Low expression of phosphatase and tensin homolog in clear‑cell renal cell carcinoma contributes to chemoresistance through activating the Akt/HDM2 signaling pathway.

abstract：:MicroRNA (miR)-185, which has been reported to be abnormally expressed in some types of cancer, exerts significant effects on the proliferation, apoptosis, drug resistance and metastasis of cancer cells. The present study aimed to explore the effects and underlying molecular mechanisms of miR‑185 upregulation on the a...

journal_title：Molecular medicine reports

authors： Fan L,Tan B,Li Y,Zhao Q,Yuan H,Liu Y,Wang D,Zhang Z

更新日期：2018-02-01 00:00:00

abstract：:This study investigated the role of microRNA-21 (miR-21) and microRNA-24 (miR-24) in the pathological processes that follow cerebral ischemic injury and examined the potential use of miR-21 and -24 in stroke diagnostics as sensitive plasma biomarkers. An oxygen-glucose deprivation (OGD) model was constructed using mou...

journal_title：Molecular medicine reports

authors： Zhou J,Zhang J

更新日期：2014-08-01 00:00:00

abstract：:Previously, we demonstrated that 8-methoxypsoralen (methoxsalen), a potent human cytochrome P450 2A6 (CYP2A6) inhibitor, strongly suppresses lung adenoma induction by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in female A/J mice. In the present study, we examined the inhibitory effects of methoxsalen on the ...

journal_title：Molecular medicine reports

authors： Takeuchi H,Saoo K,Matsuda Y,Yokohira M,Yamakawa K,Zeng Y,Kuno T,Kamataki T,Imaida K

更新日期：2009-07-01 00:00:00

abstract：:The aim of the present study was to identify candidate microRNAs (miRNAs) involved in the progression of renal fibrosis. Dataset GSE42716 of miRNAs extracted from kidneys from mice with unilateral ureteral obstruction (UUO), and mice without UUO was downloaded from the Gene Expression Omnibus database. The Limma packa...

journal_title：Molecular medicine reports

authors： Xin G,Zhou G,Zhang X,Wang W

更新日期：2017-09-01 00:00:00

abstract：:IQ motif containing GTPase activating protein 1 (IQGAP1) is a scaffold protein, which is aberrantly expressed in several tumor types and is closely associated with the development, metastasis and prognosis of cancer. Several studies have demonstrated that IQGAP1 has broad prospects in the basic and clinical research o...

journal_title：Molecular medicine reports

authors： Diao B,Liu Y,Zhang Y,Yu J,Xie J,Xu GZ

更新日期：2017-04-01 00:00:00

abstract：:As the resident macrophages of the brain's innate immune system, microglial cells are key modulators in the neurodegenerative disease Alzheimer's disease (AD). In particular, the activation and accumulation of microglial cells around amyloid plaques is considered to result in chronic neuroinflammation. Although the pa...

journal_title：Molecular medicine reports

authors： Chen PL,Wang WJ,Rao YQ,Li J,Cheng MJ

更新日期：2018-04-01 00:00:00

abstract：:Patients with skull base chordomas have a poor prognosis, and the role of the protein expression of brachyury in chordomas remains to be fully elucidated. The present study used immunohistochemistry to analyze 57 cases of skull base chordoma, and analyzed the clinical data of the patients. The results demonstrated tha...

journal_title：Molecular medicine reports

authors： Wang K,Tian K,Wang L,Wu Z,Ren C,Hao S,Feng J,Li J,Wan H,Jia G,Zhang L,Zhang J

更新日期：2015-09-01 00:00:00

abstract：:The multipotent and easily accessible characteristics of dental pulp stem cells (DPSCs) make them a promising target for bone tissue engineering. Long non‑coding RNAs (lncRNAs) have an important role in the osteogenic differentiation of mesenchymal stem cells. Nevertheless, whether lncRNAs are involved in the osteogen...

journal_title：Molecular medicine reports

authors： Tao R,Li YX,Liu YK,Liu F,Zhou ZY

更新日期：2019-04-01 00:00:00

abstract：:Paraquat (PQ) poisoning‑induced pulmonary fibrosis is one of the primary causes of mortality in patients with PQ poisoning. The potential mechanism of PQ‑induced pulmonary fibrosis was thought to be mediated by inflammation. Recently, bone marrow‑derived mesenchymal stem cells (BMSCs) have been considered as a potenti...

journal_title：Molecular medicine reports

authors： Chen J,Si L,Zhou L,Deng Y

更新日期：2019-04-01 00:00:00

abstract：:Human keratinocytes are located in the outermost skin layer and thus particularly vulnerable to ultraviolet B (UVB) radiation exposure. Previous studies have focused on the cellular and molecular perspectives of UVB-induced keratinocyte damage. In the present study, it was demonstrated that pretreatment with the phyto...

journal_title：Molecular medicine reports

authors： Cha HJ,Lee GT,Lee KS,Lee KK,Hong JT,Lee NK,Kim SY,Lee BM,An IS,Hahn HJ,Ahn KJ,Lee SJ,An S,Bae S

更新日期：2014-09-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) comprises a range of liver diseases, between steatosis and non‑alcoholic steatohepatitis and liver cirrhosis, which are closely associated with diabetes mellitus. Previous studies have indicated that oxidative stress is a key factor in the development of NAFLD. Molecular hydro...

journal_title：Molecular medicine reports

authors： Zhai X,Chen X,Lu J,Zhang Y,Sun X,Huang Q,Wang Q

更新日期：2017-03-01 00:00:00

abstract：:The extracellular signal-regulated kinase (ERK) signaling transduction pathway has been implicated in multiple physiological processes. It is not clear whether the ERK1/2 pathway participates in post-traumatic stress disorder (PTSD). The aim of this study was to provide novel insights into the mechanisms of how the am...

journal_title：Molecular medicine reports

authors： Xiao B,Han F,Wang HT,Shi YX

更新日期：2011-05-01 00:00:00

abstract：:Chronic myeloid leukemia (CML) was the first hematological malignancy to be associated with a specific genetic lesion. The Philadelphia translocation, producing a BCR‑ABL hybrid oncogene, is the most common mechanism of CML development. However, in the present study, b3a2, b2a2 and ela2 fusion junctions of the breakpo...

journal_title：Molecular medicine reports

authors： Zhou JB,Zhang T,Wang BF,Gao HZ,Xu X

更新日期：2013-02-01 00:00:00

abstract：:MicroRN-143 (miR‑143) has been previously reported to be downregulated in specific types of cancer, including colorectal, bladder, oral squamous cell, pituitary, cervical, nasopharyngeal, lymphoma and prostate cancer. In the present study, the effects of miR-143 on prostate cancer cell migration and invasion were exam...

journal_title：Molecular medicine reports

authors： Wu D,Huang P,Wang L,Zhou Y,Pan H,Qu P

更新日期：2013-08-01 00:00:00

abstract：:It has been suggested that survivin, a member of the inhibitor of apoptosis protein (IAP) family, is an attractive novel target for anticancer therapy. The present study investigated the expression of survivin during the early stages of hepatocellular carcinoma (HCC) and associated hepatitis, and attempted to elucidat...

journal_title：Molecular medicine reports

authors： Mamori S,Matsushima M,Matsuura T,Tajiri H

更新日期：2009-11-01 00:00:00

abstract：:Isoniazid (INH) and rifampicin (RIF) continue to be first line anti‑tuberculosis (TB) drugs. However, the use of these drugs is associated with hepatotoxicity. Nuclear factor‑κB (NF‑κB) plays a crucial role in regulating immunity and inflammation. It has been reported that pyrrolidine dithiocarbamate (PDTC), an inhibi...

journal_title：Molecular medicine reports

authors： He X,Song Y,Wang L,Xu J

更新日期：2020-01-01 00:00:00

abstract：:Twenty‑three clinical Streptococcus pneumoniae (SP) strains were isolated from blood and sputum specimens from the Second Affiliated Hospital of Wenzhou Medical College in 2009. These strains and the ATCC 49619 standard strain were cultured and suspended in normal saline (at a turbidity of 1.0 McFarland). The producti...

journal_title：Molecular medicine reports

authors： Zhang J,Hu DK,Wang DG,Liu Y,Liu CB,Yu LH,Qu Y,Luo XH,Yang JH,Yu J,Liu SC,Li XY

更新日期：2013-11-01 00:00:00

abstract：:Micro (mi)RNAs are short non‑coding RNA molecules, which post‑transcriptionally regulate gene expression and exert key roles in cell growth, differentiation and apoptosis. In the present study, the mechanism and the function of miR‑1915‑3p in the apoptotic regulation of lung cancer cell lines (NCI‑H441 and NCI‑H1650) ...

journal_title：Molecular medicine reports

authors： Xu C,Li H,Zhang L,Jia T,Duan L,Lu C

更新日期：2016-01-01 00:00:00

abstract：:LIM homeobox domain 6 (LHX6), a member of the LHX family of proteins, has been implicated in cancer development. However, the involvement of LHX6 in the development of breast cancer remains unclear. In the present study, the epigenetic regulation, biological function and associated molecular mechanisms of LHX6 in brea...

journal_title：Molecular medicine reports

authors： Hu Z,Xie L

更新日期：2015-09-01 00:00:00

abstract：:Cancer stem cells (CSCs) are proposed to be responsible for tumor recurrence, metastasis and the high mortality rate of cancer patients. Isolation and identification of CSCs is crucial for basic and preclinical studies. However, as there are currently no universal markers for the isolation and identification of CSCs i...

journal_title：Molecular medicine reports

authors： Wang L,Guo H,Lin C,Yang L,Wang X

更新日期：2014-06-01 00:00:00

abstract：:Exploring the genetic basis for idiopathic congenital nystagmus is critical for improving our understanding of its molecular pathogenesis. In the present study, direct sequencing using gene specific primers was performed in order to identify the causative mutations in two brothers from a Chinese family who had been di...

journal_title：Molecular medicine reports

authors： Xiu Y,Yao Y,Yang T,Pan M,Yang H,Fang W,Gu F,Zhao J,Zhu Y

更新日期：2018-09-01 00:00:00

abstract：:It has been previously reported that increased expression of coiled‑coil domain containing 34 (CCDC34), a member of the CCDCs family, may promote the proliferation and invasion of bladder cancer cells. However, its role in colorectal cancer (CRC) remains unclear. The present study investigated CCDC34 expression in CRC...

journal_title：Molecular medicine reports

authors： Geng W,Liang W,Fan Y,Ye Z,Zhang L

更新日期：2018-01-01 00:00:00

abstract：:Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates T-cell activation and Th1/Th2 cytokine production and is involved in the immune response against Hepatitis B virus (HBV) infection. To detect the association of the CTLA-4 gene polymorphisms with susceptibility to HBV infection a hospital-based case-contro...

journal_title：Molecular medicine reports

authors： Chen M,Chang Y,Tang F,Xie QH,Li J,Yang H,He XX,Lin JS

更新日期：2014-02-01 00:00:00

abstract：:Cell division cycle 42 (CDC42), which is a member of the Rho GTPase family, has been reported to regulate the metastasis of various human cancer cells; however, the role of CDC42 in gastric cancer (GC) remains unclear. The present study aimed to investigate the effects of CDC42 on the proliferation, migration and inva...

journal_title：Molecular medicine reports

authors： Du DS,Yang XZ,Wang Q,Dai WJ,Kuai WX,Liu YL,Chu D,Tang XJ

更新日期：2016-01-01 00:00:00

abstract：:The aim of the present study was to investigate the effects of high mobility group protein B1 (HMGB1), which is expressed in the serum of patients with sepsis, on vascular endothelial permeability. Sera from patients with sepsis were used to treat endothelial cells (ECs), and the effect on endothelial permeability was...

journal_title：Molecular medicine reports

authors： Zheng YJ,Xu WP,Ding G,Gao YH,Wang HR,Pan SM

更新日期：2016-01-01 00:00:00

abstract：:Fine particulate matter (PM2.5) has been linked to exacerbation of allergic airway inflammation in mice. However, the mechanism underlying exposure to PM2.5 and subsequent and adverse effects remains to be fully elucidated. Therefore, the present study aimed to investigate the effects of PM2.5 by different levels on a...

journal_title：Molecular medicine reports

authors： Liu Y,Feng GZ,Du Q,Jin XX,Du XR

更新日期：2017-10-01 00:00:00

abstract：:Neuregulin-1 (NRG-1) is a type of epidermal growth factor‑like protein primarily distributed in the nervous and cardiovascular systems. When sepsis occurs, the incidence of cardiac dysfunction in myocardial injury is high and the mechanism is complicated. It directly causes myocardial cell damage, whilst also causing ...

journal_title：Molecular medicine reports

authors： Kang W,Cheng Y,Wang X,Zhou F,Zhou C,Wang L,Zhong L

更新日期：2020-06-01 00:00:00

abstract：:Previous studies have demonstrated the overexpression of paired basic amino acid cleaving enzyme 4 (PACE4) mRNA in prostate cancer tissues. This overexpression is correlated with higher circulating protein levels in certain patients, however, the role of PACE4 in apoptosis and the potential molecular mechanisms of pan...

journal_title：Molecular medicine reports

authors： Tian XF,Huang GM,Zang HL,Cao H

更新日期：2016-12-01 00:00:00

abstract：:The use of human bone marrow mesenchymal stem cells (hBMSCs) as a tissue engineering application for individuals affected by osteoporosis and other types of bone loss diseases has been well studied in recent years. The osteogenic differentiation of hBMSCs can be regulated by a number of cues. MicroRNAs (miRNAs/miRs) s...

journal_title：Molecular medicine reports

authors： Zhang Y,Zhou L,Zhang Z,Ren F,Chen L,Lan Z

更新日期：2020-07-01 00:00:00

abstract：:Several environmental contaminants have been linked to the development of diabetes and increased diabetes‑associated mortality. Perfluorooctanoic acid (PFOA) is a widely used perfluoroalkane found in surfactants and lubricants, and in processing aids used in the production of polymers. Furthermore, PFOA has been detec...

journal_title：Molecular medicine reports

authors： Suh KS,Choi EM,Kim YJ,Hong SM,Park SY,Rhee SY,Oh S,Kim SW,Pak YK,Choe W,Chon S

更新日期：2017-06-01 00:00:00