Effects of Tanshinone IIA on the modulation of miR‑33a and the SREBP‑2/Pcsk9 signaling pathway in hyperlipidemic rats.

abstract：:To determine the effect of thymosin α1 (Tα1) on the phenotypic and functional maturation of HL‑60 cells, freeze‑thaw antigen‑loaded dendritic cells (DCs) were derived from peripheral blood mononuclear cells (PBMCs) of children with acute lymphoblastic leukemia (ALL). The DCs were generated from the PBMC samples that w...

journal_title：Molecular medicine reports

authors： Li X,Liu X,Zhao Y,Zhong R,Song A,Sun L

更新日期：2015-10-01 00:00:00

abstract：:The aim of this study was to investigate the correlation between brain-derived neurotrophic factor (BDNF) expression and cognitive impairment in post‑stroke depression (PSD) rats and to explore the mechanism(s) involved in the process of cognitive impairment. A rat model of focal ce...

journal_title：Molecular medicine reports

authors： Zhang ZH,Wu LN,Song JG,Li WQ

更新日期：2012-10-01 00:00:00

abstract：:Ectomesenchymal stem cells (EMSCs) represent a type of adult stem cells derived from the cranial neural crest. These cells are capable of self‑renewal and have the potential for multidirectional differentiation. Tissue transglutaminase type 2 (TG2) is a ubiquitously expressed member of the transglutaminase family of C...

journal_title：Molecular medicine reports

authors： Shi W,Que Y,Lv D,Bi S,Xu Z,Wang D,Zhang Z

更新日期：2019-09-01 00:00:00

abstract：:Bladder cancer (BCa) is the most common tumor of the urinary system. Chronic inflammation in the papillary urothelial neoplasm of low malignant potential (PUNLMP)may contribute to carcinogenesis, including that of BCa, via poorly understood mechanisms. In this study, we show that the lymphotoxin β receptor (LTβR) is u...

journal_title：Molecular medicine reports

authors： Shen M,Duan X,Zhou P,Zhou W,Wu X,Xu S,Chen Y,Tao Z

更新日期：2015-02-01 00:00:00

abstract：:Cholangiocarcinoma is an intractable carcinoma originating from the bile duct epithelium. To gain an understanding of the cell biology of cholangiocarcinoma, in vitro cell culture is valuable. However, well‑characterized cell lines are limited. In the present study, the morphology of the TK cholangiocarcinoma cell lin...

journal_title：Molecular medicine reports

authors： Akiyoshi K,Kamada M,Akiyama N,Suzuki M,Watanabe M,Fujioka K,Ikeda K,Mizuno S,Manome Y

更新日期：2014-04-01 00:00:00

abstract：:The present study aimed to investigate the expression and function of aquaporin (AQP)9 in the intestinal tract of acute liver injury rat models. A total of 20 Sprague Dawley rats were randomly divided into four groups: Normal control (NC) group and acute liver injury groups (24, 48 and 72 h). Acute liver injury rat mo...

journal_title：Molecular medicine reports

authors： Xiang T,Ge S,Wen J,Xie J,Yang L,Wu X,Cheng N

更新日期：2018-12-01 00:00:00

abstract：:The corticotropin-releasing factor (CRF) family is involved in modulating gastrointestinal motility, sensitivity and inflammation. CRF signalling exerts an important role in inflammatory bowel disease (IBD), predominantly by activating CRF receptors. The aim of the present study was to investigate the function of CRF ...

journal_title：Molecular medicine reports

authors： Chen H,Shi H,Liu Y,Ren X,He S,Chang X,Yin Y

更新日期：2018-01-01 00:00:00

abstract：:Lupus nephritis (LN) is a common complication of systemic lupus erythematosus. The present study aimed to elucidate the protective effect of magnolol (MG) on the progression of LN, via inhibition of key signaling pathways. The results of the present study demonstrated that administration of MG caused inhibition of the...

journal_title：Molecular medicine reports

authors： Huang F,Zhang RY,Song L

更新日期：2017-10-01 00:00:00

abstract：:MicroRNAs (miRs) can lead to mRNA degradation or inhibit protein translation through directly binding to the 3'‑untranslational region (UTR) of their target mRNAs. Deregulation of miR‑10b has been reported to be associated with chondrosarcoma. However, the role of miR‑10b in chondrosarcoma cell migration and invasion,...

journal_title：Molecular medicine reports

authors： Aili A,Chen Y,Zhang H

更新日期：2016-01-01 00:00:00

abstract：:The problems of aging, obesity and a number of types of metabolic syndromes, including diabetes, are associated with a higher risk of non-alcoholic fatty liver disease (NAFLD). However, the mechanisms of occurrence and development of NAFLD in humans remain unclear. Sterol regulatory...

journal_title：Molecular medicine reports

authors： Tu K,Zheng X,Yin G,Zan X,Yao Y,Liu Q

更新日期：2012-09-01 00:00:00

abstract：:Radix Salviae miltiorrhizae (SM) and Lignum Dalbergiae odoriferae (DO) are traditional Chinese medicinal herbs used to treat ischemic heart disease and other cardiovascular diseases; however, to the best of our knowledge, there are currently few studies regarding their effects. The present study aimed to investigate t...

journal_title：Molecular medicine reports

authors： Mu F,Duan J,Bian H,Yin Y,Zhu Y,Wei G,Guan Y,Wang Y,Guo C,Wen A,Yang Y,Xi M

更新日期：2017-08-01 00:00:00

abstract：:Chronic constipation (CC) is a highly prevalent heterogeneous disorder. Although CC is not known to be associated with the development of serious disease or with excess mortality, it considerably reduces the patients quality of life. In addition, it represents an economic burden to patients and society. The majority o...

journal_title：Molecular medicine reports

authors： El-Salhy M,Svensen R,Hatlebakk JG,Gilja OH,Hausken T

更新日期：2014-01-01 00:00:00

abstract：:A previous study has demonstrated a progression in the nerve regeneration by polyaniline/cellulose (PANI/RC), although the underlying mechanism was not elucidated. In the present study, regenerated nerves were investigated, using histological techniques, functional assays and western blot analysis. The triceps surae m...

journal_title：Molecular medicine reports

authors： Fan L,Xiong Y,Fu Z,Xu D,Wang L,Chen Y,Xia H,Peng N,Ye S,Wang Y,Zhang L,Ye Q

更新日期：2017-11-01 00:00:00

abstract：:Clear-cell renal cell carcinoma (CCRCC) is the most frequent primary malignancy in the adult kidney. Most patients with advanced CCRCC have poor prognosis as CCRCC remains resistant to chemotherapy. The present study explored the possible mechanism underlying CCRCC resistance to chemotherapy and found that loss of PTE...

journal_title：Molecular medicine reports

authors： Chen J,Zhu H,Zhang Y,Cui MH,Han LY,Jia ZH,Wang L,Teng H,Miao LN

更新日期：2015-08-01 00:00:00

abstract：:Numerous mechanisms and factors have been implicated in liver damage; however, the involvement of autophagy and endoplasmic reticulum (ER) stress during early‑stage liver injury remains to be fully elucidated. The present study was conducted to determine the expression of autophagy and ER‑stress‑associated proteins in...

journal_title：Molecular medicine reports

authors： Shi T,Song W,Xu R

更新日期：2017-11-01 00:00:00

abstract：:The aim of the present study was to develop a reliable and reproducible canine model to mimic human diffuse hepatic vein obstruction (Budd‑Chiari syndrome, BCS). A total of 24 canines were divided into an experimental (n=18) and a control (n=6) group. Under the guidance of digital subtraction angiography, a balloon ca...

journal_title：Molecular medicine reports

authors： Shen B,Zhang Q,Wang X,Xu H,Zu M,Wu M,Gao Z,Wang W,Xiao J,Wang Y

更新日期：2014-02-01 00:00:00

abstract：:Curcumin is a well‑known phenolic substance and has many pharmacological effects associated with metabolism. However, the exact molecular mechanisms underlying this process have yet to be determined. The Notch pathway is a signal transduction pathway involved in energy metabolism. The present study aimed to investigat...

journal_title：Molecular medicine reports

authors： Zhao NJ,Liao MJ,Wu JJ,Chu KX

更新日期：2018-01-01 00:00:00

abstract：:Senescence is a result of cellular stress and is a potential mechanism for regulating cancer. As a member of the mitogen‑activated protein kinase family, ERK1/2 (extracellular signal‑regulated protein kinase) has an important role in delivering extracellular signals to the nucleus, and these signals regulate the cell ...

journal_title：Molecular medicine reports

authors： Zou J,Lei T,Guo P,Yu J,Xu Q,Luo Y,Ke R,Huang D

更新日期：2019-02-01 00:00:00

abstract：:Apoptosis serves a pivotal role in the pathogenesis of osteoarthritis (OA). Increasing evidence has demonstrated that paeoniflorin exerts key properties (including anticancer, anti-inflammation and neuroprotective) for clinical applications. However, the precise role of paeoniflorin in articular cartilage apoptosis re...

journal_title：Molecular medicine reports

authors： Hu PF,Chen WP,Bao JP,Wu LD

更新日期：2018-04-01 00:00:00

abstract：:Cisplatin‑based chemotherapy may greatly enhance patient prognosis; however, chemotherapy resistance remains an obstacle to curing patients with non‑small cell lung cancer (NSCLC). The aim of the present study was to explore the microRNAs (miRs) that could regulate cisplatin sensitivity and provide a potential treatme...

journal_title：Molecular medicine reports

authors： Chen X,Zhu H,Ye W,Cui Y,Chen M

更新日期：2019-02-01 00:00:00

abstract：:The present study aimed to reveal the underlying mechanism of angiotensin II (AngII)‑induced cardiac remodeling and to identify potential therapeutic targets for prevention. Rat cardiac fibroblasts (CFs) were cultured with 10 nM AngII for 12 h, and CFs without AngII were used as the control. Following RNA isolation fr...

journal_title：Molecular medicine reports

authors： Shu J,Liu Z,Jin L,Wang H

更新日期：2018-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) are frequently dysregulated in human cancer and can act as either potent oncogenes or tumor suppressor genes. The aberrant expression of miRNA‑409 (miR‑409) has been found in certain types of cancer, however, its expression and potential biological role in endometrial cancer remain to be fully eluci...

journal_title：Molecular medicine reports

authors： Zhang C,Wang B,Wu L

更新日期：2019-01-01 00:00:00

abstract：:Diabetes mellitus is known to cause kidney impairment; however, the mechanism remains elusive. The aim of this study was to investigate the role of C/EBP homologous protein (CHOP), an important protein in endoplasmic reticulum stress‑mediated mesangial cell apoptosis in hyperglycemia. Mesangial cells were cultured in ...

journal_title：Molecular medicine reports

authors： He D,Li J,Zhao J,Fei J,Zhang X

更新日期：2013-02-01 00:00:00

abstract：:To investigate the role of microRNA (miR)‑149 in the cardiac differentiation of mouse bone marrow mesenchymal stem cells (MSCs) in vitro, MSCs were infected with a lentivirus overexpressing miR‑149 and the effect on cardiac differentiation was determined. The quantitative polymerase chain reaction results demonstrated...

journal_title：Molecular medicine reports

authors： Lu M,Xu L,Wang M,Guo T,Luo F,Su N,Yi S,Chen T

更新日期：2018-06-01 00:00:00

abstract：:Hepatic stellate cells (HSCs) have an important role in liver fibrosis. Epithelial‑to‑mesenchymal transition (EMT), which is promoted by the Hedgehog (Hh) signaling pathway, is involved in the activation of HSCs. MicroRNAs (miRNAs/miRs) have been reported to be involved in the progression of liver fibrosis. A previous...

journal_title：Molecular medicine reports

authors： Yu F,Zheng Y,Hong W,Chen B,Dong P,Zheng J

更新日期：2015-12-01 00:00:00

abstract：:As the resident macrophages of the brain's innate immune system, microglial cells are key modulators in the neurodegenerative disease Alzheimer's disease (AD). In particular, the activation and accumulation of microglial cells around amyloid plaques is considered to result in chronic neuroinflammation. Although the pa...

journal_title：Molecular medicine reports

authors： Chen PL,Wang WJ,Rao YQ,Li J,Cheng MJ

更新日期：2018-04-01 00:00:00

abstract：:The present study aimed to identify the differentially expressed genes (DEGs) between lung adenocarcinoma and normal lung tissues, and between lung squamous cell carcinoma and normal lung tissues, with the purpose of identifying potential biomarkers for the treatment of lung cancer. The gene expression profile (GSE604...

journal_title：Molecular medicine reports

authors： Lu C,Chen H,Shan Z,Yang L

更新日期：2016-08-01 00:00:00

abstract：:Nestin, a type-VI intermediate filament protein, serves as a marker for neural stem cells, and is also known to be expressed in follicle stem cells. Hair follicles go through repeated cycles of anagen (growth), catagen (regression) and telogen (quiescence) throughout the life of mammals following morphogenesis. In the...

journal_title：Molecular medicine reports

authors： Chen R,Miao Y,Hu Z

更新日期：2019-01-01 00:00:00

abstract：:Arsenic trioxide (As2O3; ATO), a compound which is characterized by its ability to function as a potent anticancer agent, has been investigated in a variety of carcinomas. B7‑H4, a transmembrane protein, may inhibit the function of the T cell effector, and therefore, may be useful in investigating different types of t...

journal_title：Molecular medicine reports

authors： Cui L,Gao B,Cao Z,Chen X,Zhang S,Zhang W

更新日期：2016-03-01 00:00:00

abstract：:Cytokines and their intercellular signals regulate the multipotency of mesenchymal stem cells (MSCs). The present study established the MSC lines SG‑2, ‑3, and ‑5 from the bone marrow of green fluorescent protein (GFP)‑transgenic mice. These cell lines clearly expressed mouse MSC markers Sca‑1 and CD44, and SG‑2 and ‑...

journal_title：Molecular medicine reports

authors： Sawada S,Chosa N,Takizawa N,Yokota J,Igarashi Y,Tomoda K,Kondo H,Yaegashi T,Ishisaki A

更新日期：2016-03-01 00:00:00