Omnibus database, which included 52 biopsy specimens from patients with melano...

journal_title：Molecular medicine reports

authors： Chen J,Wu F,Shi Y,Yang D,Xu M,Lai Y,Liu Y

更新日期：2019-08-01 00:00:00

abstract：:Aldose reductase (AR) is involved in the pathogenesis of nonalcoholic steatohepatitis. This study aimed to determine the mechanism by which AR affects the development of murine diet-induced nonalcoholic steatohepatitis. Steatohepatitis was induced in C57BL/6 mice by administration of a methionine-choline-deficient (MC...

journal_title：Molecular medicine reports

authors： Chen T,Shi D,Chen J,Yang Y,Qiu M,Wang W,Qiu L

更新日期：2015-01-01 00:00:00

abstract：:Nerve growth factor (NGF) is expressed in the human corneal epithelium and stroma. It is an efficient therapy for human corneal ulcers caused by neurotropic disease. However, little is known about the molecular mechanism of NGF in healing human corneal epithelial diseases. Numerous microRNAs (miRNAs) are expressed in ...

journal_title：Molecular medicine reports

authors： Wu D,Qian T,Hong J,Li G,Shi W,Xu J

更新日期：2017-10-01 00:00:00

abstract：:Lung cancer is one of the primary causes of mortality worldwide and drug resistance is the key contributing factor which results in the failure of lung cancer chemotherapy. Previous studies have shown that microRNA (miR)‑10a was involved in the reversal of cisplatin (DDP) resistance in numerous types of tumors; howeve...

journal_title：Molecular medicine reports

authors： Sun W,Ma Y,Chen P,Wang D

更新日期：2015-05-01 00:00:00

abstract：:The present study aimed to investigate the expression of the Hedgehog (Hh) signaling pathway between microsatellite-unstable (MSI) and microsatellite-unstable (MSS) colorectal cancers (CRCs). A total of 61 samples of CRC tissue and corresponding blood samples were obtained from the surgical department of our hospital....

journal_title：Molecular medicine reports

authors： Hu X,Lai D,Chen W,Zi S,Li J,Du P,Wang Z,Huang S,Long C

更新日期：2011-09-01 00:00:00

abstract：:Bone injury following radiotherapy has been confirmed by epidemiological and animal studies. However, the underlying mechanism remains to be elucidated and no preventive or curative solution has been identified for this bone loss. The present study aimed to investigate the irradiation‑altered osteogenesis and adipogen...

journal_title：Molecular medicine reports

authors： Wang Y,Zhu G,Wang J,Chen J

更新日期：2016-01-01 00:00:00

abstract：:In recent years, accumulating evidence has demonstrated that microRNAs (miRs, miRNAs) may serve an important role in the occurrence and development of tumors. miR‑23a‑5p has been confirmed as an oncogene in numerous diseases through gene chip analysis. However, as the most common type of renal tumor, the expression an...

journal_title：Molecular medicine reports

authors： Quan J,Jin L,Pan X,He T,Lai Y,Chen P,Lin C,Yang S,Zeng H,Lai Y

更新日期：2017-08-01 00:00:00

abstract：:Vascular smooth muscle cells (VSMCs) are an important component of arterial walls, and their dysfunction may serve an important role in the development of cardiovascular diseases, including atherosclerosis and restenosis. Paeoniflorin (PF) is a principal component of the commonly used traditional Chinese medicine, peo...

journal_title：Molecular medicine reports

authors： Guo Y,Zhao Y,Li L,Wei X,Gao P,Zhou Y,Liu Y,Yang H

更新日期：2017-12-01 00:00:00

abstract：:Osteopetrosis is a monogenic condition with various inheritance patterns, including autosomal dominant, autosomal recessive and X‑linked. Several disease‑causing genes have been identified and three distinguished types of osteopetrosis have been reported. In the present study, a family with osteopetrosis was investiga...

journal_title：Molecular medicine reports

authors： Yang Y,Ye W,Guo J,Zhao L,Tu M,Zheng Y,Li L

更新日期：2019-01-01 00:00:00

abstract：:De novo sequence variants, including truncating and splicing variants, in the additional sex‑combs like 3 gene (ASXL3) have been described as the cause of Bainbridge‑Ropers syndrome (BRS). This pathology is characterized by delayed psychomotor development, severe intellectual disability, growth delay, hypotonia and fa...

journal_title：Molecular medicine reports

authors： Wayhelova M,Oppelt J,Smetana J,Hladilkova E,Filkova H,Makaturova E,Nikolova P,Beharka R,Gaillyova R,Kuglik P

更新日期：2019-07-01 00:00:00

abstract：:The present study aimed to investigate the effects of electrical stimulation (ES) on cell activity, cell cycle and apoptosis in injured rat dorsal root ganglion (DRG) cells induced by cyclic mechanical stretching (CMS). The present study also investigated whether the Wnt/β‑catenin pathway is involved in this process. ...

journal_title：Molecular medicine reports

authors： Hu M,Hong L,He S,Huang G,Cheng Y,Chen Q

更新日期：2020-06-01 00:00:00

abstract：:Obesity has a negative effect on ovarian functions, which is reported to increase the risk of infertility. The mechanism underlying obesity‑induced infertility is not yet clear. The present study established a high‑fat diet (HFD)‑induced obesity mouse model to elucidate the mechanisms underlying the effect of HFD‑indu...

journal_title：Molecular medicine reports

authors： Wu Y,Zhang Z,Liao X,Qi L,Liu Y,Wang Z

更新日期：2016-10-01 00:00:00