MicroRNA-22 is downregulated in clear cell renal cell carcinoma, and inhibits cell growth, migration and invasion by targeting PTEN.

abstract：:Our previous study demonstrated that human umbilical cord mesenchymal stem cells (HUMSCs) were capable of differentiation into germ cells in vitro. To assess this potential in vivo, HUMSCs were microinjected into the lumen of seminiferous tubules of immunocompetent mice, which were treated with busulfan to destroy end...

journal_title：Molecular medicine reports

authors： Chen H,Tang QL,Wu XY,Xie LC,Lin LM,Ho GY,Ma L

更新日期：2015-07-01 00:00:00

abstract：:Diabetic nephropathy (DN) is a serious complication of diabetes and can cause an increased mortality risk. It was previously reported that NLR family pyrin domain containing 3 (NLRP3) inflammasome is involved in the pathogenesis of diabetes. However, the underlying mechanism is not clearly understood. In the present s...

journal_title：Molecular medicine reports

authors： Qiao Y,Tian X,Men L,Li S,Chen Y,Xue M,Hu Y,Zhou P,Long G,Shi Y,Liu R,Liu Y,Qi Z,Cui Y,Shen Y

更新日期：2018-08-01 00:00:00

abstract：:The aim of the present study was to identify miRNAs that were differentially expressed in hepatocellular carcinoma (HCC) by comparing normal and cancer tissue samples and to analyze the correlation of the target genes and HCC. The gene expression profile of GSE31383 was downloaded from the Gene Expression Omnibus data...

journal_title：Molecular medicine reports

authors： Han K,Li J,Zhao H,Liang P,Huang X,Zheng L,Li Y,Yang T,Wang L

更新日期：2014-07-01 00:00:00

abstract：:P-glycoprotein (P-gp) overexpression and tumor stem cells are thought to be important factors in the cross-resistance of cancer cells. There have been no studies on whether diallyl trisulfide (DATS) can reverse drug resistance in human osteosarcoma cells. In the present study, we demonstrated that DATS down-regulated ...

journal_title：Molecular medicine reports

authors： Li J,Liu W,Zhao K,Zhang Y,Li X,Yang Q,Li Z,Li J

更新日期：2009-03-01 00:00:00

abstract：:The present study aimed to evaluate the effects of Krüppel‑like factor 2 (KLF2) on the differentiation of endothelial progenitor cells (EPCs) to endothelial cells (ECs) induced by shear stress, and to investigate the corresponding mechanisms. Cultured rat late EPCs were exposed to shear stress (12 dyn/cm2) for differe...

journal_title：Molecular medicine reports

authors： Chu HR,Sun YC,Gao Y,Guan XM,Yan H,Cui XD,Zhang XY,Li X,Li H,Cheng M

更新日期：2019-03-01 00:00:00

abstract：:The baseline concentration of C-reactive protein (CRP) has been associated with a wide array of human diseases. In epidemiological studies and in the clinic, CRP is typically measured as a pentamer, composed of 5 identical CRP subunits. The present study aimed to determine whether other isoforms were present in the bl...

journal_title：Molecular medicine reports

authors： Li Q,Xu W,Xue X,Wang Q,Han L,Li W,Lv S,Liu D,Richards J,Shen Z,Ma L,Song Q

更新日期：2016-12-01 00:00:00

abstract：:Endoplasmic reticulum stress (ERS) is correlated with insulin resistance and islet‑cell function. In the present study, the sub‑cellular localization and role of ER protein 29 (Erp29) were investigated in an in vitro ERS model of islet beta cells. The INS‑1 islet cell line was treated with various concentrations of tu...

journal_title：Molecular medicine reports

authors： Gao J,Zhang Y,Wang L,Xia L,Lu M,Zhang B,Chen Y,He L

更新日期：2016-01-01 00:00:00

abstract：:To investigate the genotype-phenotype correlation in Chinese familial and sporadic hypertrophic cardiomyopathy, specific exons of the myosin binding protein-c gene (MYBPC3) were screened in six families with hypertrophic cardiomyopathy (HCM; FHCM) and in 20 patients with sporadic HCM (SHCM) from the Anhui Province reg...

journal_title：Molecular medicine reports

authors： Wang AL,Kong DH,Chen DX,Wan J,Yu YX

更新日期：2010-09-01 00:00:00

abstract：:In the present study a rat model of oval cell‑mediated liver regeneration was constructed to examine the molecular mechanisms of matrine in oval cell‑mediated liver regeneration and the effects of matrine on hepatic function and the expression of OV6 protein and recombination signal sequence‑binding protein Jκ (RBP‑Jκ...

journal_title：Molecular medicine reports

authors： Yang ZY,Wang L,Hou YX,Wang XB

更新日期：2013-05-01 00:00:00

abstract：:Osteosarcoma, which is the most common type of primary bone tumor in adolescents, is characterized by complex genetic alterations and frequent resistance to conventional treatments. MicroRNAs (miRs) have emerged as fundamental regulators in gene expression through their ability to silence gene expression at post-trans...

journal_title：Molecular medicine reports

authors： Chen R,Li X,He B,Hu W

更新日期：2017-03-01 00:00:00

abstract：:In recent years hydrogen sulfide (H2S) has demonstrated vasculoprotective effects against cell death, which suggests its promising therapeutic potential for numerous types of disease. Additionally, a protective effect of exogenous H2S in HG‑induced injuries in HUVECs was demonstrated, suggesting a potential protective...

journal_title：Molecular medicine reports

authors： Lin J,Li X,Lin Y,Huang Z,Wu W

更新日期：2021-01-01 00:00:00

abstract：:Cardiac fibrosis is considered an important pathological mechanism in the progression of cardiac remodeling and heart failure. Astragaloside IV (AsIV) is a major active ingredient in Astragalus membranaceus. In a preliminary experiment, it was demonstrated that this naturally occurring substance exhibited cardioprotec...

journal_title：Molecular medicine reports

authors： Dai H,Jia G,Lu M,Liang C,Wang Y,Wang H

更新日期：2017-04-01 00:00:00

abstract：:There is a distinct lack of knowledge on the prevalence of skin disorders in Tuvalu. The aim of the current study was to assess the prevalence of cutaneous diseases and to evaluate access dermatological care in Tuvalu. Cutaneous disorders in the people of Tuvalu between 2009 and 2012 were examined. The most common ski...

journal_title：Molecular medicine reports

authors： Lan LJ,Lien YS,Wang SC,Ituaso-Conway N,Tsai MC,Tseng PY,Yeh YL,Chen CT,Lue KH,Chung JG,Hsiao YP

更新日期：2015-09-01 00:00:00

abstract：:Predominant T helper (Th)2 and impaired Th1 cell polarization has a crucial role in the development of asthma. Cluster of differentiation (CD)38 is associated with the increased release of interleukin (IL)‑12 from dendritic cells (DCs) and DC‑induced Th1 cell polarization. However, whether CD38 expression affects DC f...

journal_title：Molecular medicine reports

authors： Wang J,Zhu W,Chen Y,Lin Z,Ma S

更新日期：2016-11-01 00:00:00

abstract：:Lipopolysaccharide (LPS), the major outer surface membrane component of Gram-negative bacteria, is one of the main etiological factors in the pathogenesis of several lung diseases, such as chronic obstructive pulmonary disease. The respiratory epithelium and the macrophages comprise the dynamic interface between the o...

journal_title：Molecular medicine reports

authors： Liu X,Yin S,Chen Y,Wu Y,Zheng W,Dong H,Bai Y,Qin Y,Li J,Feng S,Zhao P

更新日期：2018-04-01 00:00:00

abstract：:Muscle atrophy is a disease that is usually caused by denervation. The aim of the present study was to determine whether electrical stimulation by semi-implantable electrodes is capable of decreasing the levels of specific proteins associated with sciatic nerve injury-induced muscle atrophy. Male Sprague Dawley (SD) r...

journal_title：Molecular medicine reports

authors： Liu J,Li K,Huang X,Xie J,Huang X

更新日期：2013-07-01 00:00:00

abstract：:In the past decade, a group of cases with persisting haemocytopenia were separated from those with idiopathic cytopenia of undetermined significance due to the optimal response of these patients to immunosuppression therapy and due to the detection of autoantibodies in the bone marrow of haemopoietic cells. This condi...

journal_title：Molecular medicine reports

authors： Chen J,Liu H,Li L,Wang H,Li Y,Wang Y,Ding K,Hao S,Shao Y,Li L,Song J,Wang G,Shao Z,Fu R

更新日期：2019-11-01 00:00:00

abstract：:Human glucose-6-phosphate dehydrogenase (G6PD) is a crucial enzyme in the pentose phosphate pathway, and serves an important role in biosynthesis and the redox balance. G6PD deficiency is a major cause of neonatal jaundice and acute hemolyticanemia, and recently, G6PD has been associated with diseases including inflam...

journal_title：Molecular medicine reports

authors： Chen L,Zhang C,Wang Y,Li Y,Han Q,Yang H,Zhu Y

更新日期：2017-08-01 00:00:00

abstract：:Lower back pain (LBP) is one of the predominant factors contributing to dyskinesia and remains a serious social and economic burden worldwide. Intervertebral disc degeneration (IDD) is the leading cause of LBP; the existing IDD treatments cannot completely prevent IDD. Circular RNAs (circRNAs) are non‑coding RNAs resu...

journal_title：Molecular medicine reports

authors： Li Y,Zhou S,Peng P,Wang X,Du L,Huo Z,Xu B

更新日期：2020-10-01 00:00:00

abstract：:In the present study, it was demonstrated that the protein level of the apoptosis inhibitor Aven is regulated by the Akt signaling pathway, evidenced by the observation that Aven levels were significantly increased in MCF7 constitutively active (CA)‑Akt cells and significantly inhibited following treatment with LY2940...

journal_title：Molecular medicine reports

authors： Han KY,Hwang JW,Bae GU,Kim SN,Kim YK

更新日期：2015-05-01 00:00:00

abstract：:Pirarubicin is frequently used in chemotherapy against tumors. However, clinical use is severely limited by the development of progressive dose-dependent cardiomyopathy and acquired drug resistance. LY294002 is a commonly used pharmacologic inhibitor, which selectively inhibits the phosphoinositide 3-kinase-AKT nexus....

journal_title：Molecular medicine reports

authors： Long XH,Zhong ZH,Peng AF,Zhu LB,Wang H,Zhang GM,Liu ZL

更新日期：2014-12-01 00:00:00

abstract：:Tanshinone IIA is the active compound isolated from Salvia miltiorrhiza bunge, which is a traditional Chinese medicine known as Danshen. The aim of the present study was to assess the effect of Tanshinone IIA on the regulation of lipid metabolism in the livers of hyperlipidemic rats and the underlying molecular events...

journal_title：Molecular medicine reports

authors： Jia L,Song N,Yang G,Ma Y,Li X,Lu R,Cao H,Zhang N,Zhu M,Wang J,Leng X,Cao Y,Du Y,Xu Y

更新日期：2016-06-01 00:00:00

abstract：:Pentatricopeptide repeat domain protein 3 (PTCD3) is a mitochondrial RNA‑binding protein that serves a role in mitochondrial translation. PTCD3 was originally reported as an oncogene that is involved in breast cancer and lymphoma. However, the expression and function of PTCD3 in prostate cancer (PCa) are unknown. Ther...

journal_title：Molecular medicine reports

authors： Huang Y,Jiang G,Liang X,Lan Z,Su Z,Wu H,Weng J,Jiang X

更新日期：2018-10-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have been investigated in the treatment of numerous autoimmune diseases. However, the immune properties of MSCs on the development of asthma have remained to be fully elucidated. Airway dendritic cells (DCs) have an important role in the pathogenesis of allergic asthma, and disrupting the...

journal_title：Molecular medicine reports

authors： Zeng SL,Wang LH,Li P,Wang W,Yang J

更新日期：2015-08-01 00:00:00

abstract：:Tissue-engineered bone substitutes are frequently used to repair bone defects. Adipose-derived stem cells (ASCs) are a promising source of cells for repairing bone tissue, however, insufficient osteogenic potency remains the main obstacle for their application. The present study aimed to enhance the osteogenic potency...

journal_title：Molecular medicine reports

authors： Wang Z,Zhang D,Hu Z,Cheng J,Zhuo C,Fang X,Xing Y

更新日期：2015-09-01 00:00:00

abstract：:Glucagon-like peptide-1 (GLP-1) analogues are likely to exert cardioprotective effects via balancing the energy metabolism in cardiomyocytes following ischemic or hypoxic insults. The present study aimed to explore the protective effects and mechanism of exendin-4, a GLP-1 analogue, on cardiomyocyte glucose uptake usi...

journal_title：Molecular medicine reports

authors： Lu K,Chang G,Ye L,Zhang P,Li Y,Zhang D

更新日期：2015-08-01 00:00:00

abstract：:Dendritic cells (DCs) serve crucial roles in the activation of the immune response, and imbalance in the activation or inhibition of DCs has been associated with an increased susceptibility to develop immune‑induced diseases. However, the molecular mechanisms of regulating immune‑induced diseases of DCs are not well u...

journal_title：Molecular medicine reports

authors： Zheng Y,Zheng X,Li S,Zhang H,Liu M,Yang Q,Zhang M,Sun Y,Wu J,Yu B

更新日期：2018-06-01 00:00:00

abstract：:High glucose (HG) in peritoneal dialysates has been demonstrated to induce extracellular matrix (ECM) synthesis by peritoneal mesothelial cells (PMCs) and to contribute to peritoneal fibrosis during continuous ambulatory peritoneal dialysis (CAPD). In the present study, we investigated the effects of pioglitazone, a p...

journal_title：Molecular medicine reports

authors： Zhou G,Su X,Ma J,Wang L,Li D

更新日期：2013-04-01 00:00:00

abstract：:A polymorphism within the 3'-UTR 8473T↷C of the cyclooxygenase-2 (COX-2) gene, which plays a role in gastrointestinal cancer development, has been associated with susceptibility to malignant disease. Here, we report on the interaction between the COX-2 3'-UTR T↷C polymorphism and gastric cancer development. DNA from 1...

journal_title：Molecular medicine reports

authors： Shibata T,Arisawa T,Tahara T,Hirata I,Nakano H

更新日期：2008-07-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) cells invade interstitial connective tissue and proliferate. Suppression of this invasion and proliferation could serve as a novel molecular therapy. Since insulin-like growth factor-I receptor (IGF-IR) interacts with components of interstitial tissue, we focused on the inhibition of IGF...

journal_title：Molecular medicine reports

authors： Tomizawa M,Yokosuka O

更新日期：2008-09-01 00:00:00